{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:21:49Z","timestamp":1790446909270,"version":"4.1.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Fundacion Caja Rural Asturial (ES)","award":["2015-2016"],"award-info":[{"award-number":["2015-2016"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12885-017-3136-5","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T08:01:20Z","timestamp":1487664080000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Identification of somatic and germ-line DICER1 mutations in pleuropulmonary blastoma, cystic nephroma and rhabdomyosarcoma tumors within a DICER1 syndrome pedigree"],"prefix":"10.1186","volume":"17","author":[{"given":"Lorena","family":"Fern\u00e1ndez-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Villegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cd\u00f1igo","family":"Santamar\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana S.","family":"Pitiot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta G.","family":"Alvarado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngeles","family":"Paredes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Blay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milagros","family":"Balb\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"3136_CR1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/jmg.2010.083790","volume":"48","author":"I Slade","year":"2011","unstructured":"Slade I, Bacchelli C, Davies H, Murray A, Abbaszadeh F, Hanks S, et al. DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome. J Med Genet. 2011;48:273\u20138.","journal-title":"J Med Genet"},{"key":"3136_CR2","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1126\/science.1174334","volume":"325","author":"DA Hill","year":"2009","unstructured":"Hill DA, Ivanovich J, Priest JR, Gurnett CA, Dehner LP, Desruisseau D, et al. DICER1 mutations in familial pleuropulmonary blastoma. Science. 2009;325:965.","journal-title":"Science"},{"key":"3136_CR3","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nrc3802","volume":"14","author":"WD Foulkes","year":"2014","unstructured":"Foulkes WD, Priest JR, Duchaine TF. DICER1: mutations, microRNAs and mechanisms. Nat Rev Cancer. 2014;14:662\u201372.","journal-title":"Nat Rev Cancer"},{"key":"3136_CR4","first-page":"487","volume":"10","author":"R G\u00f3mez de la Torre","year":"1993","unstructured":"G\u00f3mez de la Torre R, Enguix Armada A, Garc\u00eda L, Otero J. Thyroid nodule disease in a previously endemic goiter area. An Med Interna. 1993;10:487\u20139.","journal-title":"An Med Interna"},{"key":"3136_CR5","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/cdd.2009.202","volume":"17","author":"I Lambertz","year":"2010","unstructured":"Lambertz I, Nittner D, Mestdagh P, Denecker G, Vandesompele J, Dyer MA, Marine JC. Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo. Cell Death Differ. 2010;17:633\u201341.","journal-title":"Cell Death Differ"},{"key":"3136_CR6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1056\/NEJMoa1102903","volume":"366","author":"A Heravi-Moussavi","year":"2012","unstructured":"Heravi-Moussavi A, Anglesio MS, Cheng SW, Senz J, Yang W, Prentice L, et al. Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers. N Engl J Med. 2012;366:234\u201342.","journal-title":"N Engl J Med"},{"key":"3136_CR7","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/path.4135","volume":"229","author":"MS Anglesio","year":"2013","unstructured":"Anglesio MS, Wang Y, Yang W, Senz J, Wan A, Heravi-Moussavi A, et al. Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage. J Pathol. 2013;229:400\u20139.","journal-title":"J Pathol"},{"key":"3136_CR8","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.neo.2015.08.003","volume":"17","author":"Y Wang","year":"2015","unstructured":"Wang Y, Chen J, Yang W, Mo F, Senz J, Yap D, et al. The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors. Neoplasia. 2015;17:650\u201360.","journal-title":"Neoplasia"},{"key":"3136_CR9","doi-asserted-by":"crossref","first-page":"14616","DOI":"10.1074\/jbc.M610515200","volume":"282","author":"L Nie","year":"2007","unstructured":"Nie L, Sasaki M, Maki CG. Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination. J Biol Chem. 2007;282:14616\u201325.","journal-title":"J Biol Chem"},{"key":"3136_CR10","doi-asserted-by":"crossref","first-page":"17356","DOI":"10.1073\/pnas.1310908110","volume":"110","author":"J Zhuang","year":"2013","unstructured":"Zhuang J, Wang PY, Huang X, Chen X, Kang JG, Hwang PN. Mithochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. Proc Natl Acad Sci U S A. 2013;110:17356\u201361.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3136_CR11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1074\/jbc.M113.502138","volume":"289","author":"PA Muller","year":"2014","unstructured":"Muller PA, Trinidad AG, Caswell PT, Norman JC, Vousden KH. Mutant p53 regulates Dicer through p63-dependent and \u2014independent mechanisms to promote an invasive phenotype. J Biol Chem. 2014;289:122\u201332.","journal-title":"J Biol Chem"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-017-3136-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T07:01:14Z","timestamp":1498374074000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-017-3136-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["3136"],"URL":"https:\/\/doi.org\/10.1186\/s12885-017-3136-5","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]},"article-number":"146"}}