{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:56:42Z","timestamp":1781229402112,"version":"3.54.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Ophthalmol"],"DOI":"10.1186\/s12886-026-04844-3","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T02:34:44Z","timestamp":1777257284000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-term effects of adenoviral keratoconjunctivitis on conjunctival goblet cell density and tear film parameters: a prospective case-control study"],"prefix":"10.1186","volume":"26","author":[{"given":"Mehmet Masum","family":"Tas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Levent","family":"Karabas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demir Kursat","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ecem Onder","family":"Tokuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arta","family":"Shukriu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4146-8190","authenticated-orcid":false,"given":"Fatma","family":"Sumer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"issue":"5","key":"4844_CR1","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.survophthal.2015.04.001","volume":"60","author":"V Jhanji","year":"2015","unstructured":"Jhanji V, Chan TCY, Li EYM, et al. Adenoviral keratoconjunctivitis. Survey of Ophthalmology. Elsevier USA. 2015;60(5):435\u201343. https:\/\/doi.org\/10.1016\/j.survophthal.2015.04.001.","journal-title":"Elsevier USA"},{"issue":"27","key":"4844_CR2","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3238\/ARZTEBL.2011.0475","volume":"108","author":"B Meyer-R\u00fcsenberg","year":"2011","unstructured":"Meyer-R\u00fcsenberg B, Loderst\u00e4dt U, Richard G, et al. Epidemic keratoconjunctivitis: the current situation and recommendations for prevention and treatment. Deutsches Arzteblatt international. Dtsch Arztebl Int. 2011;108(27):475\u201380. https:\/\/doi.org\/10.3238\/ARZTEBL.2011.0475.","journal-title":"Dtsch Arztebl Int"},{"key":"4844_CR3","doi-asserted-by":"publisher","first-page":"981","DOI":"10.2147\/IDR.S162669","volume":"11","author":"DI Chigbu","year":"2018","unstructured":"Chigbu DI, Labib BA. Pathogenesis and management of adenoviral keratoconjunctivitis. Infection and drug resistance. Dove Med Press Ltd. 2018;11:981\u201393. https:\/\/doi.org\/10.2147\/IDR.S162669.","journal-title":"Dove Med Press Ltd"},{"issue":"4","key":"4844_CR4","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1097\/ICU.0B013E3283477CB5","volume":"22","author":"HE Kaufman","year":"2011","unstructured":"Kaufman HE. Adenovirus advances: new diagnostic and therapeutic options. Current opinion in ophthalmology. Curr Opin Ophthalmol. 2011;22(4):290\u20133. https:\/\/doi.org\/10.1097\/ICU.0B013E3283477CB5.","journal-title":"Curr Opin Ophthalmol"},{"key":"4844_CR5","doi-asserted-by":"publisher","unstructured":"Labib BA, Minhas BK, Chigbu DI. Management of Adenoviral Keratoconjunctivitis: Challenges and Solutions. Clin Ophthalmol (Auckland, N.Z.). 2020;14:837\u2013852 https:\/\/doi.org\/10.2147\/OPTH.S207976.","DOI":"10.2147\/OPTH.S207976"},{"issue":"6","key":"4844_CR6","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S1350-9462(02)00038-1","volume":"21","author":"DA Dartt","year":"2002","unstructured":"Dartt DA. Regulation of mucin and fluid secretion by conjunctival epithelial cells. Progress in Retinal and Eye Research. Prog Retin Eye Res. 2002;21(6):555\u201376. https:\/\/doi.org\/10.1016\/S1350-9462(02)00038-1.","journal-title":"Prog Retin Eye Res"},{"key":"4844_CR7","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/J.PRETEYERES.2016.04.005","volume":"54","author":"IK Gipson","year":"2016","unstructured":"Gipson IK. Goblet cells of the conjunctiva: A review of recent findings. Progress in retinal and eye research. Prog Retin Eye Res. 2016;54:49\u201363. https:\/\/doi.org\/10.1016\/J.PRETEYERES.2016.04.005.","journal-title":"Prog Retin Eye Res"},{"issue":"11S","key":"4844_CR8","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1016\/J.OPHTHA.2017.07.010","volume":"124","author":"SC Pflugfelder","year":"2017","unstructured":"Pflugfelder SC, de Paiva CS. The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research. Ophthalmol Ophthalmol. 