{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:26:00Z","timestamp":1793795160968,"version":"4.6.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010477","name":"Intuitive Surgical","doi-asserted-by":"publisher","award":["2019 grand cycle"],"award-info":[{"award-number":["2019 grand cycle"]}],"id":[{"id":"10.13039\/100010477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014584","name":"Universit\u00e4tsmedizin der Johannes Gutenberg-Universit\u00e4t Mainz","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014584","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>For patients with esophageal adenocarcinoma or cancer of the gastroesophageal junction, radical esophagectomy with 2-field lymphadenectomy is the cornerstone of the multimodality treatment with curative intent. Both conventional minimally invasive esophagectomy (MIE) and robot assisted minimally invasive esophagectomy (RAMIE) were shown to be superior compared to open transthoracic esophagectomy considering postoperative complications. However, no randomized comparison exists between MIE and RAMIE in the Western World for patients with esophageal adenocarcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is an investigator-initiated and investigator-driven multicenter randomized controlled parallel-group superiority trial. All adult patients (age\u2009\u2265\u200918 and\u2009\u2264\u200990\u2009years) with histologically proven, surgically resectable (cT1-4a, N0\u20133, M0) esophageal adenocarcinoma of the intrathoracic esophagus or adenocarcinoma of the gastroesophageal junction and with European Clinical Oncology Group performance status 0, 1 or 2 will be assessed for eligibility and included after obtaining informed consent. Patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009218) with resectable esophageal adenocarcinoma of the intrathoracic esophagus or adenocarcinoma of the gastroesophageal junction are randomized to either RAMIE (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009109) or MIE (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009109). The primary outcome of this study is the total number of resected abdominal and mediastinal lymph nodes specified per lymph node station.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first randomized controlled trial designed to compare RAMIE to MIE as surgical treatment for resectable esophageal adenocarcinoma or adenocarcinoma of the gastroesophageal junction in the Western World. The hypothesis of the proposed study is that RAMIE will result in a higher abdominal and mediastinal lymph node yield specified per station compared to conventional MIE.<\/jats:p>\n                    <jats:p>Short-term results and the primary endpoint (total number of resected abdominal and mediastinal lymph nodes per lymph node station) will be analyzed and published after discharge of the last randomized patient within this trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      Identifier:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04306458\">NCT04306458<\/jats:ext-link>\n                      . Registered 13th March 2020,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04306458;\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04306458;<\/jats:ext-link>\n                      Date of first enrolment 18.01.2021; Target sample size 218; Recruitment status: Recruiting; Protocol version 2; Issue date 10.03.2020; Rev. 02.02.2021; Authors ET, PCvdS, PPG.