{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T09:34:39Z","timestamp":1794476079380,"version":"4.9.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Ophthalmol"],"DOI":"10.1186\/s12886-025-04483-0","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T13:11:46Z","timestamp":1764076306000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is the C reactive protein\/albumin ratio a good tool for retinal vein occlusion?"],"prefix":"10.1186","volume":"25","author":[{"given":"Esra","family":"Vural","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Hazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"4483_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1080\/02713680701851902","volume":"33","author":"J Rehak","year":"2008","unstructured":"Rehak J, Rehak M. Branch retinal vein occlusion: pathogenesis, visual prognosis, and treatment modalities. Curr Eye Res. 2008;33:111\u201331.","journal-title":"Curr Eye Res"},{"key":"4483_CR2","doi-asserted-by":"crossref","unstructured":"Rogers S, McIntosh RL, Cheung N, Lim L, Wang JJ, Mitchell P, International Eye Disease Consortium. The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia and Australia. Ophthalmology. 2010;117(2):313\u20139.e1.","DOI":"10.1016\/j.ophtha.2009.07.017"},{"key":"4483_CR3","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ejim.2017.06.022","volume":"44","author":"P Bucciarelli","year":"2017","unstructured":"Bucciarelli P, Passamonti SM, Gianniello F, Artoni A, Martinelli I. Thrombophilic and cardiovascular risk factors for retinal vein occlusion. Eur J Intern Med. 2017;44:44\u20138.","journal-title":"Eur J Intern Med"},{"issue":"1","key":"4483_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1080\/09286586.2020.1791349","volume":"28","author":"A Pinna","year":"2021","unstructured":"Pinna A, Porcu T, Marzano J, Boscia F, Paliogiannis P, Dore S, et al. Mean platelet Volume, red cell distribution Width, and complete blood cell count indices in retinal vein occlusions. Ophthalmic Epidemiol. 2021;28(1):39\u201347.","journal-title":"Ophthalmic Epidemiol"},{"key":"4483_CR5","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1097\/MBC.0b013e3282f2b60e","volume":"19","author":"A Kesler","year":"2008","unstructured":"Kesler A, Shalev V, Rogowski O, Shimron O, Shainberg B, Sela BA, et al. Comparative analysis of homocysteine concentrations in patients with retinal vein occlusion versus thrombotic and atherosclerotic disorders. Blood Coagul Fibrinolysis. 2008;19:259\u201362.","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"3","key":"4483_CR6","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1007\/s40123-022-00511-0","volume":"11","author":"D Kazantzis","year":"2022","unstructured":"Kazantzis D, Machairoudia G, Kroupis C, et al. Complete blood Count-Derived inflammation indices and retinal vein occlusion: A Case-Control study. Ophthalmol Ther. 2022;11(3):1241\u20139.","journal-title":"Ophthalmol Ther"},{"issue":"2","key":"4483_CR7","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1177\/1076029613494469","volume":"21","author":"EM Bakirci","year":"2015","unstructured":"Bakirci EM, Topcu S, Kalkan K, Tanboga IH, Borekci A, Sevimli S, Acikel M. The role of the nonspecific inflammatory markers in determining the anatomic extent of venous thromboembolism. Clin Appl Thromb Hemost. 2015;21(2):181\u20135.","journal-title":"Clin Appl Thromb Hemost"},{"key":"4483_CR8","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1001\/jama.279.18.1477","volume":"279","author":"J Danesh","year":"1998","unstructured":"Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA. 1998;279:1477\u201382.","journal-title":"JAMA"},{"key":"4483_CR9","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1093\/aje\/kwj312","volume":"164","author":"B Schalk","year":"2006","unstructured":"Schalk B, Visser M, Bremmer M, Penninx B, Bouter L, Deeg D. Change of serum albumin and risk of cardiovascular disease and all-cause mortality: longitudinal aging study Amsterdam. Am J Epidemiol. 2006;164:969\u201377.","journal-title":"Am J Epidemiol"},{"issue":"4","key":"4483_CR10","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.ophtha.2004.10.039","volume":"112","author":"TY Wong","year":"2005","unstructured":"Wong TY, Larsen EKM, Klein R, Mitchell P, Couper DJ, Klein BE, Sharrett AR. Cardiovascular risk factors for retinal vein occlusion and arteriolar emboli: the atherosclerosis risk in communities & cardiovascular health studies. Ophthalmology. 2005;112(4):540\u20137.","journal-title":"Ophthalmology"},{"issue":"3","key":"4483_CR11","doi-asserted-by":"publisher","first-page":"80","DOI":"10.3390\/biom8030080","volume":"8","author":"Y Zhu","year":"2018","unstructured":"Zhu Y, Xian X, Wang Z, Bi Y, Chen Q, Han X, Chen R. Research progress on the relationship between atherosclerosis and inflammation. Biomolecules. 