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With this backdrop, the study was undertaken to evaluate the susceptibility trend of\n                      <jats:italic>Salmonella enterica<\/jats:italic>\n                      against the commonly prescribed antibiotics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      All isolates of\n                      <jats:italic>Salmonella enterica<\/jats:italic>\n                      were identified by standard protocols of biotyping and serotyping, then tested against antibiotics by the modified Kirby disk-diffusion method. Minimum Inhibitory Concentration (MIC) of isolates was determined by the agar-dilution method and compared with disk diffusion results and on nalidixic-acid sensitive\/resistant strains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 1815 febrile-pediatric patients, 90(4.9%) isolates of\n                      <jats:italic>Salmonella enterica<\/jats:italic>\n                      [serovar:\n                      <jats:italic>Salmonella<\/jats:italic>\n                      Typhi 62(68.8%) and\n                      <jats:italic>Salmonella<\/jats:italic>\n                      Paratyphi A 28(31.1%)] were recovered. The incidence of infection was higher among males, age groups 5 to 9, and patients enrolling in the out-patient department (OPD). On the disk-diffusion test, most isolates were sensitive against first-line drugs i.e.cephalosporins, and macrolides. However, against quinolones, a huge percentile 93.3%, of isolates were resistant [including 58 Typhiand 26 Paratyphiserovar] while nearly 14% were resistant against fluoroquinolones.\n                    <\/jats:p>\n                    <jats:p>When MICs breakpoint were adjusted as follows: 4\u2009\u03bcg\/ml for azithromycin, \u22651\u2009\u03bcg\/ml for ciprofloxacin, 2\u2009\u03bcg\/ml for ofloxacin, 8\u2009\u03bcg\/ml for nalidixic acid, and 1\u2009\u03bcg\/ml for cefixime, higher sensitivity and specificity achieved. Compared to other tested antibiotics, a low rate of azithromycin resistance was observed. Nevertheless, higher resistance against fluoroquinolones was observed on NARS strain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Higher susceptibility of\n                      <jats:italic>Salmonella enterica<\/jats:italic>\n                      to the conventional anti-typhoidal drugs (amoxicillin, chloramphenicol, cotrimoxazole, cephotaxime) advocates for its reconsideration. Although, the lower susceptibility against fluoroquinolones among nalidixic-acid-resistant Salmonella (NARS) strain negates its empirical use among the study age group.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12887-021-02497-3","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T23:27:45Z","timestamp":1610666865000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Susceptibility pattern of Salmonella enterica against commonly prescribed antibiotics, to febrile-pediatric cases, in low-income countries"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1525-8130","authenticated-orcid":false,"given":"Priyatam","family":"Khadka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Januka","family":"Thapaliya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shovana","family":"Thapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"2497_CR1","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","volume":"392","author":"MA Rahman","year":"2018","unstructured":"Rahman MA, Lorkowski S, et al. 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