{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:31:31Z","timestamp":1787020291732,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/100007658","name":"Baxter Healthcare Corporation (US)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007658","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12887-016-0652-4","type":"journal-article","created":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T22:08:33Z","timestamp":1470089313000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A randomized trial of Plasma-Lyte A and 0.9\u00a0% sodium chloride in acute pediatric gastroenteritis"],"prefix":"10.1186","volume":"16","author":[{"given":"Coburn H.","family":"Allen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran D.","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold K.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc H.","family":"Gorelick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Spandorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Spiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon E.","family":"Mace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Higginbotham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan J.","family":"Smyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol R.","family":"Schermer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,2]]},"reference":[{"key":"652_CR1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/MOG.0b013e32835a352f","volume":"29","author":"E Bruzzese","year":"2013","unstructured":"Bruzzese E, Lo Vecchio A, Guarino A. Hospital management of children with acute gastroenteritis. Curr Opin Gastroenterol. 2013;29:23\u201330.","journal-title":"Curr Opin Gastroenterol"},{"key":"652_CR2","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1016\/j.vaccine.2013.06.085","volume":"31","author":"A Kilgore","year":"2013","unstructured":"Kilgore A, Donauer S, Edwards KM, Weinberg GA, Payne DC, Szilagyi PG, et al. Rotavirus-associated hospitalization and emergency department costs and rotavirus vaccine program impact. Vaccine. 2013;31:4164\u201371.","journal-title":"Vaccine"},{"key":"652_CR3","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1440-1754.2012.02445.x","volume":"48","author":"DO Matson","year":"2012","unstructured":"Matson DO, Staat MA, Azimi P, Itzler R, Bernstein DI, Ward RL, et al. Burden of rotavirus hospitalisations in young children in three paediatric hospitals in the United States determined by active surveillance compared to standard indirect methods. J Paediatr Child Health. 2012;48:698\u2013704.","journal-title":"J Paediatr Child Health"},{"key":"652_CR4","first-page":"1","volume":"61","author":"ME Wikswo","year":"2012","unstructured":"Wikswo ME, Hall AJ. Outbreaks of acute gastroenteritis transmitted by person-to-person contact--United States, 2009\u20132010. MMWR Surveill Summ. 2012;61:1\u201312.","journal-title":"MMWR Surveill Summ"},{"key":"652_CR5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1017\/S0950268806006765","volume":"135","author":"TF Jones","year":"2007","unstructured":"Jones TF, McMillian MB, Scallan E, Frenzen PD, Cronquist AB, et al. A population-based estimate of the substantial burden of diarrhoeal disease in the United States; FoodNet, 1996\u20132003. Epidemiol Infect. 2007;135:293\u2013301.","journal-title":"Epidemiol Infect"},{"key":"652_CR6","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.pop.2013.05.006","volume":"40","author":"NS Graves","year":"2013","unstructured":"Graves NS. Acute gastroenteritis. Prim Care. 2013;40:727\u201341.","journal-title":"Prim Care"},{"key":"652_CR7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S1473-3099(11)70253-5","volume":"12","author":"JE Tate","year":"2012","unstructured":"Tate JE, Burton AH, Boschi-Pinto C, Steele AD, Duque J, Parashar UD, et al. 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5\u00a0years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infect Dis. 2012;12:136\u201341.","journal-title":"Lancet Infect Dis"},{"key":"652_CR8","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.2215\/CJN.02450508","volume":"3","author":"FJ Gennari","year":"2008","unstructured":"Gennari FJ, Weise WJ. Acid\u2013base disturbances in gastrointestinal disease. Clin J Am Soc Nephrol. 