{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:56:42Z","timestamp":1792828602927,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"plan on enhancing scientific research in GMU"},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515110596"],"award-info":[{"award-number":["2021A1515110596"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Basic and Applied Basic Research Fund of Guangzhou science project","award":["2024A04J3630"],"award-info":[{"award-number":["2024A04J3630"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"DOI":"10.1186\/s12885-024-12735-3","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T06:02:21Z","timestamp":1722924141000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hypopituitarism after gamma knife radiosurgery for pituitary adenomas: long-term results from a single-center experience"],"prefix":"10.1186","volume":"24","author":[{"given":"Jinxiu","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanye","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"issue":"suppl5","key":"12735_CR1","first-page":"v1","volume":"18","author":"QT Ostrom","year":"2016","unstructured":"Ostrom QT, Gittleman H, Xu J, Kromer C, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS. CBTRUS Statistical Report: primary brain and other Central Nervous System tumors diagnosed in the United States in 2009\u20132013. Neurooncology. 2016;18(suppl5):v1\u201375.","journal-title":"Neurooncology"},{"issue":"4","key":"12735_CR2","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1007\/s11102-019-00960-0","volume":"22","author":"D Esposito","year":"2019","unstructured":"Esposito D, Olsson DS, Ragnarsson O, Buchfelder M, Skoglund T, Johannsson G. Non-functioning pituitary adenomas: indications for pituitary surgery and post-surgical management. Pituitary. 2019;22(4):422\u201334.","journal-title":"Pituitary"},{"issue":"4","key":"12735_CR3","doi-asserted-by":"publisher","first-page":"736","DOI":"10.3171\/JNS\/2008\/108\/4\/0736","volume":"108","author":"EF Chang","year":"2008","unstructured":"Chang EF, Zada G, Kim S, Lamborn KR, Quinones-Hinojosa A, Tyrrell JB, Wilson CB, Kunwar S. Long-term recurrence and mortality after surgery and adjuvant radiotherapy for nonfunctional pituitary adenomas. J Neurosurg. 2008;108(4):736\u201345.","journal-title":"J Neurosurg"},{"issue":"1","key":"12735_CR4","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1227\/NEU.0000000000000563","volume":"76","author":"RF Dallapiazza","year":"2015","unstructured":"Dallapiazza RF, Grober Y, Starke RM, Laws ER Jr., Jane JA Jr. Long-term results of endonasal endoscopic transsphenoidal resection of nonfunctioning pituitary macroadenomas. Neurosurgery. 2015;76(1):42\u201352. discussion 52\u2009\u2013\u200943.","journal-title":"Neurosurgery"},{"issue":"6","key":"12735_CR5","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1530\/eje.1.02298","volume":"155","author":"E Ferrante","year":"2006","unstructured":"Ferrante E, Ferraroni M, Castrignano T, Menicatti L, Anagni M, Reimondo G, Del Monte P, Bernasconi D, Loli P, Faustini-Fustini M, et al. Non-functioning pituitary adenoma database: a useful resource to improve the clinical management of pituitary tumors. Eur J Endocrinol. 2006;155(6):823\u20139.","journal-title":"Eur J Endocrinol"},{"key":"12735_CR6","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3171\/sup.2005.102.s_supplement.0071","volume":"102","author":"P Picozzi","year":"2005","unstructured":"Picozzi P, Losa M, Mortini P, Valle MA, Franzin A, Attuati L, Ferrari da Passano C, Giovanelli M. Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas. J Neurosurg. 2005;102:71\u20134.","journal-title":"J Neurosurg"},{"issue":"1","key":"12735_CR7","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1227\/01.NEU.0000126885.71242.D7","volume":"55","author":"P Park","year":"2004","unstructured":"Park P, Chandler WF, Barkan AL, Orrego JJ, Cowan JA, Griffith KA, Tsien C. The role of radiation therapy after surgical resection of nonfunctional pituitary macroadenomas. Neurosurgery. 2004;55(1):100\u20136. discussion 106\u2013107.","journal-title":"Neurosurgery"},{"issue":"4","key":"12735_CR8","doi-asserted-by":"publisher","first-page":"E533","DOI":"10.1227\/NEU.0000000000001389","volume":"79","author":"JW Lucas","year":"2016","unstructured":"Lucas JW, Bodach ME, Tumialan LM, Oyesiku NM, Patil CG, Litvack Z, Aghi MK, Zada G. Congress of Neurological Surgeons Systematic Review and evidence-based Guideline on Primary Management of patients with nonfunctioning pituitary adenomas. Neurosurgery. 2016;79(4):E533\u2013535.","journal-title":"Neurosurgery"},{"issue":"3","key":"12735_CR9","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3171\/2013.11.JNS131757","volume":"120","author":"CC Lee","year":"2014","unstructured":"Lee CC, Kano H, Yang HC, Xu Z, Yen CP, Chung WY, Pan DH, Lunsford LD, Sheehan JP. Initial Gamma Knife radiosurgery for nonfunctioning pituitary adenomas. J Neurosurg. 