{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:15:30Z","timestamp":1790111730717,"version":"4.0.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Hebei Provincial Natural Science Foundation precision medicine joint project","award":["H2020206485"],"award-info":[{"award-number":["H2020206485"]}]},{"name":"Hebei Provincial Natural Science Foundation precision medicine joint project","award":["H2020206485"],"award-info":[{"award-number":["H2020206485"]}]},{"name":"Hebei Provincial Department of science and technology key project","award":["206Z7705G"],"award-info":[{"award-number":["206Z7705G"]}]},{"name":"Hebei Provincial Department of science and technology key project","award":["206Z7705G"],"award-info":[{"award-number":["206Z7705G"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Whether Transanal drainage tubes (TDTs) placement reduces the occurrence of anastomotic leakage (AL) after rectal cancer (RC) surgery remains controversial. Most existing meta-analyses rely on retrospective studies, while the prospective studies present an inadequate level of evidence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A systematic review and meta-analysis of prospective studies on TDTs placement in RC patients after surgery was conducted. The main analysis index was the incidence of AL, Grade B AL, and Grade C AL, while secondary analysis index was the incidence of anastomotic bleeding, incision infection, and anastomotic stenosis. A comprehensive literature search was performed utilizing the databases Cochrane Library, Embase, PubMed, and Web of Science. We recorded Risk ratios (RRs) and 95% confidence intervals (CI) for each included study, and a fixed-effect model or random-effect model was used to investigate the correlation between TDTs placement and four outcomes after RC surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Seven studies (1774 participants, TDT 890 vs non-TDT 884) were considered eligible for quantitative synthesis and meta-analysis. The meta-analysis revealed that the incidence of AL was 9.3% (83\/890) in the TDT group and 10.2% (90\/884) in the non-TDT group. These disparities were found to lack statistical significance (<jats:italic>P<\/jats:italic>\u2009=\u20090.58). A comprehensive meta-analysis, comprising four studies involving a cumulative sample size of 1259 participants, revealed no discernible disparity in the occurrence of Grade B AL or Grade C AL between the TDT group and the non-TDT group (Grade B AL: TDT 34\/631 vs non-TDT 26\/628, <jats:italic>P<\/jats:italic>\u2009=\u20090.30; Grade C AL: TDT 11\/631 vs non-TDT 27\/628, <jats:italic>P<\/jats:italic>\u2009=\u20090.30). Similarly, the incidences of anastomotic bleeding (4 studies, 876 participants), incision infection (3studies, 713 participants), and anastomotic stenosis (2studies, 561 participants) were 5.5% (24\/440), 8.1% (29\/360), and 2.9% (8\/280), respectively, in the TDT group, and 3.0% (13\/436), 6.5% (23\/353), and 3.9% (11\/281), respectively, in the non-TDT group. These differences were also determined to lack statistical significance (<jats:italic>P<\/jats:italic>\u2009=\u20090.08, <jats:italic>P<\/jats:italic>\u2009=\u20090.43, <jats:italic>P<\/jats:italic>\u2009=\u20090.48, respectively).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The placement of TDTs does not significantly affect the occurrence of AL, Grade B AL, and Grade C AL following surgery for rectal cancer. Additionally, TDTs placement does not be associated with increased complications such as anastomotic bleeding, incision infection, or anastomotic stenosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>PROSPERO: CRD42023427914<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12885-024-11990-8","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T12:02:09Z","timestamp":1708776129000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Does transanal drainage tubes placement have an impact on the incidence of anastomotic leakage after rectal cancer surgery? a systematic review and meta-analysis"],"prefix":"10.1186","volume":"24","author":[{"given":"Yating","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoguang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"issue":"3","key":"11990_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries [J]. CA Cancer J Clin. 2021;71(3):209\u201349.","journal-title":"CA Cancer J Clin"},{"issue":"28","key":"11990_CR2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016374","volume":"98","author":"XC Zhou","year":"2019","unstructured":"Zhou XC, Chen QL, Huang CQ, et al. The clinical application value of multi-slice spiral CT enhanced scans combined with multiplanar reformations images in preoperative T staging of rectal cancer [J]. Medicine (Baltimore). 