{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:06:52Z","timestamp":1773760012160,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["HRC 12\/525"],"award-info":[{"award-number":["HRC 12\/525"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]},{"name":"A+ Trust (Auckland District Health Board)","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Queensland Emergency Medicine Research Foundation (AU)","award":["EMPJ-105R21-2014-FURYK"],"award-info":[{"award-number":["EMPJ-105R21-2014-FURYK"]}]},{"name":"Private Practice Research and Education Trust Fund, Townsville Hospital","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Eric Ormond Baker Charitable Fund, Equity Trustees","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/100010289","name":"Princess Margaret Hospital Foundation","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100010289","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12887-017-0887-8","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T07:31:10Z","timestamp":1498116670000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A multicentre randomised controlled trial of levetiracetam versus phenytoin for convulsive status epilepticus in children (protocol): Convulsive Status Epilepticus Paediatric Trial (ConSEPT) - a PREDICT study"],"prefix":"10.1186","volume":"17","author":[{"name":"On Behalf of the PREDICT research network","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart R.","family":"Dalziel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Furyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Bonisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ed","family":"Oakley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Borland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyn","family":"Neutze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Donath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Sharpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Craig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjun","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kam","family":"Sinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Kochar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Brabyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz E.","family":"Babl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,6,22]]},"reference":[{"key":"887_CR1","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1136\/adc.2006.107516","volume":"92","author":"CL Novorol","year":"2007","unstructured":"Novorol CL, Chin RFM, Scott RC. Outcome of convulsive status epilepticus: a review. Arch Dis Child. 2007;92:948\u201351.","journal-title":"Arch Dis Child"},{"issue":"9531","key":"887_CR2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0140-6736(06)69043-0","volume":"368","author":"RF Chin","year":"2006","unstructured":"Chin RF, Neville BG, Peckham C, Bedford H, Wade A, Scott RC. Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study. Lancet. 2006;368(9531):222\u20139.","journal-title":"Lancet"},{"key":"887_CR3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1474-4422(06)70546-4","volume":"5","author":"M Raspall-Chaure","year":"2006","unstructured":"Raspall-Chaure M, Chin RFM, Neville BG, Scott RC. Outcome of paediatric convulsive status epilepticus: a systematic review. Lancet Neurol. 2006;5:769\u201379.","journal-title":"Lancet Neurol"},{"key":"887_CR4","doi-asserted-by":"crossref","unstructured":"Advanced Life Support Group. Advanced Paediatric Life Support: The Practical Approach. 4th ed. London: BMJ Publishing Group; 2005.","DOI":"10.1002\/9780470757369"},{"key":"887_CR5","volume-title":"Diagnosis and management of epilepsies in children and young people: a national guideline","author":"Scottish Intercollegiate Guidelines Network","year":"2005","unstructured":"Scottish Intercollegiate Guidelines Network. Diagnosis and management of epilepsies in children and young people: a national guideline. 2005."},{"issue":"5","key":"887_CR6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1136\/adc.83.5.415","volume":"83","author":"R Appleton","year":"2000","unstructured":"Appleton R, Choonara I, Martland T, Phillips B, Scott R, Whitehouse W. The treatment of convulsive status epilepticus in children. The status Epilepticus Working Party, members of the status Epilepticus Working Party. Arch Dis Child. 2000;83(5):415\u20139.","journal-title":"Arch Dis Child"},{"key":"887_CR7","volume-title":"Tesxtbook of paediatric emergency medicine","author":"P Cameron","year":"2006","unstructured":"Cameron P, Jelinek G, Everitt I, Browne G, Raftos J. Tesxtbook of paediatric emergency medicine. 1st ed. Philadelphia: Churchill Livingstone; 2006.","edition":"1"},{"key":"887_CR8","volume-title":"Nelson textbook of pediatrics","author":"RM Kliegman","year":"2007","unstructured":"Kliegman RM, Behrman RE, Jenson HB, Stanton BF. Nelson textbook of pediatrics. 