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12885-021-08780-x","type":"journal-article","created":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T12:06:20Z","timestamp":1632657980000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":103,"title":["Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy versus minimally invasive esophagectomy for resectable esophageal adenocarcinoma, a randomized controlled trial (ROBOT-2 trial)"],"prefix":"10.1186","volume":"21","author":[{"given":"E.","family":"Tagkalos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C.","family":"van der Sluis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Berlth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Poplawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hadzijusufovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. I.","family":"van Berge Henegouwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"Gisbertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. P.","family":"M\u00fcller-Stich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"Ruurda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schiesser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"van Hillegersberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. P.","family":"Grimminger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,26]]},"reference":[{"issue":"2","key":"8780_CR1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1097\/CEJ.0000000000000249","volume":"26","author":"B Gupta","year":"2017","unstructured":"Gupta B, Kumar N. Worldwide incidence, mortality and time trends for cancer of the oesophagus. ECP. 2017;26(2):107\u201318. https:\/\/doi.org\/10.1097\/CEJ.0000000000000249.","journal-title":"ECP"},{"issue":"6","key":"8780_CR2","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1097\/SLA.0b013e31815c4037","volume":"246","author":"JMT Omloo","year":"2007","unstructured":"Omloo JMT, Lagarde SM, Hulscher JBF, Reitsma JB, Fockens P, van Dekken H, et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the mid\/distal esophagus. Ann Surg. 2007;246(6):992\u20131001. https:\/\/doi.org\/10.1097\/SLA.0b013e31815c4037.","journal-title":"Ann Surg"},{"issue":"6","key":"8780_CR3","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S1470-2045(07)70172-9","volume":"8","author":"C Mariette","year":"2007","unstructured":"Mariette C, Piessen G, Triboulet JP. Therapeutic strategies in oesophageal carcinoma: role of surgery and other modalities. Lancet Oncol. 2007;8(6):545\u201353. https:\/\/doi.org\/10.1016\/S1470-2045(07)70172-9.","journal-title":"Lancet Oncol"},{"issue":"9","key":"8780_CR4","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/S1470-2045(05)70288-6","volume":"6","author":"BH Burmeister","year":"2005","unstructured":"Burmeister BH, Smithers BM, Gebski V, Fitzgerald L, Simes RJ, Devitt P, et al. Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: a randomised controlled phase III trial. Lancet Oncol. 2005;6(9):659\u201368. https:\/\/doi.org\/10.1016\/S1470-2045(05)70288-6.","journal-title":"Lancet Oncol"},{"issue":"3","key":"8780_CR5","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/S1470-2045(07)70039-6","volume":"8","author":"V Gebski","year":"2007","unstructured":"Gebski V, Burmeister B, Smithers BM, Foo K, Zalcberg J, Simes J. Australasian gastro-intestinal trials group. Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis. Lancet Oncol. 2007;8(3):226\u201334. https:\/\/doi.org\/10.1016\/S1470-2045(07)70039-6.","journal-title":"Lancet Oncol."},{"issue":"9829","key":"8780_CR6","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1016\/S0140-6736(12)60516-9","volume":"379","author":"SS Biere","year":"2012","unstructured":"Biere SS, van Berge Henegouwen MI, Maas KW, Bonavina L, Rosman C, Garcia JR, et al. Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial. Lancet. 2012;379(9829):1887\u201392. https:\/\/doi.org\/10.1016\/S0140-6736(12)60516-9.","journal-title":"Lancet."},{"issue":"8","key":"8780_CR7","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1007\/s00268-015-3100-y","volume":"39","author":"KW Maas","year":"2015","unstructured":"Maas KW, Cuesta MA, van Berge Henegouwen MI, Roig J, Bonavina L, Rosman C, et al. Quality of life and late complications after minimally invasive compared to open Esophagectomy: results of a randomized trial. World J Surg. 2015;39(8):1986\u201393. https:\/\/doi.org\/10.1007\/s00268-015-3100-y.","journal-title":"World J Surg"},{"key":"8780_CR8","doi-asserted-by":"crossref","unstructured":"Mariette C, Markar SR, Dabakuyo-Yonli TS, Meunier B, Pezet D, Collet D, D'Journo