{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:51:09Z","timestamp":1740135069872,"version":"3.37.3"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPD1H0521"],"award-info":[{"award-number":["CMRPD1H0521"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"DOI":"10.1186\/s12885-024-13048-1","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T15:01:52Z","timestamp":1729868512000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic significance of adjuvant therapy and specific radiation dosages in Taiwanese patients with oral cavity cancer and extra-nodal extension: a nationwide cohort study"],"prefix":"10.1186","volume":"24","author":[{"given":"Yao-Te","family":"Tsai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Wen","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang-Hsing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Ching","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Hang","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Ru","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Jan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Yu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Yen","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Hung","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyuang-Der","family":"Terng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Ying","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hsun","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Hua","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Hung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Kan","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nai-Ming","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuan-Jen","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiang-Fu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ku-Hao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chien","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Ni","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Jen","family":"Hsin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Chen","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Ta","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"13048_CR1","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/1097-0142(19900701)66:1<109::AID-CNCR2820660120>3.0.CO;2-A","volume":"66","author":"JP Shah","year":"1990","unstructured":"Shah JP, Candela FC, Poddar AK. The patterns of cervical lymph node metastases from squamous carcinoma of the oral cavity. Cancer. 1990;66:109\u201313.","journal-title":"Cancer"},{"key":"13048_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.oraloncology.2005.05.008","volume":"42","author":"JA Woolgar","year":"2006","unstructured":"Woolgar JA. Histopathological prognosticators in oral and oropharyngeal squamous cell carcinoma. Oral Oncol. 2006;42:229\u201339.","journal-title":"Oral Oncol"},{"key":"13048_CR3","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1002\/hed.20279","volume":"27","author":"J Bernier","year":"2005","unstructured":"Bernier J, Cooper JS, Pajak TF, van Glabbeke M, Bourhis J, Forastiere A, et al. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck. 2005;27:843\u201350.","journal-title":"Head Neck"},{"key":"13048_CR4","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.oraloncology.2018.09.021","volume":"86","author":"CT Liao","year":"2018","unstructured":"Liao CT, Lee LY, Hsueh C, Lin CY, Fan KH, Wang HM, et al. Pathological risk factors stratification in pN3b oral cavity squamous cell carcinoma: focus on the number of positive nodes and extranodal extension. Oral Oncol. 2018;86:188\u201394.","journal-title":"Oral Oncol"},{"key":"13048_CR5","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.ijrobp.2010.07.1988","volume":"81","author":"CT Liao","year":"2011","unstructured":"Liao CT, Lee LY, Huang SF, Chen IH, Kang CJ, Lin CY, et al. Outcome analysis of patients with oral cavity cancer and extracapsular spread in neck lymph nodes. Int J Radiat Oncol Biol Phys. 2011;81:930\u20137.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"13048_CR6","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.1002\/1097-0142(20011215)92:12<3030::AID-CNCR10148>3.0.CO;2-P","volume":"92","author":"JN Myers","year":"2001","unstructured":"Myers JN, Greenberg JS, Mo V, Roberts D. Extracapsular spread. A significant predictor of treatment failure in patients with squamous cell carcinoma of the tongue. Cancer. 2001;92:3030\u20136.","journal-title":"Cancer"},{"key":"13048_CR7","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.oraloncology.2015.11.010","volume":"53","author":"T Mucke","year":"2016","unstructured":"Mucke T, Kanatas A, Ritschl LM, Koerdt S, Tannapfel A, Wolff KD, et al. Tumor thickness and risk of lymph node metastasis in patients with squamous cell carcinoma of the tongue. Oral Oncol. 