{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:38:44Z","timestamp":1788518324502,"version":"build-2803163510"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660209"],"award-info":[{"award-number":["81660209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ewing\u2019s sarcoma is a common malignant bone tumor in children and young adults. Rarely, extra-skeletal soft tissues and visceral organs can also be the site of origin of Ewing\u2019s sarcoma. Primary pulmonary Ewing\u2019s sarcoma is an extremely rare malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report an unusual case of primary pulmonary Ewing\u2019s sarcoma in a 15-year-old girl who initially presented with massive hemothorax. By histopathology evaluation of surgical biopsy specimens, the diagnosis of extraosseous Ewing\u2019s sarcoma was confirmed by both light microscopy and immunohistochemistry. Emergency, open surgery was performed by thoracic surgery at an early stage. After 3 cycles of chemotherapy, the patient was found to be stable at follow-up examination. No more hydrothorax or other symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We have described an extremely rare case of primary pulmonary Ewing\u2019s sarcoma with massive hemothorax. The patient underwent surgical resection and postoperative chemotherapy, no sign of recurrence to date as an outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12887-021-02672-6","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T03:04:39Z","timestamp":1619060679000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Primary pulmonary Ewing\u2019s sarcoma: rare cause of massive hemothorax in a young girl-case report"],"prefix":"10.1186","volume":"21","author":[{"given":"Xuefeng","family":"Ling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"2672_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3390\/children5120165","volume":"5","author":"JP Gurria","year":"2018","unstructured":"Gurria JP, Dasgupta R. Rhabdomyosarcoma and extraosseous ewing sarcoma. Children. 2018;5:165.","journal-title":"Children"},{"key":"2672_CR2","doi-asserted-by":"publisher","unstructured":"Chen J, Yuan T, Liu X, Hua B, Dong C, Liu Y, et al. Ewing\u2019s sarcoma\/peripheral primitive neuroectodermal tumors in bronchus. Am J Med Sci. 2019;357(1):75\u201380. https:\/\/doi.org\/10.1016\/j.amjms.2018.08.009.","DOI":"10.1016\/j.amjms.2018.08.009"},{"key":"2672_CR3","doi-asserted-by":"publisher","unstructured":"Takigami A, Yamasawa H, Kurosaki A, Sakamoto N, Onuki T, Mato N, et al. Pazopanib confers a progression-free survival in a patient with Ewing\u2019s sarcoma\/primitive neuroectodermal tumor of the lung. Intern Med. 2019;58(9):1335\u20139. https:\/\/doi.org\/10.2169\/internalmedicine.1549-18.","DOI":"10.2169\/internalmedicine.1549-18"},{"issue":"5","key":"2672_CR4","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1111\/1759-7714.12347","volume":"7","author":"K Mizuguchi","year":"2016","unstructured":"Mizuguchi K, Minato H, Onishi H, Mitani Y, Kawai J. Cytopathological findings of primary pulmonary Ewing family of tumors with EWSR1 translocation: a case report. Thorac Cancer. 2016;7(5):602\u20136. https:\/\/doi.org\/10.1111\/1759-7714.12347.","journal-title":"Thorac Cancer"},{"key":"2672_CR5","doi-asserted-by":"publisher","unstructured":"Hirano H, Maeda H, Takeuchi Y, Ose N, Fujita H, Sugita S, et al. Primary pulmonary Ewing sarcoma. Pathol Int. 2016;66(4):239\u201341. https:\/\/doi.org\/10.1111\/pin.12372.","DOI":"10.1111\/pin.12372"},{"key":"2672_CR6","doi-asserted-by":"crossref","unstructured":"Dong M, Liu J, Song Z, Li X, Shi T, Wang D, et al. Primary multiple pulmonary primitive neuroectodermal tumor: case report and literature review. Medicine. 2015;94:e1136.","DOI":"10.1097\/MD.0000000000001136"},{"key":"2672_CR7","first-page":"D5","volume":"8","author":"S Mehra","year":"2014","unstructured":"Mehra S, Atwal SS, Garga UC. Primary pulmonary Ewing\u2019s sarcoma: rare cause of superior vena cava syndrome in children. J Clin Diagn Res. 2014;8:D5\u20136.","journal-title":"J Clin Diagn Res"},{"issue":"2","key":"2672_CR8","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4161\/cbt.22635","volume":"14","author":"M Andrei","year":"2013","unstructured":"Andrei M, Cramer SF, Kramer ZB, Zeidan A, Faltas B. Adult primary pulmonary primitive neuroectodermal tumor: molecular features and translational opportunities. Cancer Biol Ther. 2013;14(2):75\u201380. https:\/\/doi.org\/10.4161\/cbt.22635.","journal-title":"Cancer Biol Ther"},{"key":"2672_CR9","doi-asserted-by":"publisher","unstructured":"Sanna S, Bertolaccini L, Brandolini J, Argnani D, Mengozzi M, Pardolesi A, et al. Uniportal video-assisted thoracoscopic surgery in hemothorax. J Vis Surg. 2017;3:126. https:\/\/doi.org\/10.21037\/jovs.2017.08.06.","DOI":"10.21037\/jovs.2017.08.06"},{"issue":"2","key":"2672_CR10","doi-asserted-by":"publisher","first-page":"832","DOI":"10.2484\/rcr.v8i2.832","volume":"8","author":"N Shet","year":"2013","unstructured":"Shet N, Stanescu L, Deutsch G. Primary extraosseous Ewing sarcoma of the lung: case report and literature review. Radiol Case Rep. 2013;8(2):832. https:\/\/doi.org\/10.2484\/rcr.v8i2.832.","journal-title":"Radiol Case Rep"},{"issue":"6","key":"2672_CR11","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00408-012-9405-9","volume":"190","author":"A Weissferdt","year":"2012","unstructured":"Weissferdt A, Moran CA. Primary pulmonary primitive neuroectodermal tumor (PNET): a clinicopathological and immunohistochemical study of six cases. Lung. 2012;190(6):677\u201383. https:\/\/doi.org\/10.1007\/s00408-012-9405-9.","journal-title":"Lung."},{"issue":"8","key":"2672_CR12","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1097\/RLU.0000000000002659","volume":"44","author":"J Zhang","year":"2019","unstructured":"Zhang J, Dong A, Cui Y, Wang Y. FDG PET\/CT in a case of primary pulmonary Ewing sarcoma. 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A copy of the consent form is available for review by the Editor of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"There is no conflict of interest in this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"194"}}