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is becoming a huge burden on the world\u2019s public health systems. The purpose of this study was to explore the effect of brimonidine in the treatment of form-deprivation myopia (FDM) and the relationship between intraocular pressure (IOP) and myopia development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Monocular form deprivation myopia (FDM) was induced in three-week-old pigmented male guinea pigs. They were treated with 3 different methods of brimonidine administration (eye drops, and subconjunctival or intravitreal injections). Four different concentrations of brimonidine were tested for each method (2\n                      <jats:italic>\u00b5<\/jats:italic>\n                      g\/\n                      <jats:italic>\u00b5<\/jats:italic>\n                      L, 4\n                      <jats:italic>\u00b5<\/jats:italic>\n                      g\/\n                      <jats:italic>\u00b5<\/jats:italic>\n                      L, 20\n                      <jats:italic>\u00b5<\/jats:italic>\n                      g\/\n                      <jats:italic>\u00b5<\/jats:italic>\n                      L, and 40\n                      <jats:italic>\u00b5<\/jats:italic>\n                      g\/\n                      <jats:italic>\u00b5<\/jats:italic>\n                      L). All treatments continued for a period of 21 days. Tonometry, retinoscopy, and A-scan ultrasonography were used to monitor intraocular pressure, refractive error and axial length (AL), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Treatment with subconjunctival brimonidine at 40\n                      <jats:italic>\u00b5<\/jats:italic>\n                      g\/\n                      <jats:italic>\u00b5<\/jats:italic>\n                      L, and intravitreal brimonidine at 2\n                      <jats:italic>\u00b5<\/jats:italic>\n                      g\/\n                      <jats:italic>\u00b5<\/jats:italic>\n                      L and 4\n                      <jats:italic>\u00b5<\/jats:italic>\n                      g\/\n                      <jats:italic>\u00b5<\/jats:italic>\n                      L, inhibited the development of FDM. The myopic refraction, excessive axial length, and elevation of IOP were significantly decreased. Brimonidine in eye drops was ineffective.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Brimonidine at appropriate doses significantly reduced the development of FD myopia in guinea pigs. The IOP may change with FD myopia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12886-024-03433-6","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T04:02:09Z","timestamp":1712808129000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Brimonidine as a possible treatment for myopia"],"prefix":"10.1186","volume":"24","author":[{"given":"Zixuan","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiqun","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunliang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"issue":"7543","key":"3433_CR1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/519276a","volume":"519","author":"E Dolgin","year":"2015","unstructured":"Dolgin E. 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