2016;53:80\u20134.","journal-title":"Oral Oncol"},{"key":"13048_CR8","volume-title":"AJCC cancer staging manual","year":"2017","unstructured":"Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, Washington MK, editors. AJCC cancer staging manual. 8th ed. New York: Springer-; 2017.","edition":"8"},{"key":"13048_CR9","unstructured":"National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology, Head and Neck Cancers, Version IV. 2024 http:\/\/www.nccn.org\/. Accessed July 14 2024."},{"key":"13048_CR10","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1056\/NEJMoa032641","volume":"350","author":"J Bernier","year":"2004","unstructured":"Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lef\u00e8bvre JL, Greiner RH, et al. Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004;350:1945\u201352.","journal-title":"N Engl J Med"},{"key":"13048_CR11","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1056\/NEJMoa032646","volume":"350","author":"JS Cooper","year":"2004","unstructured":"Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004;350:1937\u201344.","journal-title":"N Engl J Med"},{"key":"13048_CR12","doi-asserted-by":"publisher","first-page":"3073","DOI":"10.1002\/cam4.1611","volume":"7","author":"YJ Cheng","year":"2018","unstructured":"Cheng YJ, Tsai MH, Chiang CJ, Tsai ST, Liu TW, Lou PJ, et al. Adjuvant radiotherapy after curative surgery for oral cavity squamous cell carcinoma and treatment effect of timing and duration on outcome-A Taiwan Cancer Registry national database analysis. Cancer Med. 2018;7:3073\u201383.","journal-title":"Cancer Med"},{"key":"13048_CR13","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1093\/jnci\/djy088","volume":"110","author":"W Sauerbrei","year":"2018","unstructured":"Sauerbrei W, Taube SE, McShane LM, Cavenagh MM, Altman DG. Reporting recommendations for tumor marker prognostic studies (REMARK): an abridged explanation and elaboration. J Natl Cancer Inst. 2018;110:803\u201311.","journal-title":"J Natl Cancer Inst"},{"key":"13048_CR14","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/sj.bjc.6602678","volume":"93","author":"LM McShane","year":"2005","unstructured":"McShane LM, Altman DG, Sauerbrei Wet, Taube SE, Gion M, Clark GM. REporting recommendations for tumour MARKer prognostic studies (REMARK). Br J Cancer. 2005;93:387\u201391.","journal-title":"Br J Cancer"},{"key":"13048_CR15","unstructured":"American College of Surgeons. Standards for Oncology Registry Entry. STORE 2024. Effective for Cases Diagnosed. https:\/\/www.facs.org\/media\/vssjur3j\/store_manual_2024.pdf. Updated January 1, 2024. Accessed July 14, 2024."},{"key":"13048_CR16","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1093\/aje\/154.9.854","volume":"154","author":"S Schneeweiss","year":"2001","unstructured":"Schneeweiss S, Seeger JD, Maclure M, Wang PS, Avorn J, Glynn RJ. Performance of comorbidity scores to control for confounding in epidemiologic studies using claims data. Am J Epidemiol. 2001;154:854\u201364.","journal-title":"Am J Epidemiol"},{"key":"13048_CR17","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373\u201383.","journal-title":"J Chronic Dis"},{"key":"13048_CR18","doi-asserted-by":"publisher","first-page":"106366","DOI":"10.1016\/j.oraloncology.2023.106366","volume":"140","author":"CY Chien","year":"2023","unstructured":"Chien CY, Wang CP, Lee LY, Lee SR, Ng SH, Kang CJ, et al. Indications for elective neck dissection in cT1N0M0 oral cavity cancer according to the AJCC eight edition: a nationwide study. Oral Oncol. 2023;140:106366.","journal-title":"Oral Oncol"},{"key":"13048_CR19","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s00259-019-04453-x","volume":"47","author":"CT Liao","year":"2020","unstructured":"Liao CT, Hsieh CH, Fan WL, Ng SH, Cheng NM, Lee LY, et al. A combined analysis of maximum standardized uptake value on FDG-PET, genetic markers, and clinicopathological risk factors in the prognostic stratification of patients with resected oral cavity squamous cell carcinoma. Eur J Nucl Med Mol Imaging. 2020;47:84\u201393.","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"13048_CR20","doi-asserted-by":"publisher","first-page":"3231","DOI":"10.1002\/cam4.3883","volume":"10","author":"J Tasoulas","year":"2021","unstructured":"Tasoulas J, Lenze NR, Farquhar D, Schrank P, Shen T, Shazib C. The addition of chemotherapy to adjuvant radiation is associated with inferior survival outcomes in intermediate-risk HPV-negative HNSCC. Cancer Med. 2021;10:3231\u20139.","journal-title":"Cancer Med"},{"key":"13048_CR21","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1200\/JCO.2016.68.2336","volume":"35","author":"DM Trifiletti","year":"2017","unstructured":"Trifiletti DM, Smith A, Mitra N, Grover S, Lukens JN, Cohen RB, et al. Beyond positive margins and extracapsular extension: evaluating the utilization and clinical impact of postoperative chemoradiotherapy in resected locally advanced head and neck cancer. J Clin Oncol. 