{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:08:36Z","timestamp":1785150516505,"version":"3.55.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:00:00Z","timestamp":1565136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:00:00Z","timestamp":1565136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","award":["R01CA127971"],"award-info":[{"award-number":["R01CA127971"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NCRR Clinical and Translational Science Award","award":["UL1TR000071"],"award-info":[{"award-number":["UL1TR000071"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12885-019-6006-5","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T12:02:53Z","timestamp":1565179373000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of adjunct testosterone on cardiac morphology and function in advanced cancers: an ancillary analysis of a randomized controlled trial"],"prefix":"10.1186","volume":"19","author":[{"given":"Jessica M.","family":"Scott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Lichar","family":"Dillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Chamberlain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"McCammon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Jupiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Willis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Hatch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwyn","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Danesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Randolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Durham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Traver","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6579-4655","authenticated-orcid":false,"given":"Melinda","family":"Sheffield-Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,7]]},"reference":[{"issue":"5","key":"6006_CR1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","volume":"12","author":"K Fearon","year":"2011","unstructured":"Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489\u201395.","journal-title":"Lancet Oncol"},{"issue":"4","key":"6006_CR2","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s13539-014-0164-8","volume":"5","author":"S von Haehling","year":"2014","unstructured":"von Haehling S, Anker SD. Prevalence, incidence and clinical impact of cachexia: facts and numbers-update 2014. J Cachexia Sarcopenia Muscle. 2014;5(4):261\u20133.","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"6","key":"6006_CR3","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1200\/JCO.2009.24.9730","volume":"28","author":"S Antoun","year":"2010","unstructured":"Antoun S, Birdsell L, Sawyer MB, Venner P, Escudier B, Baracos VE. Association of skeletal muscle wasting with treatment with sorafenib in patients with advanced renal cell carcinoma: results from a placebo-controlled study. J Clin Oncol. 2010;28(6):1054\u201360.","journal-title":"J Clin Oncol"},{"issue":"2","key":"6006_CR4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s13539-014-0137-y","volume":"5","author":"SM Kazemi-Bajestani","year":"2014","unstructured":"Kazemi-Bajestani SM, Becher H, Fassbender K, Chu Q, Baracos VE. Concurrent evolution of cancer cachexia and heart failure: bilateral effects exist. J Cachexia Sarcopenia Muscle. 2014;5(2):95\u2013104.","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"4","key":"6006_CR5","doi-asserted-by":"publisher","first-page":"H466","DOI":"10.1152\/ajpheart.00720.2015","volume":"310","author":"KT Murphy","year":"2016","unstructured":"Murphy KT. The pathogenesis and treatment of cardiac atrophy in cancer cachexia. Am J Physiol Heart Circ Physiol. 2016;310(4):H466\u201377.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"6006_CR6","first-page":"327","volume":"87","author":"W Gordon","year":"1904","unstructured":"Gordon W. The cardiac Dulness in cases of Cancer. Med Chir Trans. 1904;87:327\u201337.","journal-title":"Med Chir Trans"},{"issue":"1","key":"6006_CR7","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1161\/01.CIR.1.1.93","volume":"1","author":"H. K. HELLERSTEIN","year":"1950","unstructured":"Hellerstein HK, Santiago-Stevenson D. Atrophy of the heart; a correlative study of 85 proved cases. Circulation. 1950;1(1):93\u2013126, illust.","journal-title":"Circulation"},{"issue":"14","key":"6006_CR8","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1093\/eurheartj\/eht302","volume":"35","author":"J Springer","year":"2014","unstructured":"Springer J, Tschirner A, Haghikia A, von Haehling S, Lal H, Grzesiak A, et al. Prevention of liver cancer cachexia-induced cardiac wasting and heart failure. Eur Heart J. 2014;35(14):932\u201341.","journal-title":"Eur Heart J"},{"issue":"5","key":"6006_CR9","first-page":"1321","volume":"39","author":"M Tian","year":"2011","unstructured":"Tian M, Asp ML, Nishijima Y, Belury MA. Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice. Int J Oncol. 2011;39(5):1321\u20136.","journal-title":"Int J Oncol"},{"issue":"1","key":"6006_CR10","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1001\/jama.2007.51","volume":"299","author":"MH Emmelot-Vonk","year":"2008","unstructured":"Emmelot-Vonk MH, Verhaar HJ, Nakhai Pour HR, Aleman A, Lock TM, Bosch JL, et al. Effect of testosterone supplementation on functional mobility, cognition, and other parameters in older men: a randomized controlled trial. JAMA. 2008;299(1):39\u201352.","journal-title":"JAMA."},{"issue":"4","key":"6006_CR11","doi-asserted-by":"publisher","first-page":"E433","DOI":"10.1152\/ajpendo.00592.2013","volume":"306","author":"SE Borst","year":"2014","unstructured":"Borst SE, Yarrow JF, Conover CF, Nseyo U, Meuleman JR, Lipinska JA, et al. Musculoskeletal and prostate effects of combined testosterone and finasteride administration in older hypogonadal men: a randomized, controlled trial. Am J Physiol Endocrinol Metab. 2014;306(4):E433\u201342.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"11","key":"6006_CR12","doi-asserted-by":"publisher","first-page":"E1831","DOI":"10.1210\/jc.2011-1262","volume":"96","author":"M Sheffield-Moore","year":"2011","unstructured":"Sheffield-Moore M, Dillon EL, Casperson SL, Gilkison CR, Paddon-Jones D, Durham WJ, et al. A randomized pilot study of monthly cycled testosterone replacement or continuous testosterone replacement versus placebo in older men. J Clin Endocrinol Metab. 2011;96(11):E1831\u20137.","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"6006_CR13","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1139\/y91-252","volume":"69","author":"GA Kinson","year":"1991","unstructured":"Kinson GA, Layberry RA, Hebert B. Influences of anabolic androgens on cardiac growth and metabolism in the rat. Can J Physiol Pharmacol. 1991;69(11):1698\u2013704.","journal-title":"Can J Physiol Pharmacol"},{"issue":"3","key":"6006_CR14","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1161\/CIRCHEARTFAILURE.111.965632","volume":"5","author":"M Toma","year":"2012","unstructured":"Toma M, McAlister FA, Coglianese EE, Vidi V, Vasaiwala S, Bakal JA, et al. Testosterone supplementation in heart failure: a meta-analysis. Circ Heart Fail. 2012;5(3):315\u201321.","journal-title":"Circ Heart Fail"},{"issue":"3","key":"6006_CR15","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1002\/jcsm.12295","volume":"9","author":"TJ Wright","year":"2018","unstructured":"Wright TJ, Dillon EL, Durham WJ, Chamberlain A, Randolph KM, Danesi C, et al. A randomized trial of adjunct testosterone for cancer-related muscle loss in men and women. J Cachexia Sarcopenia Muscle. 2018;9(3):482\u201396.","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"12","key":"6006_CR16","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1016\/j.echo.2005.10.005","volume":"18","author":"RM Lang","year":"2005","unstructured":"Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography's guidelines and standards committee and the chamber quantification writing group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18(12):1440\u201363.","journal-title":"J Am Soc Echocardiogr"},{"issue":"2","key":"6006_CR17","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1161\/01.CIR.86.2.513","volume":"86","author":"RP Kelly","year":"1992","unstructured":"Kelly RP, Ting CT, Yang TM, Liu CP, Maughan WL, Chang MS, et al. Effective arterial elastance as index of arterial vascular load in humans. Circulation. 1992;86(2):513\u201321.","journal-title":"Circulation."},{"issue":"2","key":"6006_CR18","doi-asserted-by":"publisher","first-page":"H350","DOI":"10.1152\/ajpheart.01100.2008","volume":"296","author":"JM Scott","year":"2009","unstructured":"Scott JM, Esch BT, Haykowsky MJ, Warburton DE, Toma M, Jelani A, et al. Cardiovascular responses to incremental and sustained submaximal exercise in heart transplant recipients. Am J Physiol Heart Circ Physiol. 2009;296(2):H350\u20138.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"10","key":"6006_CR19","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nrcardio.2010.121","volume":"7","author":"MS Ewer","year":"2010","unstructured":"Ewer MS, Ewer SM. Cardiotoxicity of anticancer treatments: what the cardiologist needs to know. Nat Rev Cardiol. 2010;7(10):564\u201375.","journal-title":"Nat Rev Cardiol"},{"issue":"8","key":"6006_CR20","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.jcmg.2018.05.012","volume":"11","author":"T Ferreira de Souza","year":"2018","unstructured":"Ferreira de Souza T, Quinaglia ACST, Osorio Costa F, Shah R, Neilan TG, Velloso L, et al. Anthracycline therapy is associated with cardiomyocyte atrophy and preclinical manifestations of heart disease. JACC Cardiovasc Imaging. 