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All eyes underwent functional and morphologic examination of the macular area using microperimetry and optical coherence tomography (OCT) before and after intravitreal anti-VEGF injection. To determine significant differences between the values, paired\n                      <jats:italic>t<\/jats:italic>\n                      test was used. A correlation between CMT and RS was made using Spearman\u2019s test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients were evaluated at baseline, one week and one month after injection. The central macular thickness (CMT) decreased significantly from 449.33\u2009\n                      <jats:italic>\u00b1<\/jats:italic>\n                      \u2009100.79\u00a0\u03bcm to 427.94\u2009\n                      <jats:italic>\u00b1<\/jats:italic>\n                      \u200985.76\u00a0\u03bcm to 357.93\u2009\n                      <jats:italic>\u00b1<\/jats:italic>\n                      \u200975.92\u00a0\u03bcm. The RS improved significantly from 7.94\u2009\n                      <jats:italic>\u00b1<\/jats:italic>\n                      \u20096.43 dB to 11.09\u2009\n                      <jats:italic>\u00b1<\/jats:italic>\n                      \u20097.42 dB at one week and to 14.22\u2009\n                      <jats:italic>\u00b1<\/jats:italic>\n                      \u20097.66 dB at one month after treatment. The CMT was significant negatively correlated to RS (\n                      <jats:italic>r=-0.259<\/jats:italic>\n                      ,\n                      <jats:italic>p\u2009=\u2009&lt;\u20090.001)<\/jats:italic>\n                      , with decay of 0.025 dB for every 1\u00a0\u03bcm increase of CMT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Retinal thickening due to DME can be adequately quantified using OCT, while microperimetry can offer information about retinal sensitivity in the exact location. Therefore, microperimetry can be a useful tool in predicting the functional outcome and determining the efficacy of anti-VEGF treatment for DME patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12886-024-03744-8","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T03:52:44Z","timestamp":1735271564000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Early response of anti-vascular endothelial growth factor (anti-VEGF) in diabetic macular edema (DME) management: microperimetry and optical coherence tomography (OCT) findings: a pilot study at national eye center of third world country"],"prefix":"10.1186","volume":"24","author":[{"given":"Grimaldi","family":"Ihsan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameliza","family":"Kwartika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Made Indra","family":"Widyanatha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rova","family":"Virgana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Iskandar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arief Sjamsulaksan","family":"Kartasasmita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"3744_CR1","doi-asserted-by":"publisher","first-page":"3044","DOI":"10.1167\/iovs.05-1141","volume":"47","author":"S Vujosevic","year":"2006","unstructured":"Vujosevic S, Midena E, Pilotto E, et al. 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Further, no tissue specimens were analyzed in the project. Ethics approval and consent to participate that this study was approved by \u201cKomite Etik Pusat Mata Nasional Rumah Sakit Cicendo\u201d ethics committee. The requirement for informed consent was waived by \u201cKomite Etik Pusat Mata Nasional Rumah Sakit Mata Cicendo\u201d considering that the study used no sensitive patient information; did not entail any treatment, other interventions, tests, examinations, or interviews; did not affect follow-up; did not expose patients to any risk of physical, psychological or other harm; and used no biological samples. The study adhered to the tenets of the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"551"}}