{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:53:36Z","timestamp":1788299616869,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"DOI":"10.1186\/s12885-024-13281-8","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:38:38Z","timestamp":1734655118000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dose-volume predictors of cardiac adverse events after high-dose thoracic radiation therapy for lung cancer: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"24","author":[{"given":"M\u00e9d\u00e9a","family":"Locquet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Geets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Beaudart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"issue":"8","key":"13281_CR1","doi-asserted-by":"publisher","first-page":"150","DOI":"10.21037\/atm.2016.03.11","volume":"4","author":"J Didkowska","year":"2016","unstructured":"Didkowska J, Wojciechowska U, Ma\u0144czuk M, \u0141obaszewski J. Lung cancer epidemiology: contemporary and future challenges worldwide. Ann Transl Med. 2016;4(8):150\u2013150. https:\/\/doi.org\/10.21037\/atm.2016.03.11.","journal-title":"Ann Transl Med"},{"key":"13281_CR2","doi-asserted-by":"publisher","first-page":"e43651","DOI":"10.2196\/43651","volume":"9","author":"G Luo","year":"2023","unstructured":"Luo G, Zhang Y, Etxeberria J, et al. Projections of lung cancer incidence by 2035 in 40 countries worldwide: population-based study. JMIR Public Health Surveill. 2023;9:e43651. https:\/\/doi.org\/10.2196\/43651.","journal-title":"JMIR Public Health Surveill"},{"issue":"2","key":"13281_CR3","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.radonc.2017.10.001","volume":"125","author":"K Wang","year":"2017","unstructured":"Wang K, Pearlstein KA, Patchett ND, et al. Heart dosimetric analysis of three types of cardiac toxicity in patients treated on dose-escalation trials for Stage III non-small-cell lung cancer. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2017;125(2):293\u2013300. https:\/\/doi.org\/10.1016\/j.radonc.2017.10.001.","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"13281_CR4","doi-asserted-by":"publisher","first-page":"1007577","DOI":"10.3389\/fonc.2022.1007577","volume":"12","author":"K Banfill","year":"2022","unstructured":"Banfill K, Abravan A, van Herk M, et al. Heart dose and cardiac comorbidities influence death with a cardiac cause following hypofractionated radiotherapy for lung cancer. Front Oncol. 2022;12:1007577. https:\/\/doi.org\/10.3389\/fonc.2022.1007577.","journal-title":"Front Oncol"},{"issue":"11","key":"13281_CR5","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa1209825","volume":"368","author":"SC Darby","year":"2013","unstructured":"Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368(11):987\u201398. https:\/\/doi.org\/10.1056\/NEJMoa1209825.","journal-title":"N Engl J Med"},{"key":"13281_CR6","unstructured":"PRISMA 2020 checklist. PRISMA statement. https:\/\/www.prisma-statement.org\/prisma-2020-checklist. Accessed 5 Aug 2024."},{"issue":"2","key":"13281_CR7","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1017\/S0266462312000086","volume":"28","author":"A Morrison","year":"2012","unstructured":"Morrison A, Polisena J, Husereau D, et al. The effect of English-language restriction on systematic review-based meta-analyses: a systematic review of empirical studies. Int J Technol Assess Health Care. 2012;28(2):138\u201344. https:\/\/doi.org\/10.1017\/S0266462312000086.","journal-title":"Int J Technol Assess Health Care"},{"issue":"10","key":"13281_CR8","doi-asserted-by":"publisher","first-page":"e1001744","DOI":"10.1371\/journal.pmed.1001744","volume":"11","author":"KGM Moons","year":"2014","unstructured":"Moons KGM, de Groot JAH, Bouwmeester W, et al. Critical appraisal and data extraction for systematic reviews of prediction modelling studies: The CHARMS checklist. PLOS Med. 2014;11(10):e1001744. https:\/\/doi.org\/10.1371\/journal.pmed.1001744.","journal-title":"PLOS Med"},{"issue":"11","key":"13281_CR9","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1001\/jamaoncol.2022.4202","volume":"8","author":"KH Kim","year":"2022","unstructured":"Kim KH, Oh J, Yang G, et al. Association of sinoatrial node radiation dose with atrial fibrillation and mortality in patients with lung cancer. JAMA Oncol. 