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Hence, we designed this study to analyze the latest data and the possible predictive factors on transient and permanent CH in this province.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>This cross sectional study is based on the Fars province screening data from 2013 to 2016. A total of 294,214 newborns were screened with 938 confirmed cases of CH, which were included in this study. After recall and completion of the missing data, follow-up data for 642 CH cases with thyroid stimulating hormone (TSH) concentrations and levothyroxine doses for ten outpatient visits and final transient vs. permanent CH diagnosis were included.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The incidence rate was 1:313.66, and out of the 642 CH cases, 66.04\u2009% had permanent CH, while 33.96\u2009% had transient CH. TSH level trend during the outpatient visits were not statistically different between the two groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.312). A cutoff point of &gt;\u20092.25 levothyroxine \u00b5g\/kg (sensitivity: 76.11\u2009%, specificity: 58.52\u2009%) at the third year and a TSH concentration of &gt;\u200943.35 mIU\/L at the venous sampling (initial TSH) (sensitivity: 31.66\u2009%, specificity: 90.32\u2009%) were the predictive factors for permanent CH.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Fars province has one of the highest incidence rate of CH in Iran. Levothyroxine dose at the 3rd year and the 1st venous TSH sample are the predictive factors for permanent CH in the Iranian population; however, TSH concentrations during follow ups are unreliable predictors.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12887-021-02729-6","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T06:04:54Z","timestamp":1622873094000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prevalence and predictive factors of transient and permanent congenital hypothyroidism in Fars province, Iran"],"prefix":"10.1186","volume":"21","author":[{"given":"Ashkan","family":"Habib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Shojazadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohadeseh","family":"Molayemat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asadollah","family":"Habib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Jeddi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Arabsolghar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Nahas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazila","family":"Rahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba Moradi","family":"Ardekani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,5]]},"reference":[{"issue":"11","key":"2729_CR1","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1089\/105072503770867174","volume":"13","author":"J Bernal","year":"2003","unstructured":"Bernal J, Guada\u00f1o-Ferraz A, Morte B. 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Signed informed consent was taken from the recalled participants\u2019 parents. Retrospective data were anonymized with randomly assigned case numbers. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"264"}}