{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:28:28Z","timestamp":1789018108741,"version":"build-2803163510"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chonnam National University Hwasun Hospital Institute for Biomedical Science","award":["HCRI14027-22"],"award-info":[{"award-number":["HCRI14027-22"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Alcohol consumption is a major risk factor for esophageal cancer; however, a high incidence of esophageal cancer is observed particularly among Eastern Asians, although they consume relatively less alcohol, presumably due to the high frequency of aldehyde dehydrogenase 2 (<jats:italic>ALDH2<\/jats:italic>) rs671 polymorphisms. Nevertheless, the association between <jats:italic>ALDH2<\/jats:italic> polymorphisms and esophageal cancer remains under debate. In the present study, we evaluated the association between <jats:italic>ALDH2<\/jats:italic> rs671 polymorphisms and the risk of esophageal cancer in the South Korean population.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This study included 783 hospital based-cases and 8732 population-based controls. Information on smoking history and alcohol consumption was obtained from the medical records or interview questionnaires. Age-adjusted logistic regression analysis was performed to assess the association between <jats:italic>ALDH2<\/jats:italic> rs671 polymorphisms and esophageal cancer.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Odds ratios (ORs) for esophageal cancer in men with GA and AA genotypes were 2.75 (95% confidence interval [CI]: 2.34\u20133.23) and 0.08 (95% CI: 0.00\u20130.35), respectively; whereas, in women, these ratios were 2.99 (95% CI: 1.43\u20136.34) and 6.18 (95% CI: 1.40\u201319.62), respectively, taking subjects with the <jats:italic>ALDH2<\/jats:italic> GG genotype as a reference. In men, the association between <jats:italic>ALDH2<\/jats:italic> polymorphisms and esophageal cancer was modified by alcohol consumption.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In Eastern Asians, <jats:italic>ALDH2<\/jats:italic> rs671 polymorphisms are associated with esophageal cancer, which may be linked to acetaldehyde accumulation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12885-021-07993-4","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T11:03:46Z","timestamp":1615287826000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association between ALDH2 polymorphism and esophageal cancer risk in South Koreans: a case-control study"],"prefix":"10.1186","volume":"21","author":[{"given":"Chang Kyun","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungho","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Seog","family":"Kweon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Hee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun","family":"Myung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2217-5624","authenticated-orcid":false,"given":"Min-Ho","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"7993_CR1","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/S0140-6736(18)31310-2","volume":"392","author":"MG Griswold","year":"2018","unstructured":"Griswold MG, Fullman N, Hawley C, Arian N, Zimsen SRM, Tymeson HD, et al. 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This study was reviewed and approved by the Institutional Review Boards (IRBs) of Chonnam National University Hospital Hwasun (IBRB-2007-3) and Chonnam National University Hospital (I-2008-05-056).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"254"}}