{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:26:38Z","timestamp":1782815198269,"version":"3.54.5"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Ministry for Innovation and Technology, Hungary","award":["2020-4.1.1.-TKP2020"],"award-info":[{"award-number":["2020-4.1.1.-TKP2020"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Epidemiological evidence suggests that synchronous or metachronous presentation of breast and thyroid cancers exceeds that predicted by chance alone. The following potential explanations have been hypothesized: common environmental or hormonal factors, oncogenic effect of the treatment for the first cancer, closer follow-up of cancer survivors, shared underlying genetic risk factors. While some cases were found to be related to monogenic disorders with autosomal inheritance, the genetic background of most cases of co-occurring breast and thyroid cancer is thought to be polygenic.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this retrospective case-control study we compared the genetic profile of patients with a history of breast cancer (<jats:italic>n<\/jats:italic>\u00a0=\u200915) to patients with co-occurring breast and thyroid cancer (<jats:italic>n<\/jats:italic>\u00a0=\u200919) using next generation sequencing of 112 hereditary cancer risk genes. Identified variants were categorized based on their known association with breast cancer and oncogenesis in general.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>No difference between patients with breast and double cancers was observed in clinical and pathological characteristics or the number of neutral SNPs. The unweighted and weighted number of SNPs with an established or potential association with breast cancer was significantly lower in the group with breast cancer only (mean difference\u2009\u2212\u20090.58, BCa 95% CI [\u2212\u20091.09, \u2212\u20090.06], <jats:italic>p<\/jats:italic>\u00a0=\u20090.029, and mean difference\u2009\u2212\u20090.36, BCa 95% CI [\u2212\u20090.70, \u2212\u20090.02], <jats:italic>p<\/jats:italic>\u00a0=\u20090.039, respectively). The difference was also significant when we compared the number of SNPs with potential or known association with any malignancy (mean difference\u2009\u2212\u20091.19, BCa 95% CI [\u2212\u20092.27, \u2212\u20090.11], <jats:italic>p<\/jats:italic>\u00a0=\u20090.032 for unweighted, and mean difference\u2009\u2212\u20090.73, BCa 95% CI [\u2212\u20091.32, \u2212\u20090.14], <jats:italic>p<\/jats:italic>\u00a0=\u20090.017 for weighted scores).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our findings are compatible with the hypothesis of genetic predisposition in the co-occurrence of breast and thyroid cancer. Further exploration of the underlying genetic mechanisms may help in the identification of patients with an elevated risk for a second cancer at the diagnosis of the first cancer.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12885-021-08377-4","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T18:02:53Z","timestamp":1623780173000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Co-occurrence of thyroid and breast cancer is associated with an increased oncogenic SNP burden"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2073-6536","authenticated-orcid":false,"given":"Bence","family":"Bakos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krist\u00f3f","family":"\u00c1rvai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Szili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"De\u00e1k-Kocsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1lint","family":"Tobi\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Putz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rich\u00e1rd","family":"\u00c1rm\u00f3s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadett","family":"Balla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"K\u00f3sa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdolna","family":"Dank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Valkusz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Tak\u00e1cs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1d\u00e1m","family":"Tab\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Lakatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"issue":"1","key":"8377_CR1","first-page":"292","volume":"47","author":"A