{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:19:50Z","timestamp":1774261190986,"version":"3.50.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Scurvy is an uncommon disease in developed countries caused by deficiency of vitamin C. We present a case of scurvy in a 14-year-old male with autism with both novel presentation and imaging findings. This case had the novel presentation of lower limb deep vein thrombosis (DVT) secondary to compression of the external iliac vein from large bilateral iliac wing subperiosteal hematomas. Subperiosteal hematoma is a well-recognised feature of scurvy but large and bilateral pelvic subperiosteal hematoma causing DVT has not previously been described.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 14 year old Caucasian male with background of autism and severe dietary restriction presented with lower limb swelling and immobility. He was diagnosed with lower limb DVT. Further investigation revealed an iron deficiency anaemia, and he was found on MRI to have large bilateral subperiosteal iliac hematomata causing compression of the iliac vessels. He improved following treatment with vitamin C replacement and follow-up imaging demonstrated resolution of the DVT and hematoma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>DVT is rare in children and when diagnosed should prompt investigation as to the underlying cause. This case demonstrates an unusual cause of DVT and as an unusual presentation of paediatric scurvy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12887-024-04579-4","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T09:03:47Z","timestamp":1708074227000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pediatric scurvy case report: a novel presentation with deep vein thrombosis secondary to large bilateral spontaneous iliac subperiosteal hematomas"],"prefix":"10.1186","volume":"24","author":[{"given":"Henry Charles","family":"de Boer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasdev Singh","family":"Sawhney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"4579_CR1","doi-asserted-by":"crossref","unstructured":"Khalife R, Grieco A, Khamisa K, Tinmouh A, McCudden C, Saidenberg E. Scurvy, an old story in a new time: the hematologist\u2019s experience. Blood Cells Mol Dis. 2019;76.","DOI":"10.1016\/j.bcmd.2019.01.004"},{"key":"4579_CR2","doi-asserted-by":"crossref","unstructured":"Rowe S, Carr AC. Global vitamin c status and prevalence of deficiency: A cause for concern? Nutrients. 2020.","DOI":"10.3390\/nu12072008"},{"key":"4579_CR3","doi-asserted-by":"crossref","unstructured":"Hiramatsu N, Kuwano S, Tokuyama K, Iwasaki T. A case of repeated hemorrhage of Lower Legs finally diagnosed as Scurvy. Nihon Naika Gakkai Zasshi. 2021;110.","DOI":"10.2169\/naika.110.2256"},{"key":"4579_CR4","doi-asserted-by":"crossref","unstructured":"Ganske A, Kolbe AB, Thomas K, Hull N. Pediatric Scurvy MRI appearance. Radiol Case Rep. 2021;16.","DOI":"10.1016\/j.radcr.2021.02.045"},{"key":"4579_CR5","doi-asserted-by":"crossref","unstructured":"Pan T, Hennrikus EF, Hennrikus WL. Modern day scurvy in pediatric orthopaedics: a forgotten illness. J Pediatr Orthop. 2021;41.","DOI":"10.1097\/BPO.0000000000001731"},{"key":"4579_CR6","doi-asserted-by":"crossref","unstructured":"Gulko E, Collins LK, Murphy RC, Thornhill BA, Taragin BH. MRI findings in pediatric patients with scurvy. Skeletal Radiol. 2015;44.","DOI":"10.1007\/s00256-014-1962-y"},{"key":"4579_CR7","doi-asserted-by":"crossref","unstructured":"Zessis NR, Peters SW, Samet JD, Parzen-Johnson S, Russo LT, Samady W et al. Unusual presentation of Pediatric Scurvy: a necrotic gastrostomy tube site in a 14-Year-old boy. Am J Case Rep. 2023;24.","DOI":"10.12659\/AJCR.940770"},{"key":"4579_CR8","doi-asserted-by":"crossref","unstructured":"Jaffray J, Young G. Deep vein thrombosis in pediatric patients. Pediatr Blood Cancer. 2018.","DOI":"10.1002\/pbc.26881"},{"key":"4579_CR9","doi-asserted-by":"publisher","first-page":"e772","DOI":"10.1097\/MPH.0000000000001679","volume":"42","author":"K Culler","year":"2020","unstructured":"Culler K, Eiswirth P, Donaldson J, Green J, Rajeswaran S. Deep vein thrombosis due to Fecal Impaction. J Pediatr Hematol Oncol. 2020;42:e772\u20134.","journal-title":"J Pediatr Hematol Oncol"},{"key":"4579_CR10","doi-asserted-by":"crossref","unstructured":"Ji L, Yang F, Chen X, Chen J, Cheng X, Yin J et al. Case Report: Rare Iliac Vein Compression (May\u2013Thurner) Syndrome in a Pediatric patient. Front Pediatr. 2021;9.","DOI":"10.3389\/fped.2021.694782"},{"key":"4579_CR11","doi-asserted-by":"crossref","unstructured":"Spentzouris G, Gasparis A, Scriven RJ, Lee TK, Labropoulos N. Natural history of deep vein thrombosis in children. Phlebology. 2015;30.","DOI":"10.1177\/0268355514536154"},{"key":"4579_CR12","doi-asserted-by":"publisher","first-page":"443","DOI":"10.3348\/kjr.2007.8.5.443","volume":"8","author":"SW Choi","year":"2007","unstructured":"Choi SW, Park S-W, Kwon YS, Oh IS, Lim MK, Kim WH, et al. MR Imaging in a child with Scurvy: a Case Report. Korean J Radiol. 2007;8:443.","journal-title":"Korean J Radiol"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-024-04579-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12887-024-04579-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12887-024-04579-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T09:07:34Z","timestamp":1708074454000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/s12887-024-04579-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,16]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4579"],"URL":"https:\/\/doi.org\/10.1186\/s12887-024-04579-4","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,16]]},"assertion":[{"value":"22 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"ethics approval was not applicable for this case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent for publication of their clinical details and\/or clinical images was obtained from the parent of the patient. A copy of the consent form is available for review by the Editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"126"}}