2008;3:1861\u201368.","journal-title":"Clin J Am Soc Nephrol"},{"key":"652_CR9","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1046\/j.1440-1754.2002.00792.x","volume":"38","author":"K Yilmaz","year":"2002","unstructured":"Yilmaz K, Karabocuoglu M, Citak A, Uzel N. Evaluation of laboratory tests in dehydrated children with acute gastroenteritis. J Paediatr Child Health. 2002;38:226\u201328.","journal-title":"J Paediatr Child Health"},{"key":"652_CR10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jemermed.2013.04.044","volume":"46","author":"SB Freedman","year":"2014","unstructured":"Freedman SB, DeGroot JM, Parkin PC. Successful discharge of children with gastroenteritis requiring intravenous rehydration. J Emerg Med. 2014;46:9\u201320.","journal-title":"J Emerg Med"},{"key":"652_CR11","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/adc.2005.084103","volume":"91","author":"KA Neville","year":"2006","unstructured":"Neville KA, Verge CF, Rosenberg AR, O\u2019Meara MW, Walker JL. Isotonic is better than hypotonic saline for intravenous rehydration of children with gastroenteritis: a prospective randomised study. Arch Dis Child. 2006;91:226\u201332.","journal-title":"Arch Dis Child"},{"key":"652_CR12","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1007\/s13312-012-0251-x","volume":"49","author":"V Mahajan","year":"2012","unstructured":"Mahajan V, Sajan SS, Sharma A, Kaur J. Ringers lactate vs Normal saline for children with acute diarrhea and severe dehydration- a double blind randomized controlled trial. Indian Pediatr. 2012;49:963\u201368.","journal-title":"Indian Pediatr"},{"key":"652_CR13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/SLA.0b013e318295feba","volume":"259","author":"JB Young","year":"2014","unstructured":"Young JB, Utter GH, Schermer CR, Galante JM, Phan HH, Yang Y, et al. Saline versus Plasma-Lyte A in initial resuscitation of trauma patients: a randomized trial. Ann Surg. 2014;259:255\u201362.","journal-title":"Ann Surg"},{"key":"652_CR14","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1365-2044.1994.tb04450.x","volume":"49","author":"C McFarlane","year":"1994","unstructured":"McFarlane C, Lee A. A comparison of Plasmalyte 148 and 0.9\u00a0% saline for intra-operative fluid replacement. Anaesthesia. 1994;49:779\u201381.","journal-title":"Anaesthesia"},{"key":"652_CR15","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1213\/ane.0b013e3181732d64","volume":"107","author":"N Hadimioglu","year":"2008","unstructured":"Hadimioglu N, Saadawy I, Saglam T, Ertug Z, Dinckan A. The effect of different crystalloid solutions on acid\u2013base balance and early kidney function after kidney transplantation. Anesth Analg. 2008;107:264\u201369.","journal-title":"Anesth Analg"},{"key":"652_CR16","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1001\/jama.2012.13356","volume":"308","author":"NM Yunos","year":"2012","unstructured":"Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M. Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA. 2012;308:1566\u201372.","journal-title":"JAMA"},{"key":"652_CR17","volume-title":"Guidelines for Management of Acute Diarrhea: Disaster Safety","author":"Centers for Disease Control and Prevention","year":"2005","unstructured":"Centers for Disease Control and Prevention. Guidelines for Management of Acute Diarrhea: Disaster Safety. 2005. http:\/\/emergency.cdc.gov\/disasters\/disease\/diarrheaguidelines.asp . Accessed 25 July 2016."},{"key":"652_CR18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.emc.2011.01.011","volume":"29","author":"JM Fields","year":"2011","unstructured":"Fields JM, Dean AJ. Systemic causes of abdominal pain. Emerg Med Clin North Am. 2011;29:195\u2013210.","journal-title":"Emerg Med Clin North Am"},{"key":"652_CR19","first-page":"42","volume-title":"Metabolic Acidosis in Patients with Gastrointestinal Disorders: Metabolic and Clinical Consequences. Nutrition Issues in Gastroenterology, Series #73. Practical Gastroenterology","author":"MH Rosner","year":"2009","unstructured":"Rosner MH. Metabolic Acidosis in Patients with Gastrointestinal Disorders: Metabolic and Clinical Consequences. Nutrition Issues in Gastroenterology, Series #73. Practical Gastroenterology. 2009. p. 42\u201352."},{"key":"652_CR20","doi-asserted-by":"crossref","DOI":"10.1542\/peds.99.5.e6","volume":"99","author":"MH Gorelick","year":"1997","unstructured":"Gorelick MH, Shaw KN, Murphy KO. Validity and reliability of clinical signs in the diagnosis of dehydration in children. Pediatrics. 