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Metabonomics has gradually developed as a convenient, inexpensive and non-destructive technique for the study of cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 150 tissue samples from 25 rectal cancer patients were analyzed by liquid chromatography\u2013mass spectrometry (LC\u2013MS), and 6 tissue samples were collected from each patient (group 1: tumor; group 2: 0.5\u00a0cm from tumor; group 3:1\u00a0cm from tumor; group 4:2\u00a0cm from tumor; group 5:3\u00a0cm from tumor and group 6:5\u00a0cm from tumor). The differential metabolites of tumor tissues and 5\u00a0cm from the tumor (normal tissues) were first selected. The differential metabolites between tumor tissues and normal tissues were regrouped by hierarchical clustering analysis, and further selected by discriminant analysis according to the regrouping of clustering results. The potential safe margin of clinical T(cT)1,cT2 stage rectal cancer and cT3,cT4 stage rectal cancer at the metabolomic level was further identified by observing the changes in the level of differential metabolites within the samples from group 1 to group 6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found 22 specific metabolites to distinguish tumor tissue and normal tissue. The most significant changes in metabolite levels were observed at 0.5\u00a0cm (cT1, cT2) and 2.0\u00a0cm (cT3, cT4) from the tumor, while the changes in the tissues afterwards showed a stable trend.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There are differential metabolites between tumor tissues and normal tissues in rectal cancer. Based on our limited sample size, the safe distal incision margin for rectal cancer surgery in metabolites may be 0.5\u00a0cm in patients with cT1 and cT2 stage rectal cancer and 2.0\u00a0cm in patients with cT3 and cT4 stage rectal cancer.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12885-022-10124-2","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T08:02:53Z","timestamp":1664956973000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of levels of metabolites with the safe margin of rectal cancer surgery: a metabolomics study"],"prefix":"10.1186","volume":"22","author":[{"given":"Shaopeng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqiang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhifeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"key":"10124_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.canep.2019.02.003","volume":"59","author":"S Hasanpour-Heidari","year":"2019","unstructured":"Hasanpour-Heidari S, Fazel A, Semnani S, Khandoozi SR, Amiriani T, Sedaghat S, Hosseinpoor R, Azarhoush R, Poorabbasi M, Naeimi-Tabiei M, et al. 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