{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:11:29Z","timestamp":1761156689253,"version":"3.37.3"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National key research and development project","award":["2017YFC131100"],"award-info":[{"award-number":["2017YFC131100"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12885-019-5692-3","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T04:55:30Z","timestamp":1558500930000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Postoperative radiotherapy is effective in improving survival of patients with stage pIII-N2 non-small-cell lung Cancer after pneumonectomy"],"prefix":"10.1186","volume":"19","author":[{"given":"Wenhui","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Men","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongmei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongfu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zefen","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinfu","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jima","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shugeng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7189-4692","authenticated-orcid":false,"given":"Zhouguang","family":"Hui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"5692_CR1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1097\/JTO.0000000000000406","volume":"10","author":"CD Corso","year":"2015","unstructured":"Corso CD, Rutter CE, Wilson LD, et al. Re-evaluation of the role of postoperative radiotherapy and the impact of radiation dose for non-small-cell lung cancer using the National Cancer Database. J Thorac Oncol. 2015;10:148\u201355. https:\/\/doi.org\/10.1097\/JTO.0000000000000406 .","journal-title":"J Thorac Oncol"},{"key":"5692_CR2","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1097\/JTO.0b013e318292c53e","volume":"8","author":"D Urban","year":"2013","unstructured":"Urban D, Bar J, Solomon B, Ball D. Lymph node ratio may predict the benefit of postoperative radiotherapy in non-small-cell lung cancer. J Thorac Oncol. 2013;8:940\u20136. https:\/\/doi.org\/10.1097\/JTO.0b013e318292c53e .","journal-title":"J Thorac Oncol"},{"key":"5692_CR3","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1097\/JTO.0000000000000411","volume":"10","author":"JL Mikell","year":"2015","unstructured":"Mikell JL, Gillespie TW, Hall WA, et al. Postoperative radiotherapy is associated with better survival in non-small cell lung cancer with involved N2 lymph nodes: results of an analysis of the National Cancer Data Base. J Thorac Oncol. 2015;10:462\u201371. https:\/\/doi.org\/10.1097\/JTO.0000000000000411 .","journal-title":"J Thorac Oncol"},{"key":"5692_CR4","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1200\/JCO.2014.58.5380","volume":"33","author":"CG Robinson","year":"2015","unstructured":"Robinson CG, Patel AP, Bradley JD, et al. Postoperative radiotherapy for pathologic N2 non-small-cell lung cancer treated with adjuvant chemotherapy: a review of the National Cancer Data Base. J Clin Oncol. 2015;33:870\u20136. https:\/\/doi.org\/10.1200\/JCO.2014.58.5380 .","journal-title":"J Clin Oncol"},{"key":"5692_CR5","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1016\/j.athoracsur.2006.12.036","volume":"83","author":"N Ramnath","year":"2007","unstructured":"Ramnath N, Demmy TL, Antun A, et al. Pneumonectomy for bronchogenic carcinoma: analysis of factors predicting survival. Ann Thorac Surg. 2007;83:1831\u20136. https:\/\/doi.org\/10.1016\/j.athoracsur.2006.12.036 .","journal-title":"Ann Thorac Surg"},{"key":"5692_CR6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0096-5588(20)31640-8","volume":"20","author":"VO Bjork","year":"1950","unstructured":"Bjork VO, Carlens E. The prevention of spread during pulmonary resection by the use of a double-lumen catheter. J Thorac Surg. 1950;20:151\u20137.","journal-title":"J Thorac Surg"},{"key":"5692_CR7","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.soc.2016.02.012","volume":"25","author":"DJ Sugarbaker","year":"2016","unstructured":"Sugarbaker DJ, Haywood-Watson RJ, Wald O. Pneumonectomy for non-small cell lung Cancer. Surg Oncol Clin N Am. 2016;25:533\u201351. https:\/\/doi.org\/10.1016\/j.soc.2016.02.012 .","journal-title":"Surg Oncol Clin N Am"},{"key":"5692_CR8","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1159\/000262466","volume":"42","author":"S Hillinger","year":"2010","unstructured":"Hillinger S, Weder W. Extended surgical resection in stage III non-small cell lung Cancer. Controversies in Treatment of Lung Cancer. 