{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:55:45Z","timestamp":1794002145222,"version":"4.8.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"DOI":"10.1186\/s12885-024-12819-0","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T12:04:30Z","timestamp":1725537870000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The preoperative scoring system combining neutrophil\/lymphocyte ratio and CA19-9 predicts the long-term prognosis of intrahepatic cholangiocarcinoma patients undergoing curative liver resection"],"prefix":"10.1186","volume":"24","author":[{"given":"Shilei","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhe","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"issue":"6","key":"12819_CR1","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1016\/j.jhep.2014.01.021","volume":"60","author":"J Bridgewater","year":"2014","unstructured":"Bridgewater J, Galle PR, Khan SA, Llovet JM, Park JW, Patel T, Pawlik TM, Gores GJ. Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. J Hepatol. 2014;60(6):1268\u201389.","journal-title":"J Hepatol"},{"issue":"2","key":"12819_CR2","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3322\/caac.21759","volume":"73","author":"D Moris","year":"2023","unstructured":"Moris D, Palta M, Kim C, Allen PJ, Morse MA, Lidsky ME. Advances in the treatment of intrahepatic cholangiocarcinoma: An overview of the current and\u00a0future\u00a0therapeutic landscape for clinicians. CA Cancer J Clin. 2023;73(2):198\u2013222.","journal-title":"CA Cancer J Clin"},{"issue":"4","key":"12819_CR3","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3322\/caac.21779","volume":"73","author":"SM Ruff","year":"2023","unstructured":"Ruff SM, Diaz DA, Pitter KL, Hartwell BC, Pawlik TM. Multidisciplinary management in the treatment of intrahepatic cholangiocarcinoma. CA Cancer J Clin. 2023;73(4):346\u201352.","journal-title":"CA Cancer J Clin"},{"issue":"9","key":"12819_CR4","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1200\/JCO.2012.41.5984","volume":"31","author":"Y Wang","year":"2013","unstructured":"Wang Y, Li J, Xia Y, Gong R, Wang K, Yan Z, Wan X, Liu G, Wu D, Shi L, et al. Prognostic nomogram for intrahepatic cholangiocarcinoma after partial hepatectomy. J Clin Oncol. 2013;31(9):1188\u201395.","journal-title":"J Clin Oncol"},{"issue":"7","key":"12819_CR5","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1016\/j.ejso.2022.01.023","volume":"48","author":"YW Zhou","year":"2022","unstructured":"Zhou YW, Li QF, Chen YY, Wang K, Pu D, Chen XR, Li CH, Jiang L, Wang Y, Li Q, et al. Clinicopathologic features, treatment, survival, and prognostic factors of combined hepatocellular and cholangiocarcinoma: a nomogram development based on SEER database and validation in multicenter study. Eur J Surg Oncol. 2022;48(7):1559\u201366.","journal-title":"Eur J Surg Oncol"},{"issue":"9","key":"12819_CR6","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1007\/s11605-021-04947-w","volume":"25","author":"H Shen","year":"2021","unstructured":"Shen H, Zhang S, Xia Y, Chen C, Huo L, Gan L, Li J, Wang K, Pawlik TM, Lau WY, et al. A Nomogram in predicting risks of intrahepatic cholangiocarcinoma after partial hepatectomy for hepatolithiasis. J Gastrointest Surg. 2021;25(9):2258\u201367.","journal-title":"J Gastrointest Surg"},{"issue":"2","key":"12819_CR7","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1097\/SLA.0b013e318297ad6b","volume":"258","author":"Y Mano","year":"2013","unstructured":"Mano Y, Shirabe K, Yamashita Y, Harimoto N, Tsujita E, Takeishi K, Aishima S, Ikegami T, Yoshizumi T, Yamanaka T, et al. Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis. Ann Surg. 2013;258(2):301\u20135.","journal-title":"Ann Surg"},{"issue":"12","key":"12819_CR8","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1038\/modpathol.2012.114","volume":"25","author":"M Sasaki","year":"2012","unstructured":"Sasaki M, Yoneda N, Kitamura S, Sato Y, Nakanuma Y. A serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis: a previously unrecognized type of inflammatory hepatocellular tumor. Modern Pathol. 