{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T16:45:39Z","timestamp":1761324339718},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Syringomyelia secondary to tuberculous meningitis (TBM) is rarely reported, and is usually a late complication. Acute development of syringomyelia following TBM is an exceedingly rare condition with only a few cases published in adults and no previous reports in children.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present a case of syringomyelia as an acute complication of TBM in a 12-year-old boy despite appropriate chemotherapy. The patient developed spastic paraplegia of the lower limbs with fecal and urinary retention seventeen days after the initial symptoms of TBM. He was managed successfully with continued chemotherapy and high-dose intravenous immunoglobulin (IVIG).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This case reminds us that syrinx formation may be responsible for early neurological deterioration in children being managed for TBM. IVIG may be considered as an effective treatment option for this situation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12887-021-02493-7","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T10:04:01Z","timestamp":1610618641000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute development of syringomyelia following TBM in a pediatric case"],"prefix":"10.1186","volume":"21","author":[{"given":"Ningyuan","family":"Wen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenglin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaomin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"key":"2493_CR1","unstructured":"WHO. Global tuberculosis report 2019. World Health Organization 2019 [cited 2020 July]; Available from: https:\/\/www.who.int\/tb\/publications\/global_report\/en\/."},{"issue":"3","key":"2493_CR2","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.jinf.2009.06.011","volume":"59","author":"G Thwaites","year":"2009","unstructured":"Thwaites G, et al. British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children. J Infect. 2009;59(3):167\u201387.","journal-title":"J Infect"},{"issue":"9","key":"2493_CR3","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/sc.2015.58","volume":"53","author":"RK Garg","year":"2015","unstructured":"Garg RK, Malhotra HS, Gupta R. Spinal cord involvement in tuberculous meningitis. Spinal Cord. 2015;53(9):649\u201357.","journal-title":"Spinal Cord"},{"issue":"3","key":"2493_CR4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1552-6569.2006.00032.x","volume":"16","author":"M Wasay","year":"2006","unstructured":"Wasay M, et al. Neuroimaging of tuberculous myelitis: analysis of ten cases and review of literature. J Neuroimaging. 2006;16(3):197\u2013205.","journal-title":"J Neuroimaging"},{"issue":"3","key":"2493_CR5","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1939-1676.2006.tb02884.x","volume":"20","author":"C Rusbridge","year":"2006","unstructured":"Rusbridge C, Greitz D, Iskandar BJ. Syringomyelia: current concepts in pathogenesis, diagnosis, and treatment. J Vet Intern Med. 2006;20(3):469\u201379.","journal-title":"J Vet Intern Med"},{"issue":"1\u20132","key":"2493_CR6","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/BF01428512","volume":"134","author":"HL Tanghe","year":"1995","unstructured":"Tanghe HL. Magnetic resonance imaging (MRI) in syringomyelia. Acta Neurochir. 1995;134(1\u20132):93\u20139.","journal-title":"Acta Neurochir"},{"issue":"17","key":"2493_CR7","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1056\/NEJMoa040573","volume":"351","author":"GE Thwaites","year":"2004","unstructured":"Thwaites GE, et al. Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N Engl J Med. 2004;351(17):1741\u201351.","journal-title":"N Engl J Med"},{"issue":"1","key":"2493_CR8","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1017\/S0317167100021156","volume":"24","author":"AK Daif","year":"1997","unstructured":"Daif AK, et al. Syringomyelia developing as an acute complication of tuberculous meningitis. Can J Neurolog Sci Le journal canadien des sciences neurologiques. 1997;24(1):73\u20136.","journal-title":"Can J Neurolog Sci Le journal canadien des sciences neurologiques"},{"issue":"4","key":"2493_CR9","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1258\/004947506778604959","volume":"36","author":"A Moghtaderi","year":"2006","unstructured":"Moghtaderi A, Alavi-Naini R, Rahimi-Movaghar V. Syringomyelia: an early complication of tuberculous meningitis. Tropical Doctor. 2006;36(4):254\u20135.","journal-title":"Tropical Doctor"},{"key":"2493_CR10","doi-asserted-by":"crossref","unstructured":"Pandey S, Nayak R, Mehndiratta MM, Early Syringomyelia in Tubercular Meningitis: A Rare Occurrence. J Neurol Res. 2013;3(1):46-8.","DOI":"10.4021\/jnr172w"},{"issue":"10","key":"2493_CR11","first-page":"90","volume":"66","author":"S Ratre","year":"2018","unstructured":"Ratre S, et al. Early Syringomyelia in Tubercular Meningitis. J Assoc Phys India. 2018;66(10):90\u20131.","journal-title":"J Assoc Phys India"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-021-02493-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12887-021-02493-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-021-02493-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T10:08:46Z","timestamp":1610618926000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/s12887-021-02493-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,14]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2493"],"URL":"https:\/\/doi.org\/10.1186\/s12887-021-02493-7","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,14]]},"assertion":[{"value":"20 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s guardian for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"36"}}