{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:48:33Z","timestamp":1789753713813,"version":"4.0.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>The aims of this study were to characterize the evolution of routine blood values within the first 10\u2009days of illness and coronary artery outcome in infants &lt;\u20098\u2009months with Kawasaki disease (KD) and to identify risk factors for coronary artery aneurysm (CAA).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Laboratory data, clinical features and coronary artery outcomes from 78 infants &lt;\u20098\u2009months old and 86 patients between 8\u2009months and 7\u2009years old were retrospectively analyzed. Logistic regression analysis was conducted to evaluate the potential risk factors for CAA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Infants &lt;\u20098\u2009months old were more likely to present with incomplete KD (37.2% vs 4.7%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), erythema and induration at the BCG inoculation site (24.4% vs 3.5%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and CAA (47.4% vs 15.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) even with timely diagnosis and treatment with intravenous immunoglobulin (IVIG) compared with patients \u22658\u2009months old. Clinical feature related to diagnostic criteria for KD including bilateral conjunctival injection, oral changes, unilateral cervical lymphadenopathy and extremity changes were less common in the younger group. During the acute phase, the percentage neutrophils and neutrophil to lymphocyte ratio [NLR] peaked on median illness day 3, followed by white blood cell (WBC) and CRP on median illness day 4, hemoglobin on median illness day 7 and platelet count on median illness day 9. CAA occurred on median illness day 6 and regressed on median illness day 28. Multivariate logistic regression analysis revealed that the peak percentage neutrophils (odds ratio [OR] per 0.1: 1.597, 95% confidence interval [CI]: 1.041\u20132.452, <jats:italic>P<\/jats:italic>\u2009=\u20090.032) and the peak platelet count (OR per 10\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L: 1.029, 95% CI: 1.004\u20131.055, <jats:italic>P<\/jats:italic>\u2009=\u20090.024) were independent risk factors for CAA. Hemoglobin on the 5th day was associated with persistent CAA at 1\u2009year after KD onset.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Factors associated with CAA include a high peak percentage neutrophils, increased peak platelet count, and reduced hemoglobin within 4\u20136\u2009days during the acute phase of KD. Therefore, this population should receive primary therapy with IVIG and adjunctive anti-inflammatory medications.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12887-021-03083-3","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T11:03:35Z","timestamp":1641553415000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Blood routine risk factors for coronary artery aneurysm in infants younger than 8\u2009months with Kawasaki disease"],"prefix":"10.1186","volume":"22","author":[{"given":"Ge","family":"Haiyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Jianming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Suqian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Shuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"issue":"17","key":"3083_CR1","doi-asserted-by":"publisher","first-page":"e927","DOI":"10.1161\/CIR.0000000000000484","volume":"135","author":"BW McCrindle","year":"2017","unstructured":"McCrindle BW, Rowley AH, Newburger JW, et al. 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