{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:26:41Z","timestamp":1785331601514,"version":"3.55.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2024-17-24"],"award-info":[{"award-number":["320.6750.2024-17-24"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"DOI":"10.1186\/s12885-026-15899-2","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:37:15Z","timestamp":1774532235000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Study protocol for hyperthermic intraperitoneal chemotherapy in the treatment of locally advanced gastric cancer after laparoscopic or robotic Gastrectomy with D2 lymphadenectomy: a phase III multicentre prospective randomized controlled clinical trial (HIPEC-09)"],"prefix":"10.1186","volume":"26","author":[{"given":"Xiaodong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shougen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zequn","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen qing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixiong","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"issue":"3","key":"15899_CR1","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229\u201363.","journal-title":"CA Cancer J Clin"},{"issue":"5","key":"15899_CR2","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1097\/CM9.0000000000002108","volume":"135","author":"C Xia","year":"2022","unstructured":"Xia C, Dong X, Li H, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin Med J (Engl). 2022;135(5):584\u201390.","journal-title":"Chin Med J (Engl)"},{"issue":"9813","key":"15899_CR3","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/S0140-6736(11)61873-4","volume":"379","author":"YJ Bang","year":"2012","unstructured":"Bang YJ, Kim YW, Yang HK, et al. Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial. Lancet. 2012;379(9813):315\u201321.","journal-title":"Lancet"},{"issue":"18","key":"15899_CR4","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1056\/NEJMoa072252","volume":"357","author":"S Sakuramoto","year":"2007","unstructured":"Sakuramoto S, Sasako M, Yamaguchi T, et al. Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med. 2007;357(18):1810\u201320.","journal-title":"N Engl J Med"},{"key":"15899_CR5","doi-asserted-by":"publisher","first-page":"709617","DOI":"10.3389\/fonc.2021.709617","volume":"11","author":"W Xu","year":"2021","unstructured":"Xu W, Liu W, Wang L, et al. Is D2 Lymphadenectomy Alone Suitable for Gastric Cancer With Bulky N2 and\/or Para-Aortic Lymph Node Metastases After Preoperative Chemotherapy. Front Oncol. 2021;11:709617.","journal-title":"Front Oncol"},{"issue":"2","key":"15899_CR6","first-page":"146","volume":"4","author":"S Kitano","year":"1994","unstructured":"Kitano S, Iso Y, Moriyama M, Sugimachi K. Laparoscopy-assisted Billroth I gastrectomy. Surg Laparosc Endosc. 1994;4(2):146\u20138.","journal-title":"Surg Laparosc Endosc"},{"issue":"2","key":"15899_CR7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/00129689-200104000-00003","volume":"11","author":"PM Goh","year":"2001","unstructured":"Goh PM, Khan AZ, So JB, et al. Early experience with laparoscopic radical gastrectomy for advanced gastric cancer. Surg Laparosc Endosc Percutan Tech. 2001;11(2):83\u20137.","journal-title":"Surg Laparosc Endosc Percutan Tech"},{"issue":"6","key":"15899_CR8","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1016\/S0039-6109(03)00158-0","volume":"83","author":"M Hashizume","year":"2003","unstructured":"Hashizume M, Sugimachi K. Robot-assisted gastric surgery. Surg Clin North Am. 2003;83(6):1429\u201344.","journal-title":"Surg Clin North Am"},{"issue":"1","key":"15899_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1001\/jamasurg.2021.5104","volume":"157","author":"C Huang","year":"2022","unstructured":"Huang C, Liu H, Hu Y, et al. Laparoscopic vs Open Distal Gastrectomy for Locally Advanced Gastric Cancer: Five-Year Outcomes From the CLASS-01 Randomized Clinical Trial. JAMA Surg. 2022;157(1):9\u201317.","journal-title":"JAMA Surg"},{"issue":"28","key":"15899_CR10","doi-asserted-by":"publisher","first-page":"3304","DOI":"10.1200\/JCO.20.01210","volume":"38","author":"WJ Hyung","year":"2020","unstructured":"Hyung WJ, Yang HK, Park YK, et al. Long-Term Outcomes of Laparoscopic Distal Gastrectomy for Locally Advanced Gastric Cancer: The KLASS-02-RCT Randomized Clinical Trial. J Clin Oncol. 