{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T11:29:28Z","timestamp":1777202968418,"version":"3.51.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["2R01 AG20118"],"award-info":[{"award-number":["2R01 AG20118"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Supervised physical activity interventions improve functional health during cancer survivorship, but remain costly and inaccessible for many. We previously reported on the benefits of a DVD-delivered physical activity program (<jats:italic>FlexToBa\u2122)<\/jats:italic> in older adults. This is a secondary analysis of the intervention effects among cancer survivors in the original sample.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Low active, older adults who self-reported a history of cancer (<jats:italic>N<\/jats:italic>\u2009=\u200946; <jats:italic>M<\/jats:italic> time since diagnosis\u2009=\u200910.7\u2009\u00b1\u20099.4\u2009years) participated in a 6-month, home-based physical activity intervention. Participants were randomized to either the DVD-delivered physical activity program focused on flexibility, toning, and balance (<jats:italic>FlexToBa\u2122<\/jats:italic>; <jats:italic>n<\/jats:italic>\u2009=\u200922) or an attentional control condition (<jats:italic>n<\/jats:italic>\u2009=\u200924). Physical function was assessed by the Short Physical Performance Battery (SPPB) at baseline, end of intervention, and at 12 and 24\u2009months after baseline.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Repeated measures linear mixed models indicated a significant group*time interaction for the SPPB total score (\u03b2\u2009=\u2009\u2212\u20091.14, <jats:italic>p<\/jats:italic>\u2009=\u20090.048), driven by improved function from baseline to six months in the <jats:italic>FlexToBa\u2122<\/jats:italic> group. The intervention group also had improved balance (\u03b2\u2009=\u2009\u2212\u20090.56, <jats:italic>p<\/jats:italic>\u2009=\u20090.041) compared with controls. Similar trends emerged for the SPPB total score during follow-up; the group*time interaction from 0 to 12\u2009months approached significance (\u03b2\u2009=\u2009\u2212\u20090.97, <jats:italic>p<\/jats:italic>\u2009=\u20090.089) and was significant from 0 to 24\u2009months (\u03b2\u2009=\u2009\u2212\u20091.84, <jats:italic>p<\/jats:italic>\u2009=\u20090.012). No significant interactions emerged for other outcomes (<jats:italic>p<\/jats:italic>s\u2009&gt;\u20090.11).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>A DVD-delivered physical activity intervention designed for cancer-free older adults was capable of eliciting and maintaining clinically meaningful functional improvements in a subgroup of cancer survivors, with similar effects to the original full sample. These findings inform the dissemination of evidence-based physical activity programs during survivorship.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01030419\">NCT01030419<\/jats:ext-link>. Registered 11 December 2009<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12885-021-08608-8","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T12:04:02Z","timestamp":1627560242000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of a DVD-delivered randomized controlled physical activity intervention on functional health in cancer survivors"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5152-3168","authenticated-orcid":false,"given":"Elizabeth A.","family":"Salerno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha P.","family":"Gothe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Fanning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay L.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham A.","family":"Colditz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"McAuley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"issue":"11","key":"8608_CR1","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","volume":"51","author":"KL Campbell","year":"2019","unstructured":"Campbell KL, et al. 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