2017;124(11S):S4\u201313. https:\/\/doi.org\/10.1016\/J.OPHTHA.2017.07.010.","journal-title":"Ophthalmol Ophthalmol"},{"issue":"3","key":"4844_CR9","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1001\/ARCHOPHT.120.3.330","volume":"120","author":"KS Kunert","year":"2002","unstructured":"Kunert KS, Tisdale; AS, Gipson IK. Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine. Archives of ophthalmology (Chicago, Ill.: 1960). Arch Ophthalmol. 2002;120(3):330\u20137. https:\/\/doi.org\/10.1001\/ARCHOPHT.120.3.330.","journal-title":"Arch Ophthalmol"},{"issue":"1","key":"4844_CR10","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1097\/00003226-199801000-00007","volume":"17","author":"SC Pflugfelder","year":"1998","unstructured":"Pflugfelder SC, Tseng SCG, Sanabria O, et al. Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation. Cornea Cornea. 1998;17(1):38\u201356. https:\/\/doi.org\/10.1097\/00003226-199801000-00007.","journal-title":"Cornea Cornea"},{"issue":"12","key":"4844_CR11","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1136\/BJO.2005.073916","volume":"89","author":"R Singh","year":"2005","unstructured":"Singh R, Joseph A, Umapathy T, et al. Impression cytology of the ocular surface. The British journal of ophthalmology. Br J Ophthalmol. 2005;89(12):1655\u20139. https:\/\/doi.org\/10.1136\/BJO.2005.073916.","journal-title":"Br J Ophthalmol"},{"key":"4844_CR12","doi-asserted-by":"publisher","unstructured":"Rajaiya J, Saha A, Ismail AM, et al. Adenovirus and the cornea: more than meets the eye. Viruses. 2021;13(2). https:\/\/doi.org\/10.3390\/v13020293.","DOI":"10.3390\/v13020293"},{"issue":"3","key":"4844_CR13","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0166-3542(01)00166-8","volume":"52","author":"EG Romanowski","year":"2001","unstructured":"Romanowski EG, Yates KA, Gordon YJ. Antiviral prophylaxis with twice daily topical cidofovir protects against challenge in the adenovirus type 5\/New Zealand rabbit ocular model. Antiviral Res Elsevier. 2001;52(3):275\u201380. https:\/\/doi.org\/10.1016\/S0166-3542(01)00166-8.","journal-title":"Antiviral Res Elsevier"},{"issue":"7","key":"4844_CR14","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1080\/08164622.2021.1984180","volume":"105","author":"ES Shorter","year":"2022","unstructured":"Shorter ES, Whiteside MM, Harthan JS, et al. Diagnostic accuracy of clinical signs, symptoms and point-of-care testing for early adenoviral conjunctivitis. Clinical & experimental optometry. Clin Exp Optom. 2022;105(7):702\u20137. https:\/\/doi.org\/10.1080\/08164622.2021.1984180.","journal-title":"Clin Exp Optom"},{"issue":"2","key":"4844_CR15","doi-asserted-by":"publisher","first-page":"52","DOI":"10.4081\/IDR.2010.E17","volume":"2","author":"TJ Doyle","year":"2010","unstructured":"Doyle TJ, King D, Cobb J, et al. An outbreak of epidemic keratoconjunctivitis at an outpatient ophthalmology clinic. Infectious disease reports. Infect Dis Rep. 2010;2(2):52\u20135. https:\/\/doi.org\/10.4081\/IDR.2010.E17.","journal-title":"Infect Dis Rep"},{"issue":"10","key":"4844_CR16","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1016\/j.ophtha.2006.06.029","volume":"113","author":"R Sambursky","year":"2006","unstructured":"Sambursky R, Tauber S, Schirra F, et al. The RPS Adeno Detector for Diagnosing Adenoviral Conjunctivitis. Ophthalmol Ophthalmol. 