2018;11(8):1045\u201355.","journal-title":"JACC Cardiovasc Imaging"},{"issue":"11","key":"6006_CR21","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1016\/j.amjcard.2012.07.040","volume":"110","author":"TG Neilan","year":"2012","unstructured":"Neilan TG, Coelho-Filho OR, Pena-Herrera D, Shah RV, Jerosch-Herold M, Francis SA, et al. Left ventricular mass in patients with a cardiomyopathy after treatment with anthracyclines. Am J Cardiol. 2012;110(11):1679\u201386.","journal-title":"Am J Cardiol"},{"issue":"1","key":"6006_CR22","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1186\/s12885-018-5080-4","volume":"18","author":"SM Advani","year":"2018","unstructured":"Advani SM, Advani PG, VonVille HM, Jafri SH. Pharmacological management of cachexia in adult cancer patients: a systematic review of clinical trials. BMC Cancer. 2018;18(1):1174.","journal-title":"BMC Cancer"},{"key":"6006_CR23","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.jsbmb.2013.05.015","volume":"137","author":"JR Bell","year":"2013","unstructured":"Bell JR, Bernasochi GB, Varma U, Raaijmakers AJ, Delbridge LM. Sex and sex hormones in cardiac stress--mechanistic insights. J Steroid Biochem Mol Biol. 2013;137:124\u201335.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5","key":"6006_CR24","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/cen.12990","volume":"84","author":"C Kim","year":"2016","unstructured":"Kim C, Bebu I, Braffett B, Cleary PA, Arends V, Steffes M, et al. Testosterone and cardiac mass and function in men with type 1 diabetes in the epidemiology of diabetes interventions and complications study (EDIC). Clin Endocrinol. 2016;84(5):693\u20139.","journal-title":"Clin Endocrinol"},{"key":"6006_CR25","doi-asserted-by":"crossref","unstructured":"Subramanya V, Zhao D, Ouyang P, Ying W, Vaidya D, Ndumele CE, et al. Association of endogenous sex hormone levels with coronary artery calcium progression among post-menopausal women in the multi-ethnic study of atherosclerosis (MESA). J Cardiovasc Comput Tomogr. 2018.","DOI":"10.1016\/j.jcct.2018.09.010"},{"issue":"1","key":"6006_CR26","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/cen.12842","volume":"84","author":"EJ Gianatti","year":"2016","unstructured":"Gianatti EJ, Hoermann R, Lam Q, Dupuis P, Zajac JD, Grossmann M. Effect of testosterone treatment on cardiac biomarkers in a randomized controlled trial of men with type 2 diabetes. Clin Endocrinol. 2016;84(1):55\u201362.","journal-title":"Clin Endocrinol"},{"issue":"5","key":"6006_CR27","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1177\/41.5.8468448","volume":"41","author":"N Kimura","year":"1993","unstructured":"Kimura N, Mizokami A, Oonuma T, Sasano H, Nagura H. Immunocytochemical localization of androgen receptor with polyclonal antibody in paraffin-embedded human tissues. J Histochem Cytochem. 1993;41(5):671\u20138.","journal-title":"J Histochem Cytochem"},{"issue":"10","key":"6006_CR28","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/S0195-668X(03)00083-6","volume":"24","author":"PJ Pugh","year":"2003","unstructured":"Pugh PJ, Jones TH, Channer KS. Acute haemodynamic effects of testosterone in men with chronic heart failure. Eur Heart J. 2003;24(10):909\u201315.","journal-title":"Eur Heart J"},{"issue":"2","key":"6006_CR29","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/8756-3282(95)00441-6","volume":"18","author":"FH Anderson","year":"1996","unstructured":"Anderson FH, Francis RM, Faulkner K. Androgen supplementation in eugonadal men with osteoporosis-effects of 6 months of treatment on bone mineral density and cardiovascular risk factors. Bone. 1996;18(2):171\u20137.","journal-title":"Bone."},{"issue":"36","key":"6006_CR30","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1093\/eurheartj\/ehw211","volume":"37","author":"JL Zamorano","year":"2016","unstructured":"Zamorano JL, Lancellotti P, Rodriguez Munoz D, Aboyans V, Asteggiano R, Galderisi M, et al. 2016 ESC position paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for practice guidelines: the task force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC). Eur Heart J. 2016;37(36):2768\u2013801.","journal-title":"Eur Heart J"},{"issue":"2","key":"6006_CR31","doi-asserted-by":"publisher","first-page":"e002843","DOI":"10.1161\/CIRCHEARTFAILURE.115.002843","volume":"9","author":"CE Hamo","year":"2016","unstructured":"Hamo CE, Bloom MW, Cardinale D, Ky B, Nohria A, Baer L, et al. Cancer therapy-related cardiac dysfunction and heart failure: part 2: prevention, treatment, guidelines, and future directions. Circ Heart Fail. 2016;9(2):e002843.","journal-title":"Circ Heart Fail"},{"issue":"15","key":"6006_CR32","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1161\/CIRCULATIONAHA.116.025434","volume":"135","author":"H Saiki","year":"2017","unstructured":"Saiki H, Petersen IA, Scott CG, Bailey KR, Dunlay SM, Finley RR, et al. Risk of heart failure with preserved ejection fraction in older women after contemporary radiotherapy for breast Cancer. Circulation. 