2022;8(11):1624\u201334. https:\/\/doi.org\/10.1001\/jamaoncol.2022.4202.","journal-title":"JAMA Oncol"},{"issue":"1","key":"13281_CR10","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ultrasmedbio.2018.09.012","volume":"45","author":"L Chen","year":"2019","unstructured":"Chen L, Ta S, Wu W, Wang C, Zhang Q. Prognostic and added value of echocardiographic strain for prediction of adverse outcomes in patients with locally advanced non-small cell lung cancer after radiotherapy. Ultrasound Med Biol. 2019;45(1):98\u2013107. https:\/\/doi.org\/10.1016\/j.ultrasmedbio.2018.09.012.","journal-title":"Ultrasound Med Biol"},{"issue":"1","key":"13281_CR11","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ijrobp.2017.05.022","volume":"99","author":"MS Ning","year":"2017","unstructured":"Ning MS, Tang L, Gomez DR, et al. Incidence and predictors of pericardial effusion after chemoradiation therapy for locally advanced non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2017;99(1):70\u20139. https:\/\/doi.org\/10.1016\/j.ijrobp.2017.05.022.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"23","key":"13281_CR12","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.1016\/j.jacc.2019.03.500","volume":"73","author":"KM Atkins","year":"2019","unstructured":"Atkins KM, Rawal B, Chaunzwa TL, et al. Cardiac radiation dose, cardiac disease, and mortality in patients with lung cancer. J Am Coll Cardiol. 2019;73(23):2976\u201387. https:\/\/doi.org\/10.1016\/j.jacc.2019.03.500.","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"13281_CR13","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1001\/jamaoncol.2020.6332","volume":"7","author":"KM Atkins","year":"2021","unstructured":"Atkins KM, Chaunzwa TL, Lamba N, et al. Association of left anterior descending coronary artery radiation dose with major adverse cardiac events and mortality in patients with non-small cell lung cancer. JAMA Oncol. 2021;7(2):206\u201319. https:\/\/doi.org\/10.1001\/jamaoncol.2020.6332.","journal-title":"JAMA Oncol"},{"issue":"6","key":"13281_CR14","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.cllc.2019.05.014","volume":"20","author":"JF Borkenhagen","year":"2019","unstructured":"Borkenhagen JF, Bergom C, Rapp CT, Klawikowski SJ, Rein LE, Gore EM. Dosimetric predictors of cardiotoxicity in thoracic radiotherapy for lung cancer. Clin Lung Cancer. 2019;20(6):435\u201341. https:\/\/doi.org\/10.1016\/j.cllc.2019.05.014.","journal-title":"Clin Lung Cancer"},{"issue":"5","key":"13281_CR15","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s12149-022-01724-w","volume":"36","author":"SG Cho","year":"2022","unstructured":"Cho SG, Kim YH, Park H, et al. Prediction of cardiac events following concurrent chemoradiation therapy for non-small-cell lung cancer using FDG PET. Ann Nucl Med. 2022;36(5):439\u201349. https:\/\/doi.org\/10.1007\/s12149-022-01724-w.","journal-title":"Ann Nucl Med"},{"issue":"13","key":"13281_CR16","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1200\/JCO.2016.71.6142","volume":"35","author":"RT Dess","year":"2017","unstructured":"Dess RT, Sun Y, Matuszak MM, et al. cardiac events after radiation therapy: combined analysis of prospective multicenter trials for locally advanced non-small-cell lung cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2017;35(13):1395\u2013402. https:\/\/doi.org\/10.1200\/JCO.2016.71.6142.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"13281_CR17","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.radonc.2020.09.050","volume":"152","author":"BS Jang","year":"2020","unstructured":"Jang BS, Cha MJ, Kim HJ, et al. Heart substructural dosimetric parameters and risk of cardiac events after definitive chemoradiotherapy for stage III non-small cell lung cancer. