{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:56:51Z","timestamp":1790117811300,"version":"4.0.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Massive neurocysticercosis is a rare form of neurocysticercosis, and can lead to serious conditions and even death.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>Here we present a case of ten-year-old Tibetan girl who developed headache and vomiting. Her brain magnetic resonance imaging (MRI) illustrated lots of intracranial cystic lesions, and no obvious extracranial lesions were found. Serum immunoglobulin G antibodies against cysticerci were positive by the use of an enzyme-linked immunosorbent assay (ELISA). These results in combination with her medical history were in line with massive neurocysticercosis. The patients recovered well after supportive management and antiparasitic treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This case provides insights on the diagnosis and treatment of massive neurocysticercosis. The treatment of patients with massive neurocysticercosis should be in an individualized fashion, and the use of antiparasitic drugs in these patients must be decided after carefully weighing the risks and benefits.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12887-024-04530-7","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T10:02:20Z","timestamp":1706090540000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Massive neurocysticercosis in a ten-year-old girl: a case report"],"prefix":"10.1186","volume":"24","author":[{"given":"Guoguang","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"key":"4530_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1684\/epd.2021.1255","volume":"23","author":"S Balestrini","year":"2021","unstructured":"Balestrini S, Arzimanoglou A, Bl\u00fcmcke I, Scheffer IE, Wiebe S, Zelano J, et al. The aetiologies of epilepsy. Epileptic Disord. 2021;23:1\u201316.","journal-title":"Epileptic Disord"},{"key":"4530_CR2","doi-asserted-by":"publisher","first-page":"e0005153","DOI":"10.1371\/journal.pntd.0005153","volume":"11","author":"G Debacq","year":"2017","unstructured":"Debacq G, Moyano LM, Garcia HH, Boumediene F, Marin B, Ngoungou EB, et al. Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy. PLoS Negl Trop Dis. 2017;11:e0005153.","journal-title":"PLoS Negl Trop Dis"},{"key":"4530_CR3","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1056\/NEJMicm1810953","volume":"380","author":"N Dev","year":"2019","unstructured":"Dev N, Abbas SZ. Disseminated cysticercosis. N Engl J Med. 2019;380:1267.","journal-title":"N Engl J Med"},{"key":"4530_CR4","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/trstmh\/trac097","volume":"117","author":"K Wangda","year":"2023","unstructured":"Wangda K, Kumar N, Garg RK, Malhotra HS, Rizvi I, Uniyal R, et al. Value of whole-body MRI for the assessment of response to albendazole in disseminated neurocysticercosis: a prospective follow-up study. Trans R Soc Trop Med Hyg. 2023;117:271\u20138.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"4530_CR5","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1136\/practneurol-2017-001788","volume":"19","author":"G Delgado-Garc\u00eda","year":"2019","unstructured":"Delgado-Garc\u00eda G, M\u00e9ndez-Zurita VA, Bayliss L, Flores-Rivera J, Fleury A. Neurocysticercosis: mimics and chameleons. Pract Neurol. 2019;19:88\u201395.","journal-title":"Pract Neurol"},{"key":"4530_CR6","doi-asserted-by":"publisher","first-page":"e4882","DOI":"10.1097\/MD.0000000000004882","volume":"95","author":"A Qavi","year":"2016","unstructured":"Qavi A, Garg RK, Malhotra HS, Jain A, Kumar N, Malhotra KP, et al. Disseminated cysticercosis: clinical spectrum, toll-like receptor-4 gene polymorphisms and role of albendazole: a prospective follow-up of 60 cases with a review of 56 published cases. Med (Baltim). 2016;95:e4882.","journal-title":"Med (Baltim)"},{"key":"4530_CR7","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1097\/QCO.0000000000000831","volume":"35","author":"R Pineda-Reyes","year":"2022","unstructured":"Pineda-Reyes R, White AC Jr. Neurocysticercosis: an update on diagnosis, treatment, and prevention. Curr Opin Infect Dis. 2022;35:246\u201354.","journal-title":"Curr Opin Infect Dis"},{"key":"4530_CR8","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jns.2016.11.045","volume":"372","author":"OH Del Brutto","year":"2017","unstructured":"Del Brutto OH, Nash TE, White AC Jr, Rajshekhar V, Wilkins PP, Singh G, et al. Revised diagnostic criteria for neurocysticercosis. J Neurol Sci. 2017;372:202\u201310.","journal-title":"J Neurol Sci"},{"key":"4530_CR9","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1093\/cid\/cix1084","volume":"66","author":"AC White Jr","year":"2018","unstructured":"White AC Jr, Coyle CM, Rajshekhar V, Singh G, Hauser WA, Mohanty A, et al. Diagnosis and treatment of neurocysticercosis: 2017 clinical practice guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH). Clin Infect Dis. 2018;66:e49\u2013e75.","journal-title":"Clin Infect Dis"},{"key":"4530_CR10","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.3390\/pathogens11101212","volume":"11","author":"OH Del Brutto","year":"2022","unstructured":"Del Brutto OH. Human neurocysticercosis: an overview. Pathogens. 2022;11:1212.","journal-title":"Pathogens"},{"key":"4530_CR11","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.cca.2020.05.006","volume":"508","author":"N Arora","year":"2020","unstructured":"Arora N, Kaur R, Rawat SS, Kumar A, Singh AK, Tripathi S, et al. Evaluation of Taenia solium cyst fluid-based enzyme linked immunoelectro transfer blot for neurocysticercosis diagnosis in urban and highly endemic rural population of North India. Clin Chim Acta. 2020;508:16\u201321.","journal-title":"Clin Chim Acta"},{"key":"4530_CR12","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1093\/cid\/ciz541","volume":"70","author":"EM O\u2019Connell","year":"2020","unstructured":"O\u2019Connell EM, Harrison S, Dahlstrom E, Nash T, Nutman TBA, Novel. Highly sensitive quantitative polymerase chain reaction assay for the diagnosis of subarachnoid and ventricular neurocysticercosis and for assessing responses to treatment. Clin Infect Dis. 2020;70:1875\u201381.","journal-title":"Clin Infect Dis"},{"key":"4530_CR13","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1001\/jamaneurol.2018.0463","volume":"75","author":"MR Wilson","year":"2018","unstructured":"Wilson MR, O\u2019Donovan BD, Gelfand JM, Sample HA, Chow FC, Betjemann JP, et al. Chronic meningitis investigated via Metagenomic Next-Generation sequencing. 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In the form the patient\u2019s parents have given their consent for clinical information to be reported in the journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent from the patient and her legal guardians for publication of identifying information\/images in an online open-access publication was obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"79"}}