{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,15]],"date-time":"2026-11-15T00:06:55Z","timestamp":1794701215160,"version":"4.9.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019M3E5D1A01069352"],"award-info":[{"award-number":["NRF-2019M3E5D1A01069352"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1A2C1011676"],"award-info":[{"award-number":["NRF-2019R1A2C1011676"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Ophthalmol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Disc hemorrhage (DH) is an important factor often associated with the development and especially progression of glaucoma. In contrast, some studies have reported peripapillary retinoschisis in glaucoma, but it is not recognized as a pathognomonic finding, and opinions on the clinical significance of retinoschisis are not consistent. Here,we present the case of DH following peripapillary retinoschisis in the same area within the same glaucomatous eye.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 70-year-old man with high intraocular pressure (IOP) was referred to the glaucoma clinic. At the time of the baseline study, the IOP was 30mmHg, and peripapillary retinoschisis was discovered at 7 o\u2019clock on the periphery of the optic nerve with swept-source optical coherence tomography. Accompanying retinal nerve fiber layer defect were manifest in the inferotemporal part with red-free fundus photography. Under the impression of open-angle glaucoma, we prescribe latanoprost ophthalmic solution. Eight months later, the IOP was 17mmHg, and the peripapillary retinoschisis had disappeared. DH was observed in the inferotemporal area in the same direction as that of the previous peripapillary retinoschisis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The case presented here are the first to report on the relationship between peripapillary retinoschisis and DH. Hopefully future studies will reveal the actual connection between peripapillary retinoschisis and DH.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12886-021-02010-5","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T18:12:54Z","timestamp":1623089574000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Disc hemorrhage following peripapillary retinoschisis in glaucoma: a case report"],"prefix":"10.1186","volume":"21","author":[{"given":"Won June","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mincheol","family":"Seong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"issue":"9422","key":"2010_CR1","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","volume":"363","author":"RN Weinreb","year":"2004","unstructured":"Weinreb RN, Khaw PT. Primary open-angle glaucoma. The Lancet. 2004;363(9422):1711\u201320.","journal-title":"The Lancet"},{"key":"2010_CR2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.preteyeres.2017.08.002","volume":"60","author":"EJ Lee","year":"2017","unstructured":"Lee EJ, Han JC, Kee C. A novel hypothesis for the pathogenesis of glaucomatous disc hemorrhage. Prog Retin Eye Res. 2017;60:20\u201343.","journal-title":"Prog Retin Eye Res"},{"issue":"3","key":"2010_CR3","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/eye.2016.235","volume":"31","author":"N Dhingra","year":"2017","unstructured":"Dhingra N, Manoharan R, Gill S, Nagar M. Peripapillary schisis in open-angle glaucoma. Eye. 2017;31(3):499\u2013502.","journal-title":"Eye"},{"issue":"5","key":"2010_CR4","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1136\/bjophthalmol-2013-303931","volume":"98","author":"YH Hwang","year":"2014","unstructured":"Hwang YH, Kim YY, Kim HK, Sohn YH. Effect of peripapillary retinoschisis on retinal nerve fibre layer thickness measurement in glaucomatous eyes. Br J Ophthalmol. 2014;98(5):669\u201374.","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"2010_CR5","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1097\/OPX.0000000000001474","volume":"97","author":"JD Roberts","year":"2020","unstructured":"Roberts JD, Hunter A, Mega J, Cesaro T, Greenberg PB. Case Report: Glaucoma-associated Peripapillary Retinoschisis with Corresponding Lamina Cribrosa Defect. Optometry vision science: official publication of the American Academy of Optometry. 2020;97(2):104\u20139.","journal-title":"Optometry vision science: official publication of the American Academy of Optometry"},{"issue":"7","key":"2010_CR6","doi-asserted-by":"publisher","first-page":"2818","DOI":"10.1167\/iovs.18-24160","volume":"59","author":"B Fortune","year":"2018","unstructured":"Fortune B, Ma KN, Gardiner SK, Demirel S, Mansberger SL. Peripapillary Retinoschisis in Glaucoma: Association With Progression and OCT Signs of M\u00fcller Cell Involvement. Invest Ophthalmol Vis Sci. 2018;59(7):2818\u201327.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"2010_CR7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1167\/iovs.62.2.16","volume":"62","author":"EJ Lee","year":"2021","unstructured":"Lee EJ, Kee HJ, Han JC, Kee C. The Progression of Peripapillary Retinoschisis May Indicate the Progression of Glaucoma. Invest Ophthalmol Vis Sci. 2021;62(2):16.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"2010_CR8","doi-asserted-by":"publisher","first-page":"e90129","DOI":"10.1371\/journal.pone.0090129","volume":"9","author":"EJ Lee","year":"2014","unstructured":"Lee EJ, Kim TW, Kim M, Choi YJ. Peripapillary retinoschisis in glaucomatous eyes. PLoS One. 2014;9(2):e90129.","journal-title":"PLoS One"},{"issue":"1","key":"2010_CR9","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1167\/iovs.18-25837","volume":"60","author":"B Fortune","year":"2019","unstructured":"Fortune B. Pulling and Tugging on the Retina: Mechanical Impact of Glaucoma Beyond the Optic Nerve Head. Invest Ophthalmol Vis Sci. 2019;60(1):26\u201335.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"2010_CR10","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S1350-9462(99)00017-8","volume":"19","author":"MR Hernandez","year":"2000","unstructured":"Hernandez MR. The optic nerve head in glaucoma: role of astrocytes in tissue remodeling. Prog Retin Eye Res. 2000;19(3):297\u2013321.","journal-title":"Prog Retin Eye Res"}],"container-title":["BMC Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12886-021-02010-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12886-021-02010-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12886-021-02010-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T18:13:30Z","timestamp":1623089610000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcophthalmol.biomedcentral.com\/articles\/10.1186\/s12886-021-02010-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,7]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2010"],"URL":"https:\/\/doi.org\/10.1186\/s12886-021-02010-5","relation":{},"ISSN":["1471-2415"],"issn-type":[{"value":"1471-2415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,7]]},"assertion":[{"value":"1 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The local ethics committee ruled that no formal ethics approval was required in this case report.The authors declare that they adhered to the CARE guidelines\/methodology.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication of potentially identifying information and clinical images was obtained from the patient. The copy of written consent to publish is available for the journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"253"}}