McTiernan","year":"1987","unstructured":"McTiernan A, Weiss NS, Daling JR. Incidence of thyroid cancer in women in relation to known or suspected risk factors for breast cancer. Cancer Res. 1987;47(1):292\u20135.","journal-title":"Cancer Res"},{"issue":"12","key":"8377_CR2","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1089\/thy.2014.0561","volume":"25","author":"JH An","year":"2015","unstructured":"An JH, Hwangbo Y, Ahn HY, Keam B, Lee KE, Han W, et al. A possible association between thyroid Cancer and breast Cancer. Thyroid. 2015;25(12):1330\u20138. https:\/\/doi.org\/10.1089\/thy.2014.0561.","journal-title":"Thyroid."},{"issue":"2","key":"8377_CR3","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1158\/1055-9965.EPI-15-0833","volume":"25","author":"SM Nielsen","year":"2016","unstructured":"Nielsen SM, White MG, Hong S, Aschebrook-Kilfoy B, Kaplan EL, Angelos P, et al. The breast-thyroid Cancer link: a systematic review and meta-analysis. Cancer Epidemiol Biomark Prev. 2016;25(2):231\u20138. https:\/\/doi.org\/10.1158\/1055-9965.EPI-15-0833.","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"1","key":"8377_CR4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s10549-015-3456-6","volume":"152","author":"KR Joseph","year":"2015","unstructured":"Joseph KR, Edirimanne S, Eslick GD. The association between breast cancer and thyroid cancer: a meta-analysis. Breast Cancer Res Treat. 2015;152(1):173\u201381. https:\/\/doi.org\/10.1007\/s10549-015-3456-6.","journal-title":"Breast Cancer Res Treat"},{"key":"8377_CR5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3389\/fendo.2017.00111","volume":"8","author":"M Moleti","year":"2017","unstructured":"Moleti M, Sturniolo G, Di Mauro M, Russo M, Vermiglio F. Female Reproductive Factors and Differentiated Thyroid Cancer. Front Endocrinol (Lausanne). 2017;8:111.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"8377_CR6","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s10549-012-2019-3","volume":"133","author":"PJ Hardefeldt","year":"2012","unstructured":"Hardefeldt PJ, Eslick GD, Edirimanne S. Benign thyroid disease is associated with breast cancer: a meta-analysis. Breast Cancer Res Treat. 2012;133(3):1169\u201377. https:\/\/doi.org\/10.1007\/s10549-012-2019-3.","journal-title":"Breast Cancer Res Treat"},{"issue":"6","key":"8377_CR7","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1002\/cncr.20881","volume":"103","author":"M Cristofanilli","year":"2005","unstructured":"Cristofanilli M, Yamamura Y, Kau SW, Bevers T, Strom S, Patangan M, et al. Thyroid hormone and breast carcinoma. Primary hypothyroidism is associated with a reduced incidence of primary breast carcinoma. Cancer. 2005;103(6):1122\u20138. https:\/\/doi.org\/10.1002\/cncr.20881.","journal-title":"Cancer."},{"issue":"16","key":"8377_CR8","doi-asserted-by":"publisher","first-page":"6643","DOI":"10.7314\/APJCP.2014.15.16.6643","volume":"15","author":"XZ Shi","year":"2014","unstructured":"Shi XZ, Jin X, Xu P, Shen HM. Relationship between breast cancer and levels of serum thyroid hormones and antibodies: a meta-analysis. Asian Pac J Cancer Prev. 2014;15(16):6643\u20137. https:\/\/doi.org\/10.7314\/APJCP.2014.15.16.6643.","journal-title":"Asian Pac J Cancer Prev"},{"key":"8377_CR9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.mehy.2018.10.008","volume":"122","author":"A Kurata","year":"2019","unstructured":"Kurata A. Differentiated thyroid cancer: why does it affect predominantly women during the reproductive period and have higher incidence of mutual association with breast cancer? Med Hypotheses. 