{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:20:11Z","timestamp":1772583611146,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The State Key Project on Inflection Disease of China","award":["2012ZX10002016-004"],"award-info":[{"award-number":["2012ZX10002016-004"]}]},{"name":"The State Key Project on Inflection Disease of China","award":["2012ZX10002010-001-004"],"award-info":[{"award-number":["2012ZX10002010-001-004"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12885-018-4969-2","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T06:20:49Z","timestamp":1540794049000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Synchronous cancers of gallbladder carcinoma and combined hepatocellular cholangiocarcinoma: an unusual case and literature review"],"prefix":"10.1186","volume":"18","author":[{"given":"Zhan-Guo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Jie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lily","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2227-0613","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,10,29]]},"reference":[{"key":"4969_CR1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/1471-2407-12-148","volume":"12","author":"QA Zeng","year":"2012","unstructured":"Zeng QA, Qiu J, Zou R, et al. Clinical features and outcome of multiple primary malignancies involving hepatocellular carcinoma: a long-term follow-up study. BMC Cancer. 2012;12:148.","journal-title":"BMC Cancer"},{"key":"4969_CR2","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1097\/00000421-200302000-00015","volume":"26","author":"CG Demandante","year":"2003","unstructured":"Demandante CG, Troyer DA, Miles TP. Multiple primary malignant neoplasms: case report and a comprehensive review of the literature. Am J Clin Oncol. 2003;26:79\u201383.","journal-title":"Am J Clin Oncol"},{"key":"4969_CR3","first-page":"1358","volume":"16","author":"S Warren","year":"1932","unstructured":"Warren S, Gates O. Multiple primary maligant tumors: a survey of the literature and a statistical study. Am J Cancer. 1932;16:1358\u2013414.","journal-title":"Am J Cancer"},{"key":"4969_CR4","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.3748\/wjg.v12.i16.2588","volume":"12","author":"JH Lee","year":"2006","unstructured":"Lee JH, Bae JS, Ryu KW, Lee JS, Park SR, Kim CG, Kook MC, Choi IJ, Kim YW, Park JG, Bae JM. Gastric cancer patients at high-risk of having synchronous cancer. World J Gastroenterol. 2006;12:2588\u201392.","journal-title":"World J Gastroenterol"},{"key":"4969_CR5","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/j.1440-1746.1996.tb01700.x","volume":"11","author":"J Imada","year":"1996","unstructured":"Imada J, Hoshino H, Nishimura D, et al. Case report: multiple cancers: hepatocellular carcinoma and adenocarcinomas of the common bile duct and the gall-bladder in a woman with primary biliary cirrhosis. J Gastroenterol Hepatol. 1996;11:546\u201350.","journal-title":"J Gastroenterol Hepatol"},{"key":"4969_CR6","first-page":"121","volume":"47","author":"N Taniai","year":"2000","unstructured":"Taniai N, Onda M, Tajiri T, et al. Synchronous carcinoma of the gallbladder in a patient with intrahepatic bile duct carcinoma. Hepatogastroenterology. 2000;47:121\u20134.","journal-title":"Hepatogastroenterology"},{"key":"4969_CR7","first-page":"571","volume":"56","author":"G La Greca","year":"2004","unstructured":"La Greca G, Barbagallo F, Rodolico M, et al. Hepatocarcinoma, gallstone disease and gallbladder carcinoma: a case report of a rare incidental association. Chir Ital. 2004;56:571\u20134.","journal-title":"Chir Ital"},{"key":"4969_CR8","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/1477-7819-9-84","volume":"9","author":"JW Kim","year":"2011","unstructured":"Kim JW, Han JW, Jung SY, et al. Synchronous double primary malignant tumor of the gallbladder and liver: a case report. World J Surg Oncol. 