2018;8(3):80.","journal-title":"Biomolecules"},{"key":"4483_CR12","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/01.moh.0000190107.54790.de","volume":"13","author":"V Afshar-Kharghan","year":"2006","unstructured":"Afshar-Kharghan V, Thiagarajan P. Leukocyte adhesion and thrombosis. Curr Opin Hematol. 2006;13:34\u20139.","journal-title":"Curr Opin Hematol"},{"key":"4483_CR13","first-page":"756","volume":"25","author":"Y Zeng","year":"2019","unstructured":"Zeng Y, Cao D, Yu H, Zhuang X, Yang D, Hu Y, et al. Comprehensive analysis of vitreous chemokines involved in ischemic retinal vein occlusion. Mol Vis. 2019;25:756\u201365.","journal-title":"Mol Vis"},{"key":"4483_CR14","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1167\/iovs.08-2510","volume":"50","author":"M Funk","year":"2009","unstructured":"Funk M, Kriechbaum K, Prager F, Benesch T, Georgopoulos M, Zlabinger GJ, Schmidt-Erfurth U. Intraocular concentrations of growth factors and cytokines in retinal vein occlusion and the effect of therapy with bevacizumab. Invest Ophthalmol Vis Sci. 2009;50:1025\u201332.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4483_CR15","first-page":"6043612","volume":"31","author":"DD Zhu","year":"2019","unstructured":"Zhu DD, Liu X. Neutrophil\/Lymphocyte ratio and Platelet\/Lymphocyte ratio in branch retinal vein occlusion. J Ophthalmol. 2019;31:2019:6043612.","journal-title":"J Ophthalmol"},{"issue":"12","key":"4483_CR16","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.kjms.2015.10.010","volume":"31","author":"S Alan","year":"2015","unstructured":"Alan S, Tuna S, T\u00fcrko\u011flu EB. The relation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume with the presence and severity of behcet\u2019s syndrome. Kaohsiung J Med Sci. 2015;31(12):626\u201331.","journal-title":"Kaohsiung J Med Sci"},{"issue":"1","key":"4483_CR17","doi-asserted-by":"publisher","first-page":"32","DOI":"10.5114\/aic.2017.66184","volume":"13","author":"F Uzun","year":"2017","unstructured":"Uzun F, Erturk M, Cakmak HA, Kalkan AK, Akturk IF, Yalcin AA, Oz K. Usefulness of the platelet-to-lymphocyte ratio in predicting long-term cardiovascular mortality in patients with peripheral arterial occlusive disease. Post\u0119py W Kardiologii Interwencyjnej = Adv Interventional Cardiol. 2017;13(1):32.","journal-title":"Post\u0119py W Kardiologii Interwencyjnej = Adv Interventional Cardiol"},{"issue":"2","key":"4483_CR18","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.sjopt.2016.02.003","volume":"30","author":"E Turkseven Kumral","year":"2016","unstructured":"Turkseven Kumral E, Yenerel NM, Ercalik NY, Imamoglu S, Vural ET. Neutrophil\/lymphocyte ratio and mean platelet volume in branch retinal vein occlusion. Saudi J Ophthalmol. 2016;30(2):105\u20138.","journal-title":"Saudi J Ophthalmol"},{"issue":"19","key":"4483_CR19","first-page":"2778","volume":"18","author":"N Ornek","year":"2014","unstructured":"Ornek N, Ogurel T, Ornek K, Onaran Z. Mean platelet volume in retinal vein occlusion. Eur Rev Med Pharmacol Sci. 2014;18(19):2778\u201382.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"3","key":"4483_CR20","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1080\/09273948.2022.2032199","volume":"31","author":"W Zuo","year":"2023","unstructured":"Zuo W, Chen T, Song J, et al. Assessment of systemic Immune-inflammation index levels in patients with retinal vein occlusion. Ocul Immunol Inflamm. 2023;31(3):491\u20135.","journal-title":"Ocul Immunol Inflamm"},{"issue":"2","key":"4483_CR21","doi-asserted-by":"publisher","first-page":"177","DOI":"10.4103\/joco.joco_44_23","volume":"35","author":"E Do\u011fan","year":"2023","unstructured":"Do\u011fan E, G\u00fcndo\u011fdu K\u00d6, Bursal\u0131 \u00d6, \u00c7elik E, Alag\u00f6z G. Systemic inflammatory marker levels in serous macular detachment secondary to retinal vein occlusion. J Curr Ophthalmol. 2023;35(2):177\u201381.","journal-title":"J Curr Ophthalmol"},{"key":"4483_CR22","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cca.2020.07.008","volume":"510","author":"JR Delanghe","year":"2020","unstructured":"Delanghe JR, Speeckaert MM, De Buyzere ML. On the use of lymphocyte to neutrophil ratios in laboratory medicine. Clin Chim Acta. 2020;510:26\u20137.","journal-title":"Clin Chim Acta"},{"key":"4483_CR23","doi-asserted-by":"crossref","unstructured":"Hage FG, Szalai AJ. C-reactive protein gene polymorphisms, C-reactive protein blood levels and cardiovascular disease risk. J Am Coll Cardiol. 