{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:36:20Z","timestamp":1782398180810,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Patent ductus arteriosus (PDA) is a common complication in very preterm infants. It is known that there is an association between PDA and development of bronchopulmonary dysplasia (BPD) or death before the postmenstrual age (PMA) of 36\u2009weeks, but this association remains one of the most controversial aspects of the problem. The study aimed to evaluate the relationship between PDA, serum NT-proBNP levels at 2\u20133 and 8\u20139\u2009days of life, and BPD\/death in very preterm infants.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Data of 52 preterm infants with a gestational age\u2009&lt;\u200932\u2009weeks, chronological age\u2009&lt;\u200972\u2009h, and PDA diameter\u2009&gt;\u20091.5\u2009mm, enrolled in a randomized controlled trial, were used for the retrospective analysis. All patients underwent daily echocardiographic and two serum NT-proBNP measurements within the first 10\u2009days after birth. Two groups of infants were formed retrospectively at PMA of 36\u2009weeks depending on the outcome, BPD (<jats:italic>n<\/jats:italic>\u2009=\u200918)\/death (<jats:italic>n<\/jats:italic>\u2009=\u20097) or survival without BPD (<jats:italic>n<\/jats:italic>\u2009=\u200927). Receiver operator characteristic (ROC) curve was used to evaluate the predictive performance of serum NT-proBNP levels for BPD\/death occurrence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The percentage of infants who received pharmacological treatment for PDA did not differ between the groups. Based on the area under the ROC curve, serum NT-proBNP levels on the 2\u20133\u2009day of life (AUC\u2009=\u20090.71; 95% confidence interval (CI): 0.56\u20130.9; <jats:italic>p<\/jats:italic>\u2009=\u20090.014)) and on the 8\u20139\u2009day of life (AUC\u2009=\u20090.76; 95% CI: 0.6\u20130.9; <jats:italic>p<\/jats:italic>\u2009=\u20090.002) could reliably predict BPD\/death in very preterm infants who had PDA diameter\u2009&gt;\u20091.5\u2009mm in the first 72\u2009h of life. Hemodynamically significant PDA (hsPDA) was significantly more often detected in newborns with BPD\/death, however, treatment of infants with hsPDA did not reduce the incidence of BPD\/death.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In very preterm infants with PDA &gt;\u20091.5\u2009mm at the age of 24\u201348\u2009h, serum NT-proBNP concentration could reliably predict the development of BPD or death, regardless of the persistence of PDA, with the highest diagnostic value at 8\u20139\u2009days.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>This study is registered in ClinicalTrials.gov - <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03860428\">NCT03860428<\/jats:ext-link> on March 4, 2019.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12887-021-02750-9","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T07:06:01Z","timestamp":1624086361000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Patent ductus arteriosus, systemic NT-proBNP concentrations and development of bronchopulmonary dysplasia in very preterm infants: retrospective data analysis from a randomized controlled trial"],"prefix":"10.1186","volume":"21","author":[{"given":"Solomiia","family":"Potsiurko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmytro","family":"Dobryanskyy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesya","family":"Sekretar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,19]]},"reference":[{"key":"2750_CR1","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jpeds.2016.06.046","volume":"177","author":"SI Sung","year":"2016","unstructured":"Sung SI, Chang YS, Chun JY, Yoon SA, Yoo HS, Ahn SY, et al. 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Informed consent was obtained in written form from parents or legal guardians of all patients involved in the study. All methods in the study were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"286"}}