2014;120(3):647\u201354.","journal-title":"J Neurosurg"},{"issue":"2","key":"12735_CR10","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s12020-020-02260-1","volume":"68","author":"J Yu","year":"2020","unstructured":"Yu J, Li Y, Quan T, Li X, Peng C, Zeng J, Liang S, Huang M, He Y, Deng Y. Initial Gamma Knife radiosurgery for nonfunctioning pituitary adenomas: results from a 26-year experience. Endocrine. 2020;68(2):399\u2013410.","journal-title":"Endocrine"},{"issue":"5","key":"12735_CR11","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1001\/jama.2016.19699","volume":"317","author":"ME Molitch","year":"2017","unstructured":"Molitch ME. Diagnosis and treatment of Pituitary adenomas: a review. JAMA. 2017;317(5):516\u201324.","journal-title":"JAMA"},{"issue":"1","key":"12735_CR12","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/s11102-012-0376-x","volume":"16","author":"X Liu","year":"2013","unstructured":"Liu X, Kano H, Kondziolka D, Park KJ, Iyer A, Shin S, Niranjan A, Flickinger JC, Lunsford LD. Gamma knife stereotactic radiosurgery for drug resistant or intolerant invasive prolactinomas. Pituitary. 2013;16(1):68\u201375.","journal-title":"Pituitary"},{"issue":"1","key":"12735_CR13","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1227\/01.NEU.0000068702.00330.47","volume":"53","author":"Z Petrovich","year":"2003","unstructured":"Petrovich Z, Yu C, Giannotta SL, Zee CS, Apuzzo ML. Gamma knife radiosurgery for pituitary adenoma: early results. Neurosurgery. 2003;53(1):51\u20139. discussion 59\u201361.","journal-title":"Neurosurgery"},{"issue":"4","key":"12735_CR14","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s11102-019-00971-x","volume":"22","author":"J Jezkova","year":"2019","unstructured":"Jezkova J, Hana V, Kosak M, Krsek M, Liscak R, Vymazal J, Pecen L, Marek J. Role of gamma knife radiosurgery in the treatment of prolactinomas. Pituitary. 2019;22(4):411\u201321.","journal-title":"Pituitary"},{"issue":"10058","key":"12735_CR15","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1016\/S0140-6736(16)30053-8","volume":"388","author":"CE Higham","year":"2016","unstructured":"Higham CE, Johannsson G, Shalet SM, Hypopituitarism. Lancet (London England). 2016;388(10058):2403\u201315.","journal-title":"Lancet (London England)"},{"issue":"1","key":"12735_CR16","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.radonc.2012.03.021","volume":"104","author":"G Sicignano","year":"2012","unstructured":"Sicignano G, Losa M, del Vecchio A, Cattaneo GM, Picozzi P, Bolognesi A, Mortini P, Calandrino R. Dosimetric factors associated with pituitary function after Gamma Knife surgery (GKS) of pituitary adenomas. Radiotherapy Oncology: J Eur Soc Therapeutic Radiol Oncol. 2012;104(1):119\u201324.","journal-title":"Radiotherapy Oncology: J Eur Soc Therapeutic Radiol Oncol"},{"key":"12735_CR17","doi-asserted-by":"crossref","unstructured":"Cordeiro D, Xu Z, Mehta GU, Ding D, Vance ML, Kano H, Sisterson N, Yang HC, Kondziolka D, Lunsford LD et al. Hypopituitarism after Gamma Knife radiosurgery for pituitary adenomas: a multicenter, international study. Journal of neurosurgery 2018.","DOI":"10.3171\/2018.5.JNS18509"},{"key":"12735_CR18","doi-asserted-by":"crossref","unstructured":"Sun S, Liu A, Zhang Y. Long-term Follow-Up studies of Gamma Knife Radiosurgery for Postsurgical Nonfunctioning Pituitary Adenomas. World neurosurgery; 2019.","DOI":"10.1016\/j.wneu.2019.01.009"},{"issue":"6","key":"12735_CR19","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1227\/NEU.0b013e318222afed","volume":"69","author":"KJ Park","year":"2011","unstructured":"Park KJ, Kano H, Parry PV, Niranjan A, Flickinger JC, Lunsford LD, Kondziolka D. Long-term outcomes after gamma knife stereotactic radiosurgery for nonfunctional pituitary adenomas. Neurosurgery. 2011;69(6):1188\u201399.","journal-title":"Neurosurgery"},{"issue":"2","key":"12735_CR20","doi-asserted-by":"publisher","first-page":"446","DOI":"10.3171\/2013.3.JNS12766","volume":"119","author":"JP Sheehan","year":"2013","unstructured":"Sheehan JP, Starke RM, Mathieu D, Young B, Sneed PK, Chiang VL, Lee JY, Kano H, Park KJ, Niranjan A, et al. Gamma Knife radiosurgery for the management of nonfunctioning pituitary adenomas: a multicenter study. J Neurosurg. 2013;119(2):446\u201356.","journal-title":"J Neurosurg"},{"issue":"4","key":"12735_CR21","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1227\/NEU.0b013e3182846e44","volume":"72","author":"Z Xu","year":"2013","unstructured":"Xu Z, Lee Vance M, Schlesinger D, Sheehan JP. Hypopituitarism after stereotactic radiosurgery for pituitary adenomas. Neurosurgery. 2013;72(4):630\u20137.","journal-title":"Neurosurgery"},{"issue":"11","key":"12735_CR22","doi-asserted-by":"publisher","first-page":"3888","DOI":"10.1210\/jc.2016-2118","volume":"101","author":"M Fleseriu","year":"2016","unstructured":"Fleseriu M, Hashim IA, Karavitaki N, Melmed S, Murad MH, Salvatori R, Samuels MH. Hormonal replacement in hypopituitarism in adults: an endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(11):3888\u2013921.