2020;38(28):3304\u201313.","journal-title":"J Clin Oncol"},{"issue":"5","key":"15899_CR11","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1001\/jamasurg.2023.0096","volume":"158","author":"T Etoh","year":"2023","unstructured":"Etoh T, Ohyama T, Sakuramoto S, et al. Five-Year Survival Outcomes of Laparoscopy-Assisted vs Open Distal Gastrectomy for Advanced Gastric Cancer: The JLSSG0901 Randomized Clinical Trial. JAMA Surg. 2023;158(5):445\u201354.","journal-title":"JAMA Surg"},{"key":"15899_CR12","doi-asserted-by":"crossref","unstructured":"Japanese Gastric Cancer Treatment Guidelines. 2021 (6th edition). Gastric Cancer. 2023;26(1): 1\u201325.","DOI":"10.1007\/s10120-022-01331-8"},{"issue":"5","key":"15899_CR13","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1002\/(SICI)1097-0142(19990901)86:5<770::AID-CNCR11>3.0.CO;2-3","volume":"86","author":"J Volz","year":"1999","unstructured":"Volz J, K\u00f6ster S, Spacek Z, Paweletz N. The influence of pneumoperitoneum used in laparoscopic surgery on an intraabdominal tumor growth. Cancer. 1999;86(5):770\u20134.","journal-title":"Cancer"},{"issue":"Suppl 3","key":"15899_CR14","doi-asserted-by":"publisher","first-page":"S1540","DOI":"10.1245\/s10434-015-4508-1","volume":"22","author":"S Carpinteri","year":"2015","unstructured":"Carpinteri S, Sampurno S, Bernardi MP, et al. Peritoneal Tumorigenesis and Inflammation are Ameliorated by Humidified-Warm Carbon Dioxide Insufflation in the Mouse. Ann Surg Oncol. 2015;22(Suppl 3):S1540\u20137.","journal-title":"Ann Surg Oncol"},{"issue":"12","key":"15899_CR15","doi-asserted-by":"publisher","first-page":"733","DOI":"10.6061\/clinics\/2016(12)10","volume":"71","author":"F Tustumi","year":"2016","unstructured":"Tustumi F, Bernardo WM, Dias AR, et al. Detection value of free cancer cells in peritoneal washing in gastric cancer: a systematic review and meta-analysis. Clin (Sao Paulo). 2016;71(12):733\u201345.","journal-title":"Clin (Sao Paulo)"},{"issue":"11","key":"15899_CR16","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1093\/humrep\/deh495","volume":"19","author":"MM Binda","year":"2004","unstructured":"Binda MM, Molinas CR, Mailova K, Koninckx PR. Effect of temperature upon adhesion formation in a laparoscopic mouse model. Hum Reprod. 2004;19(11):2626\u201332.","journal-title":"Hum Reprod"},{"issue":"9","key":"15899_CR17","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1007\/s00464-003-8238-2","volume":"18","author":"SJ Neuhaus","year":"2004","unstructured":"Neuhaus SJ, Watson DI. Pneumoperitoneum and peritoneal surface changes: a review. Surg Endosc. 2004;18(9):1316\u201322.","journal-title":"Surg Endosc"},{"issue":"2","key":"15899_CR18","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s004649900098","volume":"14","author":"P Wittich","year":"2000","unstructured":"Wittich P, Marquet RL, Kazemier G, Bonjer HJ. Port-site metastases after CO(2) laparoscopy. Is aerosolization of tumor cells a pivotal factor. Surg Endosc. 2000;14(2):189\u201392.","journal-title":"Surg Endosc"},{"key":"15899_CR19","doi-asserted-by":"publisher","first-page":"745548","DOI":"10.3389\/fendo.2021.745548","volume":"12","author":"PR Koninckx","year":"2021","unstructured":"Koninckx PR, Fernandes R, Ussia A, et al. Pathogenesis Based Diagnosis and Treatment of Endometriosis. Front Endocrinol (Lausanne). 2021;12:745548.