{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:17:31Z","timestamp":1785773851661,"version":"3.56.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The most critical concern for the management of childhood intussusception is bowel resection due to intestinal ischemia and necrosis. The early prediction of this problem is of great importance. We investigated the value of various combinations of inflammatory factors to predict intestinal necrosis and resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the medical records of pediatric patients with intussusception who underwent surgical management. During the research period, 47 patients who underwent intestinal resection due to intestinal necrosis and 68 patients who did not undergo intestinal resection were enrolled. We evaluated the diagnostic value of various combinations of inflammatory markers from preoperative laboratory analyses using the receiver operating characteristic (ROC) method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the current cohort, 115 patients underwent operations for intussusception; among them, 47 patients (40.9%) underwent intestinal resections. In the patients with intestinal resection, the neutrophil count(\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013), CRP level(\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), platelet\u2013lymphocyte ratio (PLR,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), NLR (neutrophil\u2013lymphocyte ratio,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026), and LCR (lymphocyte\u2013CRP ratio,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) values were significantly higher than those in the patients without any resection. The receiver operating characteristic (ROC) analysis results showed that the combination of lymphocytic count along with C-reactive protein levels (LCR) demonstrated the highest correlation with intestinal resection due to intussusception compared with other parameters in the patients, with a sensitivity of 0.82 (0.73\u20130.86) and specificity of 0.80 (0.57\u20130.94) for the diagnosis of strangulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The preoperative LCR level is a useful marker to predict the need for intestinal resection due to intestinal necrosis in patients with intussusception.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12887-021-03068-2","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T03:02:44Z","timestamp":1639623764000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A promising new predictive factor for detecting bowel resection in childhood intussusception: the lymphocyte-C-reactive protein ratio"],"prefix":"10.1186","volume":"21","author":[{"given":"Bailin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"issue":"9","key":"3068_CR1","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1002\/bjs.1800790906","volume":"79","author":"MD Stringer","year":"1992","unstructured":"Stringer MD, Pablot SM, Brereton RJ. Paediatric intussusception. Br J Surg. 1992 Sep;79(9):867\u201376.","journal-title":"Br J Surg"},{"issue":"8","key":"3068_CR2","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1016\/j.jpedsurg.2017.08.005","volume":"53","author":"X Xie","year":"2018","unstructured":"Xie X, Wu Y, Wang Q, Zhao Y, Chen G, Xiang B. A randomized trial of pneumatic reduction versus hydrostatic reduction for intussusception in pediatric patients. J Pediatr Surg. 2018;53(8):1464\u20138.","journal-title":"J Pediatr Surg"},{"issue":"8","key":"3068_CR3","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1016\/j.jpedsurg.2020.01.049","volume":"55","author":"M Kolar","year":"2020","unstructured":"Kolar M, Pilkington M, Winthrop A, Theivendram A, Lajkosz K, Brogly SB. Diagnosis and treatment of childhood intussusception from 1997 to 2016: a population-based study. J Pediatr Surg. 2020;55(8):1562\u20139.","journal-title":"J Pediatr Surg"},{"issue":"3","key":"3068_CR4","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.jpedsurg.2019.07.003","volume":"55","author":"VV Akello","year":"2020","unstructured":"Akello VV, Cheung M, Kurigamba G, Semakula D, Healy JM, Grabski D, et al. Pediatric intussusception in Uganda: differences in management and outcomes with high-income countries. J Pediatr Surg. 2020;55(3):530\u20134.","journal-title":"J Pediatr Surg"},{"key":"3068_CR5","doi-asserted-by":"publisher","unstructured":"Yildirim M, Dasiran F, Angin YS, Okan I. Lymphocyte-C-reactive protein ratio: a putative predictive factor for intestinal ischemia in strangulated abdominal wall hernias. Hernia. 