{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T21:16:19Z","timestamp":1782767779583,"version":"3.54.5"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>This study aimed to provide UK data describing the incidence of patent ductus arteriosus (PDA) surgery in the neonatal population, including: pre-ligation management, and outcomes until discharge. We used British Paediatric Surveillance Unit (BPSU) methodology; collecting data via questionnaires for preterm neonates undergoing PDA ligation (PDAL) between 1st Sept 2012 \u2013 30th Sept 2013. Infants born less than 37\u2009weeks gestation, who underwent PDAL prior to discharge home, with no other structural cardiac abnormality, were included. Information collected included: patient demographics, pre and post-operative clinical characteristics, pre-operative medical management, post-operative complications and outcome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Over the study, 263 infants underwent PDAL an incidence of 3.07 per 10,000 live births. 88% were born extremely preterm (&lt;\u200928\u2009weeks) and 60% were male. The commonest reasons for ligation were inability to wean respiratory support (83.7%) and haemodynamically significant PDA (87.8%). Pre-operatively 65.7% received medical therapy. Surgery was performed at a median age of 33\u2009days (range 9-260, IQR 24-48); the corrected age was less than 31\u2009+\u20096\u2009week in 50.6% babies at PDAL. Most, (90%), of procedures were open ligation; only 9 (3.4%) were catheter occlusions (PDACO). 20.5% of patients had post-operative complications. The 30-day mortality was 3%, with 93.5% surviving to hospital discharge.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This study showed there was little consensus over medical and surgical management of the PDA or timing of surgery.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12887-021-02734-9","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T06:18:37Z","timestamp":1623219517000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Surgical management of patent ductus arteriosus in pre-term infants - a british paediatric surveillance study"],"prefix":"10.1186","volume":"21","author":[{"given":"A.","family":"Warnock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Szatkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lakshmanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Kelsall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"2734_CR1","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1542\/peds.106.4.659","volume":"106","author":"K Costeloe","year":"2000","unstructured":"Costeloe K, Hennesy E, Gibson AT, Marlow N, Wilkinson AR. The EPIcure study: outcomes to discharge from hospital for infants born at the threshold of viability. Pediatrics. 2000;106:659\u201371.","journal-title":"Pediatrics"},{"key":"2734_CR2","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1542\/peds.2005-1528","volume":"117","author":"J Koch","year":"2006","unstructured":"Koch J, Hensley G, Roy L, Brown S, Ramaciotti C, Rosenfeld C. Prevalence of spontaneous closure of the ductus arteriosus in infants at birthweight of 1000g OR LESS. Pediatrics. 2006;117:1113\u201321.","journal-title":"Pediatrics"},{"key":"2734_CR3","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1067\/mpd.2000.106569","volume":"137","author":"M Kluckow","year":"2000","unstructured":"Kluckow M, Evans N. Ductal shunting, high pulmonary blood flow and pulmonary hemorrhage. 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PDA-TOLERATE Trial: An exploratory randomized controlled trial of treatment of moderate-to-large patent ductus arteriosus at 1 week of age. J Pediatr. 2019;205:41\u201348.e6. https:\/\/doi.org\/10.1016\/j.jpeds.2018.09.012 Epub 2018 Oct 16.PMID: 30340932.","journal-title":"J Pediatr"},{"issue":"1","key":"2734_CR36","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1002\/ccd.27808","volume":"93","author":"S Sathanandam","year":"2019","unstructured":"Sathanandam S, Balduf K, Chilakala S, Washington K, Allen K, Knott-Craig C, et al. Role of Transcatheter patent ductus arteriosus closure in extremely low birth weight infants. 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Funding was through the Sir Peter Tizard Bursary (held by Dr. Lee). Study ethics approval was granted by NRES Committee - East Midlands - Derby (Reference: ECC 3-02(FT6)\/2012.All clinical and study procedures were performed according to approved local protocol. Informed consent from study participants, their parents\/guardians (written or verbal) for use of routinely collected, then anonymized data was not necessary as per BPSU agreement with the national Confidentiality Advisory Group and Health Research Authority.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"270"}}