{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T01:51:21Z","timestamp":1711504281846},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Epithelial ingrowth is a rare but potentially sight-threatening complication caused by the invasion of corneal or conjunctival epithelial cells into the eye during ocular surgeries. DMEK is emerging as a widely used surgery for endothelial keratoplasty with its improved safety profile. We describe a case of epithelial ingrowth in the graft-host interface after uneventful DMEK associated with vitreous prolapse in the anterior chamber.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>An 81-year-old female with Fuchs endothelial dystrophy underwent DMEK for corneal decompensation following cataract surgery. During the DMEK procedure, vitreous prolapse was observed around the intraocular lens (IOL). Her early postoperative course was unremarkable, but a dense paracentral interface opacity was observed during the 3-month follow-up. The area of epithelial ingrowth was imaged with optical coherence tomography (OCT) as a uniform nodule with a discrete increase in interface hyperreflectivity. A low-energy YAG laser was applied to remove the opacity. She maintained good vision and clear cornea without reoccurrence after treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We propose that, in addition to the introduction of epithelial cells during surgery, vitreous retention in the anterior chamber may be a risk factor by providing a scaffold that potentially aggravates epithelial ingrowth in DMEK. Our case demonstrated that early YAG intervention may disrupt interface epithelial cell growth, and the transmitted laser energy may fragment the scaffold vitreous noninvasively.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12886-024-03370-4","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T12:02:49Z","timestamp":1711454569000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epithelial ingrowth in descemet membrane endothelial keratoplasty associated with vitreous loss"],"prefix":"10.1186","volume":"24","author":[{"given":"Anny M.S.","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anup","family":"Kubal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailesh K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil S.","family":"Vedula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.Y.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aarup A.","family":"Kubal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"3370_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1136\/bjo.73.1.6","volume":"73","author":"MJ Weiner","year":"1989","unstructured":"Weiner MJ, Trentacoste J, Pon DM, Albert DM. Epithelial downgrowth: a 30-year clinicopathological review. Br J Ophthalmol. 1989;73:6\u201311. https:\/\/doi.org\/10.1136\/bjo.73.1.6.","journal-title":"Br J Ophthalmol"},{"key":"3370_CR2","doi-asserted-by":"publisher","first-page":"906087","DOI":"10.1155\/2014\/906087","volume":"2014","author":"F Semeraro","year":"2014","unstructured":"Semeraro F, Di Salvatore A, Bova A, Forbice E. Etiopathogenesis and therapy of epithelial ingrowth after Descemet\u2019s stripping automated endothelial keratoplasty. Biomed Res Int. 2014;2014:906087. https:\/\/doi.org\/10.1155\/2014\/906087.","journal-title":"Biomed Res Int"},{"key":"3370_CR3","doi-asserted-by":"publisher","first-page":"1819454","DOI":"10.1155\/2021\/1819454","volume":"2021","author":"D Borroni","year":"2021","unstructured":"Borroni D, Rocha de Lossada C, Parekh M, et al. Tips, tricks, and guides in Descemet membrane endothelial keratoplasty learning curve. J Ophthalmol. 2021;2021:1819454. https:\/\/doi.org\/10.1155\/2021\/1819454.","journal-title":"J Ophthalmol"},{"key":"3370_CR4","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1097\/ICO.0000000000002401","volume":"39","author":"A Tzamalis","year":"2020","unstructured":"Tzamalis A, Vinciguerra R, Romano V, et al. The \u2018Yogurt\u2019 technique for Descemet membrane endothelial Keratoplasty Graft Preparation: a Novel Quick and Safe Method for both Inexperienced and Senior surgeons. Cornea. 2020;39:1190\u20135. https:\/\/doi.org\/10.1097\/ICO.0000000000002401.","journal-title":"Cornea"},{"key":"3370_CR5","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1097\/ICO.0000000000002338","volume":"39","author":"D Borroni","year":"2020","unstructured":"Borroni D, Gadhvi K, Wojcik G, et al. The influence of Speed during stripping in Descemet membrane endothelial keratoplasty tissue Preparation. Cornea. 