1997;99, E6.","journal-title":"Pediatrics"},{"key":"652_CR21","volume-title":"World Health Organization (WHO) Guidelines on Treatment of Diarrhea","author":"World Health Organization","year":"2005","unstructured":"World Health Organization. World Health Organization (WHO) Guidelines on Treatment of Diarrhea. 2005. http:\/\/www.who.int\/maternal_child_adolescent\/documents\/9241593180\/en\/ Accessed September 15, 2014."},{"key":"652_CR22","doi-asserted-by":"crossref","first-page":"e1542","DOI":"10.1542\/peds.2010-1410","volume":"127","author":"AL Baxter","year":"2011","unstructured":"Baxter AL, Watcha MF, Baxter WV, Leong T, Wyatt MM. Development and validation of a pictorial nausea rating scale for children. Pediatrics. 2011;127:e1542\u201349.","journal-title":"Pediatrics"},{"issue":"3","key":"652_CR23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00006565-199706000-00001","volume":"13","author":"RM Vega","year":"1997","unstructured":"Vega RM, Avner JR. A prospective study of the usefulness of clinical and laboratory parameters for predicting percentage of dehydration in children. Pediatr Emerg Care. 1997;13(3):179\u201382.","journal-title":"Pediatr Emerg Care"},{"key":"652_CR24","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0196-0644(96)70032-X","volume":"28","author":"SR Reid","year":"1996","unstructured":"Reid SR, Bonadio WA. Outpatient rapid intravenous rehydration to correct dehydration and resolve vomiting in children with acute gastroenteritis. Ann Emerg Med. 1996;28:318\u201323.","journal-title":"Ann Emerg Med"},{"key":"652_CR25","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1542\/peds.2004-0457","volume":"114","author":"JE Wathen","year":"2004","unstructured":"Wathen JE, MacKenzie T, Bothner JP. Usefulness of the serum electrolyte panel in the management of pediatric dehydration treated with intravenously administered fluids. Pediatrics. 2004;114:1227\u201334.","journal-title":"Pediatrics"},{"key":"652_CR26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/MPG.0000000000000375","volume":"59","author":"A Guarino","year":"2014","unstructured":"Guarino A, Ashkenazi S, Gendrel D, Vecchio AL, Shamir R, Szajewska H. European society for paediatric gastroenterology, hepatology, and nutrition\/European society for paediatric infectious diseases evidence-based guidelines for the management of acute gastroenteritis in children in europe: update 2014. J Pediatr Gastroenterol Nutr. 2014;59:132\u201352.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"652_CR27","first-page":"560","volume":"92","author":"M Eisenhut","year":"2007","unstructured":"Eisenhut M. Hyperchloraemic acidosis in patients given rapid isotonic saline infusions. Arch Dis Child. 2007;92:560.","journal-title":"Arch Dis Child"},{"key":"652_CR28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/SLA.0b013e318256be72","volume":"256","author":"AH Chowdhury","year":"2012","unstructured":"Chowdhury AH, Cox EF, Francis ST, Lobo DN. A randomized, controlled, double-blind crossover study on the effects of 2-L infusions of 0.9\u00a0% saline and plasma-lyte\u00ae 148 on renal blood flow velocity and renal cortical tissue perfusion in healthy volunteers. Ann Surg. 2012;256:18\u201324.","journal-title":"Ann Surg"},{"key":"652_CR29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/cs1040017","volume":"104","author":"F Reid","year":"2003","unstructured":"Reid F, Lobo DN, Williams RN, Rowlands BJ, Allison SP. (Ab) normal saline and physiological Hartmann\u2019s solution: a randomized double-blind crossover study. Clin Sci (Lond). 2003;104:17\u201324.","journal-title":"Clin Sci (Lond)"},{"key":"652_CR30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1179\/146532805X72395","volume":"25","author":"CA Juca","year":"2005","unstructured":"Juca CA, Rey LC, Martins CV. Comparison between normal saline and a polyelectrolyte solution for fluid resuscitation in severely dehydrated infants with acute diarrhoea. Ann Trop Paediatr. 2005;25:253\u201360.","journal-title":"Ann Trop Paediatr"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-016-0652-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T13:40:03Z","timestamp":1656942003000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/s12887-016-0652-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,2]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["652"],"URL":"https:\/\/doi.org\/10.1186\/s12887-016-0652-4","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,2]]},"article-number":"117"}}