2020. https:\/\/doi.org\/10.1007\/s10029-020-02174-x.","DOI":"10.1007\/s10029-020-02174-x"},{"issue":"4","key":"3068_CR6","first-page":"593","volume":"26","author":"M \u015eahin","year":"2020","unstructured":"\u015eahin M, Bulu\u015f H, Yavuz A, Turhan VB, \u00d6zt\u00fcrk B, K\u0131l\u0131\u00e7 NA, et al. The role of the lactate level in determining the risk rates of small bowel resection in incarcerated hernias. Ulus Travma Acil Cerrahi Derg. 2020;26(4):593\u20139.","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"issue":"2","key":"3068_CR7","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1097\/SLA.0000000000003239","volume":"272","author":"Y Okugawa","year":"2020","unstructured":"Okugawa Y, Toiyama Y, Yamamoto A, Shigemori T, Ide S, Kitajima T, et al. Lymphocyte-C-reactive protein ratio as promising new marker for predicting surgical and oncological outcomes in colorectal Cancer. Ann Surg. 2020;272(2):342\u201351.","journal-title":"Ann Surg"},{"issue":"1","key":"3068_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3390\/healthcare8010039","volume":"8","author":"E Daldal","year":"2020","unstructured":"Daldal E, Dagmura H. The correlation between complete blood count parameters and appendix diameter for the diagnosis of acute appendicitis. Healthcare (Basel). 2020;8(1):39.","journal-title":"Healthcare (Basel)"},{"issue":"6","key":"3068_CR9","doi-asserted-by":"publisher","first-page":"e575","DOI":"10.1097\/CCM.0000000000003091","volume":"46","author":"J Stroeder","year":"2018","unstructured":"Stroeder J, Bomberg H, Wagenpfeil S, Buecker A, Schaefers HJ, Katoh M, et al. Presepsin and inflammatory markers correlate with occurrence and severity of nonocclusive mesenteric ischemia after cardiovascular surgery. Crit Care Med. 2018;46(6):e575\u201383.","journal-title":"Crit Care Med"},{"issue":"3","key":"3068_CR10","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.clinre.2018.11.002","volume":"43","author":"G Liu","year":"2019","unstructured":"Liu G, Tao J, Zhu Z, Wang W. The early prognostic value of inflammatory markers in patients with acute pancreatitis. Clin Res Hepatol Gastroenterol. 2019;43(3):330\u20137.","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"3068_CR11","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1111\/ped.13003","volume":"58","author":"K Yoshimaru","year":"2016","unstructured":"Yoshimaru K, Kinoshita Y, Matsuura T, Esumi G, Wada M, Takahashi Y, et al. Bowel obstruction without history of laparotomy: clinical analysis of 70 patients. Pediatr Int. 2016;58:1205\u201310.","journal-title":"Pediatr Int"},{"issue":"3","key":"3068_CR12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.5223\/pghn.2019.22.3.291","volume":"22","author":"HH Kim","year":"2019","unstructured":"Kim HH, Kang H, Park CH, Kwon YJ, Jung E, Lim M. Rapidly progressive small bowel necrosis in a previously healthy child without proven mechanical obstruction. Pediatr Gastroenterol Hepatol Nutr. 2019;22(3):291\u20137.","journal-title":"Pediatr Gastroenterol Hepatol Nutr"},{"key":"3068_CR13","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1007\/s00383-021-04946-7","volume":"37","author":"S Cox","year":"2021","unstructured":"Cox S, Withers A, Arnold M, Chitnis M, de Vos C, Kirsten M, et al. Clinical presentation and management of childhood intussusception in South Africa. Pediatr Surg Int. 2021;37:1361\u201370.","journal-title":"Pediatr Surg Int"},{"key":"3068_CR14","doi-asserted-by":"publisher","first-page":"100360","DOI":"10.1016\/j.tcam.2019.100360","volume":"37","author":"MN Patsikas","year":"2019","unstructured":"Patsikas MN, Papazoglou LG, Paraskevas GK. Current views in the diagnosis and treatment of intestinal intussusception. Top Companion Anim Med. 2019;37:100360.","journal-title":"Top