{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:23:21Z","timestamp":1793852601502,"version":"4.6.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Friede Springer endowed professorship for Global Child Health"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We looked at existing recommendations and supporting evidence on the effectiveness of vitamin K given after birth in preventing the haemorrhagic disease of the newborn (HDN).<\/jats:p><jats:p>We conducted a literature search up to the 10th of December 2019 by using key terms and manual search in selected sources. We summarized the recommendations and the strength of the recommendation when and as reported by the authors. We summarized the main findings of systematic reviews with the certainty of the evidence as reported.<\/jats:p><jats:p>All newborns should receive vitamin K prophylaxis, as it has been proven that oral and intramuscular prophylactic vitamin K given after birth are effective for preventing classical HDN. There are no randomized trials looking at the efficacy of vitamin K supplement on late HDN. There are no randomized trials comparing the oral and intramuscular route of administration of prophylactic vitamin K in newborns. From older trials and surveillance data, it seems that there is no significant difference between the intramuscular and the oral regimens for preventing classical and late HDN, provided that the oral regimen is duly completed. Evidence assessing vitamin K prophylaxis in preterm infants is scarce.<\/jats:p>","DOI":"10.1186\/s12887-021-02701-4","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T09:03:07Z","timestamp":1631091787000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Vitamin K prophylaxis in newborns"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5587-626X","authenticated-orcid":false,"given":"Sophie","family":"Jullien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"issue":"10","key":"2701_CR1","doi-asserted-by":"publisher","first-page":"8308","DOI":"10.3390\/nu7105393","volume":"7","author":"P Clarke","year":"2015","unstructured":"Clarke P, Mitchell SJ, Shearer MJ. Total and differential phylloquinone (vitamin K1) intakes of preterm infants from all sources during the neonatal period. Nutrients. 2015;7(10):8308\u201320. https:\/\/doi.org\/10.3390\/nu7105393.","journal-title":"Nutrients."},{"issue":"S1","key":"2701_CR2","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1038\/jp.2016.30","volume":"36","author":"M Sankar","year":"2016","unstructured":"Sankar M, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul V. Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review. J Perinatol. 2016;36(S1):S29\u201335. https:\/\/doi.org\/10.1038\/jp.2016.30.","journal-title":"J Perinatol"},{"key":"2701_CR3","volume-title":"WHO recommendations on newborn health. Guidelines approved by the WHO guidelines review committee. Geneva","author":"World Health Organization","year":"2017","unstructured":"World Health Organization. WHO recommendations on newborn health. Guidelines approved by the WHO guidelines review committee. Geneva; 2017 [cited 2019 Jun 10]. Available from: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/259269\/WHO-MCA-17.07-eng.pdf;jsessionid=CF264F9448EAE361B5BE63F6B8BD284B?sequence=1"},{"key":"2701_CR4","volume-title":"Pregnancy, Childbirth, Postpartum and Newborn CARE: A guide for essential practice","author":"World Health Organization","year":"2015","unstructured":"World Health Organization. Pregnancy, Childbirth, Postpartum and Newborn CARE: A guide for essential practice. 2015."},{"key":"2701_CR5","volume-title":"Recommendations for management of common childhood conditions: evidence for technical update of pocket book recommendations","author":"World Health Organization","year":"2012","unstructured":"World Health Organization. Recommendations for management of common childhood conditions: evidence for technical update of pocket book recommendations. 2012 [cited 2019 Jun 25]. Available from: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/44774\/9789241502825_eng.pdf?sequence=1"},{"key":"2701_CR6","first-page":"2","volume-title":"Uso profil\u00e1ctico de la vitamina K para la enfermedad hemorr\u00e1gica del reci\u00e9n nacido [Internet]. Recomendaciones PrevInfad\/PAPPS","author":"AC Pall\u00e1s","year":"2010","unstructured":"Pall\u00e1s AC. Uso profil\u00e1ctico de la vitamina K para la enfermedad hemorr\u00e1gica del reci\u00e9n nacido [Internet]. Recomendaciones PrevInfad\/PAPPS; 2010. p. 2\u20136. [cited 2019 Jun 10]. Available from: http:\/\/previnfad.aepap.org\/monografia\/vitamina-k"},{"key":"2701_CR7","volume-title":"Postnatal care up to 8 weeks after birth (CG37)","author":"National Institute for Health and Care Excellence (NICE)","year":"2015","unstructured":"National Institute for Health and Care Excellence (NICE). Postnatal care up to 8 weeks after birth (CG37). 2015."},{"key":"2701_CR8","volume-title":"Vitamin K deficiency bleeding","author":"CDC","year":"2018","unstructured":"CDC. Vitamin K deficiency bleeding. 2018 [cited 2019 Jun 27]. Available from: https:\/\/www.cdc.gov\/ncbddd\/vitamink\/index.html"},{"key":"2701_CR9","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1542\/peds.112.1.191","volume":"112","author":"American Academy of Pediatrics C on F and N","year":"2003","unstructured":"American Academy of Pediatrics C on F and N. Controversies concerning vitamin K and the newborn. Pediatrics. 