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"15899_CR20","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1002\/ijc.28373","volume":"134","author":"I Thomassen","year":"2014","unstructured":"Thomassen I, van Gestel YR, van Ramshorst B, et al. Peritoneal carcinomatosis of gastric origin: a population-based study on incidence, survival and risk factors. Int J Cancer. 2014;134(3):622\u20138.","journal-title":"Int J Cancer"},{"issue":"3","key":"15899_CR21","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/jso.23632","volume":"110","author":"JP De Andrade","year":"2014","unstructured":"De Andrade JP, Mezhir JJ. The critical role of peritoneal cytology in the staging of gastric cancer: an evidence-based review. J Surg Oncol. 2014;110(3):291\u20137.","journal-title":"J Surg Oncol"},{"issue":"8","key":"15899_CR22","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1054\/bjoc.2000.1408","volume":"83","author":"N Mori","year":"2000","unstructured":"Mori N, Oka M, Hazama S, et al. Detection of telomerase activity in peritoneal lavage fluid from patients with gastric cancer using immunomagnetic beads. Br J Cancer. 2000;83(8):1026\u201332.","journal-title":"Br J Cancer"},{"issue":"5B","key":"15899_CR23","first-page":"2131","volume":"14","author":"M Ikeguchi","year":"1994","unstructured":"Ikeguchi M, Oka A, Tsujitani S, Maeta M, Kaibara N. Relationship between area of serosal invasion and intraperitoneal free cancer cells in patients with gastric cancer. Anticancer Res. 1994;14(5B):2131\u20134.","journal-title":"Anticancer Res"},{"issue":"3","key":"15899_CR24","doi-asserted-by":"publisher","first-page":"266","DOI":"10.2174\/157488711796575603","volume":"6","author":"S Shimada","year":"2011","unstructured":"Shimada S, Kuramoto M, Marutsuka T, Yagi Y, Baba H. Adopting extensive intra-operative peritoneal lavage (EIPL) as the standard prophylactic strategy for peritoneal recurrence. Rev Recent Clin Trials. 2011;6(3):266\u201370.","journal-title":"Rev Recent Clin Trials"},{"issue":"5","key":"15899_CR25","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1080\/02656736.2017.1387939","volume":"34","author":"W Wang","year":"2018","unstructured":"Wang W, Tan G, Skanthakumar T, Chia CS, Soo KC, Teo M. Exploring the trend in referrals for consideration of CRS and HIPEC to understand the attitudes of clinicians in the development of a national cancer centre programme in peritoneal disease. Int J Hyperth. 2018;34(5):551\u20138.","journal-title":"Int J Hyperth"},{"issue":"6","key":"15899_CR26","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1097\/SLA.0000000000001593","volume":"263","author":"R Kwakman","year":"2016","unstructured":"Kwakman R, Schrama AM, van Olmen JP, et al. Clinicopathological Parameters in Patient Selection for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Cancer Metastases: A Meta-analysis. Ann Surg. 2016;263(6):1102\u201311.","journal-title":"Ann Surg"},{"issue":"6","key":"15899_CR27","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1245\/s10434-015-5081-3","volume":"23","author":"CS Chia","year":"2016","unstructured":"Chia CS, You B, Decullier E, et al. Patients with Peritoneal Carcinomatosis from Gastric Cancer Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Is Cure a Possibility. Ann Surg Oncol. 2016;23(6):1971\u20139.","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"15899_CR28","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1080\/02656736.2020.1772511","volume":"37","author":"O Sgarbura","year":"2020","unstructured":"Sgarbura O, Al Hosni M, Petruzziello A, et al. Complete pathologic response after two-stage cytoreductive surgery with HIPEC for bulky pseudomyxoma peritonei: proof of concept. Int J Hyperth. 2020;37(1):585\u201391.","journal-title":"Int J Hyperth"},{"issue":"3","key":"15899_CR29","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1056\/NEJMoa1708618","volume":"378","author":"WJ van Driel","year":"2018","unstructured":"van Driel WJ, Koole SN, Sikorska K, et al. Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer. N Engl J Med. 2018;378(3):230\u201340.","journal-title":"N Engl J Med"},{"issue":"1","key":"15899_CR30","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1186\/s12885-019-6125-z","volume":"19","author":"MK Beeharry","year":"2019","unstructured":"Beeharry MK, Zhu ZL, Liu WT, Yao XX, Yan M, Zhu ZG. Prophylactic HIPEC with radical D2 gastrectomy improves survival and peritoneal recurrence rates for locally advanced gastric cancer: personal experience from a randomized case control study. BMC Cancer. 2019;19(1):932.","journal-title":"BMC Cancer"},{"key":"15899_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejca.2017.03.030","volume":"79","author":"J Desiderio","year":"2017","unstructured":"Desiderio J, Chao J, Melstrom L, et al. The 30-year experience-A meta-analysis of randomised and high-quality non-randomised studies of hyperthermic intraperitoneal chemotherapy in the treatment of gastric cancer. Eur J Cancer. 2017;79:1\u201314.","journal-title":"Eur J Cancer"},{"issue":"2","key":"15899_CR32","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1245\/s10434-016-5487-6","volume":"24","author":"Y Yonemura","year":"2017","unstructured":"Yonemura Y, Ishibashi H, Hirano M, et al. Effects of Neoadjuvant Laparoscopic Hyperthermic Intraperitoneal Chemotherapy and Neoadjuvant Intraperitoneal\/Systemic Chemotherapy on Peritoneal Metastases from Gastric Cancer. Ann Surg Oncol. 2017;24(2):478\u201385.","journal-title":"Ann Surg Oncol"},{"issue":"24","key":"15899_CR33","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1200\/JCO.21.02745","volume":"40","author":"YX Gwee","year":"2022","unstructured":"Gwee YX, Chia D, So J, et al. Integration of Genomic Biology Into Therapeutic Strategies of Gastric Cancer Peritoneal Metastasis. J Clin Oncol. 2022;40(24):2830.","journal-title":"J Clin Oncol"},{"issue":"7","key":"15899_CR34","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1053\/j.gastro.2024.08.007","volume":"167","author":"JJ Zhao","year":"2024","unstructured":"Zhao JJ, Ong CJ, Srivastava S, et al. Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases. Gastroenterology. 2024;167(7):1384\u2013e13984.","journal-title":"Gastroenterology"},{"issue":"1\u20132","key":"15899_CR35","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1159\/000093778","volume":"23","author":"ZG Zhu","year":"2006","unstructured":"Zhu ZG, Tang R, Yan M, et al. Efficacy and safety of intraoperative peritoneal hyperthermic chemotherapy for advanced gastric cancer patients with serosal invasion. A long-term follow-up study. Dig Surg. 2006;23(1\u20132):93\u2013102.","journal-title":"Dig Surg"},{"issue":"1","key":"15899_CR36","first-page":"49","volume":"73","author":"JM Foster","year":"2023","unstructured":"Foster JM, Zhang C, Rehman S, Sharma P, Alexander HR. The contemporary management of peritoneal metastasis: A journey from the cold past of treatment futility to a warm present and a bright future. CA Cancer J Clin. 2023;73(1):49\u201371.","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"15899_CR37","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ejso.2022.08.023","volume":"49","author":"R Yang","year":"2023","unstructured":"Yang R, Su YD, Ma R, Li Y. Clinical epidemiology of peritoneal metastases in China: The construction of professional peritoneal metastases treatment centers based on the prevalence rate. Eur J Surg Oncol. 2023;49(1):173\u20138.","journal-title":"Eur J Surg Oncol"},{"issue":"1","key":"15899_CR38","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/s41467-020-20429-0","volume":"12","author":"D Chen","year":"2021","unstructured":"Chen D, Liu Z, Liu W, et al. Predicting postoperative peritoneal metastasis in gastric cancer with serosal invasion using a collagen nomogram. Nat Commun. 