2012;25(12):1584\u201393.","journal-title":"Modern Pathol"},{"issue":"1","key":"12819_CR9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41421-022-00445-8","volume":"8","author":"X Wang","year":"2022","unstructured":"Wang X, Liu C, Chen J, Chen L, Ren X, Hou M, Cui X, Jiang Y, Liu E, Zong Y, et al. Single-cell dissection of remodeled inflammatory ecosystem in primary and metastatic gallbladder carcinoma. Cell discovery. 2022;8(1):101.","journal-title":"Cell discovery"},{"issue":"6","key":"12819_CR10","doi-asserted-by":"publisher","first-page":"749","DOI":"10.21037\/hbsn-20-332","volume":"10","author":"X Shen","year":"2021","unstructured":"Shen X, Zhao H, Jin X, Chen J, Yu Z, Ramen K, Zheng X, Wu X, Shan Y, Bai J, et al. Development and validation of a machine learning-based nomogram for prediction of intrahepatic cholangiocarcinoma in patients with intrahepatic lithiasis. Hepatobiliary Surg Nutr. 2021;10(6):749\u201365.","journal-title":"Hepatobiliary Surg Nutr"},{"issue":"7","key":"12819_CR11","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1002\/jso.23900","volume":"111","author":"G Spolverato","year":"2015","unstructured":"Spolverato G, Maqsood H, Kim Y, Margonis G, Luo T, Ejaz A, Pawlik TM. Neutrophil-lymphocyte and platelet-lymphocyte ratio in patients after resection for hepato-pancreatico-biliary malignancies. J Surg Oncol. 2015;111(7):868\u201374.","journal-title":"J Surg Oncol"},{"issue":"1","key":"12819_CR12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jhep.2012.08.017","volume":"58","author":"T Motomura","year":"2013","unstructured":"Motomura T, Shirabe K, Mano Y, Muto J, Toshima T, Umemoto Y, Fukuhara T, Uchiyama H, Ikegami T, Yoshizumi T, et al. Neutrophil-lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment. J Hepatol. 2013;58(1):58\u201364.","journal-title":"J Hepatol"},{"issue":"10","key":"12819_CR13","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1007\/s10147-021-01962-4","volume":"26","author":"K Yugawa","year":"2021","unstructured":"Yugawa K, Itoh S, Yoshizumi T, Morinaga A, Iseda N, Toshima T, Harada N, Kohashi K, Oda Y, Mori M. Lymphocyte-C-reactive protein ratio as a prognostic marker associated with the tumor immune microenvironment in intrahepatic cholangiocarcinoma. Int J Clin Oncol. 2021;26(10):1901\u201310.","journal-title":"Int J Clin Oncol"},{"issue":"1","key":"12819_CR14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/hepr.13958","volume":"54","author":"N Iseda","year":"2024","unstructured":"Iseda N, Itoh S, Toshida K, Nakayama Y, Ishikawa T, Tsutsui Y, Izumi T, Bekki Y, Yoshiya S, Toshima T, et al. Impact of albumin-lymphocyte-platelet-C-reactive protein index as a prognostic indicator of hepatocellular carcinoma after resection: Associated with nuclear factor erythroid 2-related factor 2. Hepatol Res. 2024;54(1):91\u2013102.","journal-title":"Hepatol Res"},{"issue":"10","key":"12819_CR15","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1007\/s10147-021-01985-x","volume":"26","author":"N Iseda","year":"2021","unstructured":"Iseda N, Itoh S, Yoshizumi T, Tomiyama T, Morinaga A, Shimagaki T, Wang H, Kurihara T, Toshima T, Nagao Y, et al. Lymphocyte-to-C-reactive protein ratio as a prognostic factor for hepatocellular carcinoma. Int J Clin Oncol. 2021;26(10):1890\u2013900.","journal-title":"Int J Clin Oncol"},{"issue":"3","key":"12819_CR16","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.surg.2018.05.002","volume":"164","author":"S Buettner","year":"2018","unstructured":"Buettner S, Spolverato G, Kimbrough CW, Alexandrescu S, Marques HP, Lamelas J, Aldrighetti L, Gamblin TC, Maithel SK, Pulitano C, et al. The impact of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio among patients with intrahepatic cholangiocarcinoma. Surgery. 2018;164(3):411\u20138.","journal-title":"Surgery"},{"issue":"2","key":"12819_CR17","doi-asserted-by":"publisher","first-page":"538","DOI":"10.4143\/crt.2017.106","volume":"50","author":"L Liu","year":"2018","unstructured":"Liu L, Wang W, Zhang Y, Long J, Zhang Z, Li Q, Chen B, Li S, Hua Y, Shen S, et al. Declined preoperative aspartate aminotransferase to neutrophil ratio index predicts poor prognosis in patients with intrahepatic cholangiocarcinoma after hepatectomy. Cancer Res Treat. 