2011;9:84.","journal-title":"World J Surg Oncol"},{"key":"4969_CR9","doi-asserted-by":"publisher","first-page":"561","DOI":"10.14740\/jmc1961w","volume":"5","author":"M Unver","year":"2014","unstructured":"Unver M, Ozturk S, Bozbiyik O, et al. Incidental early gallbladder carcinoma with hepatocellular carcinoma: a rare synchronous double primary malignant tumor. J Med Cases. 2014;5:561\u20133.","journal-title":"J Med Cases"},{"key":"4969_CR10","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1111\/jgh.12626","volume":"29","author":"J Lu","year":"2014","unstructured":"Lu J, Xiong XZ, Cheng NS. Hepatobiliary and pancreatic: coexisting cancers: hepatic neuroendocrine carcinomas with gallbladder adenocarcinoma. J Gastroenterol Hepatol. 2014;29:1343.","journal-title":"J Gastroenterol Hepatol"},{"key":"4969_CR11","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1556\/AVet.59.2011.1.9","volume":"59","author":"C Jakab","year":"2011","unstructured":"Jakab C, Rusvai M, Szab\u00f3 Z, et al. Claudin-7-positive synchronous spontaneous intrahepatic cholangiocarcinoma, adenocarcinoma and adenomasof the gallbladder in a bearded dragon (Pogona vittticeps). Acta Vet Hung. 2011;59:99\u2013112.","journal-title":"Acta Vet Hung"},{"key":"4969_CR12","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1245\/s10434-008-0278-3","volume":"16","author":"KH Kim","year":"2009","unstructured":"Kim KH, Lee SG, Park EH, et al. Surgical treatments and prognoses of patients with combined hepatocellular carcinoma and cholangiocarcinoma. Ann Surg Oncol. 2009;16:623\u20139.","journal-title":"Ann Surg Oncol"},{"key":"4969_CR13","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/jso.23762","volume":"110","author":"B Groot Koerkamp","year":"2014","unstructured":"Groot Koerkamp B, Fong Y. Outcomes in biliary malignancy. J Surg Oncol. 2014;110:585\u201391.","journal-title":"J Surg Oncol"},{"key":"4969_CR14","first-page":"221","volume":"3","author":"M Raki\u0107","year":"2014","unstructured":"Raki\u0107 M, Patrlj L, Kopljar M, et al. Gallbladder cancer. Hepatobiliary Surg Nutr. 2014;3:221\u20136.","journal-title":"Hepatobiliary Surg Nutr"},{"key":"4969_CR15","first-page":"99","volume":"6","author":"R Hundal","year":"2014","unstructured":"Hundal R, Shaffer EA. Gallbladder cancer: epidemiology and outcome. Clin Epidemiol. 2014;6:99\u2013109.","journal-title":"Clin Epidemiol"},{"key":"4969_CR16","doi-asserted-by":"publisher","first-page":"231","DOI":"10.12998\/wjcc.v3.i3.231","volume":"3","author":"AN Dwivedi","year":"2015","unstructured":"Dwivedi AN, Jain S, Dixit R. Gall bladder carcinoma: aggressive malignancy with protean loco-regional and distant spread. World J Clin Cases. 2015;3:231\u201344.","journal-title":"World J Clin Cases"},{"key":"4969_CR17","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1111\/j.1440-1746.2011.07048.x","volume":"27","author":"U Dutta","year":"2012","unstructured":"Dutta U. Gallbladder cancer: can newer insights improve the outcome? J Gastroenterol Hepatol. 2012;27:642\u201353.","journal-title":"J Gastroenterol Hepatol"},{"key":"4969_CR18","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/BF01889073","volume":"13","author":"PM Bret","year":"1988","unstructured":"Bret PM, Labadie M, Bretagnolle M, et al. Hepatocellular carcinoma: diagnosis by percutaneous fine needle biopsy. Gastrointest Radiol. 1988;13:253\u20135.","journal-title":"Gastrointest Radiol"},{"key":"4969_CR19","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/s002610000025","volume":"25","author":"SH Kim","year":"2000","unstructured":"Kim SH, Lim HK, Lee WJ, et al. Needle-tract implantation in hepatocellular carcinoma: frequency and CT findings after biopsy with a 19.5-gauge automated biopsy gun. Abdom Imaging. 2000;25:246\u201350.","journal-title":"Abdom Imaging"},{"key":"4969_CR20","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1186\/1471-2407-13-394","volume":"13","author":"C Kim","year":"2013","unstructured":"Kim C, Chon H, Kang B, Jung JP, Kim JW. Prediction of metachronous multiple primary cancers following the curative resection of gastric cancer. BMC Cancer. 