2021;12(1):179.","journal-title":"Nat Commun"},{"issue":"2","key":"15899_CR39","doi-asserted-by":"publisher","first-page":"e220749","DOI":"10.1148\/radiol.220749","volume":"306","author":"Y Mori","year":"2023","unstructured":"Mori Y, Dendl K, Cardinale J, Kratochwil C, Giesel FL, Haberkorn U. FAPI PET: Fibroblast Activation Protein Inhibitor Use in Oncologic and Nononcologic Disease. Radiology. 2023;306(2):e220749.","journal-title":"Radiology"},{"issue":"2","key":"15899_CR40","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1007\/s00464-021-08430-0","volume":"36","author":"ZN Huang","year":"2022","unstructured":"Huang ZN, Ma Y, Chen QY, et al. Potential survival benefits of open over laparoscopic radical gastrectomy for gastric cancer patients beyond three years after surgery: result from multicenter in-depth analysis based on propensity matching. Surg Endosc. 2022;36(2):1456\u201365.","journal-title":"Surg Endosc"},{"issue":"2","key":"15899_CR41","first-page":"256","volume":"40","author":"JS Spratt","year":"1980","unstructured":"Spratt JS, Adcock RA, Muskovin M, Sherrill W, McKeown J. Clinical delivery system for intraperitoneal hyperthermic chemotherapy. Cancer Res. 1980;40(2):256\u201360.","journal-title":"Cancer Res"},{"issue":"2","key":"15899_CR42","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.ejca.2013.09.024","volume":"50","author":"D Elias","year":"2014","unstructured":"Elias D, Go\u00e9r\u00e9 D, Dumont F, et al. Role of hyperthermic intraoperative peritoneal chemotherapy in the management of peritoneal metastases. Eur J Cancer. 2014;50(2):332\u201340.","journal-title":"Eur J Cancer"},{"issue":"7","key":"15899_CR43","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1002\/jso.23728","volume":"110","author":"A Prada-Villaverde","year":"2014","unstructured":"Prada-Villaverde A, Esquivel J, Lowy AM, et al. The American Society of Peritoneal Surface Malignancies evaluation of HIPEC with Mitomycin C versus Oxaliplatin in 539 patients with colon cancer undergoing a complete cytoreductive surgery. J Surg Oncol. 2014;110(7):779\u201385.","journal-title":"J Surg Oncol"},{"issue":"10","key":"15899_CR44","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/S2468-1253(19)30239-0","volume":"4","author":"C Klaver","year":"2019","unstructured":"Klaver C, Wisselink DD, Punt C, et al. Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicentre, open-label, randomised trial. Lancet Gastroenterol Hepatol. 2019;4(10):761\u201370.","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"3","key":"15899_CR45","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3109\/02656736.2014.893451","volume":"30","author":"RR Yarema","year":"2014","unstructured":"Yarema RR, Ohorchak MA, Zubarev GP, et al. Hyperthermic intraperitoneal chemoperfusion in combined treatment of locally advanced and disseminated gastric cancer: results of a single-centre retrospective study. Int J Hyperth. 2014;30(3):159\u201365.","journal-title":"Int J Hyperth"},{"issue":"8","key":"15899_CR46","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.jcma.2013.04.004","volume":"76","author":"LY Kang","year":"2013","unstructured":"Kang LY, Mok KT, Liu SI, et al. Intraoperative hyperthermic intraperitoneal chemotherapy as adjuvant chemotherapy for advanced gastric cancer patients with serosal invasion. J Chin Med Assoc. 2013;76(8):425\u201331.","journal-title":"J Chin Med Assoc"},{"issue":"1","key":"15899_CR47","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3109\/0284186X.2011.594809","volume":"51","author":"B Hultman","year":"2012","unstructured":"Hultman B, Lundkvist J, Glimelius B, Nygren P, Mahteme H. Costs and clinical outcome of neoadjuvant systemic chemotherapy followed by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from gastric cancer. Acta Oncol. 