2019;122:5\u20137. https:\/\/doi.org\/10.1016\/j.mehy.2018.10.008.","journal-title":"Med Hypotheses"},{"key":"8377_CR10","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.envint.2017.06.021","volume":"107","author":"K Hoffman","year":"2017","unstructured":"Hoffman K, Lorenzo A, Butt CM, Hammel SC, Henderson BB, Roman SA, et al. Exposure to flame retardant chemicals and occurrence and severity of papillary thyroid cancer: a case-control study. Environ Int. 2017;107:235\u201342. https:\/\/doi.org\/10.1016\/j.envint.2017.06.021.","journal-title":"Environ Int"},{"issue":"4","key":"8377_CR11","doi-asserted-by":"publisher","first-page":"684","DOI":"10.4103\/0973-1482.167613","volume":"11","author":"MA Tunio","year":"2015","unstructured":"Tunio MA, Al Asiri M, Bayoumi Y, Stanciu LG, Al Johani N, Al Saeed EF. Is thyroid gland an organ at risk in breast cancer patients treated with locoregional radiotherapy? Results of a pilot study. J Cancer Res Ther. 2015;11(4):684\u20139. https:\/\/doi.org\/10.4103\/0973-1482.167613.","journal-title":"J Cancer Res Ther"},{"issue":"2","key":"8377_CR12","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/MNM.0000000000000419","volume":"37","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Liang J, Li H, Cong H, Lin Y. Risk of second primary breast cancer after radioactive iodine treatment in thyroid cancer: a systematic review and meta-analysis. Nucl Med Commun. 2016;37(2):110\u20135. https:\/\/doi.org\/10.1097\/MNM.0000000000000419.","journal-title":"Nucl Med Commun"},{"issue":"1","key":"8377_CR13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1159\/000011928","volume":"56","author":"J Zidan","year":"1999","unstructured":"Zidan J, Rubenstein W. Effect of adjuvant tamoxifen therapy on thyroid function in postmenopausal women with breast cancer. Oncology. 1999;56(1):43\u20135. https:\/\/doi.org\/10.1159\/000011928.","journal-title":"Oncology."},{"issue":"17","key":"8377_CR14","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1200\/JCO.2013.53.6656","volume":"32","author":"J Ngeow","year":"2014","unstructured":"Ngeow J, Stanuch K, Mester JL, Barnholtz-Sloan JS, Eng C. Second malignant neoplasms in patients with Cowden syndrome with underlying germline PTEN mutations. J Clin Oncol. 2014;32(17):1818\u201324. https:\/\/doi.org\/10.1200\/JCO.2013.53.6656.","journal-title":"J Clin Oncol"},{"issue":"2","key":"8377_CR15","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1093\/hmg\/ddr459","volume":"21","author":"Y Ni","year":"2012","unstructured":"Ni Y, He X, Chen J, Moline J, Mester J, Orloff MS, et al. Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD\/NAD-dependant destabilization of p53. Hum Mol Genet. 2012;21(2):300\u201310. https:\/\/doi.org\/10.1093\/hmg\/ddr459.","journal-title":"Hum Mol Genet"},{"issue":"4","key":"8377_CR16","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1158\/1055-9965.EPI-18-0877","volume":"28","author":"EL Bolf","year":"2019","unstructured":"Bolf EL, Sprague BL, Carr FE. A linkage between thyroid and breast Cancer: a common etiology? Cancer Epidemiol Biomark Prev. 2019;28(4):643\u20139. https:\/\/doi.org\/10.1158\/1055-9965.EPI-18-0877.","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"21","key":"8377_CR17","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1093\/jnci\/86.21.1600","volume":"86","author":"DE Goldgar","year":"1994","unstructured":"Goldgar DE, Easton DF, Cannon-Albright LA, Skolnick MH. Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands. J Natl Cancer Inst. 1994;86(21):1600\u20138. https:\/\/doi.org\/10.1093\/jnci\/86.21.1600.","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"8377_CR18","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.cell.2018.07.034","volume":"174","author":"MH Bailey","year":"2018","unstructured":"Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, et al. Comprehensive characterization of Cancer driver genes and mutations. Cell. 2018;174(4):1034\u20135. https:\/\/doi.org\/10.1016\/j.cell.2018.07.034.","journal-title":"Cell."},{"issue":"20","key":"8377_CR19","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1056\/NEJMra0802968","volume":"359","author":"WD Foulkes","year":"2008","unstructured":"Foulkes WD. Inherited susceptibility to common cancers. N Engl J Med. 2008;359(20):2143\u201353. https:\/\/doi.org\/10.1056\/NEJMra0802968.","journal-title":"N Engl J Med"},{"issue":"1","key":"8377_CR20","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1146\/annurev-genom-091416-035305","volume":"18","author":"PD Shah","year":"2017","unstructured":"Shah PD, Nathanson KL. Application of panel-based tests for inherited risk of Cancer. Annu Rev Genomics Hum Genet. 2017;18(1):201\u201327. https:\/\/doi.org\/10.1146\/annurev-genom-091416-035305.","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"D1","key":"8377_CR21","doi-asserted-by":"publisher","first-page":"D862","DOI":"10.1093\/nar\/gkv1222","volume":"44","author":"MJ Landrum","year":"2016","unstructured":"Landrum MJ, Lee JM, Benson M, Brown G, Chao C, Chitipiralla S, et al. ClinVar: public archive of interpretations of clinically relevant variants. Nucleic Acids Res. 2016;44(D1):D862\u20138. https:\/\/doi.org\/10.1093\/nar\/gkv1222.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"8377_CR22","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.surg.2015.10.009","volume":"159","author":"JH Kuo","year":"2016","unstructured":"Kuo JH, Chabot JA, Lee JA. Breast cancer in thyroid cancer survivors: An analysis of the surveillance, epidemiology, and end Results-9 database. Surgery. 2016;159(1):23\u20139. https:\/\/doi.org\/10.1016\/j.surg.2015.10.009.","journal-title":"Surgery."},{"issue":"1","key":"8377_CR23","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21387","volume":"67","author":"RL Siegel","year":"2017","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67(1):7\u201330. https:\/\/doi.org\/10.3322\/caac.21387.","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"8377_CR24","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s10552-008-9260-4","volume":"20","author":"BA Kilfoy","year":"2009","unstructured":"Kilfoy BA, Zheng T, Holford TR, Han X, Ward MH, Sjodin A, et al. International patterns and trends in thyroid cancer incidence, 1973-2002. Cancer Causes Control. 2009;20(5):525\u201331. https:\/\/doi.org\/10.1007\/s10552-008-9260-4.","journal-title":"Cancer Causes Control"},{"issue":"4","key":"8377_CR25","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1001\/jamaoto.2014.1","volume":"140","author":"L Davies","year":"2014","unstructured":"Davies L, Welch HG. Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg. 2014;140(4):317\u201322. https:\/\/doi.org\/10.1001\/jamaoto.2014.1.","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"1","key":"8377_CR26","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0304-3835(94)90358-1","volume":"84","author":"K Yane","year":"1994","unstructured":"Yane K, Kitahori Y, Konishi N, Okaichi K, Ohnishi T, Miyahara H, et al. Expression of the estrogen receptor in human thyroid neoplasms. Cancer Lett. 1994;84(1):59\u201366. https:\/\/doi.org\/10.1016\/0304-3835(94)90358-1.","journal-title":"Cancer Lett"},{"issue":"1","key":"8377_CR27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1089\/thy.2009.0296","volume":"20","author":"S Rajoria","year":"2010","unstructured":"Rajoria S, Suriano R, Shanmugam A, Wilson YL, Schantz SP, Geliebter J, et al. Metastatic phenotype is regulated by estrogen in thyroid cells. Thyroid. 2010;20(1):33\u201341. https:\/\/doi.org\/10.1089\/thy.2009.0296.","journal-title":"Thyroid."