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Data of clinical features, pathological characteristics, treatment, and outcomes were evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The median age of patients with GAS and non-GAS HPVI ECA was 46 and 48\u2009years, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.93). Compared with non-GAS HPVI ECAs, GAS had more common complains of vaginal watery discharge (<jats:italic>p<\/jats:italic>\u2009=\u20090.04). GAS cases were also associated with higher clinical stage (<jats:italic>p<\/jats:italic>\u2009=\u20090.036), more common in deeper cervical stromal invasion (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) and lymphoavascular invasion (<jats:italic>p<\/jats:italic>\u2009=\u20090.044). GAS was associated with worse median progression-free survival (PFS) (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) and median overall survival (OS) (<jats:italic>p<\/jats:italic>\u2009=\u20090.03) over patients with non-GAS HPVI ECAs. MDA had similar clinical and pathological features and prognosis compared with non-MDA GAS. Of note, serum CA19\u20139 levels were significantly higher in GAS than that in non-GAS HPVI ECA cases.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>GAS cases were more likely to have high risk pathological factors and poorer PFS and OS compared with non-GAS HPVI ECAs. Serum CA19\u20139 may be helpful for diagnosis and screening in patients with GAS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12885-021-08792-7","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T16:12:51Z","timestamp":1633968771000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinicopathological features and outcomes in gastric-type of HPV-independent endocervical adenocarcinomas"],"prefix":"10.1186","volume":"21","author":[{"given":"Lili","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhen","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Louise","family":"Strickland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"8792_CR1","doi-asserted-by":"crossref","unstructured":"Adegoke O, Kulasingam S, Virnig B: Cervical cancer trends in the United States: a 35-year population-based analysis. 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