{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T03:16:05Z","timestamp":1794539765710,"version":"4.9.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401606"],"award-info":[{"award-number":["81401606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400862"],"award-info":[{"award-number":["81400862"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Project in the Science & Technology Program of Sichuan Province","award":["2019YFS0322"],"award-info":[{"award-number":["2019YFS0322"]}]},{"name":"1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University","award":["2019HXFH056"],"award-info":[{"award-number":["2019HXFH056"]}]},{"DOI":"10.13039\/501100010013","name":"Science Foundation for Excellent Youth Scholars of Sichuan University","doi-asserted-by":"publisher","award":["2015SU04A15"],"award-info":[{"award-number":["2015SU04A15"]}],"id":[{"id":"10.13039\/501100010013","id-type":"DOI","asserted-by":"publisher"}]},{"name":"1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University","award":["2020HXFH048"],"award-info":[{"award-number":["2020HXFH048"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Kaposiform haemangioendothelioma (KHE) is a rare, locally aggressive disorder. The presenting and imaging features of KHE can overlap with other vascular anomalies and tumours. We aimed to analyse the imaging findings of KHE disorder and highlight features most suggestive of this diagnosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The clinical features and imaging findings were retrospectively reviewed in 64 patients with pathological diagnosis of KHE.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of the 64 patients diagnosed with KHE, 36 patients were &lt;\u20096 months and 28 patients were \u2265\u20096 months. The most common presenting features were Kasabach-Merritt phenomenon (KMP, 42.2\u2009%), visible cutaneous lesions (90.6\u2009%), oedema or swelling (43.8\u2009%) and destructive changes or remodelling of adjacent bone (42.2\u2009%). Compared with patients in the group\u2009\u2265\u20096 months, patients in the group\u2009&lt;\u20096 months have higher odds of KMP (<jats:italic>P<\/jats:italic>\u2009=\u20090.000), infiltrative lesion with ill-defined borders (<jats:italic>P<\/jats:italic>\u2009=\u20090.044). The group\u2009\u2265\u20096 months have higher odds of destructive changes or remodelling of adjacent bone (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). In all patients, the lesions in all of the 64 patients were hypointense or isointense compared with muscle on T1-weighted sequences, and hyperintense on T2-weighted or inversion-recovery sequences, nine patients (14.1\u2009%) showed vascularity. There were 28 patients (43.8\u2009%) with characteristic enhancing and infiltrative soft-tissue thickening.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Presence of visible cutaneous lesions with ill-defined borders, destructive changes or remodelling of adjacent bone, severe thrombocytopenia and consumptive coagulopathy should favour the diagnosis of KHE.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12887-021-02573-8","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T10:05:21Z","timestamp":1614765921000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Kaposiform haemangioendothelioma: magnetic resonance imaging features in 64 cases"],"prefix":"10.1186","volume":"21","author":[{"given":"Suhua","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunchao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9289-9660","authenticated-orcid":false,"given":"Yi","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"issue":"1","key":"2573_CR1","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jpeds.2012.06.044","volume":"162","author":"SE Croteau","year":"2013","unstructured":"Croteau SE, Liang MG, Kozakewich HP, Alomari AI, Fishman SJ, Mulliken JB, Trenor CC 3rd. 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