2018;50(2):538\u201350.","journal-title":"Cancer Res Treat"},{"key":"12819_CR18","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ijsu.2018.05.022","volume":"55","author":"Y Wang","year":"2018","unstructured":"Wang Y, Peng C, Cheng Z, Wang X, Wu L, Li J, Huang C, Guo Q, Cai H. The prognostic significance of preoperative neutrophil-lymphocyte ratio in patients with hepatocellular carcinoma receiving hepatectomy: a systematic review and meta-analysis. Int J Surg. 2018;55:73\u201380.","journal-title":"Int J Surg"},{"key":"12819_CR19","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.ijsu.2020.04.047","volume":"82s","author":"G Torzilli","year":"2020","unstructured":"Torzilli G, McCormack L, Pawlik T. Parenchyma-sparing liver resections. Int J Surg. 2020;82s:192\u20137.","journal-title":"Int J Surg"},{"issue":"4","key":"12819_CR20","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.jhep.2017.11.015","volume":"68","author":"Z Lei","year":"2018","unstructured":"Lei Z, Xia Y, Si A, Wang K, Li J, Yan Z, Yang T, Wu D, Wan X, Zhou W, et al. Antiviral therapy improves survival in patients with HBV infection and intrahepatic cholangiocarcinoma undergoing liver resection. J Hepatol. 2018;68(4):655\u201362.","journal-title":"J Hepatol"},{"issue":"12","key":"12819_CR21","doi-asserted-by":"publisher","first-page":"4020","DOI":"10.1245\/s10434-015-4472-9","volume":"22","author":"G Spolverato","year":"2015","unstructured":"Spolverato G, Yakoob MY, Kim Y, Alexandrescu S, Marques HP, Lamelas J, Aldrighetti L, Gamblin TC, Maithel SK, Pulitano C, et al. The impact of surgical margin status on long-term outcome after resection for intrahepatic cholangiocarcinoma. Ann Surg Oncol. 2015;22(12):4020\u20138.","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"12819_CR22","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.surg.2018.09.016","volume":"165","author":"P Yang","year":"2019","unstructured":"Yang P, Si A, Yang J, Cheng Z, Wang K, Li J, Xia Y, Zhang B, Pawlik TM, Lau WY, et al. A wide-margin liver resection improves long-term outcomes for patients with HBV-related hepatocellular carcinoma with microvascular invasion. Surgery. 2019;165(4):721\u201330.","journal-title":"Surgery"},{"key":"12819_CR23","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver. EASL-ILCA Clinical Practice Guidelines on the management of intrahepatic cholangiocarcinoma. J Hepatol. 2023;79(1):181\u2013208.","DOI":"10.1016\/j.jhep.2023.09.006"},{"issue":"6","key":"12819_CR24","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1002\/jso.21001","volume":"97","author":"D Gomez","year":"2008","unstructured":"Gomez D, Morris-Stiff G, Toogood GJ, Lodge JP, Prasad KR. Impact of systemic inflammation on outcome following resection for intrahepatic cholangiocarcinoma. J Surg Oncol. 2008;97(6):513\u20138.","journal-title":"J Surg Oncol"},{"issue":"5","key":"12819_CR25","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.ejso.2019.12.008","volume":"46","author":"H Jansson","year":"2020","unstructured":"Jansson H, Cornillet M, Bj\u00f6rkstr\u00f6m NK, Sturesson C, Sparrelid E. Prognostic value of preoperative inflammatory markers in resectable biliary tract cancer - validation and comparison of the Glasgow prognostic score and modified Glasgow prognostic score in a Western cohort. Eur J Surg Oncol. 2020;46(5):804\u201310.","journal-title":"Eur J Surg Oncol"},{"issue":"3","key":"12819_CR26","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.semcancer.2013.02.008","volume":"23","author":"S Brandau","year":"2013","unstructured":"Brandau S. The dichotomy of neutrophil granulocytes in cancer. Semin Cancer Biol. 2013;23(3):139\u201340.","journal-title":"Semin Cancer Biol"},{"issue":"3","key":"12819_CR27","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri3399","volume":"13","author":"E Kolaczkowska","year":"2013","unstructured":"Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol. 2013;13(3):159\u201375.","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"12819_CR28","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.it.2019.01.006","volume":"40","author":"F Mollinedo","year":"2019","unstructured":"Mollinedo F. Neutrophil degranulation, plasticity, and cancer metastasis. Trends Immunol. 2019;40(3):228\u201342.","journal-title":"Trends Immunol"},{"issue":"20","key":"12819_CR29","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1182\/blood-2018-11-844548","volume":"133","author":"MA Giese","year":"2019","unstructured":"Giese MA, Hind LE, Huttenlocher A. Neutrophil plasticity in the tumor microenvironment. Blood. 