2010;42:115\u201321. https:\/\/doi.org\/10.1159\/000262466 .","journal-title":"Controversies in Treatment of Lung Cancer"},{"key":"5692_CR9","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1510\/icvts.2008.182279","volume":"7","author":"E Melloul","year":"2008","unstructured":"Melloul E, Egger B, Krueger T, et al. Mortality, complications and loss of pulmonary function after pneumonectomy vs. sleeve lobectomy in patients younger and older than 70 years. Interact Cardiovasc Thorac Surg. 2008;7:986\u20139. https:\/\/doi.org\/10.1510\/icvts.2008.182279 .","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"5692_CR10","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.21037\/jtd.2016.04.60","volume":"8","author":"QL Ma","year":"2016","unstructured":"Ma QL, Guo YQ, Shi B, et al. For non-small cell lung cancer with T3 (central) disease, sleeve lobectomy or pneumonectomy? J Thorac Dis. 2016;8:1227\u201333. https:\/\/doi.org\/10.21037\/jtd.2016.04.60 .","journal-title":"J Thorac Dis"},{"key":"5692_CR11","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.athoracsur.2013.03.065","volume":"96","author":"F Eichhorn","year":"2013","unstructured":"Eichhorn F, Storz K, Hoffmann H, et al. Sleeve pneumonectomy for central non-small cell lung cancer: indications, complications, and survival. Ann Thorac Surg. 2013;96:253\u20138. https:\/\/doi.org\/10.1016\/j.athoracsur.2013.03.065 .","journal-title":"Ann Thorac Surg"},{"key":"5692_CR12","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/1759-7714.12186","volume":"6","author":"Z Hui","year":"2015","unstructured":"Hui Z, Dai H, Liang J, et al. Selection of proper candidates with resected pathological stage IIIA-N2 non-small cell lung cancer for postoperative radiotherapy. Thorac Cancer. 2015;6:346\u201353. https:\/\/doi.org\/10.1111\/1759-7714.12186 .","journal-title":"Thorac Cancer"},{"key":"5692_CR13","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1016\/j.ijrobp.2009.09.030","volume":"78","author":"RB Barriger","year":"2010","unstructured":"Barriger RB, Fakiris AJ, Hanna N, et al. Dose-volume analysis of radiation pneumonitis in non-small-cell lung cancer patients treated with concurrent cisplatinum and etoposide with or without consolidation docetaxel. Int J Radiat Oncol Biol Phys. 2010;78:1381\u20136. https:\/\/doi.org\/10.1016\/j.ijrobp.2009.09.030 .","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"5692_CR14","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.ijrobp.2006.01.051","volume":"65","author":"FM Kong","year":"2006","unstructured":"Kong FM, Hayman JA, Griffith KA, et al. Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): predictors for radiation pneumonitis and fibrosis. Int J Radiat Oncol Biol Phys. 2006;65:1075\u201386. https:\/\/doi.org\/10.1016\/j.ijrobp.2006.01.051 .","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"5692_CR15","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1093\/annonc\/mdx009","volume":"28","author":"J Liang","year":"2017","unstructured":"Liang J, Bi N, Wu S, et al. Etoposide and cisplatin versus paclitaxel and carboplatin with concurrent thoracic radiotherapy in unresectable stage III non-small cell lung cancer: a multicenter randomized phase III trial. Ann Oncol. 2017;28:777\u201383. https:\/\/doi.org\/10.1093\/annonc\/mdx009 .","journal-title":"Ann Oncol"},{"key":"5692_CR16","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.lungcan.2007.08.010","volume":"59","author":"L Zhao","year":"2008","unstructured":"Zhao L, Sheldon K, Chen M, et al. The predictive role of plasma TGF-beta1 during radiation therapy for radiation-induced lung toxicity deserves further study in patients with non-small cell lung cancer. Lung Cancer. 