{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:04:38Z","timestamp":1788959078746,"version":"build-2803163510"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Ophthalmol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>To analyze the vessel density (VD) of the retina and choriocapillaris (CC) layer and the structure of the foveal avascular zone (FAZ) in the fellow eyes of central serous chorioretinopathy (CSC) patients by using optical coherence tomography angiography (OCTA).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This was a case\u2013control study. Unilateral CSC patients and age-matched healthy subjects were recruited from the Affiliated Eye Hospital of Wenzhou Medical University between July 2016 and July 2021. All eyes were divided into three groups: acute CSC (aCSC), chronic CSC (cCSC), and healthy controls. Both aCSC and cCSC were again divided into two subgroups: the affected eyes and the fellow eyes. In this study, all parameters of VD and FAZ were measured by self-software of OCTA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 231 eyes of 137 subjects were included, with 47 aCSC patients, 47 cCSC patients, and 43 healthy controls. In the fellow eyes of CSC, the retinal VD was significantly lower (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and the FAZ was significantly larger (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in the cCSC group than in healthy controls, while no difference was detected in the CC layer. There was no significant difference between the aCSC group and healthy controls in all OCTA parameters. In the affected eyes of CSC, the superficial retinal vessel density (SRVD) was significantly higher (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in healthy controls than in the aCSC and cCSC groups, while the deep retinal vessel density (DRVD) was significantly lower (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and the FAZ was larger (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in the cCSC group than in the aCSC group and healthy controls. A liner regression\u00a0equation was established: Y (BCVA, best corrected visual acuity)\u2009=\u20093.692\u20130.036\u2731X1 (DRVD-Fovea)-0.031\u2731X2 (FD-300, vessel density around the 300\u00a0\u03bcm width of the FAZ), R<jats:sup>2<\/jats:sup>\u2009=\u20090.427.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Based on OCTA measurements, this study revealed that the retinal microvascular network was impaired even in the fellow eyes of those with cCSC, which should arouse attention to the observation of unilateral CSC.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12886-024-03549-9","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T12:01:40Z","timestamp":1721304100000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quantitative optical coherence tomography angiography assessments in the fellow eyes of those with central serous chorioretinopathy"],"prefix":"10.1186","volume":"24","author":[{"given":"Jingjing","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"issue":"3","key":"3549_CR1","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/ceo.14201","volume":"51","author":"AT Fung","year":"2023","unstructured":"Fung AT, Yang Y, Kam AW. Central serous chorioretinopathy: A review. Clin Exp Ophthalmol. 2023;51(3):243\u201370.","journal-title":"Clin Exp Ophthalmol"},{"issue":"6","key":"3549_CR2","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1136\/bjophthalmol-2018-312431","volume":"103","author":"MG Ersoz","year":"2018","unstructured":"Ersoz MG, Arf S, Hocaoglu M, Sayman MI, Karacorlu M. Patient characteristics and risk factors for central serous chorioretinopathy an analysis of 811 patients. Br J Ophthalmol. 2018;103(6):725\u20139.","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"3549_CR3","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1097\/00006982-200506000-00005","volume":"25","author":"D Bujarborua","year":"2015","unstructured":"Bujarborua D, Samrat C, Amit C, Geetanjali B, Ajit KS. Fluorescein angiographic features of asymptomatic eyes in central serous chorioretinopathy. Retina. 2015;25(4):422\u20139.","journal-title":"Retina"},{"key":"3549_CR4","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1038\/eye.2014.219","volume":"28","author":"A Goktas","year":"2014","unstructured":"Goktas A. Correlation of subretinal fluid volume with choroidal thickness and macular volume in acute central serous chorioretinopathy. Eye (Lond). 2014;28:1431\u20136.","journal-title":"Eye (Lond)"},{"key":"3549_CR5","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/aos.12059","volume":"91","author":"LH Yang","year":"2013","unstructured":"Yang LH, Jonas Jost B, Wei WB. Choroidal vessel diameter in central serous chorioretinopathy. Acta Ophthalmol. 2013;91:358\u201362.","journal-title":"Acta Ophthalmol"},{"key":"3549_CR6","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ajo.2018.07.004","volume":"194","author":"C Rochepeau","year":"2018","unstructured":"Rochepeau C, Kodjikian L, Garcia MA, Coulon C, Burillon C, Denis P, et al. Optical coherence tomography angiography quantitative assessment of choriocapillaris blood flow in central serous chorioretinopathy. Am J Ophthalmol. 2018;194:26\u201334.","journal-title":"Am J Ophthalmol"},{"issue":"9","key":"3549_CR7","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1136\/bjophthalmol-2018-313576","volume":"105","author":"SKR Mandadi","year":"2021","unstructured":"Mandadi SKR, Singh SR, Sahoo NK, Mishra SB, Sacconi R, Iovino C, et al. Optical coherence tomography angiography findings in fellow eyes of choroidal neovascularisation associated with central serous chorioretinopathy. Br J Ophthalmol. 2021;105(9):1280\u20135.","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"3549_CR8","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.survophthal.2021.05.003","volume":"67","author":"A Pujari","year":"2022","unstructured":"Pujari A, Surve A, Azad SV, Beniwal A, Sj V, Chawla R, et al. Optical coherence tomography angiography in central serous chorioretinopathy: the current clinical role and future perspectives. Surv Ophthalmol. 