2017;135(15):1388\u201396.","journal-title":"Circulation."},{"issue":"11","key":"6006_CR33","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa1209825","volume":"368","author":"SC Darby","year":"2013","unstructured":"Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Bronnum D, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368(11):987\u201398.","journal-title":"N Engl J Med"},{"issue":"3","key":"6006_CR34","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1177\/2047487318811181","volume":"26","author":"EJ Howden","year":"2019","unstructured":"Howden EJ, Bigaran A, Beaudry R, Fraser S, Selig S, Foulkes S, et al. Exercise as a diagnostic and therapeutic tool for the prevention of cardiovascular dysfunction in breast cancer patients. Eur J Prev Cardiol. 2019;26(3):305\u201315.","journal-title":"Eur J Prev Cardiol"},{"issue":"10","key":"6006_CR35","doi-asserted-by":"publisher","first-page":"3844","DOI":"10.1210\/jc.2006-0588","volume":"91","author":"M Sheffield-Moore","year":"2006","unstructured":"Sheffield-Moore M, Paddon-Jones D, Casperson SL, Gilkison C, Volpi E, Wolf SE, et al. Androgen therapy induces muscle protein anabolism in older women. J Clin Endocrinol Metab. 2006;91(10):3844\u20139.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"6006_CR36","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1161\/01.CIR.101.3.224","volume":"101","author":"JA McCrohon","year":"2000","unstructured":"McCrohon JA, Death AK, Nakhla S, Jessup W, Handelsman DJ, Stanley KK, et al. Androgen receptor expression is greater in macrophages from male than from female donors. A sex difference with implications for atherogenesis. Circulation. 2000;101(3):224\u20136.","journal-title":"Circulation."},{"issue":"1","key":"6006_CR37","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1152\/japplphysiol.00092.2015","volume":"119","author":"Erin J. Howden","year":"2015","unstructured":"Howden EJ, Perhonen M, Peshock RM, et al. Females have a blunted cardiovascular response to one year of intensive supervised endurance training. J Appl Physiol (1985). 2015;119:37\u201346.","journal-title":"Journal of Applied Physiology"},{"issue":"2","key":"6006_CR38","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.ahj.2009.05.031","volume":"158","author":"JL Hare","year":"2009","unstructured":"Hare JL, Brown JK, Leano R, Jenkins C, Woodward N, Marwick TH. Use of myocardial deformation imaging to detect preclinical myocardial dysfunction before conventional measures in patients undergoing breast cancer treatment with trastuzumab. Am Heart J. 2009;158(2):294\u2013301.","journal-title":"Am Heart J"},{"issue":"9","key":"6006_CR39","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1249\/MSS.0000000000001619","volume":"50","author":"JESSICA M. SCOTT","year":"2018","unstructured":"Scott JM, Martin D, Ploutz-Snyder R, et al. Efficacy of Exercise and Testosterone to Mitigate Atrophic Cardiovascular Remodeling. Med Sci Sports Exerc. 2018;50:1940\u201349.","journal-title":"Medicine & Science in Sports & Exercise"},{"key":"6006_CR40","doi-asserted-by":"crossref","unstructured":"Scott JM, Zabor EC, Schwitzer E, Koelwyn GJ, Adams SC, Nilsen TS, et al. Efficacy of Exercise Therapy on Cardiorespiratory Fitness in Patients With Cancer: A Systematic Review and Meta-Analysis. J Clin Oncol. 2018:JCO2017775809.","DOI":"10.1200\/JCO.2017.77.5809"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-019-6006-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12885-019-6006-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-019-6006-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T23:14:31Z","timestamp":1596669271000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-019-6006-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,7]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["6006"],"URL":"https:\/\/doi.org\/10.1186\/s12885-019-6006-5","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,7]]},"assertion":[{"value":"15 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was conducted in accordance with the principles of the Declaration of Helsinki and approved by the Institutional Review Board at the University of Texas Medical Branch. Written informed consent was obtained from all patients prior to participation.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"778"}}