2019;98(28): e16374.","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"11990_CR3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s13304-019-00689-2","volume":"72","author":"R Peltrini","year":"2020","unstructured":"Peltrini R, Sacco M, Luglio G, et al. Local excision following chemoradiotherapy in T2\u2013T3 rectal cancer: current status and critical appraisal [J]. Updates Surg. 2020;72(1):29\u201337.","journal-title":"Updates Surg"},{"issue":"12","key":"11990_CR4","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1001\/jamasurg.2021.4568","volume":"156","author":"S Zhao","year":"2021","unstructured":"Zhao S, Zhang L, Gao F, et al. Transanal Drainage Tube Use for Preventing Anastomotic Leakage After Laparoscopic Low Anterior Resection in Patients With Rectal Cancer: A Randomized Clinical Trial [J]. JAMA Surg. 2021;156(12):1151\u20138.","journal-title":"JAMA Surg"},{"issue":"1","key":"11990_CR5","doi-asserted-by":"publisher","first-page":"e189","DOI":"10.1097\/SLA.0000000000003853","volume":"275","author":"DE Huisman","year":"2022","unstructured":"Huisman DE, Reudink M, van Rooijen SJ, et al. LekCheck: A Prospective Study to Identify Perioperative Modifiable Risk Factors for Anastomotic Leakage in Colorectal Surgery [J]. Ann Surg. 2022;275(1):e189\u201397.","journal-title":"Ann Surg"},{"issue":"7","key":"11990_CR6","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1007\/s00268-013-2428-4","volume":"38","author":"H Nishigori","year":"2014","unstructured":"Nishigori H, Ito M, Nishizawa Y, et al. Effectiveness of a transanal tube for the prevention of anastomotic leakage after rectal cancer surgery [J]. World J Surg. 2014;38(7):1843\u201351.","journal-title":"World J Surg"},{"issue":"5","key":"11990_CR7","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1097\/SLA.0b013e3182128929","volume":"253","author":"A Mirnezami","year":"2011","unstructured":"Mirnezami A, Mirnezami R, Chandrakumaran K, et al. Increased local recurrence and reduced survival from colorectal cancer following anastomotic leak: systematic review and meta-analysis [J]. Ann Surg. 2011;253(5):890\u20139.","journal-title":"Ann Surg"},{"issue":"8","key":"11990_CR8","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1002\/jso.24760","volume":"116","author":"S Goto","year":"2017","unstructured":"Goto S, Hida K, Kawada K, et al. Multicenter analysis of transanal tube placement for prevention of anastomotic leak after low anterior resection [J]. J Surg Oncol. 2017;116(8):989\u201395.","journal-title":"J Surg Oncol"},{"issue":"6","key":"11990_CR9","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1007\/s00268-011-1053-3","volume":"35","author":"L Xiao","year":"2011","unstructured":"Xiao L, Zhang WB, Jiang PC, et al. Can transanal tube placement after anterior resection for rectal carcinoma reduce anastomotic leakage rate? A single-institution prospective randomized study [J]. World J Surg. 2011;35(6):1367\u201377.","journal-title":"World J Surg"},{"issue":"12","key":"11990_CR10","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1007\/s10151-022-02665-2","volume":"26","author":"S Zhao","year":"2022","unstructured":"Zhao S, Hu K, Tian Y, et al. Role of transanal drainage tubes in preventing anastomotic leakage after low anterior resection: a meta-analysis of randomized controlled trials [J]. Tech Coloproctol. 2022;26(12):931\u20139.","journal-title":"Tech Coloproctol"},{"issue":"4","key":"11990_CR11","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00464-014-3740-2","volume":"29","author":"E Hidaka","year":"2015","unstructured":"Hidaka E, Ishida F, Mukai S, et al. Efficacy of transanal tube for prevention of anastomotic leakage following laparoscopic low anterior resection for rectal cancers: a retrospective cohort study in a single institution [J]. Surg Endosc. 2015;29(4):863\u20137.","journal-title":"Surg Endosc"},{"issue":"3","key":"11990_CR12","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.surg.2009.10.012","volume":"147","author":"NN Rahbari","year":"2010","unstructured":"Rahbari NN, Weitz J, Hohenberger W, et al. Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer [J]. Surgery. 2010;147(3):339\u201351.","journal-title":"Surgery"},{"issue":"1","key":"11990_CR13","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00268-012-1812-9","volume":"37","author":"WT Zhao","year":"2013","unstructured":"Zhao WT, Hu FL, Li YY, et al. Use of a transanal drainage tube for prevention of anastomotic leakage and bleeding after anterior resection for rectal cancer [J]. World J Surg. 2013;37(1):227\u201332.","journal-title":"World J Surg"},{"issue":"15","key":"11990_CR14","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","volume":"283","author":"D F Stroup","year":"2000","unstructured":"Stroup D F, Berlin J A, Morton S C, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group [J]. Jama. 2000;283(15):2008\u201312.","journal-title":"Jama"},{"issue":"7121","key":"11990_CR15","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1136\/bmj.315.7121.1533","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Smith GD, Phillips AN. Meta-analysis: principles and procedures [J]. BMJ. 