{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T15:12:56Z","timestamp":1744211576613,"version":"3.37.3"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Multisystem Inflammatory Syndrome in Neonates (MIS-N) can occur following antenatal COVID- 19 infection in the mother. Here we report a rare case of a neonate with Hemophilia A and MIS-N.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 2-day-old baby presented with an intramuscular hematoma, neonatal seizures, and isolated activated partial thromboplastin time (APTT) prolongation. The neurosonogram showed a subdural hematoma. A diagnosis of Hemophilia A was made and was confirmed by factor 8 assay and genetic analysis. Supportive measures and Factor 8 replacement was initiated. A rising trend of inflammatory markers and an ongoing need for mechanical ventilation were noted. As there was a history of COVID-19 in the mother in the third trimester, MIS-N was diagnosed. The baby was treated with intravenous immunoglobulin (IVIG) and steroids, and there was an improvement in the clinical and laboratory markers. However, the baby developed seizures on day 16. There was an increase in the subdural hemorrhage and a further rise in inflammatory markers. A craniostomy and hematoma evacuation was done and the baby improved.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The concurrent occurrence of hemophilia A with intracranial bleed, and MIS-N in a neonate is a diagnostic challenge. It is important to have a high index of suspicion to ensure timely diagnosis and treatment of MIS-N in this pandemic era.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12887-022-03463-3","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T13:06:28Z","timestamp":1657199188000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multisystem inflammatory syndrome in a neonate with severe hemophilia - a diagnostic challenge in COVID times: a case report"],"prefix":"10.1186","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7900-0473","authenticated-orcid":false,"given":"Sumitha","family":"Arun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taliya Grace","family":"Cherian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chepsy","family":"Philip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"issue":"23","key":"3463_CR1","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1056\/NEJM200106073442307","volume":"344","author":"PM Mannucci","year":"2001","unstructured":"Mannucci PM, Tuddenham EG. The hemophilias\u2014from royal genes to gene therapy. N Engl J Med. 2001;344(23):1773\u20139.","journal-title":"N Engl J Med"},{"issue":"7","key":"3463_CR2","doi-asserted-by":"publisher","first-page":"572","DOI":"10.3390\/children8070572","volume":"8","author":"R Pawar","year":"2021","unstructured":"Pawar R, Gavade V, Patil N, Mali V, Girwalkar A, Tarkasband V, et al. Neonatal multisystem inflammatory syndrome (MIS-N) associated with prenatal maternal SARS-CoV-2: a case series. Children. 2021;8(7):572.","journal-title":"Children"},{"issue":"3","key":"3463_CR3","doi-asserted-by":"publisher","first-page":"S166","DOI":"10.1007\/PL00014347","volume":"158","author":"H Pollmann","year":"1999","unstructured":"Pollmann H, Richter H, Ringkamp H, J\u00fcrgens H. When are children diagnosed as having severe hemophilia and when do they start to bleed? A 10-year single-center PUP study. 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Multisystem Inflammatory Syndrome (MIS) 2020 www.cdc.gov\/mis\/mis-c\/hcp\/index.html(Last accessed Nov 22)."},{"issue":"97","key":"3463_CR7","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.jped.2020.10.008","volume":"2","author":"F Lima-Setta","year":"2021","unstructured":"Lima-Setta F, Magalh\u00e3es-Barbosa MC, Rodrigues-Santos G, Figueiredo EA, Jacques MD, Zeitel RD, et al. Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study. J Pediatr. 2021;2(97):354\u201361.","journal-title":"J Pediatr"},{"issue":"6","key":"3463_CR8","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1159\/000366470","volume":"38","author":"R Senn","year":"2014","unstructured":"Senn R, Elkind MS, Montaner J, Christ-Crain M, Katan M. Potential role of blood biomarkers in the management of nontraumatic intracerebral hemorrhage. Cerebrovasc Dis. 2014;38(6):395\u2013409.","journal-title":"Cerebrovasc Dis"},{"issue":"7","key":"3463_CR9","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1097\/INF.0000000000003149","volume":"40","author":"S Godfred-Cato","year":"2021","unstructured":"Godfred-Cato S, Tsang CA, Giovanni J, Abrams J, Oster ME, Lee EH, et al. Multisystem inflammatory syndrome in infants< 12 months of age, United States, may 2020\u2013January 2021. Pediatr Infect Dis J. 2021;40(7):601\u20135.","journal-title":"Pediatr Infect Dis J"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-022-03463-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12887-022-03463-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-022-03463-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T13:10:49Z","timestamp":1657199449000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/s12887-022-03463-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,7]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["3463"],"URL":"https:\/\/doi.org\/10.1186\/s12887-022-03463-3","relation":{},"ISSN":["1471-2431"],"issn-type":[{"type":"electronic","value":"1471-2431"}],"subject":[],"published":{"date-parts":[[2022,7,7]]},"assertion":[{"value":"20 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the baby\u2019s parents to publish the clinical details.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"397"}}