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2020;152:126\u201332. https:\/\/doi.org\/10.1016\/j.radonc.2020.09.050.","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"13281_CR18","doi-asserted-by":"publisher","first-page":"1071701","DOI":"10.3389\/fcvm.2022.1071701","volume":"9","author":"E Koutroumpakis","year":"2022","unstructured":"Koutroumpakis E, Xu T, Lopez-Mattei J, et al. Coronary artery calcium score on standard of care oncologic CT scans for the prediction of adverse cardiovascular events in patients with non-small cell lung cancer treated with concurrent chemoradiotherapy. Front Cardiovasc Med. 2022;9:1071701. https:\/\/doi.org\/10.3389\/fcvm.2022.1071701.","journal-title":"Front Cardiovasc Med"},{"issue":"6","key":"13281_CR19","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.jaccao.2023.08.007","volume":"5","author":"HJ No","year":"2023","unstructured":"No HJ, Guo FB, Park NJI, et al. Predicting adverse cardiac events after radiotherapy for locally advanced non-small cell lung cancer. JACC CardioOncology. 2023;5(6):775\u201387. https:\/\/doi.org\/10.1016\/j.jaccao.2023.08.007.","journal-title":"JACC CardioOncology"},{"key":"13281_CR20","doi-asserted-by":"publisher","first-page":"100660","DOI":"10.1016\/j.ctro.2023.100660","volume":"42","author":"MC Tjong","year":"2023","unstructured":"Tjong MC, Zhang SC, Gasho JO, et al. External validation of Cardiac disease, Hypertension, and Logarithmic Left anterior descending coronary artery radiation dose (CHyLL) for predicting major adverse cardiac events after lung cancer radiotherapy. Clin Transl Radiat Oncol. 2023;42:100660. https:\/\/doi.org\/10.1016\/j.ctro.2023.100660.","journal-title":"Clin Transl Radiat Oncol"},{"key":"13281_CR21","doi-asserted-by":"publisher","first-page":"110085","DOI":"10.1016\/j.radonc.2024.110085","volume":"192","author":"GM Walls","year":"2024","unstructured":"Walls GM, McCann C, O\u2019Connor J, et al. Pulmonary vein dose and risk of atrial fibrillation in patients with non-small cell lung cancer following definitive radiotherapy: An NI-HEART analysis. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2024;192:110085. https:\/\/doi.org\/10.1016\/j.radonc.2024.110085.","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"issue":"2","key":"13281_CR22","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.clon.2023.11.029","volume":"36","author":"GM Walls","year":"2024","unstructured":"Walls GM, O\u2019Connor J, Harbinson M, et al. the association of incidental radiation dose to the heart base with overall survival and cardiac events after curative-intent radiotherapy for non-small cell lung cancer: results from the NI-HEART study. Clin Oncol. 2024;36(2):119\u201327. https:\/\/doi.org\/10.1016\/j.clon.2023.11.029.","journal-title":"Clin Oncol"},{"issue":"1","key":"13281_CR23","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.ijrobp.2021.08.017","volume":"112","author":"K Wang","year":"2022","unstructured":"Wang K, Malkin HE, Patchett ND, et al. Coronary artery calcifications and cardiac risk after radiation therapy for stage iii lung cancer. Int J Radiat Oncol Biol Phys. 2022;112(1):188\u201396. https:\/\/doi.org\/10.1016\/j.ijrobp.2021.08.017.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"13","key":"13281_CR24","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1200\/JCO.2016.70.0229","volume":"35","author":"K Wang","year":"2017","unstructured":"Wang K, Eblan MJ, Deal AM, et al. Cardiac toxicity after radiotherapy for stage III non-small-cell lung cancer: pooled analysis of dose-escalation trials delivering 70 to 90 Gy. J Clin Oncol Off J Am Soc Clin Oncol. 2017;35(13):1387\u201394. https:\/\/doi.org\/10.1200\/JCO.2016.70.0229.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"key":"13281_CR25","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.radonc.2018.10.029","volume":"133","author":"J Xue","year":"2019","unstructured":"Xue J, Han C, Jackson A, et al. Doses of radiation to the pericardium, instead of heart, are significant for survival in patients with non-small cell lung cancer. Radiother Oncol. 2019;133:213\u20139. https:\/\/doi.org\/10.1016\/j.radonc.2018.10.029.","journal-title":"Radiother Oncol"},{"issue":"10","key":"13281_CR26","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/j.jtho.2018.05.028","volume":"13","author":"N Yegya-Raman","year":"2018","unstructured":"Yegya-Raman N, Wang K, Kim S, et al. dosimetric predictors of symptomatic cardiac events after conventional-dose chemoradiation therapy for inoperable NSCLC. J Thorac Oncol Off Publ Int Assoc Study Lung Cancer. 