XB, Brigand C, Perniceni T, Carr\u00e8re N, Mabrut JY, Msika S, Peschaud F, Prudhomme M, Bonnetain F, Piessen G; F\u00e9d\u00e9ration de Recherche en Chirurgie (FRENCH) and French Eso-Gastric Tumors (FREGAT) Working Group. N Engl J Med 201;380:152\u2013162.","DOI":"10.1056\/NEJMoa1805101"},{"issue":"6","key":"8780_CR9","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s10353-018-0552-y","volume":"50","author":"M Paireder","year":"2018","unstructured":"Paireder M, Asari R, Kristo I, Rieder I, Zacherl I, Kabon B, et al. Morbidity in open versus minimally invasive hybrid esophagectomy (MIOMIE): long-term results of a randomized controlled clinical study. Eur Surg. 2018;50(6):249\u201355. https:\/\/doi.org\/10.1007\/s10353-018-0552-y.","journal-title":"Eur Surg"},{"issue":"4","key":"8780_CR10","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1097\/SLA.0000000000003031","volume":"269","author":"PC van der Sluis","year":"2019","unstructured":"van der Sluis PC, van der Horst S, May AM, Schippers C, Brosens LAA, Joore HCA, et al. Robot-assisted minimally invasive Thoracolaparoscopic Esophagectomy versus open transthoracic Esophagectomy for Resectable esophageal Cancer: a randomized controlled trial. Ann Surg. 2019;269(4):621\u201330. https:\/\/doi.org\/10.1097\/SLA.0000000000003031.","journal-title":"Ann Surg"},{"issue":"8","key":"8780_CR11","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1002\/bjs.6647","volume":"96","author":"J Boone","year":"2009","unstructured":"Boone J, Schipper ME, Moojen WA, Borel Rinkes IH, Cromheecke GJ, van Hillegersberg R. Robot-assisted thoracoscopic oesophagectomy for cancer. Br J Surg. 2009;96(8):878\u201386. https:\/\/doi.org\/10.1002\/bjs.6647.","journal-title":"Br J Surg"},{"issue":"S3","key":"8780_CR12","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1245\/s10434-015-4544-x","volume":"22","author":"PC van der Sluis","year":"2015","unstructured":"van der Sluis PC, Ruurda JP, Verhage RJ, et al. Oncologic long-term results of robot-assisted minimally invasive Thoraco-laparoscopic Esophagectomy with two-field lymphadenectomy for esophageal Cancer. Ann Surg Oncol. 2015;22(S3):1350\u20136. https:\/\/doi.org\/10.1245\/s10434-015-4544-x.","journal-title":"Ann Surg Oncol"},{"key":"8780_CR13","doi-asserted-by":"crossref","unstructured":"Jin D, Yao L, Yu J, Liu R, Guo T, Yang K, Gou Y. Robotic-assisted minimally invasive esophagectomy versus the conventional minimally invasive one: A meta-analysis and systematic review. Int J Med Robot. 2019 Epub ahead of print.","DOI":"10.1002\/rcs.1988"},{"issue":"5","key":"8780_CR14","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/j.1442-2050.2011.01246.x","volume":"25","author":"B Weksler","year":"2012","unstructured":"Weksler B, Sharma P, Moudgill N, Chojnacki KA, Rosato EL. Robot-assisted minimally invasive esophagectomy is equivalent to thoracoscopic minimally invasive esophagectomy. Dis Esophagus. 2012;25(5):403\u20139. https:\/\/doi.org\/10.1111\/j.1442-2050.2011.01246.x.","journal-title":"Dis Esophagus"},{"issue":"2","key":"8780_CR15","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.athoracsur.2016.02.078","volume":"102","author":"BA Yerokun","year":"2016","unstructured":"Yerokun BA, Sun Z, Yang CJ, Gulack BC, Speicher PJ, Adam MA, et al. Minimally invasive versus open Esophagectomy for esophageal Cancer: a population-based analysis. Ann Thorac Surg. 2016;102(2):416\u201323. https:\/\/doi.org\/10.1016\/j.athoracsur.2016.02.078.","journal-title":"Ann Thorac Surg"},{"key":"8780_CR16","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/j.athoracsur.2017.04.065","volume":"104","author":"B Weksler","year":"2017","unstructured":"Weksler B, Sullivan JL. Survival After Esophagectomy: A Propensity-Matched Study of Different Surgical Approaches. Ann Thorac Surg. 2017;104:1138\u20131146x.","journal-title":"Ann Thorac Surg"},{"key":"8780_CR17","doi-asserted-by":"crossref","unstructured":"Tagkalos E, Goense L, Hoppe-Lotichius M, Ruurda JP, Babic B, Hadzijusufovic E, Kneist W, van der Sluis PC, Lang H, van Hillegersberg R, Grimminger PP. Robot-assisted minimally invasive esophagectomy (RAMIE) compared to conventional minimally invasive esophagectomy (MIE) for esophageal cancer: a propensity-matched analysis. Dis Esophagus. 