{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:24:36Z","timestamp":1793748276933,"version":"4.6.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:00:00Z","timestamp":1520467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12887-018-1069-z","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T07:53:01Z","timestamp":1520495581000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Clinical and genetic characteristics of patients with fatty acid oxidation disorders identified by newborn screening"],"prefix":"10.1186","volume":"18","author":[{"given":"Eungu","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Myung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minji","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Hee","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu-Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Hee","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Wook","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beom Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,8]]},"reference":[{"issue":"5","key":"1069_CR1","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s10545-010-9061-2","volume":"33","author":"SM Houten","year":"2010","unstructured":"Houten SM, Wanders RJ. A general introduction to the biochemistry of mitochondrial fatty acid beta-oxidation. J Inherit Metab Dis. 2010;33(5):469\u201377.","journal-title":"J Inherit Metab Dis"},{"issue":"4","key":"1069_CR2","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1023\/A:1005504223140","volume":"22","author":"RJ Wanders","year":"1999","unstructured":"Wanders RJ, Vreken P, den Boer ME, Wijburg FA, van Gennip AH, IJlst L. Disorders of mitochondrial fatty acyl-CoA beta-oxidation. J Inherit Metab Dis. 1999;22(4):442\u201387.","journal-title":"J Inherit Metab Dis"},{"key":"1069_CR3","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1146\/annurev.physiol.64.082201.154705","volume":"64","author":"P Rinaldo","year":"2002","unstructured":"Rinaldo P, Matern D, Bennett MJ. Fatty acid oxidation disorders. Annu Rev Physiol. 2002;64:477\u2013502.","journal-title":"Annu Rev Physiol"},{"issue":"5","key":"1069_CR4","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s10545-008-0990-y","volume":"31","author":"N Gregersen","year":"2008","unstructured":"Gregersen N, Andresen BS, Pedersen CB, Olsen RK, Corydon TJ, Bross P. Mitochondrial fatty acid oxidation defects--remaining challenges. J Inherit Metab Dis. 2008;31(5):643\u201357.","journal-title":"J Inherit Metab Dis"},{"issue":"5","key":"1069_CR5","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s10545-010-9076-8","volume":"33","author":"M Lindner","year":"2010","unstructured":"Lindner M, Hoffmann GF, Matern D. Newborn screening for disorders of fatty-acid oxidation: experience and recommendations from an expert meeting. J Inherit Metab Dis. 2010;33(5):521\u20136.","journal-title":"J Inherit Metab Dis"},{"issue":"1\u20132","key":"1069_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cccn.2004.11.032","volume":"354","author":"HR Yoon","year":"2005","unstructured":"Yoon HR, Lee KR, Kang S, Lee DH, Yoo HW, Min WK, Cho DH, Shin SM, Kim J, Song J, et al. Screening of newborns and high-risk group of children for inborn metabolic disorders using tandem mass spectrometry in South Korea: a three-year report. Clin Chim Acta. 2005;354(1\u20132):167\u201380.","journal-title":"Clin Chim Acta"},{"issue":"3","key":"1069_CR7","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/humu.1174","volume":"18","author":"N Gregersen","year":"2001","unstructured":"Gregersen N, Andresen BS, Corydon MJ, Corydon TJ, Olsen RK, Bolund L, Bross P. Mutation analysis in mitochondrial fatty acid oxidation defects: exemplified by acyl-CoA dehydrogenase deficiencies, with special focus on genotype-phenotype relationship. Hum Mutat. 