Companion Anim Med"},{"issue":"Pt A","key":"3068_CR15","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ijsu.2016.10.026","volume":"36","author":"H Zhou","year":"2016","unstructured":"Zhou H, Ruan X, Shao X, Huang X, Fang G, Zheng X. Clinical value of the neutrophil\/lymphocyte ratio in diagnosing adult strangulated inguinal hernia. Int J Surg. 2016;36(Pt A):76\u201380.","journal-title":"Int J Surg"},{"key":"3068_CR16","doi-asserted-by":"publisher","unstructured":"Yasui K, Shida D, Nakamura Y, Ahiko Y, Tsukamoto S, Kanemitsu Y. Postoperative, but not preoperative, inflammation-based prognostic markers are prognostic factors in stage III colorectal cancer patients. Br J Cancer. 2020. https:\/\/doi.org\/10.1038\/s41416-020-01189-6.","DOI":"10.1038\/s41416-020-01189-6"},{"issue":"23","key":"3068_CR17","doi-asserted-by":"publisher","first-page":"5558","DOI":"10.12659\/MSM.905728","volume":"22","author":"X Xie","year":"2017","unstructured":"Xie X, Feng S, Tang Z, Chen L, Huang Y, Yang X. Neutrophil-to-lymphocyte ratio predicts the severity of incarcerated groin hernia. Med Sci Monit. 2017;22(23):5558\u201363.","journal-title":"Med Sci Monit"},{"issue":"6","key":"3068_CR18","doi-asserted-by":"publisher","first-page":"dju124","DOI":"10.1093\/jnci\/dju124","volume":"106","author":"AJ Templeton","year":"2014","unstructured":"Templeton AJ, McNamara MG, \u0160eruga B, Vera-Badillo FE, Aneja P, Oca\u00f1a A, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst. 2014;106(6):dju124.","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"3068_CR19","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.ajem.2016.10.055","volume":"35","author":"SY Hwang","year":"2017","unstructured":"Hwang SY, Shin TG, Jo IJ, Jeon K, Suh GY, Lee TR, et al. Neutrophil-to-lymphocyte ratio as a prognostic marker in critically-ill septic patients. Am J Emerg Med. 2017;35(2):234\u20139.","journal-title":"Am J Emerg Med"},{"issue":"12","key":"3068_CR20","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13017-017-0150-5","volume":"7","author":"M Bala","year":"2017","unstructured":"Bala M, Kashuk J, Moore EE, Kluger Y, Biffl W, Gomes CA, et al. Acute mesenteric ischemia: guidelines of the world Society of Emergency Surgery. World J Emerg Surg. 2017;7(12):38.","journal-title":"World J Emerg Surg"},{"issue":"6","key":"3068_CR21","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1159\/000440818","volume":"32","author":"ME Kelly","year":"2015","unstructured":"Kelly ME, Khan A, Riaz M, Bolger JC, Bennani F, Khan W, et al. The utility of neutrophil-to-lymphocyte ratio as a severity predictor of acute appendicitis, length of hospital stay and postoperative complication rates. Dig Surg. 2015;32(6):459\u201363.","journal-title":"Dig Surg"},{"key":"3068_CR22","first-page":"e6372","volume":"11","author":"V Vural","year":"2019","unstructured":"Vural V, Ozozan OV. The usefulness of inflammation-based prognostic scores for the prediction of postoperative mortality in patients who underwent intestinal resection for acute intestinal ischemia. Cureus. 2019;11:e6372.","journal-title":"Cureus"},{"issue":"4","key":"3068_CR23","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1159\/000331494","volume":"11","author":"B Azab","year":"2011","unstructured":"Azab B, Jaglall N, Atallah JP, Lamet A, Raja-Surya V, Farah B, et al. Neutrophil-lymphocyte ratio as a predictor of adverse outcomes of acute pancreatitis. Pancreatology. 2011;11(4):445\u201352.","journal-title":"Pancreatology"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-021-03068-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12887-021-03068-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-021-03068-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T03:02:48Z","timestamp":1639623768000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/s12887-021-03068-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3068"],"URL":"https:\/\/doi.org\/10.1186\/s12887-021-03068-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-936960\/v1","asserted-by":"object"}]},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"25 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"577"}}