},{"issue":"3","key":"8377_CR28","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1210\/jc.2007-2215","volume":"93","author":"MR Haymart","year":"2008","unstructured":"Haymart MR, Repplinger DJ, Leverson GE, Elson DF, Sippel RS, Jaume JC, et al. Higher serum thyroid stimulating hormone level in thyroid nodule patients is associated with greater risks of differentiated thyroid cancer and advanced tumor stage. J Clin Endocrinol Metab. 2008;93(3):809\u201314. https:\/\/doi.org\/10.1210\/jc.2007-2215.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1\u20132","key":"8377_CR29","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jsbmb.2007.12.008","volume":"109","author":"LC Hall","year":"2008","unstructured":"Hall LC, Salazar EP, Kane SR, Liu N. Effects of thyroid hormones on human breast cancer cell proliferation. J Steroid Biochem Mol Biol. 2008;109(1\u20132):57\u201366. https:\/\/doi.org\/10.1016\/j.jsbmb.2007.12.008.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"27","key":"8377_CR30","doi-asserted-by":"publisher","first-page":"4307","DOI":"10.1038\/sj.onc.1205534","volume":"21","author":"JM Silva","year":"2002","unstructured":"Silva JM, Dominguez G, Gonzalez-Sancho JM, Garcia JM, Silva J, Garcia-Andrade C, et al. Expression of thyroid hormone receptor\/erbA genes is altered in human breast cancer. Oncogene. 2002;21(27):4307\u201316. https:\/\/doi.org\/10.1038\/sj.onc.1205534.","journal-title":"Oncogene."},{"issue":"7","key":"8377_CR31","doi-asserted-by":"publisher","first-page":"3928","DOI":"10.1016\/j.bbagen.2012.04.002","volume":"1830","author":"WG Kim","year":"2013","unstructured":"Kim WG, Cheng SY. Thyroid hormone receptors and cancer. Biochim Biophys Acta. 2013;1830(7):3928\u201336. https:\/\/doi.org\/10.1016\/j.bbagen.2012.04.002.","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"8377_CR32","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1158\/0008-5472.CAN-08-2198","volume":"69","author":"O Martinez-Iglesias","year":"2009","unstructured":"Martinez-Iglesias O, Garcia-Silva S, Tenbaum SP, Regadera J, Larcher F, Paramio JM, et al. Thyroid hormone receptor beta1 acts as a potent suppressor of tumor invasiveness and metastasis. Cancer Res. 2009;69(2):501\u20139. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-2198.","journal-title":"Cancer Res"},{"issue":"8","key":"8377_CR33","doi-asserted-by":"publisher","first-page":"3278","DOI":"10.1210\/en.2015-2046","volume":"157","author":"FE Carr","year":"2016","unstructured":"Carr FE, Tai PW, Barnum MS, Gillis NE, Evans KG, Taber TH, et al. Thyroid hormone receptor-beta (TRbeta) mediates runt-related transcription factor 2 (Runx2) expression in thyroid Cancer cells: a novel signaling pathway in thyroid Cancer. Endocrinology. 2016;157(8):3278\u201392. https:\/\/doi.org\/10.1210\/en.2015-2046.","journal-title":"Endocrinology."},{"issue":"4","key":"8377_CR34","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1159\/000460246","volume":"6","author":"I Muller","year":"2017","unstructured":"Muller I, Kilburn LS, Taylor PN, Barrett-Lee PJ, Bliss JM, Ellis P, et al. TPOAb and thyroid function are not associated with breast Cancer outcome: evidence from a large-scale study using data from the Taxotere as adjuvant chemotherapy trial (TACT, CRUK01\/001). Eur Thyroid J. 2017;6(4):197\u2013207. https:\/\/doi.org\/10.1159\/000460246.","journal-title":"Eur Thyroid J"},{"issue":"10","key":"8377_CR35","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s40618-017-0679-x","volume":"40","author":"Y Fang","year":"2017","unstructured":"Fang Y, Yao L, Sun J, Yang R, Chen Y, Tian J, et al. Does thyroid dysfunction increase the risk of breast cancer? A systematic review and meta-analysis. J Endocrinol Investig. 