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The factors influencing the therapeutic effects on and survival of HB in children with HB were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      (1) The median age of the enrolled patients was 1.45\u2009years. The most common initial symptom was an abdominal mass (69.0%). The average serum alpha-fetoprotein (AFP) level and platelet count at the initial visit were (97,406.5\u2009\u00b1\u20095022.8) ng\/mL and (418\u2009\u00b1\u2009206)\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L, respectively. The epithelial type was the main pathological type (51.9%). According to the PRETEXT preoperative typing system, the most common stage was stage III (57.0%), whereas according to the postoperative Evans staging system, the most common stage was stage IV (41.8%). At the initial visit, 62 cases (19.6%) had vascular invasion, 52 cases (16.5%) had extrahepatic tumor extension, and 20 cases (6.3%) had tumor rupture. Distant metastasis occurred in 132 cases, and the most common metastatic site was the lung (80.3%). The incidence in East China was relatively high (35.4%). (2) The children were followed up until May 2020 (the median follow-up duration was 62\u2009months). It was found that 194 patients had complete remission and 62 had partial remission. The Kaplan\u2013Meier survival analysis showed that the overall survival was 95.3, 88.2, and 79.8% at 1 year, 3 years, and 5 years, respectively, and the event-free survival was 91.1, 83.2, and 75.1%, respectively. The Cox regression analysis showed that AFP level, platelet count, PRETEXT IV, vascular invasion, and distant metastasis at the initial visit were independent risk factors for the prognosis of children with HB (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 in all).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prognosis of HB was correlated with the AFP level, platelet count, PRETEXT staging, vascular invasion, and distant metastasis at initial diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12887-021-02630-2","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T07:06:28Z","timestamp":1618297588000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Clinical characteristics and prognostic factors of hepatoblastoma in 316 children aged under 3\u2009years \u2013 a 14-year retrospective single-center study"],"prefix":"10.1186","volume":"21","author":[{"given":"Tian","family":"Zhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Min","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Sheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"issue":"10","key":"2630_CR1","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1111\/hpb.12112","volume":"15","author":"BJ Allan","year":"2013","unstructured":"Allan BJ, Parikh PP, Diaz S, et al. 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This study was conducted with approval from the Ethics Committee of Beijing Tongren Hospital Capital Medical University (TRECKY2019\u2013033). This study was conducted in accordance with the declaration of Helsinki. Written informed consent was obtained from the parents of all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"170"}}