18th ed. Philadelphia: Saunders; 2007.","edition":"18"},{"key":"887_CR9","doi-asserted-by":"publisher","unstructured":"Appleton R, Macleod S, Martland T. Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children. Cochrane Database Syst Rev. 2008;(3):CD001905. doi: 10.1002\/14651858.CD001905.pub2 .","DOI":"10.1002\/14651858.CD001905.pub2"},{"key":"887_CR10","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1001\/jama.1993.03510070076040","volume":"270","author":"Epilepsy Foundation of America's Working Group on Status Epilepticus","year":"1993","unstructured":"Epilepsy Foundation of America's Working Group on Status Epilepticus. Recommendations of the Epilepsy Foundation of America's Working group on status Epilepticus. JAMA. 1993;270:854\u20139.","journal-title":"JAMA"},{"issue":"1","key":"887_CR11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1528-1157.1999.tb02000.x","volume":"40","author":"DH Lowenstein","year":"1999","unstructured":"Lowenstein DH, Bleck T, Macdonald RL. It's time to revise the definition of status epilepticus. Epilepsia. 1999;40(1):120\u20132.","journal-title":"Epilepsia"},{"issue":"Suppl 8","key":"887_CR12","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1528-1167.2007.01363.x","volume":"48","author":"DH Lowenstein","year":"2007","unstructured":"Lowenstein DH, Cloyd J. Out-of-hospital treatment of status epilepticus and prolonged seizures. Epilepsia. 2007;48(Suppl 8):96\u20138.","journal-title":"Epilepsia"},{"issue":"16","key":"887_CR13","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1001\/jama.2014.2625","volume":"311","author":"JM Chamberlain","year":"2014","unstructured":"Chamberlain JM, Okada P, Holsti M, Mahajan P, Brown KM, Vance C, et al. PECARN. Lorazepam vs diazepam for pediatric status epilepticus: a randomized controlled trial. JAMA. 2014;311(16):1652\u201360.","journal-title":"JAMA"},{"key":"887_CR14","doi-asserted-by":"crossref","unstructured":"Babl F, Sheriff N, Borland M, Acworth J, Neutze J, Krieser D, et al. Emergency management of paediatric status epilepticus in Australia and New Zealand: practice patterns in the context of clinical practice guidelines. J Paediatr Child Health. 2009;45(9):541\u20136.","DOI":"10.1111\/j.1440-1754.2009.01536.x"},{"key":"887_CR15","doi-asserted-by":"crossref","unstructured":"Lewena S, Pennington V, Acworth J, Thornton S, Ngo P, Mcintyre S, et al. Emergency management of pediatric convulsive status epilepticus. Pediatr Emerg Care. 2009;25(2):83\u20137.","DOI":"10.1097\/PEC.0b013e318196ea6e"},{"issue":"10","key":"887_CR16","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/PEC.0b013e318188fcac","volume":"24","author":"NS Abend","year":"2008","unstructured":"Abend NS, Huh JW, Helfaer MA, Dlugos DJ. Anticonvulsant medications in the pediatric emergency room and intensive care unit. Pediatr Emerg Care. 2008;24(10):705\u201318.","journal-title":"Pediatr Emerg Care"},{"issue":"s9","key":"887_CR17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1528-1167.2008.01929.x","volume":"49","author":"JW Wheless","year":"2008","unstructured":"Wheless JW, Treiman DM. The role of the newer antiepileptic drugs in the treatment of generalized convulsive status epilepticus. Epilepsia. 2008;49(s9):74\u20138.","journal-title":"Epilepsia"},{"key":"887_CR18","volume-title":"Rapid response report NPSA\/2010\/RRR018 Preventing fatalities from medication loading doses","author":"National Patient Safety Agency","year":"2010","unstructured":"National Patient Safety Agency. Rapid response report NPSA\/2010\/RRR018 Preventing fatalities from medication loading doses. London: National Patient Safety Agency; 2010."},{"key":"887_CR19","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/jnnp.2007.130260","volume":"79","author":"S Knake","year":"2008","unstructured":"Knake S, Gruener J, Hattemer K, Klein KM, Bauer S, Oertel WH, et al. Intravenous levetiracetam in the treatment of benzodiazepine refractory status epilepticus. J Neurol Neurosurg Psychiatry. 2008;79:588\u20139.","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"887_CR20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.eplepsyres.2008.05.004","volume":"81","author":"C Michaelides","year":"2008","unstructured":"Michaelides C, Thibert RL, Shapiro MJ, Kinirons P, John T, Manchharam D, et al. Tolerability and dosing experience of intravenous levetiracetam in children and infants. Epilepsy Res. 2008;81:143\u20137.","journal-title":"Epilepsy Res."},{"key":"887_CR21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.pediatrneurol.2007.11.003","volume":"38","author":"JS Goraya","year":"2008","unstructured":"Goraya JS, Khurana DS, Valencia I, Melvin JJ, Cruz M, Legido A, et al. Intravenous Levetiracetam in children with epilepsy. Pediatr Neurol. 