2008;59:232\u20139. https:\/\/doi.org\/10.1016\/j.lungcan.2007.08.010 .","journal-title":"Lung Cancer"},{"key":"5692_CR17","doi-asserted-by":"publisher","first-page":"3480","DOI":"10.1200\/JCO.2005.12.120","volume":"23","author":"JD Bradley","year":"2005","unstructured":"Bradley JD, Paulus R, Graham MV, et al. Phase II trial of postoperative adjuvant paclitaxel\/carboplatin and thoracic radiotherapy in resected stage II and IIIA non-small-cell lung cancer: promising long-term results of the radiation therapy oncology group--RTOG 9705. J Clin Oncol. 2005;23:3480\u20137. https:\/\/doi.org\/10.1200\/JCO.2005.12.120 .","journal-title":"J Clin Oncol"},{"key":"5692_CR18","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.lungcan.2012.03.017","volume":"77","author":"L Zhao","year":"2012","unstructured":"Zhao L, Ji W, Ou G, et al. Risk factors for radiation-induced lung toxicity in patients with non-small cell lung cancer who received postoperative radiation therapy. Lung Cancer. 2012;77:326\u201330. https:\/\/doi.org\/10.1016\/j.lungcan.2012.03.017 .","journal-title":"Lung Cancer"},{"key":"5692_CR19","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1200\/JCO.2017.74.4771","volume":"36","author":"S Francis","year":"2018","unstructured":"Francis S, Orton A, Stoddard G, et al. Sequencing of postoperative radiotherapy and chemotherapy for locally advanced or incompletely resected non-small-cell lung Cancer. J Clin Oncol. 2018;36:333\u201341. https:\/\/doi.org\/10.1200\/JCO.2017.74.4771 .","journal-title":"J Clin Oncol"},{"issue":"1","key":"5692_CR20","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.radonc.2013.10.008","volume":"110","author":"W Shen","year":"2014","unstructured":"Shen W, Ji J, Zuo Y, et al. Comparison of efficacy for postoperative chemotherapy and concurrent radiochemotherapy in patients with IIIA-pN2 non-small cell lung cancer: an early closed randomized controlled trial. Radiother Oncol. 2014;110(1):120\u20135. https:\/\/doi.org\/10.1016\/j.radonc.2013.10.008 .","journal-title":"Radiother Oncol"},{"key":"5692_CR21","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.ijrobp.2008.01.044","volume":"72","author":"JY Douillard","year":"2008","unstructured":"Douillard JY, Rosell R, De Lena M, et al. Impact of postoperative radiation therapy on survival in patients with complete resection and stage I, II, or IIIA non-small-cell lung cancer treated with adjuvant chemotherapy: the adjuvant Navelbine international Trialist association (ANITA) randomized trial. Int J Radiat Oncol Biol Phys. 2008;72:695\u2013701. https:\/\/doi.org\/10.1016\/j.ijrobp.2008.01.044 .","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"5692_CR22","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1016\/S0169-5002(01)00300-2","volume":"33","author":"C Rube","year":"2001","unstructured":"Rube C, Nguyen TP, Fleckenstein J, Niewald M. Postoperative radiotherapy in localized non-small cell lung cancer. Lung Cancer. 2001;33:S29\u201333.","journal-title":"Lung Cancer"},{"key":"5692_CR23","doi-asserted-by":"crossref","unstructured":"Postoperative radiotherapy in non-small-cell lung cancer: systematic review and meta-analysis of individual patient data from nine randomised controlled trials. PORT Meta-analysis Trialists Group. Lancet. 1998;352:257\u201363.","DOI":"10.1016\/S0140-6736(98)06341-7"},{"key":"5692_CR24","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1093\/jnci\/djr325","volume":"103","author":"WJ Curran Jr","year":"2011","unstructured":"Curran WJ Jr, Paulus R, Langer CJ, et al. Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410. J Natl Cancer Inst. 2011;103:1452\u201360. https:\/\/doi.org\/10.1093\/jnci\/djr325 .","journal-title":"J Natl Cancer Inst"},{"key":"5692_CR25","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/S0140-6736(09)60737-6","volume":"374","author":"KS Albain","year":"2009","unstructured":"Albain KS, Swann RS, Rusch VW, et al. Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial. Lancet. 2009;374:379\u201386. https:\/\/doi.org\/10.1016\/S0140-6736(09)60737-6 .","journal-title":"Lancet"},{"key":"5692_CR26","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.ijrobp.2015.11.020","volume":"94","author":"HW Lee","year":"2016","unstructured":"Lee HW, Noh OK, Oh YT, et al. Radiation therapy-first strategy after surgery with or without adjuvant chemotherapy in stage IIIA-N2 non-small cell lung Cancer. Int J Radiat Oncol Biol Phys. 2016;94:621\u20137. https:\/\/doi.org\/10.1016\/j.ijrobp.2015.11.020 .","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"5692_CR27","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1634\/theoncologist.2010-0343","volume":"16","author":"H Dai","year":"2011","unstructured":"Dai H, Hui Z, Ji W, et al. Postoperative radiotherapy for resected pathological stage IIIA-N2 non-small cell lung cancer: a retrospective study of 221 cases from a single institution. Oncologist. 2011;16:641\u201350. https:\/\/doi.org\/10.1634\/theoncologist.2010-0343 .","journal-title":"Oncologist"},{"key":"5692_CR28","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.ijrobp.2009.05.044","volume":"77","author":"B Zou","year":"2010","unstructured":"Zou B, Xu Y, Li T, et al. A multicenter retrospective analysis of survival outcome following postoperative chemoradiotherapy in non-small-cell lung cancer patients with N2 nodal disease. Int J Radiat Oncol Biol Phys. 2010;77:321\u20138. https:\/\/doi.org\/10.1016\/j.ijrobp.2009.05.044 .","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"5692_CR29","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1016\/j.athoracsur.2013.12.047","volume":"97","author":"A Legras","year":"2014","unstructured":"Legras A, Mordant P, Arame A, et al. Long-term survival of patients with pN2 lung cancer according to the pattern of lymphatic spread. Ann Thorac Surg. 2014;97:1156\u201362. https:\/\/doi.org\/10.1016\/j.athoracsur.2013.12.047 .","journal-title":"Ann Thorac Surg"},{"key":"5692_CR30","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1080\/17476348.2016.1188694","volume":"10","author":"F Petrella","year":"2016","unstructured":"Petrella F, Spaggiari L. Therapeutic options following pneumonectomy in non-small cell lung cancer. Expert Rev Respir Med. 2016;10:919\u201325. https:\/\/doi.org\/10.1080\/17476348.2016.1188694 .","journal-title":"Expert Rev Respir Med"},{"key":"5692_CR31","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1055\/s-0035-1562940","volume":"64","author":"TP Graeter","year":"2016","unstructured":"Graeter TP, Sebastian B, Bischof M, et al. Analysis of patients unable to undergo adjuvant chemotherapy after surgery in stage IIIA\/B non-small cell lung Cancer: will they benefit from mediastinal radiotherapy? Thorac Cardiovasc Surg. 2016;64:501\u20136. https:\/\/doi.org\/10.1055\/s-0035-1562940 .","journal-title":"Thorac Cardiovasc Surg"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-019-5692-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12885-019-5692-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-019-5692-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:18:51Z","timestamp":1607905131000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-019-5692-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["5692"],"URL":"https:\/\/doi.org\/10.1186\/s12885-019-5692-3","relation":{},"ISSN":["1471-2407"],"issn-type":[{"type":"electronic","value":"1471-2407"}],"subject":[],"published":{"date-parts":[[2019,5,22]]},"assertion":[{"value":"7 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the Institutional Review Board of National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academic of Medical Sciences and Peking Union Medical College. This is a retrospective study and written human subject consent was unnecessary.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"478"}}