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This study was performed to investigate the frequency, characteristics, and outcomes of endocrine complications of IBD in children and adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 127 patients with IBD diagnosed before 18\u00a0years of age [117 with Crohn disease (CD) and 10 with ulcerative colitis (UC)]. Growth profiles, pubertal status, 25-hydroxyvitamin D<jats:sub>3<\/jats:sub>[25(OH)D<jats:sub>3<\/jats:sub>] levels, and BMD were reviewed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Short stature was observed in 14 of 127 (11.0\u2009%) with a mean height-SDS of -2.31\u2009\u00b1\u20090.72. During a 2-year follow-up period, height-SDS did not significantly improve, while weight-SDS significantly improved. Among 109 patients who were older than 13 (girls) or 14 (boys) years of age during the study period, 11 patients (10.1\u2009%) showed delayed puberty, which was associated with low weight-SDS. Vitamin D deficiency was documented in 81.7\u2009% (94\/115) with the average 25(OH)D<jats:sub>3<\/jats:sub>level of 14.5\u2009\u00b1\u20097.0\u00a0ng\/mL. Lumbar BMD Z-score was below \u2212\u20092 SDS in 25 of 119 patients (21.0\u2009%). Height-SDS, weight-SDS, and body mass index (BMI)-SDS were lower in patients with osteoporosis than those without osteoporosis. When pediatric CD activity index scores were high (\u2265\u200930), weight-SDS, BMI-SDS, insulin-like growth factor 1 (IGF-1)-SDS, and testosterone levels were significantly decreased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vitamin D deficiency and osteoporosis are common in pediatric IBD patients. As disease severity deteriorates, weight-SDS, IGF-1-SDS, and testosterone levels were decreased. Optimal pubertal development is necessary for bone health.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12887-021-02496-4","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T10:04:01Z","timestamp":1610618641000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Growth, puberty, and bone health in children and adolescents with inflammatory bowel disease"],"prefix":"10.1186","volume":"21","author":[{"given":"Hye-Young","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Sang","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yena","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunha","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seak-Hee","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Mo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Wook","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1196-7826","authenticated-orcid":false,"given":"Jin-Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"issue":"7152","key":"2496_CR1","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/nature06005","volume":"448","author":"RJ Xavier","year":"2007","unstructured":"Xavier RJ, Podolsky DK. 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