2017;40(10):1035\u201347. https:\/\/doi.org\/10.1007\/s40618-017-0679-x.","journal-title":"J Endocrinol Investig"},{"issue":"6","key":"8377_CR36","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1210\/er.2015-1010","volume":"36","author":"AC Gore","year":"2015","unstructured":"Gore AC, Chappell VA, Fenton SE, Flaws JA, Nadal A, Prins GS, et al. EDC-2: the Endocrine Society's second scientific statement on endocrine-disrupting chemicals. Endocr Rev. 2015;36(6):E1\u2013E150. https:\/\/doi.org\/10.1210\/er.2015-1010.","journal-title":"Endocr Rev"},{"issue":"2","key":"8377_CR37","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1742-7843.2007.00165.x","volume":"102","author":"AM Soto","year":"2008","unstructured":"Soto AM, Vandenberg LN, Maffini MV, Sonnenschein C. Does breast cancer start in the womb? Basic Clin Pharmacol Toxicol. 2008;102(2):125\u201333. https:\/\/doi.org\/10.1111\/j.1742-7843.2007.00165.x.","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"8377_CR38","doi-asserted-by":"publisher","unstructured":"Harvie M, Howell A, Evans DG. Can diet and lifestyle prevent breast cancer: what is the evidence? Am Soc Clin Oncol Educ Book. 2015;(35):e66\u201373. https:\/\/doi.org\/10.14694\/EdBook_AM.2015.35.e66.","DOI":"10.14694\/EdBook_AM.2015.35.e66"},{"key":"8377_CR39","doi-asserted-by":"publisher","first-page":"283","DOI":"10.12659\/MSM.892035","volume":"21","author":"J Ma","year":"2015","unstructured":"Ma J, Huang M, Wang L, Ye W, Tong Y, Wang H. Obesity and risk of thyroid cancer: evidence from a meta-analysis of 21 observational studies. Med Sci Monit. 2015;21:283\u201391. https:\/\/doi.org\/10.12659\/MSM.892035.","journal-title":"Med Sci Monit"},{"issue":"6","key":"8377_CR40","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1053\/j.seminoncol.2003.08.022","volume":"30","author":"SM Matesich","year":"2003","unstructured":"Matesich SM, Shapiro CL. Second cancers after breast cancer treatment. Semin Oncol. 2003;30(6):740\u20138. https:\/\/doi.org\/10.1053\/j.seminoncol.2003.08.022.","journal-title":"Semin Oncol"},{"issue":"3","key":"8377_CR41","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.radonc.2016.08.017","volume":"121","author":"T Grantzau","year":"2016","unstructured":"Grantzau T, Overgaard J. Risk of second non-breast cancer among patients treated with and without postoperative radiotherapy for primary breast cancer: a systematic review and meta-analysis of population-based studies including 522,739 patients. Radiother Oncol. 2016;121(3):402\u201313. https:\/\/doi.org\/10.1016\/j.radonc.2016.08.017.","journal-title":"Radiother Oncol"},{"issue":"9","key":"8377_CR42","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1023\/A:1008942616092","volume":"11","author":"CI Li","year":"2000","unstructured":"Li CI, Rossing MA, Voigt LF, Daling JR. Multiple primary breast and thyroid cancers: role of age at diagnosis and cancer treatments (United States). Cancer Causes Control. 2000;11(9):805\u201311. https:\/\/doi.org\/10.1023\/A:1008942616092.","journal-title":"Cancer Causes Control"},{"issue":"6","key":"8377_CR43","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1002\/1097-0142(20010915)92:6<1411::AID-CNCR1464>3.0.CO;2-9","volume":"92","author":"J Huang","year":"2001","unstructured":"Huang J, Walker R, Groome PG, Shelley W, Mackillop WJ. Risk of thyroid carcinoma in a female population after radiotherapy for breast carcinoma. Cancer. 2001;92(6):1411\u20138. https:\/\/doi.org\/10.1002\/1097-0142(20010915)92:6<1411::AID-CNCR1464>3.0.CO;2-9.","journal-title":"Cancer."},{"issue":"6","key":"8377_CR44","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1245\/s10434-011-2193-2","volume":"19","author":"G Lal","year":"2012","unstructured":"Lal G, Groff M, Howe JR, Weigel RJ, Sugg SL, Lynch CF. Risk of subsequent primary thyroid cancer after another malignancy: latency trends in a population-based study. Ann Surg Oncol. 