2020;39:1086\u201390. https:\/\/doi.org\/10.1097\/ICO.0000000000002338.","journal-title":"Cornea"},{"key":"3370_CR6","doi-asserted-by":"publisher","first-page":"NP27","DOI":"10.1177\/1120672120912413","volume":"31","author":"VNH Le","year":"2021","unstructured":"Le VNH, Wabnig F, Bachmann B, Cursiefen C. Epithelial downgrowth after Descemet membrane endothelial keratoplasty. Eur J Ophthalmol. 2021;31:NP27\u201332. https:\/\/doi.org\/10.1177\/1120672120912413.","journal-title":"Eur J Ophthalmol"},{"key":"3370_CR7","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1097\/ICO.0000000000002367","volume":"39","author":"SG Jenkins","year":"2020","unstructured":"Jenkins SG, Jun AS, Woreta FA, Srikumaran D. YAG Laser Treatment for Epithelial Ingrowth in Descemet membrane endothelial keratoplasty interface. Cornea. 2020;39:1439\u201341. https:\/\/doi.org\/10.1097\/ICO.0000000000002367.","journal-title":"Cornea"},{"key":"3370_CR8","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1001\/jamaophthalmol.2019.4566","volume":"137","author":"M Gruber","year":"2019","unstructured":"Gruber M, Lang S, K\u00fcchlin S, Kayser G, Auw-Haedrich C, Reinhard T, Maier P. Epithelial Invasion following Descemet membrane endothelial keratoplasty and Associated with subsequent central graft detachment. JAMA Ophthalmol. 2019;137:1461\u20133. https:\/\/doi.org\/10.1001\/jamaophthalmol.2019.4566.","journal-title":"JAMA Ophthalmol"},{"key":"3370_CR9","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1097\/ICO.0000000000001964","volume":"38","author":"C \u00c1lvarez de Toledo","year":"2019","unstructured":"\u00c1lvarez de Toledo C, Salvador-Culla B, L\u00f3pez JC, De la Paz MF, Barraquer RI. \u00c1lvarez De Toledo J: epithelial Ingrowth after Descemet membrane endothelial keratoplasty. Cornea. 2019;38:1189\u201391. https:\/\/doi.org\/10.1097\/ICO.0000000000001964.","journal-title":"Cornea"},{"key":"3370_CR10","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jcrs.2008.07.036","volume":"35","author":"PM Phillips","year":"2009","unstructured":"Phillips PM, Terry MA, Kaufman SC, Chen ES. Epithelial downgrowth after Descemet-stripping automated endothelial keratoplasty. J Cataract Refract Surg. 2009;35:193\u20136. https:\/\/doi.org\/10.1016\/j.jcrs.2008.07.036.","journal-title":"J Cataract Refract Surg"},{"key":"3370_CR11","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ajoc.2018.02.020","volume":"10","author":"RM Jaber","year":"2018","unstructured":"Jaber RM, Harrod M, Goshe JM. Spontaneous regression of epithelial downgrowth from clear corneal phacoemulsification wound. Am J Ophthalmol Case Rep. 2018;10:159\u201362. https:\/\/doi.org\/10.1016\/j.ajoc.2018.02.020.","journal-title":"Am J Ophthalmol Case Rep"}],"container-title":["BMC Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12886-024-03370-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12886-024-03370-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12886-024-03370-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T12:06:21Z","timestamp":1711454781000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcophthalmol.biomedcentral.com\/articles\/10.1186\/s12886-024-03370-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,26]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3370"],"URL":"https:\/\/doi.org\/10.1186\/s12886-024-03370-4","relation":{},"ISSN":["1471-2415"],"issn-type":[{"value":"1471-2415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,26]]},"assertion":[{"value":"7 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Institutional approval was waived as our single case report involves retrospective medical record review of one patient and the only interaction with the patient has been for purposes of treating the patient and does not meet the Common Rule definition of research (45 CFR 164.501). Although institutional approval was not required to publish the case details, we obtained written informed consent from the patient for the publication of the case and any accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Although institutional approval was not required to publish the case details, we obtained written informed consent from the patient for the publication of the case and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"135"}}