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This study aimed to investigate the impact of chemotherapy on the metabolic activity of brown adipose tissue (BAT) and the link with weight variation.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>This was an ancillary analysis of a multicentre trial involving 109 HER2+ breast cancer patients treated with neoadjuvant chemotherapy. A centralised review of <jats:sup>18<\/jats:sup>F-FDG uptake intensity (SUV<jats:sub>max<\/jats:sub>) in specific BAT regions (cervical and supraclavicular) was conducted on two PET-CT scans for each patient (before and after the first course of chemotherapy).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Overall, after one course of chemotherapy a significant decrease of 4.4% in <jats:sup>18<\/jats:sup>F-FDG-uptake intensity was observed. It was not correlated to initial BMI, age or season. During chemotherapy, 10.1% (<jats:italic>n<\/jats:italic>\u2009=\u200911) of the patients lost weight (\u2212\u20097.7\u2009kg\u2009\u00b1\u20093.8\u2009kg; ie, \u2212\u20099.4%\u2009\u00b1\u20093.7%) and 29.4% (<jats:italic>n<\/jats:italic>\u2009=\u200932) gained weight (+\u20095.1\u2009kg\u2009\u00b1\u20091.7\u2009kg; ie, +\u20098.5%\u2009\u00b1\u20092.6%). Among these subgroups, only the patients who had gained weight underwent a significant decrease (13.42%) in <jats:sup>18<\/jats:sup>F-FDG uptake intensity (<jats:italic>p<\/jats:italic>\u2009=\u20090.042).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This study is the first to highlight in a large cohort of patients the negative impact of chemotherapy on brown adipose tissue activity. Weight gain during chemotherapy could thus potentially be explained in part by a decrease in brown adipose tissue activity.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12885-020-6591-3","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T15:03:04Z","timestamp":1580828584000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A decrease in brown adipose tissue activity is associated with weight gain during chemotherapy in early breast cancer patients"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5614-0876","authenticated-orcid":false,"given":"Angeline","family":"Ginzac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Barres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Chanchou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Gad\u00e9a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Molnar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Merlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Coudert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Thivat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Durando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,4]]},"reference":[{"issue":"7","key":"6591_CR1","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1200\/JCO.2005.01.079","volume":"23","author":"CH Kroenke","year":"2005","unstructured":"Kroenke CH, Chen WY, Rosner B, Holmes MD. 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The study was performed in accordance with the Declaration of Helsinki.As this study is a retrospective one, a non-opposition letter has been delivered to the patients in order to inform them about the research and their right to object to the use of their data.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"96"}}