2019;133(20):2159\u201367.","journal-title":"Blood"},{"issue":"3","key":"12819_CR30","doi-asserted-by":"publisher","first-page":"302","DOI":"10.7150\/ijbs.14996","volume":"12","author":"K Felix","year":"2016","unstructured":"Felix K, Gaida MM. Neutrophil-derived proteases in the microenvironment of pancreatic cancer -active players in tumor progression. Int J Biol Sci. 2016;12(3):302\u201313.","journal-title":"Int J Biol Sci"},{"issue":"4","key":"12819_CR31","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1093\/jleuko\/qiad004","volume":"113","author":"Y Sheng","year":"2023","unstructured":"Sheng Y, Peng W, Huang Y, Cheng L, Meng Y, Kwantwi LB, Yang J, Xu J, Xiao H, Kzhyshkowska J, et al. Tumor-activated neutrophils promote metastasis in breast cancer via the G-CSF-RLN2-MMP-9 axis. J Leukoc Biol. 2023;113(4):383\u201399.","journal-title":"J Leukoc Biol"},{"issue":"6","key":"12819_CR32","doi-asserted-by":"publisher","first-page":"e484","DOI":"10.1002\/ctm2.484","volume":"11","author":"ZG Shan","year":"2021","unstructured":"Shan ZG, Chen J, Liu JS, Zhang JY, Wang TT, Teng YS, Mao FY, Cheng P, Zou QM, Zhou WY, et al. Activated neutrophils polarize protumorigenic interleukin-17A-producing T helper subsets through TNF-\u03b1-B7-H2-dependent pathway in human gastric cancer. Clin Transl Med. 2021;11(6):e484.","journal-title":"Clin Transl Med"},{"issue":"8","key":"12819_CR33","doi-asserted-by":"publisher","first-page":"2888","DOI":"10.1245\/s10434-020-08350-8","volume":"27","author":"A Moro","year":"2020","unstructured":"Moro A, Mehta R, Sahara K, Tsilimigras DI, Paredes AZ, Farooq A, Hyer JM, Endo I, Shen F, Guglielmi A, et al. The impact of preoperative CA19-9 and CEA on outcomes of patients with intrahepatic cholangiocarcinoma. Ann Surg Oncol. 2020;27(8):2888\u2013901.","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"12819_CR34","doi-asserted-by":"publisher","first-page":"886","DOI":"10.4143\/crt.2020.023","volume":"52","author":"JW Lee","year":"2020","unstructured":"Lee JW, Lee JH, Park Y, Lee W, Kwon J, Song KB, Hwang DW, Kim SC. Prognostic predictability of American Joint Committee on Cancer 8th staging system for perihilar cholangiocarcinoma: limited improvement compared with the 7th Staging system. Cancer Res Treat. 2020;52(3):886\u201395.","journal-title":"Cancer Res Treat"},{"issue":"17","key":"12819_CR35","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.7150\/jca.25339","volume":"9","author":"C He","year":"2018","unstructured":"He C, Zhang Y, Song Y, Wang J, Xing K, Lin X, Li S. Preoperative CEA levels are supplementary to CA19-9 levels in predicting prognosis in patients with resectable intrahepatic cholangiocarcinoma. J Cancer. 2018;9(17):3117\u201328.","journal-title":"J Cancer"},{"issue":"7","key":"12819_CR36","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1002\/cncr.34639","volume":"129","author":"J Zhang","year":"2023","unstructured":"Zhang J, Huang Q, Yang Y, Zhang J, Fang X, Yang Y, Liang H, Wang W, Wang Y. A novel prognostic system combining carbonic anhydrase II and preoperative CA19-9 for intrahepatic cholangiocarcinoma after curative resection. Cancer. 2023;129(7):1030\u201340.","journal-title":"Cancer"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-024-12819-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12885-024-12819-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-024-12819-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T12:08:19Z","timestamp":1725538099000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-024-12819-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,5]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["12819"],"URL":"https:\/\/doi.org\/10.1186\/s12885-024-12819-0","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,5]]},"assertion":[{"value":"20 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Retrospective review and collection of patient data were approved by the Eastern Hepatobiliary Surgery Hospital ethics committee and each patient provided informed consent for the use of their data in research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1106"}}