{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:37:15Z","timestamp":1793317035137,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Backround<\/jats:title>\n                <jats:p>Osteogenesis imperfecta(OI) is a frequent bone fragility disorder in children. The purpose of this study was to assess the BMD and Vitamin D level in children with OI in southern Iran.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>This case-control study was conducted on 23 children, clinically diagnosed as osteogenesis imperfecta and 23 age- and gender-matched healthy controls. Demographic and anthropometric data, biochemical parameters, puberty, sun exposure and physical activity were assessed. Bone mineral density (BMD) was measured by Dual-energy X-ray absorptiometry (DXA). Data analysis was done by SPSS22.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Forty-three point four percent of OI patients and fifty-six point five percent of control group had vitamin D deficiency (<jats:italic>P<\/jats:italic>\u2009=\u20090.376). Thirteen OI patients (56%) had low bone mass for chronological age in lumbar area (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Fracture episodes during treatment was significantly influenced by time of Pamidronate start, courses of Pamidronate injection, puberty and sun exposure (<jats:italic>P<\/jats:italic> values\u2009=\u20090.015, 0.030, 0.044 and 0.032, respectively). Fracture episodes during treatment had significantly increased in patients who had received Pamidronate more than 3\u00a0years compared with those received less than 3 years(<jats:italic>P<\/jats:italic> values\u2009=\u20090.047).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study showed that vitamin D deficiency is prevalent amongst OI children in southern Iran. More than half of the OI children had low bone mass for chronological age in lumbar area, despite receiving bisphosphonate therapy. The present results revealed that early initiation of Pamidronate and number of Pamidronate courses are associated with lower fracture rate. However, treatment period more than 3\u00a0years can have adverse effect on fracture rates.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12887-020-02491-1","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T10:04:01Z","timestamp":1610618641000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Bone density, fractures and the associated factors in iranian children and adolescent with Osteogenesis Imperfecta"],"prefix":"10.1186","volume":"21","author":[{"given":"Pooran","family":"Mohsenzade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anis","family":"Amirhakimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naser","family":"Honar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1900-5242","authenticated-orcid":false,"given":"Forough","family":"Saki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2224-7250","authenticated-orcid":false,"given":"Gholam Hossein Ranjbar","family":"Omrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadhosein","family":"Dabbaghmanesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"issue":"ARTICLE","key":"2491_CR1","first-page":"w14322","volume":"146","author":"A Bregou Bourgeois","year":"2016","unstructured":"Bregou Bourgeois A, Aubry-Rozier B, Bonaf\u00e9 L, Laurent-Applegate LA, Pioletti D, Zambelli P-Y. Osteogenesis imperfecta: from diagnosis and multidisciplinary treatment to future perspectives. Swiss Med Wkly. 2016;146(ARTICLE):w14322.","journal-title":"Swiss Med Wkly"},{"issue":"10028","key":"2491_CR2","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1016\/S0140-6736(15)00728-X","volume":"387","author":"A Forlino","year":"2016","unstructured":"Forlino A, Marini JC. Osteogenesis imperfecta. Lancet. 