2019 Epub ahead of print.","DOI":"10.1093\/dote\/doz060"},{"key":"8780_CR18","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1186\/s12885-019-5761-7","volume":"19","author":"H ERC","year":"2019","unstructured":"ERC H, van Berge Henegouwen MI, van Sandick JW, Cuesta MA, van der Peet DL, Heisterkamp J, et al. Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study. BMC Cancer. 2019;19:662.","journal-title":"BMC Cancer"},{"key":"8780_CR19","unstructured":"The Declaration of Helsinki., (September 20th 2011). (http:\/\/www.wma.net\/en\/30publications\/10policies\/b3\/)."},{"key":"8780_CR20","unstructured":"The Good Clinical Practice Guidelines, September 20th 2011. (http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Scientific_guideline\/2009\/09\/WC500002874.pdf)."},{"key":"8780_CR21","doi-asserted-by":"crossref","unstructured":"H\u00f6lscher AH, Stahl M, Messmann H, Stuschke M, Meyer HJ, Porschen R. Die neue S3-Leitlinie zum \u00d6sophaguskarzinom : Wichtige chirurgische Aspekte [New S3 guideline for esophageal cancer : Important surgical aspects]. Chirurg. 2016 Oct;87(10):865\u201372. German.","DOI":"10.1007\/s00104-016-0214-1"},{"issue":"9","key":"8780_CR22","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/S1470-2045(15)00040-6","volume":"16","author":"J Shapiro","year":"2015","unstructured":"Shapiro J, van Lanschot JJB, MCCM H, van Hagen P, van Berge Henegouwen MI, BPL W, et al. Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial. Lancet Oncol. 2015;16(9):1090\u20138.","journal-title":"Lancet Oncol"},{"key":"8780_CR23","doi-asserted-by":"publisher","unstructured":"Hoeppner J, Lordick F, Brunner T, Glatz T, Bronsert P, R\u00f6thling N, et al. ESOPEC: prospective randomized controlled multicenter phase III trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the esophagus (NCT02509286). BMC Cancer. 2016;16(1):503. https:\/\/doi.org\/10.1186\/s12885-016-2564-y.","DOI":"10.1186\/s12885-016-2564-y"},{"issue":"5","key":"8780_CR24","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1055\/s-0038-1636933","volume":"66","author":"PP Grimminger","year":"2018","unstructured":"Grimminger PP, Hadzijusufovic E, Ruurda JP, Lang H, van Hillegersberg R. The da Vinci xi robotic four-arm approach for robotic-assisted minimally invasive Esophagectomy. Thorac Cardiovasc Surg. 2018;66(5):407\u20139. https:\/\/doi.org\/10.1055\/s-0038-1636933.","journal-title":"Thorac Cardiovasc Surg"},{"issue":"S22","key":"8780_CR25","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.21037\/jtd.2018.03.182","volume":"10","author":"XB D'Journo","year":"2018","unstructured":"D'Journo XB. Clinical implication of the innovations of the 8th edition of the TNM classification for esophageal and esophago-gastric cancer. J Thorac Dis. 2018;10(S22):2671\u2013S2681. https:\/\/doi.org\/10.21037\/jtd.2018.03.182.","journal-title":"J Thorac Dis"},{"issue":"2","key":"8780_CR26","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","volume":"240","author":"D Dindo","year":"2004","unstructured":"Dindo D, Demartines N, Clavien P. Classification of surgical complications a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205\u201313. https:\/\/doi.org\/10.1097\/01.sla.0000133083.54934.ae.","journal-title":"Ann Surg"},{"issue":"2","key":"8780_CR27","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/SLA.0000000000001098","volume":"262","author":"DE Low","year":"2015","unstructured":"Low DE, Alderson D, Cecconello I, Chang AC, Darling GE, D'Journo XB, et al. International consensus on standardization of data collection for complications associated with Esophagectomy: Esophagectomy complications consensus group (ECCG). Ann Surg. 2015;262(2):286\u201394. https:\/\/doi.org\/10.1097\/SLA.0000000000001098.","journal-title":"Ann Surg"},{"issue":"12","key":"8780_CR28","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.1245\/s10434-016-5291-3","volume":"23","author":"N Nederlof","year":"2016","unstructured":"Nederlof N, Slaman AE, van Hagen P, van der Gaast A, Slankamenac K, Gisbertz SS, et al. Using the comprehensive complication index to assess the impact of neoadjuvant Chemoradiotherapy on complication severity after Esophagectomy for Cancer. Ann Surg Oncol. 