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The experimental group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) received nicergoline (10\u2009mg.kg\n                      <jats:sup>\u2212\u20091<\/jats:sup>\n                      .day\n                      <jats:sup>\u2212\u20091<\/jats:sup>\n                      ), while the control group (n\u2009=\u200924) received a placebo. A corneal epithelial defect was induced using a corneal diamond burr, and defect area was compared at time points of 0, 12, 24, 48 and 72\u2009h after the injury using image analysis software. The probability of CCUR within 72\u2009h was assessed using the Kaplan\u2013Meier survival analysis log-rank test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      When compared, 4 of the 24 rats (17%) in the placebo group and 12 of the 24 rats (50%) in the nicergoline group were found to have CCUR within 72\u2009h (log-rank\u2009=\u20090.027). Cox regression analysis found no effect of the covariates blood glucose (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.601) or weight (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.322) on the corneal reepithelialization (survival) curve.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Nicergoline increased wound healing rates relative to placebo and may therefore be investigated as a treatment option in diabetic keratopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12886-021-01835-4","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T05:04:56Z","timestamp":1612847096000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of nicergoline in corneal wound healing in diabetic rats"],"prefix":"10.1186","volume":"21","author":[{"given":"Amanda Lemos Barros Martins","family":"Portela","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Neves","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Helena Madruga Lima","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Miguel","family":"de Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yale Viana","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Pessoa Cavalcanti","family":"Lira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"issue":"5","key":"1835_CR1","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.survophthal.2020.02.005","volume":"65","author":"S Priyadarsini","year":"2020","unstructured":"Priyadarsini S, Whelchel A, Nicholas S, Sharif R, Riaz K, Karamichos D. 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Animals underwent experimental procedures for scientific research purposes in accordance with the protocols published by the National Council for the Control of Animal Experimentation (CONCEA) and the ARRIVE guidelines. All procedures considering animals in this study adhered to the ARVO resolution for the care and use of animals in visual research.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"77"}}