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This study aimed to investigate medical and other challenges faced by pediatric CF patients in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Treatments and treatment outcomes were retrospectively analyzed for 46 pediatric CF patients diagnosed from August 2009 to June 2019. Pre- and post-treatment results were compared using independent samples t-test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 46 pediatric CF study patients, four died and five were lost to follow-up. Thirty-seven patients were monitored for 0.03 to 9.21\u2009years; patients exhibited fewer attacks of respiratory tract infections after diagnosis (4.49\u2009\u00b1\u20092.13 episodes\/year before diagnosis vs 1.97\u2009\u00b1\u20091.87 times\/year after 1-year treatment,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), significantly reduced sputum production and experienced 1.62\u2009\u00b1\u20091.71 exacerbations\/year. Patient mean body mass index was 16.87\u2009\u00b1\u20093.53 and pancreatic malfunction persisted in 15 patients. For 17 children, no significant differences in lung function were found at follow-up as compared to lung function at diagnosis (FEV\n                      <jats:sub>1<\/jats:sub>\n                      : 82.45%\u2009\u00b1\u200916.56% vs 75.26%\u2009\u00b1\u200922.34%, FVC: 87.18%\u2009\u00b1\u200913.64% vs 86.99%\u2009\u00b1\u200919.95%, FEF\n                      <jats:sub>75%<\/jats:sub>\n                      : 46.51%\u2009\u00b1\u200928.78% vs 36.63%\u2009\u00b1\u200924.30%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.27, 0.97, 0.20, respectively).\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      (17\/27) and bronchiectasis (22\/22) were found during follow-up evaluation. Twenty-four patients (64.8%) maintained good adherence to therapies. Overall, azithromycin and tobramycin treatments were administered for 0.5\u201362\u2009months and 0.5\u201348\u2009months, respectively, and triggered no obvious adverse reactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>No obvious declines in clinical presentation or lung function were found in Chinese pediatric CF patients after receiving standard therapeutic and active treatments, although malnutrition and low compliance were persistent challenges.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12887-021-02789-8","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T19:04:42Z","timestamp":1627412682000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognosis and treatment of 46 Chinese pediatric cystic fibrosis patients"],"prefix":"10.1186","volume":"21","author":[{"given":"Qionghua","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuelin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"issue":"10059","key":"2789_CR1","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1016\/S0140-6736(16)00576-6","volume":"388","author":"JS Elborn","year":"2016","unstructured":"Elborn JS. 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Informed Consent was obtained from parents and\/or legal guardians of the participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"329"}}