{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:01:06Z","timestamp":1768568466849,"version":"3.49.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prenatal diagnosis of foetal imperforate anus is difficult. Most previous studies have been case reports. To provide useful information for diagnosing foetal imperforate anus, a retrospective review of diagnostic approaches was conducted. Ultrasonography was performed in 19 cases of foetal imperforate anus from 2016 to 2019 at our prenatal diagnostic centre. The prenatal sonographic features and outcomes of each case were collected and evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The anal sphincter of a normal foetus shows the \u2018target sign\u2019 on cross-sectional observation. Of the 19 cases of imperforate anus, 16 cases were diagnosed by the ultrasound image feature called the \u2018line sign\u2019. 1 case with tail degeneration was low type imperforate anus with the irregular \u2018target sign\u2019 not a real \u2018target sign\u2019. There was two false-negative case, in which the \u2018target sign\u2019 was found, but irregular.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, we find that the anus of a foetus with imperforate anus presents a \u2018line sign\u2019 on sonographic observation. The absence of the \u2018target sign\u2019 and then the presence of the \u2018line sign\u2019 can assist in the diagnosis of imperforate anus. The \u2018line sign\u2019 can be used as a secondary assessment to determine the type of the malformation following non visualization of the \u2018target sign\u2019. The higher the position of the imperforate anus is, the more obvious the \u2018line sign\u2019. It is worth noting that the finding of the short \u2018line sign\u2019 and irregularr \u2018target sign\u2019 can not ignore the low type imperforate anus.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12887-021-03084-2","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T08:06:58Z","timestamp":1641197218000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Significance of the \u2018line sign\u2019 in the diagnosis of congenital imperforate anus on prenatal ultrasound"],"prefix":"10.1186","volume":"22","author":[{"given":"Chan","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihui","family":"Fei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqun","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"issue":"7","key":"3084_CR1","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1002\/uog.3862","volume":"28","author":"A Brantberg","year":"2006","unstructured":"Brantberg A, Blaas HGK, Haugen SE, Isaksen CV, Eik-Nes SH. 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Written informed consent was obtained prior to examination from all participants. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the pregnant woman or patient\u2019s parent for their personal or clinical details along with identifying images to be published in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15"}}