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In this study, we evaluated the in vitro photoactivity of four <jats:italic>meso<\/jats:italic>-substituted porphyrins and a porphyrin coupled to a fullerene.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The cell line employed was the LM3 mammary adenocarcinoma, and the PS with the best photokilling activity was administered to mice bearing the LM3 subcutaneously implanted adenocarcinoma. The TEMCP<jats:sup>4+<\/jats:sup> porphyrin and its analogue TEMCC<jats:sup>4+<\/jats:sup> chlorine contain four identical carbazoyl substituents at the <jats:italic>meso<\/jats:italic> positions of the tetrapyrrolic macrocycle and have A<jats:sub>4<\/jats:sub> symmetry. The TAPP derivative also has A<jats:sub>4<\/jats:sub> symmetry, and it is substituted at the <jats:italic>meso<\/jats:italic> positions by aminopropoxy groups. The DAPP molecule has ABAB symmetry with aminopropoxy and the trifluoromethyl substituents in <jats:italic>trans<\/jats:italic> positions. The TCP-C<jats:sub>60<\/jats:sub><jats:sup>4+<\/jats:sup> dyad is formed by a porphyrin unit covalently attached to the fullerene C<jats:sub>60<\/jats:sub>.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The PSs are taken up by the cells with the following efficiency: TAPP&gt; TEMCP<jats:sup>4+<\/jats:sup>\u2009=\u2009TEMCC<jats:sup>4+<\/jats:sup>\u2009&gt;\u2009DAPP &gt;TCP-C<jats:sub>60<\/jats:sub><jats:sup>4+<\/jats:sup>, and the amount of intracellular PS correlates fairly with the photodamage degree, but also the quantum yields of singlet oxygen influence the PDT outcome. TAPP, DAPP, TEMCC<jats:sup>4+<\/jats:sup> and TEMCP<jats:sup>4+<\/jats:sup> exhibit high photoactivity against LM3 mammary carcinoma cells, being TAPP the most active. After topical application of TAPP on the skin of mice bearing LM3 tumours, the molecule is localized mainly in the stratum corneum, and at a lower extent in hair follicles and sebaceous glands. Systemic administration of TAPP produces a tumour: normal skin ratio of 31.4, and high accumulation in intestine and lung.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The results suggest a potential use of topical TAPP for the treatment of actinic keratosis and skin adnexal neoplasms. In addition, selectivity for tumour tissue after systemic administration highlights the selectivity of and potentiality of TAPP as a new PS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12885-021-08286-6","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T11:02:47Z","timestamp":1620903767000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Novel meso-substituted porphyrin derivatives and its potential use in photodynamic therapy of cancer"],"prefix":"10.1186","volume":"21","author":[{"given":"Pablo","family":"Vallecorsa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Di Venosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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