2007;50(12):1115 22.10.1016\/j.jacc.2007.06.012.","DOI":"10.1016\/j.jacc.2007.06.012"},{"issue":"9","key":"4483_CR24","doi-asserted-by":"publisher","first-page":"3372","DOI":"10.1007\/s11695-024-07415-x","volume":"34","author":"L He","year":"2024","unstructured":"He L, Zhang L, Fu S, Wei S, Liu Y. Association between different inflammatory markers and generalized abdominal obesity: A Cross-Sectional study. Obes Surg. 2024;34(9):3372\u201381. https:\/\/doi.org\/10.1007\/s11695-024-07415-x. Epub 2024 Jul 24.","journal-title":"Obes Surg"},{"issue":"2","key":"4483_CR25","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.ypmed.2005.02.002","volume":"41","author":"M Ohsawa","year":"2005","unstructured":"Ohsawa M, Okayama A, Nakamura M, Onoda T, Kato K, Itai K, Yoshida Y, Ogawa A, Kawamura K, Hiramori K. CRP levels are elevated in smokers but unrelated to the number of cigarettes and are decreased by long-term smoking cessation in male smokers. Prev Med. 2005;41(2):651\u20136. https:\/\/doi.org\/10.1016\/j.ypmed.2005.02.002.","journal-title":"Prev Med"},{"key":"4483_CR26","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1373\/clinchem.2008.108886","volume":"55","author":"S Devaraj","year":"2009","unstructured":"Devaraj S, Singh U, Jialal I. The evolving role of C-reactive protein in atherothrombosis. Clin Chem. 2009;55:229\u201338.","journal-title":"Clin Chem"},{"key":"4483_CR27","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/ki.1997.393","volume":"52","author":"JA Joles","year":"1997","unstructured":"Joles JA, Willekes-Koolschijn N, Koomans HA. Hypoalbuminemia causes high blood viscosity by increasing red cell lysophosphatidylcholine. Kidney Int. 1997;52:761\u201370.","journal-title":"Kidney Int"},{"key":"4483_CR28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.3109\/09537109609023571","volume":"7","author":"D Mikhailidis","year":"1996","unstructured":"Mikhailidis D, Ganotakis E. Plasma albumin and platelet function: relevance to atherogenesis and thrombosis. Platelets. 1996;7:125\u201337.","journal-title":"Platelets"},{"key":"4483_CR29","doi-asserted-by":"publisher","unstructured":"Du Clos TW, Mold C. C-reactive protein: an activator of innate immunity and a modulator of adaptive immunity. Immunol Res 2004;30(3):261\u201377. https:\/\/doi.org\/10.1385\/IR:30:3:261.","DOI":"10.1385\/IR:30:3:261"},{"key":"4483_CR30","doi-asserted-by":"publisher","first-page":"106051","DOI":"10.1016\/j.clineuro.2020.106051","volume":"195","author":"R Wang","year":"2020","unstructured":"Wang R, He M, Ou X, Xie X, Kang Y. CRP albumin ratio is positively associated with poor outcome in patients with traumatic brain injury. Clin Neurol Neurosurg. 2020;195:106051.","journal-title":"Clin Neurol Neurosurg"},{"key":"4483_CR31","doi-asserted-by":"crossref","unstructured":"Yamagata K, Fukuzawa S, Ishibashi-Kanno N, Uchida F, Bukawa H. Association between the C-reactive protein\/albumin ratio and prognosis in patients with oral squamous cell carcinoma. Sci Rep. 20218;11(1):5446.","DOI":"10.1038\/s41598-021-83362-2"},{"issue":"12","key":"4483_CR32","doi-asserted-by":"publisher","first-page":"e0144406","DOI":"10.1371\/journal.pone.0144406","volume":"10","author":"J Song","year":"2015","unstructured":"Song J, Chen S, Liu X, Duan H, Kong J, Li Z. Relationship between C-Reactive protein level and diabetic retinopathy: A systematic review and Meta-Analysis. PLoS ONE. 2015;10(12):e0144406.","journal-title":"PLoS ONE"},{"issue":"5","key":"4483_CR33","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1167\/iovs.07-1387","volume":"49","author":"T Nagaoka","year":"2008","unstructured":"Nagaoka T, Kuo L, Ren Y, Yoshida A, Hein TW. C-reactive protein inhibits endothelium-dependent nitric oxide-mediated dilation of retinal arterioles via enhanced superoxide production. Invest Ophthalmol Vis Sci. 2008;49(5):2053\u201360.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"4483_CR34","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3129\/can j ophthalmol.06-101","volume":"42","author":"HB Lee","year":"2007","unstructured":"Lee HB, Pulido JS, McCannel CA, Buettner H. Role of inflammation in retinal vein occlusion. Can J Ophthalmol. 2007;42(1):131\u20133.","journal-title":"Can J Ophthalmol"}],"container-title":["BMC Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12886-025-04483-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12886-025-04483-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12886-025-04483-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T13:11:49Z","timestamp":1764076309000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcophthalmol.biomedcentral.com\/articles\/10.1186\/s12886-025-04483-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4483"],"URL":"https:\/\/doi.org\/10.1186\/s12886-025-04483-0","relation":{},"ISSN":["1471-2415"],"issn-type":[{"value":"1471-2415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"3 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the local ethics committee from Kayseri City Hospital. Informed consent was obtained from all of the participants in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and informed consent statements"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"664"}}