2003;112:191.","journal-title":"Pediatrics"},{"issue":"6","key":"2701_CR10","first-page":"2020","volume":"145","author":"American Academy of Pediatrics","year":"2020","unstructured":"American Academy of Pediatrics. AAP publications reaffirmed or retired. Pediatrics. 2020;145(6):2020\u20132.","journal-title":"Pediatrics"},{"key":"2701_CR11","first-page":"CD008342","volume":"2","author":"S Ardell","year":"2018","unstructured":"Ardell S, Offringa M, Ovelman C, Soll R. Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates (Review). Cochrane Database Syst Rev. 2018;2:CD008342.","journal-title":"Cochrane Database Syst Rev"},{"key":"2701_CR12","first-page":"CD002776","volume":"4","author":"R Puckett","year":"2010","unstructured":"Puckett R, Offringa M. Prophylactic vitamin K for vitamin K deficiency bleeding in neonates (Review). Cochrane Database Syst Rev. 2010;4:CD002776.","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"2701_CR13","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.farma.2010.09.001","volume":"35","author":"J Mart\u00edn-L\u00f3pez","year":"2011","unstructured":"Mart\u00edn-L\u00f3pez J, Carlos-Gil A, Rodr\u00edguez-L\u00f3pez R, Villegas-Portero R, Luque-Romero L, Flores-Moreno S. La vitamina K como profilaxis para la enfermedad hemorr\u00e1gica del reci\u00e9n nacido. Farm Hosp. 2011;35(3):148\u201355. https:\/\/doi.org\/10.1016\/j.farma.2010.09.001.","journal-title":"Farm Hosp"},{"issue":"7","key":"2701_CR14","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1007\/s00431-019-03391-y","volume":"178","author":"YN L\u00f6wensteyn","year":"2019","unstructured":"L\u00f6wensteyn YN, Jansen NJG, van Heerde M, Klein RH, Kneyber MCJ, Kuiper JW, et al. Increasing the dose of oral vitamin K prophylaxis and its effect on bleeding risk. Eur J Pediatr. 2019;178(7):1033\u201342. https:\/\/doi.org\/10.1007\/s00431-019-03391-y.","journal-title":"Eur J Pediatr"},{"issue":"5","key":"2701_CR15","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4222","volume":"137","author":"M Witt","year":"2016","unstructured":"Witt M, Kvist N, J\u00f8rgensen H, Hulscher JB, Verkade HJ. Prophylactic dosing of vitamin K to prevent bleeding. Pediatrics. 2016;137(5):e20154222. https:\/\/doi.org\/10.1542\/peds.2015-4222.","journal-title":"Pediatrics."},{"issue":"1","key":"2701_CR16","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1097\/MPG.0000000000001232","volume":"63","author":"WA Mihatsch","year":"2016","unstructured":"Mihatsch WA, Braegger C, Bronsky J, Campoy C, Domell\u00f6f M, Fewtrell M, et al. Prevention of vitamin K deficiency bleeding in newborn infants: a position paper by the ESPGHAN committee on nutrition. J Pediatr Gastroenterol Nutr. 2016;63(1):123\u20139. https:\/\/doi.org\/10.1097\/MPG.0000000000001232.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2701_CR17","volume-title":"Neonatal vitamin K administration for the prevention of hemorrhagic disease: A review of the clinical effectiveness, comparative effectiveness, and guidelines","author":"Canadian Agency for Drugs and Technologies in Health","year":"2015","unstructured":"Canadian Agency for Drugs and Technologies in Health. Neonatal vitamin K administration for the prevention of hemorrhagic disease: A review of the clinical effectiveness, comparative effectiveness, and guidelines. 2015."},{"issue":"1","key":"2701_CR18","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1136\/archdischild-2011-301029","volume":"98","author":"A Busfield","year":"2013","unstructured":"Busfield A, Samuel R, McNinch A, Tripp J. Vitamin K deficiency bleeding after NICE guidance and withdrawal of Konakion neonatal: British Paediatric surveillance unit study, 2006\u20132008. Arch Dis Child. 2013;98(1):41\u20137. https:\/\/doi.org\/10.1136\/archdischild-2011-301029.","journal-title":"Arch Dis Child"},{"key":"2701_CR19","first-page":"CD008435","volume":"2","author":"C Johnston","year":"2017","unstructured":"Johnston C, Campbell-Yeo M, Disher T, Benoit B, Fernandes A, Streiner D, et al. Skin-to-skin care for procedural pain in neonates (Review). Cochrane Database Syst Rev. 2017;2:CD008435.","journal-title":"Cochrane Database Syst Rev"},{"key":"2701_CR20","first-page":"CD004950","volume":"12","author":"P Shah","year":"2012","unstructured":"Shah P, Herboso C, Aliwalas L, Shah V. Breastfeeding or breast milk for procedural pain in neonates (Review). Cochrane Database Syst Rev. 2012;12:CD004950.","journal-title":"Cochrane Database Syst Rev"},{"key":"2701_CR21","volume-title":"Convention on the Rights of the Child","author":"Rights UNH","year":"1990","unstructured":"Rights UNH. Convention on the Rights of the Child. 1990 [cited 2019 Jul 29]. Available from: https:\/\/www.ohchr.org\/en\/professionalinterest\/pages\/crc.aspx"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-021-02701-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12887-021-02701-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-021-02701-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T09:06:17Z","timestamp":1631091977000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/s12887-021-02701-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":21,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["2701"],"URL":"https:\/\/doi.org\/10.1186\/s12887-021-02701-4","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"13 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"SJ had a contract and was paid as an independent consultant by the WHO via Witten\/ Herdecke University, ECPCP and EPA\/UNEPSA for developing the different articles of this supplement.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"350"}}