2022;67(1):68\u201382.","journal-title":"Surv Ophthalmol"},{"issue":"4","key":"3549_CR9","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1177\/1120672120952678","volume":"31","author":"NK Sahoo","year":"2021","unstructured":"Sahoo NK, Mandadi SKR, Singh SR, Sacconi R, Iovino C, Peiretti E, et al. Longitudinal changes in fellow eyes of choroidal neovascularization associated with central serous chorioretinopathy: Optical coherence tomography angiography study. Eur J Ophthalmol. 2021;31(4):1892\u20138.","journal-title":"Eur J Ophthalmol"},{"key":"3549_CR10","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1159\/000504053","volume":"243","author":"M Jianbo","year":"2020","unstructured":"Jianbo M, Jingjing L, Lin Z, Chenyi L, Xueting Yu, Caiyun Z, et al. Quantitative assessment of retinal capillary vessel density and foveal avascular zone area in central serous chorioretinopathy using OCTA. Ophthalmologica. 2020;243:370\u20138.","journal-title":"Ophthalmologica"},{"key":"3549_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/srep42201","volume":"7","author":"JP Campbell","year":"2017","unstructured":"Campbell JP, Zhang M, Hwang TS, Bailey ST, Wilson DJ, Jia Y, et al. Detailed vascular anatomy of the human retina by projection-resolved optical coherence tomography angiography. Sci Rep. 2017;7: 42201.","journal-title":"Sci Rep."},{"issue":"2","key":"3549_CR12","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1136\/bjophthalmol-2017-310398","volume":"102","author":"L Tomasso","year":"2018","unstructured":"Tomasso L, Benatti L, Rabiolo A, Carnevali A, Zucchiatti I, Querques L, et al. Retinal vessels functionality in eyes with central serous chorioretinopathy. Br J Ophthalmol. 2018;102(2):210\u20135.","journal-title":"Br J Ophthalmol"},{"key":"3549_CR13","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1167\/iovs.16-20351","volume":"58","author":"RN Vogel","year":"2017","unstructured":"Vogel RN, Langlo CS, Scoles D, Carroll J, Weinberg DV, Kim JE. High-resolution imaging of intraretinal structures in active and resolved central serous chorioretinopathy. Invest Ophthalmol Vis Sci. 2017;58:42\u20139.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"3549_CR14","first-page":"2335","volume":"17","author":"L Yu","year":"2018","unstructured":"Yu L, Shao Y, Chai Y, Ye LH, Yang QC, Ye L, et al. Retinal microvasculature alteration in central serous chorioretinopathy. Mol Med Rep. 2018;17(2):2335\u201340.","journal-title":"Mol Med Rep"},{"key":"3549_CR15","doi-asserted-by":"publisher","first-page":"4425","DOI":"10.1167\/iovs.18-24475","volume":"59","author":"PF Cardillo","year":"2018","unstructured":"Cardillo PF, Lupidi M, Cagini C, Fruttini D, Nicole M, Eandi CM, et al. Retinal vascular reactivity in central serous chorioretinopathy. Invest Ophthalmol Vis Sci. 2018;59:4425\u201333.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3549_CR16","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1111\/aos.14625","volume":"98","author":"M Karapapak","year":"2020","unstructured":"Karapapak M, Guven D, Demir M, Tiryaki DS, Uslu DC. Optical coherence tomography angiography of central serous chorioretinopathy patients\u2019 response to breath-holding maneuver. Acta Ophthalmol. 2020;98:787\u201394.","journal-title":"Acta Ophthalmol"},{"issue":"1","key":"3549_CR17","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s40123-018-0159-1","volume":"8","author":"B Cakir","year":"2019","unstructured":"Cakir B, Reich M, Lang S, B\u00fchler A, Ehlken C, Grundel B, et al. OCT angiography of the choriocapillaris in central serous chorioretinopathy: a quantitative subgroup analysis. Ophthalmol Ther. 2019;8(1):75\u20136.","journal-title":"Ophthalmol Ther."},{"key":"3549_CR18","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.brainres.2007.10.083","volume":"1189","author":"J Stone","year":"2008","unstructured":"Stone J, vanDriel D, Valter K, Rees S, Provis J. The locations of mitochondria in mammalian photoreceptors: relation to retinal vasculature. Brain Res. 2008;1189:58\u201369.","journal-title":"Brain Res"},{"issue":"3","key":"3549_CR19","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1152\/ajpheart.00221.2007","volume":"293","author":"G Birol","year":"2017","unstructured":"Birol G, Wang S, Budzynski E, Wangsa-Wirawan ND, Linsenmeier RA. Oxygen distribution and consumption in the macaque retina. Am J Physiol Heart Circ Physiol. 2017;293(3):1696\u2013704.","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"7","key":"3549_CR20","doi-asserted-by":"publisher","first-page":"3065","DOI":"10.1167\/iovs.17-21551","volume":"58","author":"DM Sampson","year":"2017","unstructured":"Sampson DM, Gong P, An D, Menghini M, Hansen A, Mackey DA, et al. Axial length variation impacts on superficial retinal vessel density and foveal avascular zone area measurements using optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2017;58(7):3065\u201372.","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["BMC Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12886-024-03549-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12886-024-03549-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12886-024-03549-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T12:04:24Z","timestamp":1721304264000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcophthalmol.biomedcentral.com\/articles\/10.1186\/s12886-024-03549-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,18]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3549"],"URL":"https:\/\/doi.org\/10.1186\/s12886-024-03549-9","relation":{},"ISSN":["1471-2415"],"issn-type":[{"value":"1471-2415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,18]]},"assertion":[{"value":"20 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Institutional Review Board and Ethics Committee of the Eye Hospital of Wenzhou Medical University (Approval No.121-K-107\u201301). All subjects adhered to the tenets of the Declaration of Helsinki. Written informed consent was obtained from patients and controlled subjects after an explanation of the nature and possible consequences of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication was obtained from patients and controlled subjects after an explanation of the nature and possible consequences of the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"295"}}