2006;113(10):1758\u201364. https:\/\/doi.org\/10.1016\/j.ophtha.2006.06.029.","journal-title":"Ophthalmol Ophthalmol"},{"issue":"9","key":"4844_CR17","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1136\/BJOPHTHALMOL-2014-306508","volume":"99","author":"KYR Kam","year":"2015","unstructured":"Kam KYR, Ong HS, Bunce C, et al. Sensitivity and specificity of the AdenoPlus point-of-care system in detecting adenovirus in conjunctivitis patients at an ophthalmic emergency department: a diagnostic accuracy study. The British journal of ophthalmology. Br J Ophthalmol. 2015;99(9):1186\u20139. https:\/\/doi.org\/10.1136\/BJOPHTHALMOL-2014-306508.","journal-title":"Br J Ophthalmol"},{"key":"4844_CR18","doi-asserted-by":"crossref","unstructured":"Jones L, Downie LE, Korb D, et al. TFOS DEWS II Management and Therapy Report. Ocular Surface. 2017;15(3):575\u2013628. https:\/\/doi.org\/310.1016\/j.jtos.2017.05.006.","DOI":"10.1016\/j.jtos.2017.05.006"},{"key":"4844_CR19","doi-asserted-by":"crossref","unstructured":"Craig JP, Nichols KK, Akpek EK, et al. TFOS DEWS II Definition and Classification Report. Ocular Surface. 2017;15(3):276\u2013283. https:\/\/doi.org\/310.1016\/j.jtos.2017.05.008.","DOI":"10.1016\/j.jtos.2017.05.008"},{"issue":"1","key":"4844_CR20","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1055\/s-2008-1050567","volume":"188","author":"ML Gotz","year":"1986","unstructured":"Gotz ML, Jaeger W, Kruse FE. Impression cytology as a non invasive examination of the conjunctiva. Klin Monatsbl Augenheilkd. 1986;188(1):23\u20138. https:\/\/doi.org\/10.1055\/s-2008-1050567.","journal-title":"Klin Monatsbl Augenheilkd"},{"issue":"12","key":"4844_CR21","doi-asserted-by":"publisher","first-page":"6176","DOI":"10.1128\/JCM.43.12.6176-6182.2005","volume":"43","author":"I Casas","year":"2005","unstructured":"Casas I, Avellon A, Mosquera M, et al. Molecular identification of adenoviruses in clinical samples by analyzing a partial hexon genomic region. Journal of clinical microbiology. J Clin Microbiol. 2005;43(12):6176\u201382. https:\/\/doi.org\/10.1128\/JCM.43.12.6176-6182.2005.","journal-title":"J Clin Microbiol"},{"issue":"3","key":"4844_CR22","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1128\/JCM.43.3.1064-1068.2005","volume":"43","author":"U Banik","year":"2005","unstructured":"Banik U, Adhikary AK, Suzuki E, et al. Multiplex PCR assay for rapid identification of oculopathogenic adenoviruses by amplification of the fiber and hexon genes. Journal of clinical microbiology. J Clin Microbiol. 2005;43(3):1064\u20138. https:\/\/doi.org\/10.1128\/JCM.43.3.1064-1068.2005.","journal-title":"J Clin Microbiol"},{"issue":"2","key":"4844_CR23","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/BF03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul F, Erdfelder E, Lang AG, et al. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior research methods. Behav Res Methods. 2007;39(2):175\u201391. https:\/\/doi.org\/10.3758\/BF03193146.","journal-title":"Behav Res Methods"},{"issue":"2","key":"4844_CR24","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/ICL.0000000000001236","volume":"52","author":"SV Kothandan","year":"2026","unstructured":"Kothandan SV, Basu S, Singh S. Dry Eye Disease After Ocular or Systemic Infection: A Systematic Review. Eye & contact lens. Eye Contact Lens. 2026;52(2):83\u201391. https:\/\/doi.org\/10.1097\/ICL.0000000000001236.","journal-title":"Eye Contact Lens"},{"key":"4844_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0074-7696(03)31001-0","volume":"231","author":"IK Gipson","year":"2003","unstructured":"Gipson IK, Arg\u00fceso P. Role of Mucins in the Function of the Corneal and Conjunctival Epithelia. Int Rev Cytol Acad Press Inc. 2003;231:1\u201349. https:\/\/doi.org\/10.1016\/S0074-7696(03)31001-0.","journal-title":"Int Rev Cytol Acad Press Inc"},{"issue":"10","key":"4844_CR26","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1080\/02713680500196715","volume":"30","author":"M