2008;38:177\u201380.","journal-title":"Pediatr Neurol."},{"issue":"1","key":"887_CR22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.pediatrneurol.2009.02.016","volume":"41","author":"BF Kirmani","year":"2009","unstructured":"Kirmani BF, Crisp ED, Kayani S, Rajab H. Role of intravenous levetiracetam in acute seizure management of children. Pediatr Neurol. 2009;41(1):37\u20139.","journal-title":"Pediatr Neurol"},{"issue":"4","key":"887_CR23","first-page":"409","volume":"3","author":"JW Wheless","year":"2007","unstructured":"Wheless JW. Levetiracetam in the treatment of childhood epilepsy. Neuropsychiatr Dis Treat. 2007;3(4):409\u201321.","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"s6","key":"887_CR24","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1528-1167.2007.01252_5.x","volume":"48","author":"M Gustafson","year":"2007","unstructured":"Gustafson M, Ritter FJ, Frost MD, Doescher J. Review of over 400 intravenous levetiracetam administrations in pediatric patients ages newborn through 11 years of age. Epilepsia. 2007;48(s6):248\u2013380.","journal-title":"Epilepsia"},{"key":"887_CR25","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.seizure.2007.02.004","volume":"16","author":"S Grosso","year":"2007","unstructured":"Grosso S, Cordelli DM, Franzoni E, Coppola G, Capovilla G, Zamponi N, et al. Efficacy and safety of levetiracetam in infants and young children with refractory epilepsy. Seizure. 2007;16:345\u201350.","journal-title":"Seizure."},{"issue":"8","key":"887_CR26","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1177\/0883073808331351","volume":"24","author":"JW Wheless","year":"2009","unstructured":"Wheless JW, Clarke D, Hovinga CA, Ellis M, Durmeier M, McGregor A, et al. Rapid infusion of a loading dose of intravenous Levetiracetam with minimal dilution: a safety study. J Child Neurol. 2009;24(8):946\u201351.","journal-title":"J Child Neurol"},{"issue":"3","key":"887_CR27","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1528-1167.2006.00959.x","volume":"48","author":"M Baulac","year":"2007","unstructured":"Baulac M, Brodie MJ, Elger CE, Krakow K, Stockis A, Meyvisch P, et al. Levetiracetam intravenous infusion as an alternative to oral dosing in patients with partial-onset seizures. Epilepsia. 2007;48(3):589\u201392.","journal-title":"Epilepsia"},{"issue":"7","key":"887_CR28","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/j.1528-1167.2006.00586.x","volume":"47","author":"S Ramael","year":"2006","unstructured":"Ramael S, Daoust A, Otoul C, Toublanc N, Troenaru M, Lu Z, et al. Levetiracetam intravenous infusion: a randomized, placebo-controlled safety and pharmacokinetic study. Epilepsia. 2006;47(7):1128\u201335.","journal-title":"Epilepsia"},{"key":"887_CR29","volume-title":"Ethical guidelines for intervention studies","author":"National Ethics Advisory Committee","year":"2009","unstructured":"National Ethics Advisory Committee. Ethical guidelines for intervention studies. Wellington: Ministry of Health; 2009."},{"key":"887_CR30","volume-title":"Australian vice-chancellors\u2019 committee. National Statement on ethical conduct in human research: National Health and Medical Research Council","author":"National Health and Medical Research Council, Australian Research Council","year":"2007","unstructured":"National Health and Medical Research Council, Australian Research Council, Australian vice-chancellors\u2019 committee. National Statement on ethical conduct in human research: National Health and Medical Research Council, 2007."},{"issue":"3","key":"887_CR31","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1542\/peds.2004-1803","volume":"117","author":"E Oakley","year":"2006","unstructured":"Oakley E, Stocker S, Staubli G, Young S. Using video recording to identify management errors in pediatric trauma resuscitation. Pediatrics. 2006;117(3):658\u201364.","journal-title":"Pediatrics"},{"issue":"2","key":"887_CR32","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","volume":"42","author":"PA Harris","year":"2009","unstructured":"Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap) - a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377\u201381.","journal-title":"J Biomed Inform"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-017-0887-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T10:46:24Z","timestamp":1569494784000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/s12887-017-0887-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,22]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["887"],"URL":"https:\/\/doi.org\/10.1186\/s12887-017-0887-8","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,22]]},"article-number":"152"}}