2001;18(3):169\u201389.","journal-title":"Hum Mutat"},{"issue":"5","key":"1069_CR8","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s10545-010-9090-x","volume":"33","author":"U Spiekerkoetter","year":"2010","unstructured":"Spiekerkoetter U. Mitochondrial fatty acid oxidation disorders: clinical presentation of long-chain fatty acid oxidation defects before and after newborn screening. J Inherit Metab Dis. 2010;33(5):527\u201332.","journal-title":"J Inherit Metab Dis"},{"issue":"5","key":"1069_CR9","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s10545-010-9115-5","volume":"33","author":"UA Schatz","year":"2010","unstructured":"Schatz UA, Ensenauer R. The clinical manifestation of MCAD deficiency: challenges towards adulthood in the screened population. J Inherit Metab Dis. 2010;33(5):513\u201320.","journal-title":"J Inherit Metab Dis"},{"issue":"1","key":"1069_CR10","first-page":"81","volume":"19","author":"JH Choi","year":"2007","unstructured":"Choi JH, Yoon HR, Kim GH, Park SJ, Shin YL, Yoo HW. Identification of novel mutations of the HADHA and HADHB genes in patients with mitochondrial trifunctional protein deficiency. Int J Mol Med. 2007;19(1):81\u20137.","journal-title":"Int J Mol Med"},{"issue":"1","key":"1069_CR11","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ymgme.2005.09.020","volume":"87","author":"L Waddell","year":"2006","unstructured":"Waddell L, Wiley V, Carpenter K, Bennetts B, Angel L, Andresen BS, Wilcken B. Medium-chain acyl-CoA dehydrogenase deficiency: genotype-biochemical phenotype correlations. Mol Genet Metab. 2006;87(1):32\u20139.","journal-title":"Mol Genet Metab"},{"issue":"2","key":"1069_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ymgme.2008.10.012","volume":"96","author":"J Purevsuren","year":"2009","unstructured":"Purevsuren J, Kobayashi H, Hasegawa Y, Mushimoto Y, Li H, Fukuda S, Shigematsu Y, Fukao T, Yamaguchi S. A novel molecular aspect of Japanese patients with medium-chain acyl-CoA dehydrogenase deficiency (MCADD): c.449-452delCTGA is a common mutation in Japanese patients with MCADD. Mol Genet Metab. 2009;96(2):77\u20139.","journal-title":"Mol Genet Metab"},{"issue":"4","key":"1069_CR13","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1620\/tjem.213.351","volume":"213","author":"K Yokoi","year":"2007","unstructured":"Yokoi K, Ito T, Maeda Y, Nakajima Y, Ueta A, Nomura T, Koyama N, Kato I, Suzuki S, Kurono Y, et al. Acylcarnitine profiles during carnitine loading and fasting tests in a Japanese patient with medium-chain acyl-CoA dehydrogenase deficiency. Tohoku J Exp Med. 2007;213(4):351\u20139.","journal-title":"Tohoku J Exp Med"},{"issue":"5","key":"1069_CR14","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1097\/01.GIM.0000164548.54482.9D","volume":"7","author":"R Ensenauer","year":"2005","unstructured":"Ensenauer R, Winters JL, Parton PA, Kronn DF, Kim JW, Matern D, Rinaldo P, Hahn SH. Genotypic differences of MCAD deficiency in the Asian population: novel genotype and clinical symptoms preceding newborn screening notification. Genet Med. 2005;7(5):339\u201343.","journal-title":"Genet Med"},{"issue":"4","key":"1069_CR15","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.ymgme.2008.09.003","volume":"95","author":"R Jethva","year":"2008","unstructured":"Jethva R, Ficicioglu C. Clinical outcomes of infants with short-chain acyl-coenzyme a dehydrogenase deficiency (SCADD) detected by newborn screening. Mol Genet Metab. 2008;95(4):241\u20132.","journal-title":"Mol Genet Metab"},{"issue":"1","key":"1069_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00439-008-0521-9","volume":"124","author":"CB Pedersen","year":"2008","unstructured":"Pedersen CB, Kolvraa S, Kolvraa A, Stenbroen V, Kjeldsen M, Ensenauer R, Tein I, Matern D, Rinaldo P, Vianey-Saban C, et al. The ACADS gene variation spectrum in 114 patients with short-chain acyl-CoA dehydrogenase (SCAD) deficiency is dominated by missense variations leading to protein misfolding at the cellular level. Hum Genet. 2008;124(1):43\u201356.","journal-title":"Hum Genet"},{"issue":"4","key":"1069_CR17","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/ana.410430422","volume":"43","author":"AH Smelt","year":"1998","unstructured":"Smelt AH, Poorthuis BJ, Onkenhout W, Scholte HR, Andresen BS, van Duinen SG, Gregersen N, Wintzen AR. Very long chain acyl-coenzyme a dehydrogenase deficiency with adult onset. Ann Neurol. 1998;43(4):540\u20134.","journal-title":"Ann Neurol"},{"issue":"2","key":"1069_CR18","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s10545-011-9391-8","volume":"35","author":"L Hoffmann","year":"2012","unstructured":"Hoffmann L, Haussmann U, Mueller M, Spiekerkoetter U. VLCAD enzyme activity determinations in newborns identified by screening: a valuable tool for risk assessment. J Inherit Metab Dis. 2012;35(2):269\u201377.","journal-title":"J Inherit Metab Dis"},{"issue":"1","key":"1069_CR19","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/5030","volume":"21","author":"J Nezu","year":"1999","unstructured":"Nezu J, Tamai I, Oku A, Ohashi R, Yabuuchi H, Hashimoto N, Nikaido H, Sai Y, Koizumi A, Shoji Y, et al. Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nat Genet. 1999;21(1):91\u20134.","journal-title":"Nat Genet"},{"issue":"12","key":"1069_CR20","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1093\/hmg\/8.12.2247","volume":"8","author":"A Koizumi","year":"1999","unstructured":"Koizumi A, Nozaki J, Ohura T, Kayo T, Wada Y, Nezu J, Ohashi R, Tamai I, Shoji Y, Takada G, et al. Genetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiency. Hum Mol Genet. 1999;8(12):2247\u201354.","journal-title":"Hum Mol Genet"},{"issue":"3","key":"1069_CR21","doi-asserted-by":"publisher","first-page":"e19","DOI":"10.1097\/MPG.0b013e3182a95a42","volume":"60","author":"BH Lee","year":"2015","unstructured":"Lee BH, Kim YM, Kim JH, Kim GH, Kim JM, Kim JH, Woo KH, Yang SH, Kim CJ, Choi IH, et al. Atypical manifestation of carnitine palmitoyltransferase 1A deficiency: hepatosplenomegaly and nephromegaly. J Pediatr Gastroenterol Nutr. 2015;60(3):e19\u201322.","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"1069_CR22","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s10545-016-0004-4","volume":"40","author":"YE Landau","year":"2017","unstructured":"Landau YE, Waisbren SE, Chan LM, Levy HL. Long-term outcome of expanded newborn screening at Boston children's hospital: benefits and challenges in defining true disease. J Inherit Metab Dis. 2017;40(2):209\u201318.","journal-title":"J Inherit Metab Dis"},{"key":"1069_CR23","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s13023-015-0236-7","volume":"10","author":"D Karall","year":"2015","unstructured":"Karall D, Brunner-Krainz M, Kogelnig K, Konstantopoulou V, Maier EM, Moslinger D, Plecko B, Sperl W, Volkmar B, Scholl-Burgi S. Clinical outcome, biochemical and therapeutic follow-up in 14 Austrian patients with long-chain 3-Hydroxy acyl CoA dehydrogenase deficiency (LCHADD). Orphanet J Rare Dis. 2015;10:21.","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"1069_CR24","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s10545-010-9244-x","volume":"34","author":"J Sykut-Cegielska","year":"2011","unstructured":"Sykut-Cegielska J, Gradowska W, Piekutowska-Abramczuk D, Andresen BS, Olsen RK, Oltarzewski M, Pronicki M, Pajdowska M, Bogdanska A, Jablonska E, et al. Urgent metabolic service improves survival in long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency detected by symptomatic identification and pilot newborn screening. J Inherit Metab Dis. 2011;34(1):185\u201395.","journal-title":"J Inherit Metab Dis"},{"issue":"4","key":"1069_CR25","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.ymgme.2016.05.007","volume":"118","author":"LD Pena","year":"2016","unstructured":"Pena LD, van Calcar SC, Hansen J, Edick MJ, Walsh Vockley C, Leslie N, Cameron C, Mohsen AW, Berry SA, Arnold GL, et al. Outcomes and genotype-phenotype correlations in 52 individuals with VLCAD deficiency diagnosed by NBS and enrolled in the IBEM-IS database. Mol Genet Metab. 2016;118(4):272\u201381.","journal-title":"Mol Genet Metab"},{"issue":"4","key":"1069_CR26","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1007\/s10545-009-1125-9","volume":"32","author":"U Spiekerkoetter","year":"2009","unstructured":"Spiekerkoetter U, Lindner M, Santer R, Grotzke M, Baumgartner MR, Boehles H, Das A, Haase C, Hennermann JB, Karall D, et al. Management and outcome in 75 individuals with long-chain fatty acid oxidation defects: results from a workshop. J Inherit Metab Dis. 2009;32(4):488\u201397.","journal-title":"J Inherit Metab Dis"},{"issue":"6","key":"1069_CR27","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1002\/humu.10211","volume":"21","author":"U Spiekerkoetter","year":"2003","unstructured":"Spiekerkoetter U, Sun B, Khuchua Z, Bennett MJ, Strauss AW. Molecular and phenotypic heterogeneity in mitochondrial trifunctional protein deficiency due to beta-subunit mutations. Hum Mutat. 2003;21(6):598\u2013607.","journal-title":"Hum Mutat"},{"issue":"4","key":"1069_CR28","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.ymgme.2011.04.006","volume":"103","author":"A Boutron","year":"2011","unstructured":"Boutron A, Acquaviva C, Vianey-Saban C, de Lonlay P, de Baulny HO, Guffon N, Dobbelaere D, Feillet F, Labarthe F, Lamireau D, et al. Comprehensive cDNA study and quantitative analysis of mutant HADHA and HADHB transcripts in a French cohort of 52 patients with mitochondrial trifunctional protein deficiency. Mol Genet Metab. 