2012;19(6):1887\u201396. https:\/\/doi.org\/10.1245\/s10434-011-2193-2.","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"8377_CR45","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1089\/thy.2011.0013","volume":"22","author":"SS Kim","year":"2012","unstructured":"Kim SS, Kim SJ, Bae YT, Lee JY, Kim BH, Kim YK, et al. Factors associated with the development of new onset diffuse thyroid F18-fluorodeoxyglucose uptake after treatment of breast cancer in patients without a history of thyroid disease or thyroid dysfunction. Thyroid. 2012;22(1):53\u20138. https:\/\/doi.org\/10.1089\/thy.2011.0013.","journal-title":"Thyroid."},{"issue":"2","key":"8377_CR46","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1210\/jc.2007-1154","volume":"93","author":"AP Brown","year":"2008","unstructured":"Brown AP, Chen J, Hitchcock YJ, Szabo A, Shrieve DC, Tward JD. The risk of second primary malignancies up to three decades after the treatment of differentiated thyroid cancer. J Clin Endocrinol Metab. 2008;93(2):504\u201315. https:\/\/doi.org\/10.1210\/jc.2007-1154.","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"8377_CR47","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1089\/thy.2008.0392","volume":"19","author":"AM Sawka","year":"2009","unstructured":"Sawka AM, Thabane L, Parlea L, Ibrahim-Zada I, Tsang RW, Brierley JD, et al. Second primary malignancy risk after radioactive iodine treatment for thyroid cancer: a systematic review and meta-analysis. Thyroid. 2009;19(5):451\u20137. https:\/\/doi.org\/10.1089\/thy.2008.0392.","journal-title":"Thyroid."},{"issue":"6","key":"8377_CR48","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1530\/eje.1.02300","volume":"155","author":"RB Verkooijen","year":"2006","unstructured":"Verkooijen RB, Smit JW, Romijn JA, Stokkel MP. The incidence of second primary tumors in thyroid cancer patients is increased, but not related to treatment of thyroid cancer. Eur J Endocrinol. 2006;155(6):801\u20136. https:\/\/doi.org\/10.1530\/eje.1.02300.","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"8377_CR49","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.ejso.2017.03.004","volume":"44","author":"Y Ito","year":"2018","unstructured":"Ito Y, Miyauchi A, Oda H. Low-risk papillary microcarcinoma of the thyroid: a review of active surveillance trials. Eur J Surg Oncol. 2018;44(3):307\u201315. https:\/\/doi.org\/10.1016\/j.ejso.2017.03.004.","journal-title":"Eur J Surg Oncol"},{"issue":"19","key":"8377_CR50","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1056\/NEJMp1409841","volume":"371","author":"HS Ahn","year":"2014","unstructured":"Ahn HS, Kim HJ, Welch HG. Korea's thyroid-cancer \"epidemic\"--screening and overdiagnosis. N Engl J Med. 2014;371(19):1765\u20137. https:\/\/doi.org\/10.1056\/NEJMp1409841.","journal-title":"N Engl J Med"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-021-08377-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12885-021-08377-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-021-08377-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T18:05:46Z","timestamp":1623780346000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-021-08377-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["8377"],"URL":"https:\/\/doi.org\/10.1186\/s12885-021-08377-4","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,15]]},"assertion":[{"value":"25 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research was approved and licenced by the Semmelweis University Regional and Institutional Committee of Science and Research Ethics, and was conducted in accordance with the World Medical Association\u2019s Declaration of Helsinki. Written informed consent was obtained from all participants before entering the study and prior to any study related procedures. This consent extended to the study team accessing their relevant medical history and genetic data. All participants were 18\u2009years or older at the time of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors state that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"706"}}