{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T08:02:28Z","timestamp":1772697748258,"version":"3.50.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002806","name":"Carl Zeiss Meditec AG","doi-asserted-by":"publisher","award":["Unrestricted Grant"],"award-info":[{"award-number":["Unrestricted Grant"]}],"id":[{"id":"10.13039\/501100002806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12885-019-5666-5","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T11:05:03Z","timestamp":1557399903000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) versus external beam radiotherapy (EBRT) for painful vertebral metastases - a randomized phase III study"],"prefix":"10.1186","volume":"19","author":[{"given":"Frederic","family":"Bludau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grit","family":"Welzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasser","family":"Abo-Madyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Sperk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Clausen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne M.","family":"Ruder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udo","family":"Obertacke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maged M.","family":"Ghaly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik","family":"Wenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank A.","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"5666_CR1","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1097\/BRS.0b013e3181b8b6f5","volume":"34","author":"PC Gerszten","year":"2009","unstructured":"Gerszten PC, Mendel E, Yamada Y. Radiotherapy and radiosurgery for metastatic spine disease: what are the options, indications, and outcomes? Spine. 2009;34:78\u201392.","journal-title":"Spine"},{"key":"5666_CR2","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s00066-009-2044-2","volume":"185","author":"R Souchon","year":"2009","unstructured":"Souchon R, Wenz F, Sedlmayer F, Budach W, Dunst J, Feyer P, et al. DEGRO practice guidelines for palliative radiotherapy of metastatic breast cancer: bone metastases and metastatic spinal cord compression (MSCC). Strahlenther Onkol. 2009;185:417\u201324.","journal-title":"Strahlenther Onkol"},{"key":"5666_CR3","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1093\/jnci\/dji139","volume":"97","author":"WF Hartsell","year":"2005","unstructured":"Hartsell WF, Scott CB, Bruner DW, Scarantino CW, Ivker RA, Roach M 3rd, et al. Randomized trial of short- versus long-course radiotherapy for palliation of painful bone metastases. J Natl Cancer Inst. 2005;97:798\u2013804.","journal-title":"J Natl Cancer Inst"},{"key":"5666_CR4","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.radonc.2006.05.006","volume":"79","author":"S Kaasa","year":"2006","unstructured":"Kaasa S, Brenne E, Lund JA, Fayers P, Falkmer U, Holmberg M, et al. Prospective randomised multicenter trial on single fraction radiotherapy (8 Gy x 1) versus multiple fractions (3 Gy x 10) in the treatment of painful bone metastases. Radiother Oncol. 2006;79:278\u201384.","journal-title":"Radiother Oncol"},{"key":"5666_CR5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0167-8140(99)00097-3","volume":"52","author":"Bone Pain Trial Working Party","year":"1999","unstructured":"Bone Pain Trial Working Party. 8 Gy single fraction radiotherapy for the treatment of metastatic skeletal pain: randomised comparison with a multifraction schedule over 12 months of patient follow-up. Radiother Oncol. 1999;52:111\u201321.","journal-title":"Radiother Oncol"},{"key":"5666_CR6","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S1470-2045(11)70008-0","volume":"12","author":"J Berenson","year":"2011","unstructured":"Berenson J, Pflugmacher R, Jarzem P, Zonder J, Schechtman K, Tillman JB, et al. Cancer Patient Fracture Evaluation (CAFE) Investigators: balloon kyphoplasty versus non-surgical fracture management for treatment of painful vertebral body compression fractures in patients with cancer: a multicentre, randomised controlled trial. Lancet Oncol. 