2017;35:1550\u201360. https:\/\/doi.org\/10.1200\/JCO.2016.68.2336.","journal-title":"J Clin Oncol"},{"key":"13048_CR22","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1002\/lary.30158","volume":"133","author":"K Joshi","year":"2023","unstructured":"Joshi K, Agarwal M, Pasricha S, Singh A, Garg S, Rai S, et al. Macroscopic extranodal extension in oral squamous cell Carcinoma-A subgroup with poor survival. Laryngoscope. 2023;133:588\u201393.","journal-title":"Laryngoscope"},{"key":"13048_CR23","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1186\/s12885-022-09393-8","volume":"22","author":"Y Noda","year":"2022","unstructured":"Noda Y, Ishida M, Ueno Y, Fujisawa T, Iwai H, Tsuta K. Novel pathological predictive factors for extranodal extension in oral squamous cell carcinoma: a retrospective cohort study based on tumor budding, desmoplastic reaction, tumor-infiltrating lymphocytes, and depth of invasion. BMC Cancer. 2022;22:402.","journal-title":"BMC Cancer"},{"key":"13048_CR24","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1111\/jop.12870","volume":"48","author":"AE Pilborough","year":"2019","unstructured":"Pilborough AE, Lambert DW, Khurram SA. Extranodal extension in oral cancer: a role for the nodal microenvironment? J Oral Pathol Med. 2019;48:863\u201370.","journal-title":"J Oral Pathol Med"},{"key":"13048_CR25","doi-asserted-by":"publisher","first-page":"754412","DOI":"10.3389\/fonc.2021.754412","volume":"11","author":"YT Tsai","year":"2021","unstructured":"Tsai YT, Chen WC, Hsu CM, Tsai MS, Chang GH, Lee YC, et al. Survival-Weighted Health profiles in patients treated for advanced oral cavity squamous cell carcinoma. Front Oncol. 2021;11:754412.","journal-title":"Front Oncol"},{"key":"13048_CR26","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1002\/lary.27508","volume":"129","author":"JP Agarwal","year":"2019","unstructured":"Agarwal JP, Kane S, Ghosh-Laskar S, Pilar A, Manik V, Oza N, et al. Extranodal extension in resected oral cavity squamous cell carcinoma: more to it than meets the eye. Laryngoscope. 2019;129:1130\u20136. https:\/\/doi.org\/10.1002\/lary.27508.","journal-title":"Laryngoscope"},{"key":"13048_CR27","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1002\/hed.26499","volume":"43","author":"I Arun","year":"2021","unstructured":"Arun I, Maity N, Hameed S, Jain PV, Manikantan K, Sharan R, et al. Lymph node characteristics and their prognostic significance in oral squamous cell carcinoma. Head Neck. 2021;43:520\u201333.","journal-title":"Head Neck"},{"key":"13048_CR28","doi-asserted-by":"publisher","first-page":"104845","DOI":"10.1016\/j.oraloncology.2020.104845","volume":"110","author":"JR de Almeida","year":"2020","unstructured":"de Almeida JR, Truong T, Khan NM, Su JS, Irish J, Gilbert R, et al. Treatment implications of postoperative chemoradiotherapy for squamous cell carcinoma of the oral cavity with minor and major extranodal extension. Oral Oncol. 2020;110:104845.","journal-title":"Oral Oncol"},{"key":"13048_CR29","doi-asserted-by":"publisher","first-page":"105169","DOI":"10.1016\/j.oraloncology.2020.105169","volume":"114","author":"CN Abdel-Halim","year":"2021","unstructured":"Abdel-Halim CN, Rosenberg T, Dyrvig AK, H\u00f8ilund-Carlsen PF, S\u00f8rensen JA, Rohde M, et al. Diagnostic accuracy of imaging modalities in detection of histopathological extranodal extension: a systematic review and meta-analysis. Oral Oncol. 2021;114:105169.","journal-title":"Oral Oncol"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-024-13048-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12885-024-13048-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-024-13048-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T15:02:44Z","timestamp":1729868564000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-024-13048-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["13048"],"URL":"https:\/\/doi.org\/10.1186\/s12885-024-13048-1","relation":{},"ISSN":["1471-2407"],"issn-type":[{"type":"electronic","value":"1471-2407"}],"subject":[],"published":{"date-parts":[[2024,10,25]]},"assertion":[{"value":"28 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted according to the guidelines of the Declaration of Helsinki. All procedures were approved by the Chang Gung Medical Foundation Institutional Review Board (reference number: 201801398B0A3). The requirement for written patient informed consent was waived by Chang Gung Medical Foundation Institutional Review Board due to the study design.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The preparation of this manuscript did not involve the use of artificial intelligence at any stage of the writing process.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration of generative AI in scientific writing"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1320"}}