2016;387(10028):1657\u201371.","journal-title":"Lancet"},{"issue":"10","key":"2491_CR3","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1007\/s00198-015-3156-4","volume":"26","author":"R Kocijan","year":"2015","unstructured":"Kocijan R, Muschitz C, Haschka J, Hans D, Nia A, Geroldinger A, et al. Bone structure assessed by HR-pQCT, TBS and DXL in adult patients with different types of osteogenesis imperfecta. Osteoporos Int. 2015;26(10):2431\u201340.","journal-title":"Osteoporos Int"},{"key":"2491_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bone.2016.02.015","volume":"87","author":"K Lindahl","year":"2016","unstructured":"Lindahl K, Kindmark A, Rubin C-J, Malmgren B, Grigelioniene G, S\u00f6derh\u00e4ll S, et al. Decreased fracture rate, pharmacogenetics and BMD response in 79 Swedish children with osteogenesis imperfecta types I, III and IV treated with Pamidronate. Bone. 2016;87:11\u20138.","journal-title":"Bone"},{"key":"2491_CR5","doi-asserted-by":"crossref","unstructured":"Dwan K, Phillipi CA, Steiner RD, Basel D. Bisphosphonate therapy for osteogenesis imperfecta. Cochrane Database Syst Rev. 2016(10).","DOI":"10.1002\/14651858.CD005088.pub4"},{"key":"2491_CR6","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.bone.2016.02.013","volume":"86","author":"L Plante","year":"2016","unstructured":"Plante L, Veilleux L-N, Glorieux FH, Weiler H, Rauch F. Effect of high-dose vitamin D supplementation on bone density in youth with osteogenesis imperfecta: a randomized controlled trial. Bone. 2016;86:36\u201342.","journal-title":"Bone"},{"issue":"2","key":"2491_CR7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1515\/sjph-2015-0018","volume":"54","author":"N Bratanic","year":"2015","unstructured":"Bratanic N, Dzodan B, Podkrajsek KT, Bertok S, Ostanek B, Marc J, et al. Childhood Osteoporosis and Presentation of Two Cases with Osteogenesis Imperfecta Type V\/Osteoporoza V Otro\u0161ki Dobi in Predstavitev Dveh Bolnikov Z Osteogenesis Imperfecta Tipa V. Slovenian J Public Health. 2015;54(2):119\u201325.","journal-title":"Slovenian J Public Health"},{"issue":"4","key":"2491_CR8","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1097\/BPO.0b013e318173a923","volume":"28","author":"S Poyrazoglu","year":"2008","unstructured":"Poyrazoglu S, Gunoz H, Darendeliler F, Bas F, Tutunculer F, Eryilmaz SK, et al. Successful results of pamidronate treatment in children with osteogenesis imperfecta with emphasis on the interpretation of bone mineral density for local standards. J Pediatr Orthop. 2008;28(4):483\u20137.","journal-title":"J Pediatr Orthop"},{"issue":"10","key":"2491_CR9","doi-asserted-by":"publisher","first-page":"3193","DOI":"10.1210\/jc.2011-1480","volume":"96","author":"T Edouard","year":"2011","unstructured":"Edouard T, Glorieux FH, Rauch F. Predictors and correlates of vitamin D status in children and adolescents with osteogenesis imperfecta. J Clin Endocrinol Metab. 2011;96(10):3193\u20138.","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2491_CR10","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3109\/17453674.2013.831321","volume":"84","author":"DH Kok","year":"2013","unstructured":"Kok DH, Sakkers RJ, Pruijs HE, Joosse P, Castelein RM. Bone mineral density in developing children with osteogenesis imperfecta: a longitudinal study with 9 years of follow-up. Acta Orthop. 2013;84(4):431\u20136.","journal-title":"Acta Orthop"},{"issue":"5","key":"2491_CR11","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1097\/BPO.0b013e318281264f","volume":"33","author":"LD Wilsford","year":"2013","unstructured":"Wilsford LD, Sullivan E, Mazur LJ. Risk factors for vitamin D deficiency in children with osteogenesis imperfecta. J Pediatr Orthop. 2013;33(5):575\u20139.","journal-title":"J Pediatr Orthop"},{"issue":"6","key":"2491_CR12","doi-asserted-by":"publisher","first-page":"e1585-e90","DOI":"10.1542\/peds.2007-2111","volume":"121","author":"SA Bowden","year":"2008","unstructured":"Bowden SA, Robinson RF, Carr R, Mahan JD. Prevalence of vitamin D deficiency and insufficiency in children with osteopenia or osteoporosis referred to a pediatric metabolic bone clinic. Pediatrics. 2008;121(6):e1585-e90.","journal-title":"Pediatrics"},{"issue":"2","key":"2491_CR13","first-page":"A4376","volume":"59","author":"SB Renstrom","year":"2012","unstructured":"Renstrom SB, Andersen CS, Pedersen CH, Madsen FF. Correct measurement of height is important when assessing lung function values. Dan Med J. 2012;59(2):A4376.","journal-title":"Dan Med J"},{"issue":"4","key":"2491_CR14","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1210\/jc.2011-3015","volume":"97","author":"T Edouard","year":"2012","unstructured":"Edouard T, Husseini A, Glorieux FH, Rauch F. Serum 24,25-dihydroxyvitamin D concentrations in osteogenesis imperfecta: relationship to bone parameters. J Clin Endocrinol Metab. 2012;97(4):1243\u20139.