2016;23(12):3964\u201371. https:\/\/doi.org\/10.1245\/s10434-016-5291-3.","journal-title":"Ann Surg Oncol"},{"issue":"5","key":"8780_CR29","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1002\/bjs.10729","volume":"105","author":"RT van der Kaaij","year":"2018","unstructured":"van der Kaaij RT, de Rooij MV, van Coevorden F, Voncken FEM, Snaebjornsson P, Boot H, et al. Using textbook outcome as a measure of quality of care in oesophagogastric cancer surgery. Br J Surg. 2018;105(5):561\u20139. https:\/\/doi.org\/10.1002\/bjs.10729.","journal-title":"Br J Surg"},{"issue":"5","key":"8780_CR30","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","volume":"85","author":"NK Aaronson","year":"1993","unstructured":"Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365\u201376. https:\/\/doi.org\/10.1093\/jnci\/85.5.365.","journal-title":"J Natl Cancer Inst"},{"issue":"10","key":"8780_CR31","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.21037\/jtd.2016.10.39","volume":"8","author":"S Park","year":"2016","unstructured":"Park S, Hwang Y, Lee HJ, Park IK, Kim YT, Kang CH. Comparison of robot-assisted esophagectomy and thoracoscopic esophagectomy in esophageal squamous cell carcinoma. J Thorac Dis. 2016;8(10):2853\u201361. https:\/\/doi.org\/10.21037\/jtd.2016.10.39.","journal-title":"J Thorac Dis."},{"issue":"2","key":"8780_CR32","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1007\/s00268-017-4179-0","volume":"42","author":"YK Chao","year":"2018","unstructured":"Chao YK, Hsieh MJ, Liu YH, Liu HP. Lymph node evaluation in robot assisted versus video-assisted thoracoscopic esophagectomy for esophageal squamous cell carcinoma: a propensity-matched analysis. World J Surg. 2018;42(2):590\u20138. https:\/\/doi.org\/10.1007\/s00268-017-4179-0.","journal-title":"World J Surg"},{"issue":"8","key":"8780_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/dote\/doy012","volume":"31","author":"HY Deng","year":"2018","unstructured":"Deng HY, Huang WX, Li G, Li SX, Luo J, Alai G, et al. Comparison of short-term outcomes between robot-assisted minimally invasive esophagectomy and video assisted minimally invasive esophagectomy in treating middle thoracic esophageal cancer. Dis Esophagus. 2018;31(8):1\u20137. https:\/\/doi.org\/10.1093\/dote\/doy012.","journal-title":"Dis Esophagus"},{"issue":"1","key":"8780_CR34","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13019-018-0727-4","volume":"13","author":"H He","year":"2018","unstructured":"He H, Wu Q, Wang Z, Zhang Y, Chen N, Fu J, et al. Short-term outcomes of robot-assisted minimally invasive esophagectomy for esophageal cancer: a propensity score matched analysis. J Cardiothorac Surg. 2018;13(1):52\u20136. https:\/\/doi.org\/10.1186\/s13019-018-0727-4.","journal-title":"J Cardiothorac Surg"},{"issue":"5","key":"8780_CR35","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1097\/SLA.0000000000002389","volume":"266","author":"E Visser","year":"2017","unstructured":"Visser E, van Rossum PSN, Ruurda JP, van Hillegersberg R. Impact of lymph node yield on overall survival in patients treated with neoadjuvant Chemoradiotherapy followed by Esophagectomy for Cancer: a population-based cohort study in the Netherlands. Ann Surg. 2017;266(5):863\u20139. https:\/\/doi.org\/10.1097\/SLA.0000000000002389.","journal-title":"Ann Surg"},{"issue":"1","key":"8780_CR36","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.athoracsur.2018.01.038","volume":"106","author":"PC van der Sluis","year":"2018","unstructured":"van der Sluis PC, Ruurda JP, van der Horst S, Goense L, van Hillegersberg R. Learning curve for robot-assisted minimally invasive Thoracoscopic Esophagectomy: results from 312 cases. Ann Thorac Surg. 2018;106(1):264\u201371. https:\/\/doi.org\/10.1016\/j.athoracsur.2018.01.038.","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"8780_CR37","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1186\/s13063-019-3441-1","volume":"20","author":"YK Chao","year":"2019","unstructured":"Chao YK, Li ZG, Wen YW, Kim DJ, Park SY, Chang YL, et al. Robotic-assisted Esophagectomy vs video-assisted Thoracoscopic Esophagectomy (REVATE): study protocol for a randomized controlled trial. Trials. 