1997;315(7121):1533\u20137.","journal-title":"BMJ"},{"issue":"3","key":"11990_CR16","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.amjsurg.2020.12.054","volume":"222","author":"K Tamura","year":"2021","unstructured":"Tamura K, Matsuda K, Horiuchi T, et al. Laparoscopic anterior resection with or without transanal tube for rectal cancer patients - A multicenter randomized controlled trial [J]. Am J Surg. 2021;222(3):606\u201312.","journal-title":"Am J Surg"},{"issue":"6","key":"11990_CR17","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/j.1463-1318.2006.00994.x","volume":"8","author":"S B\u00fclow","year":"2006","unstructured":"B\u00fclow S, Bulut O, Christensen IJ, et al. Transanal stent in anterior resection does not prevent anastomotic leakage [J]. Colorectal Dis. 2006;8(6):494\u20136.","journal-title":"Colorectal Dis"},{"issue":"7","key":"11990_CR18","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1007\/s12094-021-02775-7","volume":"24","author":"W Liang","year":"2022","unstructured":"Liang W, Jie H, Zeng Z, et al. Comparison of postoperative complication rates between a novel endoluminal balloon-assisted drainage and diverting stoma after low rectal cancer [J]. Clin Transl Oncol. 2022;24(7):1347\u201353.","journal-title":"Clin Transl Oncol"},{"issue":"10","key":"11990_CR19","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1007\/s10151-020-02265-y","volume":"24","author":"A Challine","year":"2020","unstructured":"Challine A, Cazelles A, Frontali A, et al. Does a transanal drainage tube reduce anastomotic leakage? A matched cohort study in 144 patients undergoing laparoscopic sphincter-saving surgery for rectal cancer [J]. Tech Coloproctol. 2020;24(10):1047\u201353.","journal-title":"Tech Coloproctol"},{"issue":"8","key":"11990_CR20","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1007\/s00384-022-04201-y","volume":"37","author":"SY Deng","year":"2022","unstructured":"Deng SY, Xing JD, Liu MX, et al. Effect of the transanal drainage tube on preventing anastomotic leakage after laparoscopic surgery for rectal cancer: a systematic review and meta-analysis [J]. Int J Colorectal Dis. 2022;37(8):1739\u201350.","journal-title":"Int J Colorectal Dis"},{"issue":"11","key":"11990_CR21","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1111\/codi.16231","volume":"24","author":"C Guo","year":"2022","unstructured":"Guo C, Fu Z, Qing X, et al. Prophylactic transanal drainage tube placement for preventing anastomotic leakage after anterior resection for rectal cancer: A meta-analysis [J]. Colorectal Dis. 2022;24(11):1273\u201384.","journal-title":"Colorectal Dis"},{"issue":"4","key":"11990_CR22","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00595-016-1392-7","volume":"47","author":"H Nishigori","year":"2017","unstructured":"Nishigori H, Ito M, Nishizawa Y. A novel transanal tube designed to prevent anastomotic leakage after rectal cancer surgery: the WING DRAIN [J]. Surg Today. 2017;47(4):513\u201320.","journal-title":"Surg Today"},{"issue":"4","key":"11990_CR23","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s00384-018-2970-5","volume":"33","author":"N Hoshino","year":"2018","unstructured":"Hoshino N, Hida K, Sakai Y, et al. Nomogram for predicting anastomotic leakage after low anterior resection for rectal cancer [J]. Int J Colorectal Dis. 2018;33(4):411\u20138.","journal-title":"Int J Colorectal Dis"},{"issue":"7","key":"11990_CR24","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/j.1365-2702.2005.01121.x","volume":"14","author":"A Williamson","year":"2005","unstructured":"Williamson A, Hoggart B. Pain: a review of three commonly used pain rating scales [J]. J Clin Nurs. 2005;14(7):798\u2013804.","journal-title":"J Clin Nurs"},{"issue":"7","key":"11990_CR25","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s00423-015-1336-5","volume":"400","author":"SY Lee","year":"2015","unstructured":"Lee SY, Kim CH, Kim YJ, et al. Impact of anal decompression on anastomotic leakage after low anterior resection for rectal cancer: a propensity score matching analysis [J]. Langenbecks Arch Surg. 2015;400(7):791\u20136.","journal-title":"Langenbecks Arch Surg"},{"key":"11990_CR26","doi-asserted-by":"crossref","unstructured":"EuroSurg Collaborative. Safety of hospital discharge before return of bowel function after elective colorectal surgery [J]. Br J Surg. 2020;107(5):552\u20139.","DOI":"10.1002\/bjs.11422"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-024-11990-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12885-024-11990-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-024-11990-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T12:02:19Z","timestamp":1708776139000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-024-11990-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,24]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["11990"],"URL":"https:\/\/doi.org\/10.1186\/s12885-024-11990-8","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,24]]},"assertion":[{"value":"17 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"263"}}