2013;13:394.","journal-title":"BMC Cancer"},{"key":"4969_CR21","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1158\/1055-9965.EPI-14-0129","volume":"23","author":"SL Park","year":"2014","unstructured":"Park SL, Caberto CP, Lin Y, et al. Association of cancer susceptibility variants with risk of multiple primary cancers: the population architecture using genomics and epidemiology study. Cancer Epidemiol Biomark Prev. 2014;23:2568\u201378.","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"4969_CR22","doi-asserted-by":"publisher","first-page":"172","DOI":"10.5009\/gnl.2012.6.2.172","volume":"6","author":"LM Stinton","year":"2012","unstructured":"Stinton LM, Eldon A, Shaffer EA. Epidemiology of gallbladder disease: Cholelithiasis and Cancer. Gut Liver. 2012;6:172\u201387.","journal-title":"Gut Liver"},{"key":"4969_CR23","doi-asserted-by":"publisher","first-page":"43","DOI":"10.4137\/CPath.S500","volume":"1","author":"MS Wachtel","year":"2008","unstructured":"Wachtel MS, Zhang Y, Xu T, et al. Combined hepatocellular cholangiocarcinomas; analysis of a large database. Clin Med Pathol. 2008;1:43\u20137.","journal-title":"Clin Med Pathol"},{"key":"4969_CR24","first-page":"317","volume":"13","author":"K O'Connor","year":"2014","unstructured":"O'Connor K, Walsh JC, Schaeffer DF. Combined hepatocellular- cholangiocarcinoma (cHCC-CC): a distinct entity. Ann Hematol. 2014;13:317\u201322.","journal-title":"Ann Hematol"},{"key":"4969_CR25","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1002\/hep.22238","volume":"47","author":"M Komuta","year":"2008","unstructured":"Komuta M, Spee B, Vander Borght S, et al. Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin. Hepatology. 2008;47:1544\u201356.","journal-title":"Hepatology"},{"key":"4969_CR26","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1053\/hupa.2000.9782","volume":"31","author":"H Fujii","year":"2000","unstructured":"Fujii H, Zhu XG, Matsumoto T, et al. Genetic classification of combined hepatocellular-cholangiocarcinoma. Hum Pathol. 2000;31:1011\u20137.","journal-title":"Hum Pathol"},{"key":"4969_CR27","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/j.1365-2559.2007.02929.x","volume":"52","author":"F Zhang","year":"2008","unstructured":"Zhang F, Chen XP, Zhang W, et al. Combined hepatocellular cholangiocarcinoma originating from hepatic progenitor cells: immunohistochemical and double-fluorescence immunostaining evidence. Histopathology. 2008;52:224\u201332.","journal-title":"Histopathology"},{"key":"4969_CR28","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/j.1749-6632.2009.03704.x","volume":"1155","author":"C Berasain","year":"2009","unstructured":"Berasain C, Castillo J, Perugorria MJ, et al. Inflammation and liver cancer: new molecular links. Ann N Y Acad Sci. 2009;1155:206\u201321.","journal-title":"Ann N Y Acad Sci"},{"key":"4969_CR29","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"A Mantovani","year":"2008","unstructured":"Mantovani A, Allavena P, Sica A, et al. Cancer-related inflammation. Nature. 2008;454:436\u201344.","journal-title":"Nature"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-018-4969-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12885-018-4969-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-018-4969-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T20:13:29Z","timestamp":1572293609000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-018-4969-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,29]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["4969"],"URL":"https:\/\/doi.org\/10.1186\/s12885-018-4969-2","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,29]]},"assertion":[{"value":"10 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by Institutional Review Board of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. The patient and her relations have signed an informed consent form before inclusion.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Documented written consent from the patient was obtained to report the details of the case.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests for this research.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"1046"}}