2019;20(1):346. https:\/\/doi.org\/10.1186\/s13063-019-3441-1.","journal-title":"Trials."},{"issue":"1","key":"8780_CR38","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12885-019-5799-6","volume":"19","author":"Y Yang","year":"2019","unstructured":"Yang Y, Zhang X, Li B, Li Z, Sun Y, Mao T, et al. Robot-assisted esophagectomy (RAE) versus conventional minimally invasive esophagectomy (MIE) for resectable esophageal squamous cell carcinoma: protocol for a multicenter prospective randomized controlled trial (RAMIE trial, robot-assisted minimally invasive Esophagectomy). BMC Cancer. 2019;19(1):60. https:\/\/doi.org\/10.1186\/s12885-019-5799-6.","journal-title":"BMC Cancer"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-021-08780-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12885-021-08780-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-021-08780-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T12:07:36Z","timestamp":1632658056000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-021-08780-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,26]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["8780"],"URL":"https:\/\/doi.org\/10.1186\/s12885-021-08780-x","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,26]]},"assertion":[{"value":"22 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study is conducted in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice Guidelines The independent ethics committee of the University Medical Center of the Johannes Gutenberg University, Mainz, Germany has approved the study (Nr: 2019\u201314049). Any modifications to the protocol which may impact on the conduct of the study, or may affect patient safety, including changes of study objectives, study design, patient population, sample sizes, study procedures, or significant administrative aspects will require a formal amendment to the protocol. Such amendment must be approved by the ethics committee prior to implementation. Written informed consent will be obtained from all participating patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for data publication will be obtained from all participating patients. The consent form states that the details\/images\/videos (the images of the study will be unidentifiable) will be freely available on the internet and may be seen by the general public.An interim report as well as the primary outcome papers would be generated. PI and SI as well as the lead investigators will revise the data for publication and the steering committee will control the final draft. After the end of the study the release of the results will be controlled by the steering committee after PI, SI and lead investigators have revised the later data for publication. Any investigators that will fulfil authorship criteria will have authority over manuscript content. Professional writers would not be used.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"RvH, JPR and PPG are proctors for Intuitive Surgical Inc.The study received funding by Intuitive Surgical Inc. Apart from the funding, which is listed detailed below, Intuitive Surgical Inc. did not take part in any steps of the study design and have not authority in any activities concerning the study (execution, analyses as well as interpretation of the data) and the followed publications. The study protocol therefor has not undergone peer-review by the funding body.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1060"}}