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"12735_CR23","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.wneu.2010.05.007","volume":"74","author":"S Tanaka","year":"2010","unstructured":"Tanaka S, Link MJ, Brown PD, Stafford SL, Young WF Jr., Pollock BE. Gamma knife radiosurgery for patients with prolactin-secreting pituitary adenomas. World Neurosurg. 2010;74(1):147\u201352.","journal-title":"World Neurosurg"},{"issue":"1","key":"12735_CR24","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3171\/jns.2006.104.1.157","volume":"104","author":"JW Snell","year":"2006","unstructured":"Snell JW, Sheehan J, Stroila M, Steiner L. Assessment of imaging studies used with radiosurgery: a volumetric algorithm and an estimation of its error. Technical note. J Neurosurg. 2006;104(1):157\u201362.","journal-title":"J Neurosurg"},{"issue":"6","key":"12735_CR25","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1046\/j.1365-2265.2001.01406.x","volume":"55","author":"M Regal","year":"2001","unstructured":"Regal M, Paramo C, Sierra SM, Garcia-Mayor RV. Prevalence and incidence of hypopituitarism in an adult caucasian population in northwestern Spain. Clin Endocrinol. 2001;55(6):735\u201340.","journal-title":"Clin Endocrinol"},{"issue":"2","key":"12735_CR26","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1023\/B:PITU.0000004798.27230.ed","volume":"6","author":"MD Johnson","year":"2003","unstructured":"Johnson MD, Woodburn CJ, Vance ML. Quality of life in patients with a pituitary adenoma. Pituitary. 2003;6(2):81\u20137.","journal-title":"Pituitary"},{"issue":"1","key":"12735_CR27","doi-asserted-by":"publisher","first-page":"R13","DOI":"10.1530\/EJE-17-0041","volume":"177","author":"SM Webb","year":"2017","unstructured":"Webb SM, Crespo I, Santos A, Resmini E, Aulinas A, Valassi E. MANAGEMENT OF ENDOCRINE DISEASE: quality of life tools for the management of pituitary disease. Eur J Endocrinol. 2017;177(1):R13\u201326.","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"12735_CR28","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1016\/j.ijrobp.2007.08.018","volume":"70","author":"BE Pollock","year":"2008","unstructured":"Pollock BE, Cochran J, Natt N, Brown PD, Erickson D, Link MJ, Garces YI, Foote RL, Stafford SL, Schomberg PJ. Gamma knife radiosurgery for patients with nonfunctioning pituitary adenomas: results from a 15-year experience. Int J Radiat Oncol Biol Phys. 2008;70(5):1325\u20139.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"12735_CR29","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1227\/NEU.0b013e31821bc44e","volume":"69","author":"R Gopalan","year":"2011","unstructured":"Gopalan R, Schlesinger D, Vance ML, Laws E, Sheehan J. Long-term outcomes after Gamma Knife radiosurgery for patients with a nonfunctioning pituitary adenoma. Neurosurgery. 2011;69(2):284\u201393.","journal-title":"Neurosurgery"},{"issue":"3","key":"12735_CR30","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.ijrobp.2018.02.169","volume":"101","author":"CS Graffeo","year":"2018","unstructured":"Graffeo CS, Link MJ, Brown PD, Young WF Jr., Pollock BE. Hypopituitarism after single-fraction pituitary adenoma radiosurgery: dosimetric analysis based on patients treated using contemporary techniques. Int J Radiat Oncol Biol Phys. 2018;101(3):618\u201323.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"7","key":"12735_CR31","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1210\/jc.2011-0251","volume":"96","author":"JS Loeffler","year":"2011","unstructured":"Loeffler JS, Shih HA. Radiation therapy in the management of pituitary adenomas. J Clin Endocrinol Metab. 2011;96(7):1992\u20132003.","journal-title":"J Clin Endocrinol Metab"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-024-12735-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12885-024-12735-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-024-12735-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T06:03:50Z","timestamp":1722924230000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-024-12735-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,6]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["12735"],"URL":"https:\/\/doi.org\/10.1186\/s12885-024-12735-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4601329\/v1","asserted-by":"object"}]},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,6]]},"assertion":[{"value":"18 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The studies involving human participants were reviewed and approved by the institutional committee of the Second Affiliated Hospital of Guangzhou Medical University. The patients\/ participants provided their written informed consent to participate in this study. All procedures performed were in accordance with the ethical standards of these committees and with the 1964 Declaration of Helsinki and its later amendments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"963"}}