{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:40:29Z","timestamp":1791333629277,"version":"4.3.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Innovation & Transfer Fund of Peking University Third Hospital","award":["BYSYZHKC2021108"],"award-info":[{"award-number":["BYSYZHKC2021108"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81970798"],"award-info":[{"award-number":["81970798"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Aniridia is a rare eye disorder with a high incidence of glaucoma, and surgical intervention is often needed to control the intraocular pressure (IOP). Here, we reported a case of illuminated microcatheter-assisted circumferential trabeculotomy (MAT) performed on an aniridic glaucoma patient following a previous failed angle surgery. The surgical procedures for aniridic glaucoma were also reviewed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 21-year-old man, diagnosed with aniridic glaucoma, came to our hospital consulting for the poor control of left eye\u2019s IOP despite receiving goniotomy surgery 3 years ago. The IOP was 26 mmHg with maximum topical antiglaucoma eyedrops. The central cornea was opaque and the majority of iris was absent. The gonioscopy and ultrasound biomicroscopy (UBM) demonstrated that 360\u00b0 anterior chamber angle was closed. The whole exome sequencing of peripheral blood confirmed a 13.39\u00a0Mb copy number loss at chromosome 11p15.1p13, containing <jats:italic>PAX6<\/jats:italic> and <jats:italic>WT1<\/jats:italic> gene. The 360\u00b0 MAT surgery was performed on his left eye. At 1-year follow-up, the IOP was 19mmHg with 2 kinds of topical antiglaucoma medications, and the postoperative UBM demonstrated the successful incision of the anterior chamber angle.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The case presented here exhibited a case of aniridic glaucoma treated by MAT surgery. The MAT surgery may be an effective option for IOP control in aniridic glaucoma patients following a previous failed angle surgery.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12886-024-03425-6","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T12:01:52Z","timestamp":1712664112000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcome of illuminated microcatheter-assisted circumferential trabeculotomy following failed angle surgery in PAX6 aniridic glaucoma: a case report and literature review"],"prefix":"10.1186","volume":"24","author":[{"given":"Tingyi","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"issue":"7","key":"3425_CR1","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1111\/j.1755-3768.2008.01427.x","volume":"86","author":"H Lee","year":"2008","unstructured":"Lee H, Khan R, O\u2019Keefe M. Aniridia: current pathology and management. Acta Ophthalmol. 2008;86(7):708\u201315.","journal-title":"Acta Ophthalmol"},{"issue":"5","key":"3425_CR2","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1097\/ICU.0000000000000405","volume":"28","author":"HT Lim","year":"2017","unstructured":"Lim HT, Kim DH, Kim H. PAX6 aniridia syndrome: clinics, genetics, and therapeutics. Curr Opin Ophthalmol. 2017;28(5):436\u201347.","journal-title":"Curr Opin Ophthalmol"},{"issue":"10","key":"3425_CR3","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1038\/ejhg.2012.100","volume":"20","author":"M Hingorani","year":"2012","unstructured":"Hingorani M, Hanson I, van Heyningen V. Aniridia. 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Informed consent was obtained from the patient for his case to be presented and discussed. This study was conducted in compliance with the tenets of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this Case Report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"157"}}