2018;13(10):1508\u201318. https:\/\/doi.org\/10.1016\/j.jtho.2018.05.028.","journal-title":"J Thorac Oncol Off Publ Int Assoc Study Lung Cancer"},{"key":"13281_CR27","doi-asserted-by":"publisher","first-page":"110005","DOI":"10.1016\/j.radonc.2023.110005","volume":"190","author":"N Yegya-Raman","year":"2024","unstructured":"Yegya-Raman N, Ho Lee S, Friedes C, et al. Cardiac radiation dose is associated with inferior survival but not cardiac events in patients with locally advanced non-small cell lung cancer in the era of immune checkpoint inhibitor consolidation. Radiother Oncol. 2024;190:110005. https:\/\/doi.org\/10.1016\/j.radonc.2023.110005.","journal-title":"Radiother Oncol"},{"issue":"23","key":"13281_CR28","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.1016\/j.jacc.2019.03.500","volume":"73","author":"KM Atkins","year":"2019","unstructured":"Atkins KM, Rawal B, Chaunzwa TL, et al. Cardiac radiation dose, cardiac disease, and mortality in patients with lung cancer. J Am Coll Cardiol. 2019;73(23):2976\u201387. https:\/\/doi.org\/10.1016\/j.jacc.2019.03.500.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"13281_CR29","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1200\/JCO.2016.69.1378","volume":"35","author":"SG Chun","year":"2017","unstructured":"Chun SG, Hu C, Choy H, et al. Impact of intensity-modulated radiation therapy technique for locally advanced non-small-cell lung cancer: a secondary analysis of the NRG oncology RTOG 0617 randomized clinical trial. J Clin Oncol Off J Am Soc Clin Oncol. 2017;35(1):56\u201362. https:\/\/doi.org\/10.1200\/JCO.2016.69.1378.","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"issue":"3","key":"13281_CR30","doi-asserted-by":"publisher","first-page":"S77","DOI":"10.1016\/j.ijrobp.2009.04.093","volume":"76","author":"G Gagliardi","year":"2010","unstructured":"Gagliardi G, Constine LS, Moiseenko V, et al. Radiation dose-volume effects in the heart. Int J Radiat Oncol Biol Phys. 2010;76(3):S77\u201385. https:\/\/doi.org\/10.1016\/j.ijrobp.2009.04.093.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"3","key":"13281_CR31","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.ijrobp.2018.10.025","volume":"103","author":"JN Jacobse","year":"2019","unstructured":"Jacobse JN, Duane FK, Boekel NB, et al. Radiation dose-response for risk of myocardial infarction in breast cancer survivors. Int J Radiat Oncol Biol Phys. 2019;103(3):595\u2013604. https:\/\/doi.org\/10.1016\/j.ijrobp.2018.10.025.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"13281_CR32","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.radonc.2019.06.032","volume":"152","author":"S Teoh","year":"2020","unstructured":"Teoh S, Fiorini F, George B, Vallis KA, Van den Heuvel F. Proton vs photon: A model-based approach to patient selection for reduction of cardiac toxicity in locally advanced lung cancer. Radiother Oncol. 2020;152:151\u201362. https:\/\/doi.org\/10.1016\/j.radonc.2019.06.032.","journal-title":"Radiother Oncol"},{"issue":"6","key":"13281_CR33","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.clon.2021.12.017","volume":"34","author":"G Price","year":"2022","unstructured":"Price G, Devaney S, French DP, et al. Can real-world data and rapid learning drive improvements in lung cancer survival? The RAPID-RT study. Clin Oncol R Coll Radiol G B. 2022;34(6):407\u201310. https:\/\/doi.org\/10.1016\/j.clon.2021.12.017.","journal-title":"Clin Oncol R Coll Radiol G B"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-024-13281-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12885-024-13281-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-024-13281-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T01:02:45Z","timestamp":1734656565000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-024-13281-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["13281"],"URL":"https:\/\/doi.org\/10.1186\/s12885-024-13281-8","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"assertion":[{"value":"30 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1556"}}