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Vessel density in macula and optic nerve head were measured by optical coherence tomography angiography before and after transient elevation in intraocular pressure caused by application of suction ring during surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vessel density (VD) at superficial (SCP) plexus of macular region did not differ after surgery (F(3,132)\u2009=\u20091.41,<jats:italic>P<\/jats:italic>\u2009=\u20090.24), while the deep (DCP) plexus of macular region significantly decreased 1\u2009day after surgery (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) but returned to its baseline value 1\u2009month postoperatively (<jats:italic>P<\/jats:italic>\u2009=\u20090.1). Vessel density of optic nerve head region had no significant changes after surgery (F(2.51,95.18)\u2009=\u20090.6,<jats:italic>P<\/jats:italic>\u2009=\u20090.59).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A short-term temporary decrease of vessel density at deep layer of macular region was observed in eyes undergoing FS-LASIK. However, the retinal capillary density went back to preoperative level 1\u2009month after surgery. Therefore, transient IOP spike during FS-LASIK did not cause long-term decline of retinal microcirculation.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12886-020-01368-2","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T15:02:39Z","timestamp":1584457359000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Microvascular changes in macula and optic nerve head after femtosecond laser-assisted LASIK: an optical coherence tomography angiography study"],"prefix":"10.1186","volume":"20","author":[{"given":"Yan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqing","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"issue":"5","key":"1368_CR1","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.jcrs.2007.02.017","volume":"33","author":"JC Bradley","year":"2007","unstructured":"Bradley JC, McCartney DL, Craenen GA. 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