2011;103(4):341\u20138.","journal-title":"Mol Genet Metab"},{"issue":"6","key":"1069_CR29","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1067\/mpd.2003.231","volume":"142","author":"ME den Boer","year":"2003","unstructured":"den Boer ME, Dionisi-Vici C, Chakrapani A, van Thuijl AO, Wanders RJ, Wijburg FA. Mitochondrial trifunctional protein deficiency: a severe fatty acid oxidation disorder with cardiac and neurologic involvement. J Pediatr. 2003;142(6):684\u20139.","journal-title":"J Pediatr"},{"issue":"1","key":"1069_CR30","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1002\/mus.10500","volume":"29","author":"U Spiekerkoetter","year":"2004","unstructured":"Spiekerkoetter U, Bennett MJ, Ben-Zeev B, Strauss AW, Tein I. Peripheral neuropathy, episodic myoglobinuria, and respiratory failure in deficiency of the mitochondrial trifunctional protein. Muscle Nerve. 2004;29(1):66\u201372.","journal-title":"Muscle Nerve"},{"issue":"3","key":"1069_CR31","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S0022-3476(94)70363-9","volume":"124","author":"AK Iafolla","year":"1994","unstructured":"Iafolla AK, Thompson RJ Jr, Roe CR. Medium-chain acyl-coenzyme a dehydrogenase deficiency: clinical course in 120 affected children. J Pediatr. 1994;124(3):409\u201315.","journal-title":"J Pediatr"},{"issue":"7","key":"1069_CR32","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1093\/clinchem\/47.7.1166","volume":"47","author":"DH Chace","year":"2001","unstructured":"Chace DH, DiPerna JC, Mitchell BL, Sgroi B, Hofman LF, Naylor EW. Electrospray tandem mass spectrometry for analysis of acylcarnitines in dried postmortem blood specimens collected at autopsy from infants with unexplained cause of death. Clin Chem. 2001;47(7):1166\u201382.","journal-title":"Clin Chem"},{"issue":"6","key":"1069_CR33","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s10545-009-1202-0","volume":"32","author":"TF Lang","year":"2009","unstructured":"Lang TF. Adult presentations of medium-chain acyl-CoA dehydrogenase deficiency (MCADD). J Inherit Metab Dis. 2009;32(6):675\u201383.","journal-title":"J Inherit Metab Dis"},{"issue":"4","key":"1069_CR34","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ymgme.2008.09.007","volume":"95","author":"R Jethva","year":"2008","unstructured":"Jethva R, Bennett MJ, Vockley J. Short-chain acyl-coenzyme a dehydrogenase deficiency. Mol Genet Metab. 2008;95(4):195\u2013200.","journal-title":"Mol Genet Metab"},{"issue":"5","key":"1069_CR35","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s10545-017-0047-1","volume":"40","author":"Z Nochi","year":"2017","unstructured":"Nochi Z, Olsen RKJ, Gregersen N. Short-chain acyl-CoA dehydrogenase deficiency: from gene to cell pathology and possible disease mechanisms. J Inherit Metab Dis. 2017;40(5):641\u201355.","journal-title":"J Inherit Metab Dis"},{"issue":"5","key":"1069_CR36","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s10545-012-9542-6","volume":"36","author":"J Baruteau","year":"2013","unstructured":"Baruteau J, Sachs P, Broue P, Brivet M, Abdoul H, Vianey-Saban C, Ogier de Baulny H. Clinical and biological features at diagnosis in mitochondrial fatty acid beta-oxidation defects: a French pediatric study of 187 patients. J Inherit Metab Dis. 2013;36(5):795\u2013803.","journal-title":"J Inherit Metab Dis"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-018-1069-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12887-018-1069-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-018-1069-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T03:40:57Z","timestamp":1603942857000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/s12887-018-1069-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,8]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1069"],"URL":"https:\/\/doi.org\/10.1186\/s12887-018-1069-z","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,8]]},"assertion":[{"value":"28 November 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was conducted after obtaining appropriate written informed consent from the parents of all participants, and the Institutional Review Board (IRB) at Asan Medical Center approved this study (IRB number: 2016\u20131098).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"A written informed consent for publication was obtained from each patient or responsible family member.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No potential conflict of interest relevant to this article was reported.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"103"}}