2012;51(1):112\u201321.","journal-title":"Acta Oncol"},{"key":"15899_CR48","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/1471-2407-14-183","volume":"14","author":"O Glehen","year":"2014","unstructured":"Glehen O, Passot G, Villeneuve L, et al. GASTRICHIP: D2 resection and hyperthermic intraperitoneal chemotherapy in locally advanced gastric carcinoma: a randomized and multicenter phase III study. BMC Cancer. 2014;14:183.","journal-title":"BMC Cancer"},{"issue":"1","key":"15899_CR49","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1186\/s12885-021-08872-8","volume":"21","author":"TO G\u00f6tze","year":"2021","unstructured":"G\u00f6tze TO, Piso P, Lorenzen S, et al. Preventive HIPEC in combination with perioperative FLOT versus FLOT alone for resectable diffuse type gastric and gastroesophageal junction type II\/III adenocarcinoma - the phase III PREVENT- (FLOT9) trial of the AIO \/CAOGI \/ACO. BMC Cancer. 2021;21(1):1158.","journal-title":"BMC Cancer"},{"issue":"Suppl 15","key":"15899_CR50","doi-asserted-by":"publisher","first-page":"S4538","DOI":"10.1200\/JCO.2020.38.15_suppl","volume":"38","author":"S Lui","year":"2020","unstructured":"Lui S, Liang H, Li Y, et al. PILGRIM: Phase III clinical trial in evaluating the role of hyperthermic intraperitoneal chemotherapy for locally advanced gastric cancer patients after radical gastrectomy with D2 lymphadenectomy (HIPEC-01) [J]. J Clin Oncol. 2020;38(Suppl 15):S4538\u20134538. https:\/\/doi.org\/10.1200\/JCO.2020.38.15_suppl.","journal-title":"J Clin Oncol"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12885-026-15899-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-026-15899-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12885-026-15899-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:05:02Z","timestamp":1778051102000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12885-026-15899-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,26]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["15899"],"URL":"https:\/\/doi.org\/10.1186\/s12885-026-15899-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6957503\/v1","asserted-by":"object"}]},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,26]]},"assertion":[{"value":"23 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study has been approved by the Ethics Committee of the Affiliated Hospital of Qingdao University and has already been registered at ClinicalTrial.gov with Registration ID NCT05871099. After the main center obtained ethical approval from the Ethics Committee of the Affiliated Hospital of Qingdao University, the main center will send the ethical materials to each sub-center. Each sub-center will hold an ethics committee meeting respectively in accordance with the requirements of the ethics committee, conduct ethical approval, and send the scanned copy of the ethical approval document to the main center for archiving. Each sub-center has been approved by the ethics committee of the sub-center where it is located. Subjects can only be enrolled after obtaining ethical approval. The HIPEC-09 study complies with the Declaration of Helsinki rules, the principles of the Good Clinical Practice guidelines and the Data Protection Act. The trial will also be performed in accordance with local legal and regulatory requirements. Each patient recruited to the study will provide written informed consent after receiving extensive information about the intent of the study, the study regimen, potential associated risks and side effects as well as potential alternative therapies. The investigator will not undertake any diagnostic measures specifically required for the clinical trial until valid consent has been obtained. Monitoring will be conducted throughout the trial. We have purchased insurance for this research. If subject suffers any damage related to this study or experiences a serious adverse event, appropriate compensation will be provided.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"570"}}