2011;12:225\u201335.","journal-title":"Lancet Oncol"},{"key":"5666_CR7","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1016\/j.ijrobp.2010.07.1985","volume":"81","author":"F Schneider","year":"2011","unstructured":"Schneider F, Greineck F, Clausen S, Mai S, Obertacke U, Reis T, et al. Development of a novel method for intraoperative radiotherapy during kyphoplasty for spinal metastases (Kypho-IORT). Int J Radiat Oncol Biol Phys. 2011;81:1114\u20139.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"5666_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1748-717X-5-11","volume":"5","author":"F Wenz","year":"2010","unstructured":"Wenz F, Schneider F, Neumaier C, Kraus-Tiefenbacher U, Reis T, Schmidt R, et al. Kypho-IORT \u2013 a novel approach of intraoperative radiotherapy during kyphoplasty for vertebral metastases. Radiat Oncol. 2010;5:11.","journal-title":"Radiat Oncol"},{"key":"5666_CR9","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1007\/s00264-011-1470-9","volume":"36","author":"R Schmidt","year":"2012","unstructured":"Schmidt R, Wenz F, Reis T, Janik K, Bludau F, Obertacke U, et al. Kyphoplasty and intra-operative radiotherapy, combination of kyphoplasty and intra-operative radiation for spinal metastases: technical feasibility of a novel approach. Int Orthop. 2012;36:1255\u201360.","journal-title":"Int Orthop"},{"key":"5666_CR10","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1177\/030089161209800406","volume":"98","author":"T Reis","year":"2012","unstructured":"Reis T, Schneider F, Welzel G, Schmidt R, Bludau F, Obertacke U, et al. Intraoperative radiotherapy during kyphoplasty for vertebral metastases (Kypho-IORT): first clinical results. Tumori. 2012;98:434\u201340.","journal-title":"Tumori"},{"key":"5666_CR11","doi-asserted-by":"crossref","unstructured":"Bludau F, Welzel G, Reis T, Schneider F, Sperk E, Neumaier C, Ehmann M, Clausen S, Obertacke U, Wenz F, Giordano FA. Phase I\/II trial of combined kyphoplasty and intraoperative radiotherapy in spinal metastases. Spine J. 2017; Sep 28. [Epub ahead of print].","DOI":"10.1016\/j.spinee.2017.09.011"},{"issue":"3","key":"5666_CR12","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.radonc.2006.02.007","volume":"78","author":"YM van der Linden","year":"2006","unstructured":"van der Linden YM, Steenland E, van Houwelingen HC, et al. Patients with a favourable prognosis are equally palliated with single and multiple fraction radiotherapy: results on survival in the Dutch bone metastasis study. Radiother Oncol. 2006;78(3):245\u201353.","journal-title":"Radiother Oncol"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-019-5666-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12885-019-5666-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-019-5666-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T23:08:43Z","timestamp":1588892923000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-019-5666-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,9]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["5666"],"URL":"https:\/\/doi.org\/10.1186\/s12885-019-5666-5","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,9]]},"assertion":[{"value":"7 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the local ethics committee (Medical Ethics Commission II of the Faculty of Medicine Mannheim, University of Heidelberg, 2013-593\u2009N-MA) and the Federal Office of Radiation Protection (Z5\u201322462\/2\u20132013-116). Written informed consent is obtained from all patients participating in this study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"FB, UO, ESp, YAM, FS and SC are on the Carl Zeiss Meditec AG speaker\u2019s bureau. GW received travel support from Carl Zeiss Meditec AG. FW is an advisor, consultant and\/or speaker for Celgene GmbH, Roche Pharma AG, Eli Lilly and Company, Ipsen Pharma GmbH, receives travel and research grants from Carl Zeiss Meditec AG and Elekta AB, is on the Carl Zeiss Meditec AG speaker\u2019s bureau and holds patents related with Carl Zeiss Meditec AG. FG serves as consultant and speaker for Carl Zeiss Meditec AG (the manufacturer of the device used for IORT in this trial), NOXXON Pharma AG, Merck Serono GmbH, Roche Pharma AG, Siemens Healthcare Diagnostics GmbH and holds patents related with Carl Zeiss Meditec AG.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"430"}}