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2491_CR15","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s11657-016-0290-3","volume":"11","author":"MR Bordbar","year":"2016","unstructured":"Bordbar MR, Haghpanah S, Dabbaghmanesh MH, Omrani GR, Saki F. Bone mineral density in children with acute leukemia and its associated factors in Iran: a case-control study. Arch Osteoporosis. 2016;11(1):36.","journal-title":"Arch Osteoporosis"},{"issue":"10","key":"2491_CR16","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1017\/S1368980015001925","volume":"20","author":"F Saki","year":"2017","unstructured":"Saki F, Dabbaghmanesh MH, Omrani GR, Bakhshayeshkaram M. Vitamin D deficiency and its associated risk factors in children and adolescents in southern Iran. Public Health Nutr. 2017;20(10):1851\u20136.","journal-title":"Public Health Nutr"},{"issue":"1","key":"2491_CR17","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s11657-018-0416-x","volume":"13","author":"F Saki","year":"2018","unstructured":"Saki F, Haghpanah S, Zarei T, Dabbaghmanesh MH, Omrani GR, Bordbar M. Investigating the bone mineral density in children with solid tumors in southern Iran: a case\u2013control study. Arch Osteoporosis. 2018;13(1):8.","journal-title":"Arch Osteoporosis"},{"issue":"3","key":"2491_CR18","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1159\/000381953","volume":"24","author":"MA Gouda","year":"2015","unstructured":"Gouda MA. Common Pitfalls in Reporting the Use of SPSS Software. Med Princ Pract. 2015;24(3):300.","journal-title":"Med Princ Pract"},{"issue":"9","key":"2491_CR19","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1002\/jbmr.413","volume":"26","author":"T Edouard","year":"2011","unstructured":"Edouard T, Glorieux FH, Rauch F. Relationship between vitamin D status and bone mineralization, mass, and metabolism in children with osteogenesis imperfecta: histomorphometric study. J Bone Miner Res. 2011;26(9):2245\u201351.","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2491_CR20","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1080\/07315724.2015.1057776","volume":"35","author":"MB Zambrano","year":"2016","unstructured":"Zambrano MB, Brizola E, Pinheiro B, Vanz AP, Mello ED, F\u00e9lix TM. Study of the determinants of vitamin D status in pediatric patients with osteogenesis imperfecta. J Am Coll Nutr. 2016;35(4):339\u201345.","journal-title":"J Am Coll Nutr"},{"issue":"5","key":"2491_CR21","doi-asserted-by":"publisher","first-page":"e10118","DOI":"10.1002\/jbm4.10118","volume":"3","author":"JS Bains","year":"2019","unstructured":"Bains JS, Carter EM, Citron KP, Boskey AL, Shapiro JR, Steiner RD, et al. A Multicenter Observational Cohort Study to Evaluate the Effects of Bisphosphonate Exposure on Bone Mineral Density and Other Health Outcomes in Osteogenesis Imperfecta. JBMR Plus. 2019;3(5):e10118.","journal-title":"JBMR Plus"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-020-02491-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12887-020-02491-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-020-02491-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T10:08:55Z","timestamp":1610618935000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/s12887-020-02491-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,14]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2491"],"URL":"https:\/\/doi.org\/10.1186\/s12887-020-02491-1","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,14]]},"assertion":[{"value":"26 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The local Ethics Committee and Vice-Chancellor of research at Shiraz University of Medical Sciences(SUMS) approved this study with number 95-01-01-13972. All the patients and their parents signed a written informed consent form for participation in the study and any possible publication of their data, after explaining the aim, method and goal of the study for the participants.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the patients signed a written informed consent form for publication of any data from their results after a session of explaining the aim, method, and goal of the study for each participant.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Pooran Mohsenzade, Anis Amirhakimi, Naser Honar, Forough Saki, Gholamhossein Ranjbar Omrani and Mohammadhosein Dabbaghmanesh declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"37"}}