Dogru","year":"2005","unstructured":"Dogru M, Asano-Kato N, Tanaka M, et al. Ocular surface and MUC5AC alterations in atopic patients with corneal shield ulcers. Curr Eye Res. 2005;30(10):897\u2013908. https:\/\/doi.org\/10.1080\/02713680500196715.","journal-title":"Curr Eye Res"},{"issue":"2","key":"4844_CR27","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1136\/JCP.56.2.120","volume":"56","author":"AK Adhikary","year":"2003","unstructured":"Adhikary AK, Numaga J, Kaburaki T, et al. Genetic characterisation of adenovirus type 8 isolated in Hiroshima city over a 15 year period. Journal of clinical pathology. J Clin Pathol. 2003;56(2):120\u20135. https:\/\/doi.org\/10.1136\/JCP.56.2.120.","journal-title":"J Clin Pathol"},{"key":"4844_CR28","doi-asserted-by":"crossref","unstructured":"Sullivan DA, Rocha EM, Aragona P, et al. TFOS DEWS II Sex, Gender, and Hormones Report. Ocular Surface. 2017;15(3):284\u2013333. https:\/\/doi.org\/310.1016\/j.jtos.2017.04.001.","DOI":"10.1016\/j.jtos.2017.04.001"},{"issue":"1","key":"4844_CR29","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3109\/08830185.2012.748052","volume":"32","author":"ME Stern","year":"2013","unstructured":"Stern ME, Schaumburg CS, Pflugfelder SC. Dry eye as a mucosal autoimmune disease. Int Rev Immunol. 2013;32(1):19\u201341. https:\/\/doi.org\/10.3109\/08830185.2012.748052.","journal-title":"Int Rev Immunol"},{"issue":"3","key":"4844_CR30","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","volume":"15","author":"AJ Bron","year":"2017","unstructured":"Bron AJ, de Paiva CS, Chauhan SK, et al. TFOS DEWS II pathophysiology report. Ocular Surface. Elsevier Inc. 2017;15(3):438\u2013510. https:\/\/doi.org\/10.1016\/j.jtos.2017.05.011.","journal-title":"Elsevier Inc"},{"key":"4844_CR31","doi-asserted-by":"crossref","unstructured":"Li DQ, Pflugfelder SC. Matrix metalloproteinases in corneal inflammation. Ocular Surface. 2005;3(4): S198\u2013S202. https:\/\/doi.org\/410.1016\/s1542-01241270255-0.","DOI":"10.1016\/S1542-0124(12)70255-0"},{"key":"4844_CR32","doi-asserted-by":"publisher","unstructured":"Hua R, Yao K, Hu Y, et al. Discrepancy between subjectively reported symptoms and objectively measured clinical findings in dry eye: a population based analysis. BMJ open. 2014;4(8). https:\/\/doi.org\/10.1136\/BMJOPEN-2014-005296.","DOI":"10.1136\/BMJOPEN-2014-005296"},{"issue":"4","key":"4844_CR33","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1097\/ICL.0B013E31828EF19B","volume":"39","author":"HE Ozturk","year":"2013","unstructured":"Ozturk HE, Sonmez B, Beden U. Corneal sensitivity may decrease in adenoviral epidemic keratoconjunctivitis\u2013a confocal microscopic study. Eye & contact lens. Eye Contact Lens. 2013;39(4):264\u20138. https:\/\/doi.org\/10.1097\/ICL.0B013E31828EF19B.","journal-title":"Eye Contact Lens"}],"container-title":["BMC Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12886-026-04844-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12886-026-04844-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12886-026-04844-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:15:03Z","timestamp":1781226903000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12886-026-04844-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4844"],"URL":"https:\/\/doi.org\/10.1186\/s12886-026-04844-3","relation":{},"ISSN":["1471-2415"],"issn-type":[{"value":"1471-2415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]},"assertion":[{"value":"21 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of Kocaeli University Faculty of Medicine (Decision No: 2016\/13.9). All procedures were performed in accordance with the ethical standards of the institutional research committee and with the 1964 Declaration of Helsinki and its later amendments. Written informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"326"}}